메뉴 건너뛰기




Volumn 91, Issue 1, 2004, Pages 47-53

Fatty acid synthase: A metabolic oncogene in prostate cancer?

Author keywords

Fatty acid synthase; Metabolism; Prostate cancer

Indexed keywords

FATTY ACID SYNTHASE; ENZYME INHIBITOR; LIPID MOBILIZER HORMONE; OXYGEN; PEPTIDE;

EID: 2542445809     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.10708     Document Type: Review
Times cited : (242)

References (67)
  • 1
    • 0034861042 scopus 로고    scopus 로고
    • Truncation of the Mll gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos
    • Ayton P, Sneddon SF, Palmer DB, Rosewell IR, Owen MJ, Young B, Presley R, Subramanian V. 2001. Truncation of the Mll gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos. Genesis 30:201-212.
    • (2001) Genesis , vol.30 , pp. 201-212
    • Ayton, P.1    Sneddon, S.F.2    Palmer, D.B.3    Rosewell, I.R.4    Owen, M.J.5    Young, B.6    Presley, R.7    Subramanian, V.8
  • 2
    • 0035363734 scopus 로고    scopus 로고
    • Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray
    • Bull JH, Ellison G, Patel A, Muir G, Walker M, Underwood M, Khan F, Paskins L. 2001. Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray. Br J Cancer 84:1512-1519.
    • (2001) Br J Cancer , vol.84 , pp. 1512-1519
    • Bull, J.H.1    Ellison, G.2    Patel, A.3    Muir, G.4    Walker, M.5    Underwood, M.6    Khan, F.7    Paskins, L.8
  • 3
    • 0037125383 scopus 로고    scopus 로고
    • Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer
    • Chan JM, Stampfer MJ, Ma J, Gann P, Gaziano JM, Pollak M, Giovannucci E. 2002. Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer. J Natl Cancer Inst 94:1099-1106.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1099-1106
    • Chan, J.M.1    Stampfer, M.J.2    Ma, J.3    Gann, P.4    Gaziano, J.M.5    Pollak, M.6    Giovannucci, E.7
  • 4
    • 0037637624 scopus 로고    scopus 로고
    • Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero
    • Chirala SS, Chang H, Matzuk M, Abu-Elheiga L, Mao J, Mahon K, Finegold M, Wakil SJ. 2003. Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci USA 100:6358-6363.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6358-6363
    • Chirala, S.S.1    Chang, H.2    Matzuk, M.3    Abu-Elheiga, L.4    Mao, J.5    Mahon, K.6    Finegold, M.7    Wakil, S.J.8
  • 5
    • 0033022342 scopus 로고    scopus 로고
    • A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase
    • Craft N, Shostak Y, Carey M, Sawyers CL. 1999. A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat Med 5:280-285.
    • (1999) Nat Med , vol.5 , pp. 280-285
    • Craft, N.1    Shostak, Y.2    Carey, M.3    Sawyers, C.L.4
  • 7
    • 0038418257 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells
    • De Schrijver E, Brusselmans K, Heyns W, Verhoeven G, Swinnen JV. 2003. RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Res 63:3799-3804.
    • (2003) Cancer Res , vol.63 , pp. 3799-3804
    • De Schrijver, E.1    Brusselmans, K.2    Heyns, W.3    Verhoeven, G.4    Swinnen, J.V.5
  • 8
    • 0042710263 scopus 로고    scopus 로고
    • Curcumin (Diferuloyl-Methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells
    • Deeb D, Xu YX, Jiang H, Gao X, Janakiraman N, Chapman RA, Gautam SC. 2003. Curcumin (Diferuloyl-Methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells. Mol Cancer Ther 2:95-103.
    • (2003) Mol Cancer Ther , vol.2 , pp. 95-103
    • Deeb, D.1    Xu, Y.X.2    Jiang, H.3    Gao, X.4    Janakiraman, N.5    Chapman, R.A.6    Gautam, S.C.7
  • 10
    • 0042860122 scopus 로고    scopus 로고
    • Cell biology: Metabolism meets death
    • Downward J. 2003. Cell biology: Metabolism meets death. Nature 424:896-897.
