Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice

Circulation

Volumn 104, Issue 4, 2001, Pages 448-454

  Kuhlencordt, Peter J ^b   Gyurko, Robert ^b   Han, Fred ^b   Scherrer Crosbie, Marielle ^b   Aretz, Thomas H ^a   Hajjar, Roger ^b   Picard, Michael H ^b   Huang, Paul L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Massachusetts General Hospital East ^*

Author keywords

Aneurysm; Arteriosclerosis; Coronary disease; Hypertension; Nitric oxide synthase

Indexed keywords

APOLIPOPROTEIN E; NITRIC OXIDE SYNTHASE;

ABDOMINAL AORTA ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ANEURYSM; AORTA DISSECTING ANEURYSM; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; ENZYME DEFICIENCY; HEART FAILURE; HEART INFARCTION; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HYPERTENSION; ISCHEMIC HEART DISEASE; KNOCKOUT MOUSE; LIPID DIET; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TRANSTHORACIC ECHOCARDIOGRAPHY;

EID: 0035943042     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc2901.091399     Document Type: Article

References (34)

1. Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: Use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation
2. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
3. Nitric oxide: Physiology, pathophysiology, and pharmacology
4. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
5. Hypercholesterolemia increases endothelial superoxide anion production
6. 2+/calmodulin-dependent and tetrahydrobiopterin regulatory process
7. The effect of nitric oxide-donating vasodilators on monocyte chemotaxis and intracellular cGMP concentrations in vitro
8. Endothelial dysfunction and neutrophil adherence as critical events in the development of reperfusion injury
9. Nitric oxide (NO) donor molecules: Effect of NO release rate on vascular smooth muscle cell proliferation in vitro
10. Modulation of platelet aggregation by an L-arginine-nitric oxide pathway
11. The effect of nitric oxide release rates on the oxidation of human low density lipoprotein
12. Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
13. Superoxide production and reactive oxygen species signaling by endothelial nitric-oxide synthase
14. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels
15. The role of fluid mechanics in the localization and detection of atherosclerosis
16. Vascular fluid mechanics, the arterial wall, and atherosclerosis
17. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: Cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress
18. Vascular endothelium, hemodynamic forces, and atherogenesis
19. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
20. Hypertension in mice lacking the gene for endothelial nitric oxide synthase
21. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells
22. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis: Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehydelysine in serum
23. Modulation of mouse cardiac function in vivo by eNOS and ANP
24. Echocardiographic determination of risk area size in a murine model of myocardial ischemia
25. Effects of sex and age on atherosclerosis and autoimmunity in apoE-deficient mice
26. The pathogenesis of atherosclerosis: A perspective for the 1990s
27. Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
28. Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury
29. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms
30. Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)ApoE(-/-) mice are ameliorated by enalapril treatment
31. Hypertension and endothelial dysfunction in apolipoprotein E knockout mice
32. Rapid restoration of normal endothelial functions in genetically hyperlipidemic mice by a synthetic mediator of reverse lipid transport
33. Evidence for direct local effect of angiotensin in vascular hypertrophy: In vivo gene transfer of angiotensin converting enzyme
34. Cell biology and genetics of angiotensin in cardiovascular disease