    • (2003) Nature , vol.424 , pp. 896-897
    • Downward, J.1
  • 11
    • 0027716683 scopus 로고
    • Tracing intracellular proteolytic pathways. Proteolysis of fatty acid synthase and other cytoplasmic proteins in the yeast Saccharomyces cerevisiae
    • Egner R, Thumm M, Straub M, Simeon A, Schuller HJ, Wolf DH. 1993. Tracing intracellular proteolytic pathways. Proteolysis of fatty acid synthase and other cytoplasmic proteins in the yeast Saccharomyces cerevisiae. J Biol Chem 268:27269-27276.
    • (1993) J Biol Chem , vol.268 , pp. 27269-27276
    • Egner, R.1    Thumm, M.2    Straub, M.3    Simeon, A.4    Schuller, H.J.5    Wolf, D.H.6
  • 12
    • 0028875706 scopus 로고
    • OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adenocarcinoma of the prostate
    • Epstein JI, Carmichael M, Partin AW. 1995. OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adenocarcinoma of the prostate. Urology 45: 81-86.
    • (1995) Urology , vol.45 , pp. 81-86
    • Epstein, J.I.1    Carmichael, M.2    Partin, A.W.3
  • 14
    • 0037135626 scopus 로고    scopus 로고
    • The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
    • Hannun YA, Obeid LM. 2002. The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind. J Biol Chem 277:25847-25850.
    • (2002) J Biol Chem , vol.277 , pp. 25847-25850
    • Hannun, Y.A.1    Obeid, L.M.2
  • 15
    • 0034791515 scopus 로고    scopus 로고
    • Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway
    • Heemers H, Maes B, Foufelle F, Heyns W, Verhoeven G, Swinnen JV. 2001. Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway. Mol Endocrinol 15:1817-1828.
    • (2001) Mol Endocrinol , vol.15 , pp. 1817-1828
    • Heemers, H.1    Maes, B.2    Foufelle, F.3    Heyns, W.4    Verhoeven, G.5    Swinnen, J.V.6
  • 16
    • 0036733979 scopus 로고    scopus 로고
    • Key role of mitochondria in cerulenin-mediated apoptosis
    • Heiligtag SJ, Bredehorst R, David KA. 2002. Key role of mitochondria in cerulenin-mediated apoptosis. Cell Death Differ 9:1017-1025.
    • (2002) Cell Death Differ , vol.9 , pp. 1017-1025
    • Heiligtag, S.J.1    Bredehorst, R.2    David, K.A.3
  • 19
    • 0036317070 scopus 로고    scopus 로고
    • A new role for apolipoprotein E: Modulating transport of polyunsaturated phospholipid molecular species in synaptic plasma membranes
    • Igbavboa U, Hamilton J, Kim HY, Sun GY, Wood WG. 2002. A new role for apolipoprotein E: Modulating transport of polyunsaturated phospholipid molecular species in synaptic plasma membranes. J Neurochem 80:255-261.
    • (2002) J Neurochem , vol.80 , pp. 255-261
    • Igbavboa, U.1    Hamilton, J.2    Kim, H.Y.3    Sun, G.Y.4    Wood, W.G.5
  • 22
    • 0036605827 scopus 로고    scopus 로고
    • Assay of the concentration and (13)C isotopic enrichment of propionyl-CoA, methylmalonyl-CoA, and succinyl-CoA by gas chromatography-mass spectrometry
    • Kasumov T, Martini WZ, Reszko AE, Bian F, Pierce BA, David F, Roe CR, Brunengraber H. 2002. Assay of the concentration and (13)C isotopic enrichment of propionyl-CoA, methylmalonyl-CoA, and succinyl-CoA by gas chromatography-mass spectrometry. Anal Biochem 305: 90-96.
    • (2002) Anal Biochem , vol.305 , pp. 90-96
    • Kasumov, T.1    Martini, W.Z.2    Reszko, A.E.3    Bian, F.4    Pierce, B.A.5    David, F.6    Roe, C.R.7    Brunengraber, H.8
  • 23
    • 0034002793 scopus 로고    scopus 로고
    • Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology
    • Kuhajda FP. 2000. Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology. Nutrition 16:202-208.
    • (2000) Nutrition , vol.16 , pp. 202-208
    • Kuhajda, F.P.1
  • 26
    • 0035866378 scopus 로고    scopus 로고
    • Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53
    • Li JN, Gorospe M, Chrest FJ, Kumaravel TS, Evans MK, Han WF, Pizer ES. 2001. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. Cancer Res 61:1493-1499.
    • (2001) Cancer Res , vol.61 , pp. 1493-1499
    • Li, J.N.1    Gorospe, M.2    Chrest, F.J.3    Kumaravel, T.S.4    Evans, M.K.5    Han, W.F.6    Pizer, E.S.7
  • 27
    • 0036693899 scopus 로고    scopus 로고
    • A technique for the in vivo study of multiple stable isotope-labeled essential fatty acids
    • Lin Y, Salem N, Jr. 2002. A technique for the in vivo study of multiple stable isotope-labeled essential fatty acids. Prostaglandins Leukot Essent Fatty Acids 67:141-146.
    • (2002) Prostaglandins Leukot Essent Fatty Acids , vol.67 , pp. 141-146
    • Lin, Y.1    Salem Jr., N.2
  • 28
    • 0033571640 scopus 로고    scopus 로고
    • Distinct alterations in phospholipid metabolism in brains of apolipoprotein E-deficient mice
    • Lomnitski L, Oron L, Sklan D, Michaelson DM. 1999. Distinct alterations in phospholipid metabolism in brains of apolipoprotein E-deficient mice. J Neurosci Res 58: 586-592.
    • (1999) J Neurosci Res , vol.58 , pp. 586-592
    • Lomnitski, L.1    Oron, L.2    Sklan, D.3    Michaelson, D.M.4
  • 31
    • 0037089925 scopus 로고    scopus 로고
    • Determination of travoprost and travoprost free acid in human plasma by electrospray HPLC/MS/MS
    • McCue BA, Cason MM, Curtis MA, Faulkner RD, Dahlin DC. 2002. Determination of travoprost and travoprost free acid in human plasma by electrospray HPLC/MS/MS. J Pharm Biomed Anal 28:199-208.
    • (2002) J Pharm Biomed Anal , vol.28 , pp. 199-208
    • McCue, B.A.1    Cason, M.M.2    Curtis, M.A.3    Faulkner, R.D.4    Dahlin, D.C.5
  • 32
    • 0033200172 scopus 로고    scopus 로고
    • Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high GIeason score and advanced stage
    • McMenamin ME, Soung P, Perera S, Kaplan I, Loda M, Sellers WR. 1999. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high GIeason score and advanced stage. Cancer Res 59:4291-4296.
    • (1999) Cancer Res , vol.59 , pp. 4291-4296
    • McMenamin, M.E.1    Soung, P.2    Perera, S.3    Kaplan, I.4    Loda, M.5    Sellers, W.R.6
  • 33
    • 0012249041 scopus 로고
    • Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro
    • Medes G, Thomas A, Weinhouse S. 1953. Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res 13:27-29.
    • (1953) Cancer Res , vol.13 , pp. 27-29
    • Medes, G.1    Thomas, A.2    Weinhouse, S.3
  • 34
    • 0035131412 scopus 로고    scopus 로고
    • Fatty acid synthase: An early molecular marker of progression of prostatic adenocarcinoma to androgen independence
    • Myers RB, Oelschlager DK, Weiss HL, Frost AR, Grizzle WE. 2001. Fatty acid synthase: An early molecular marker of progression of prostatic adenocarcinoma to androgen independence. J Urol 165:1027-1032.
    • (2001) J Urol , vol.165 , pp. 1027-1032
    • Myers, R.B.1    Oelschlager, D.K.2    Weiss, H.L.3    Frost, A.R.4    Grizzle, W.E.5
  • 35
    • 85047697089 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in normal prostate epithelial cells
    • Nesterov A, Ivashchenko Y, Kraft AS. 2002. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in normal prostate epithelial cells. Oncogene 21:1135-1140.
    • (2002) Oncogene , vol.21 , pp. 1135-1140
    • Nesterov, A.1    Ivashchenko, Y.2    Kraft, A.S.3
  • 36
    • 0036892209 scopus 로고    scopus 로고
    • Synergy is achieved by complementation with Apo2L/TRAIL and actinomycin D in Apo2L/TRAIL-mediated apoptosis of prostate cancer cells: Role of XIAP in resistance
    • Ng CP, Zisman A, Bonavida B. 2002. Synergy is achieved by complementation with Apo2L/TRAIL and actinomycin D in Apo2L/TRAIL-mediated apoptosis of prostate cancer cells: Role of XIAP in resistance. Prostate 53: 286-299.
    • (2002) Prostate , vol.53 , pp. 286-299
    • Ng, C.P.1    Zisman, A.2    Bonavida, B.3
  • 37
    • 0021466891 scopus 로고
    • Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor
    • Ookhtens M, Kannan R, Lyon I, Baker N. 1984. Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor. Am J Physiol 247:R146-R153.
    • (1984) Am J Physiol , vol.247
    • Ookhtens, M.1    Kannan, R.2    Lyon, I.3    Baker, N.4
  • 38
    • 0024529257 scopus 로고
    • Hormonal regulation of mouse fatty acid synthase gene transcription in liver
    • Paulauskis JD, Sul HS. 1989. Hormonal regulation of mouse fatty acid synthase gene transcription in liver. J Biol Chem 264:574-577.
    • (1989) J Biol Chem , vol.264 , pp. 574-577
    • Paulauskis, J.D.1    Sul, H.S.2
  • 39
    • 33646244839 scopus 로고    scopus 로고
    • Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model
    • Pflug BR, Pecher SM, Brink AW, Nelson JB, Foster BA. 2003. Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model. Prostate 58:1-9.
    • (2003) Prostate , vol.58 , pp. 1-9
    • Pflug, B.R.1    Pecher, S.M.2    Brink, A.W.3    Nelson, J.B.4    Foster, B.A.5
  • 41
    • 0029971427 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer
    • Pizer ES, Wood FD, Heine HS, Romantsev FE, Pasternack GR, Kuhajda FP. 1996b. Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res 56:1189-1193.
    • (1996) Cancer Res , vol.56 , pp. 1189-1193
    • Pizer, E.S.1    Wood, F.D.2    Heine, H.S.3    Romantsev, F.E.4    Pasternack, G.R.5    Kuhajda, F.P.6
  • 42
    • 0032532655 scopus 로고    scopus 로고
    • Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines
    • Pizer ES, Chrest FJ, DiGiuseppe JA, Han WF. 1998. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Res 58:4611-4615.
    • (1998) Cancer Res , vol.58 , pp. 4611-4615
    • Pizer, E.S.1    Chrest, F.J.2    Digiuseppe, J.A.3    Han, W.F.4
  • 43
    • 0034650757 scopus 로고    scopus 로고
    • Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts
    • Pizer ES, Thupari J, Han WF, Pinn ML, Chrest FJ, Frehywot GL, Townsend CA, Kuhajda FP. 2000. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res 60:213-218.
    • (2000) Cancer Res , vol.60 , pp. 213-218
    • Pizer, E.S.1    Thupari, J.2    Han, W.F.3    Pinn, M.L.4    Chrest, F.J.5    Frehywot, G.L.6    Townsend, C.A.7    Kuhajda, F.P.8
  • 44
    • 0035341888 scopus 로고    scopus 로고
    • Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression
    • Pizer ES, Pflug BR, Bova GS, Han WF, Udan MS, Nelson JB. 2001. Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression. Prostate 47:102-110.
    • (2001) Prostate , vol.47 , pp. 102-110
    • Pizer, E.S.1    Pflug, B.R.2    Bova, G.S.3    Han, W.F.4    Udan, M.S.5    Nelson, J.B.6
  • 47
    • 0037183678 scopus 로고    scopus 로고
    • Effect of a tumour-derived lipid-mobilising factor on glucose and lipid metabolism in vivo
    • Russell ST, Tisdale MJ. 2002. Effect of a tumour-derived lipid-mobilising factor on glucose and lipid metabolism in vivo. Br J Cancer 87:580-584.
    • (2002) Br J Cancer , vol.87 , pp. 580-584
    • Russell, S.T.1    Tisdale, M.J.2
  • 48
    • 0014076991 scopus 로고
    • Control of lipid metabolism in hepatomas: Insensitivity of rate of fatty acid and cholesterol synthesis by mouse hepatoma BW7756 to fasting and to feedback control
    • Sabine JR, Abraham S. 1967. Control of lipid metabolism in hepatomas: Insensitivity of rate of fatty acid and cholesterol synthesis by mouse hepatoma BW7756 to fasting and to feedback control. Cancer Res 27(4):793-799.
    • (1967) Cancer Res , vol.27 , Issue.4 , pp. 793-799
    • Sabine, J.R.1    Abraham, S.2
  • 49
    • 0031945625 scopus 로고    scopus 로고
    • Secondary acute leukemia and myelodysplastic syndrome with 11q23 abnormalities. EU Concerted Action 11q23 Workshop
    • Secker-Walker LM, Moorman AV, Bain BJ, Mehta AB. 1998. Secondary acute leukemia and myelodysplastic syndrome with 11q23 abnormalities. EU Concerted Action 11q23 Workshop. Leukemia 12:840-844.
    • (1998) Leukemia , vol.12 , pp. 840-844
    • Secker-Walker, L.M.1    Moorman, A.V.2    Bain, B.J.3    Mehta, A.B.4
  • 50
    • 0029829119 scopus 로고    scopus 로고
    • Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer
    • Shurbaji MS, Kalbfleisch JH, Thurmond TS. 1996. Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. Hum Pathol 27:917-921.
    • (1996) Hum Pathol , vol.27 , pp. 917-921
    • Shurbaji, M.S.1    Kalbfleisch, J.H.2    Thurmond, T.S.3
  • 52
    • 0030936232 scopus 로고    scopus 로고
    • Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP
    • Swinnen JV, Esquenet M, Goossens K, Heyns W, Verhoeven G. 1997. Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. Cancer Res 57:1086-1090.
    • (1997) Cancer Res , vol.57 , pp. 1086-1090
    • Swinnen, J.V.1    Esquenet, M.2    Goossens, K.3    Heyns, W.4    Verhoeven, G.5
  • 56
    • 0033210820 scopus 로고    scopus 로고
    • Neoplastic conversion of human urothelial cells in vitro by overexpression of H2O2-generating peroxisomal fatty acyl CoA oxidase
    • Tamatani T, Hattori K, Nakashiro K, Hayashi Y, Wu S, Klumpp D, Reddy JK, Oyasu R. 1999. Neoplastic conversion of human urothelial cells in vitro by overexpression of H2O2-generating peroxisomal fatty acyl CoA oxidase. Int J Oncol 15:743-749.
    • (1999) Int J Oncol , vol.15 , pp. 743-749
    • Tamatani, T.1    Hattori, K.2    Nakashiro, K.3    Hayashi, Y.4    Wu, S.5    Klumpp, D.6    Reddy, J.K.7    Oyasu, R.8
  • 57
    • 0034806134 scopus 로고    scopus 로고
    • Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity
    • Thupari JN, Pinn ML, Kuhajda FP. 2001. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun 285: 217-223.
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 217-223
    • Thupari, J.N.1    Pinn, M.L.2    Kuhajda, F.P.3
  • 58
    • 0036157817 scopus 로고    scopus 로고
    • Estrogen treatment of prostate cancer increases triglycerides in lipoproteins as demonstrated by HPLC and immunoseparation techniques
    • Usui S, Suzuki K, Yamanaka H, Nakano T, Nakajima K, Hara Y, Okazaki M. 2002. Estrogen treatment of prostate cancer increases triglycerides in lipoproteins as demonstrated by HPLC and immunoseparation techniques. Clin Chim Acta 317:133-143.
    • (2002) Clin Chim Acta , vol.317 , pp. 133-143
    • Usui, S.1    Suzuki, K.2    Yamanaka, H.3    Nakano, T.4    Nakajima, K.5    Hara, Y.6    Okazaki, M.7
  • 59
    • 0036469122 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells
    • Van de Sande T, De Schrijver E, Heyns W, Verhoeven G, Swinnen JV. 2002. Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. Cancer Res 62:642-646.
    • (2002) Cancer Res , vol.62 , pp. 642-646
    • Van De Sande, T.1    De Schrijver, E.2    Heyns, W.3    Verhoeven, G.4    Swinnen, J.V.5
  • 60
    • 0033289852 scopus 로고    scopus 로고
    • Expression of ribosomal protein S5 cloned gene during differentiation and apoptosis in murine erythroleukemia (MEL) cells
    • Vizirianakis IS, Pappas IS, Gougoumas D, Tsiftsoglou AS. 1999. Expression of ribosomal protein S5 cloned gene during differentiation and apoptosis in murine erythroleukemia (MEL) cells. Oncol Res 11:409-419.
    • (1999) Oncol Res , vol.11 , pp. 409-419
    • Vizirianakis, I.S.1    Pappas, I.S.2    Gougoumas, D.3    Tsiftsoglou, A.S.4
  • 61
    • 0036131203 scopus 로고    scopus 로고
    • Resonant electron capture mass spectrometry of free fatty acids: Examination of ion structures using deuterium-labeled fatty acids and collisional activation
    • Voinov VG, Van den Heuvel H, Claeys M. 2002. Resonant electron capture mass spectrometry of free fatty acids: Examination of ion structures using deuterium-labeled fatty acids and collisional activation. J Mass Spectrom 37:313-321.
    • (2002) J Mass Spectrom , vol.37 , pp. 313-321
    • Voinov, V.G.1    Van Den Heuvel, H.2    Claeys, M.3
  • 63
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warberg O. 1956. On the origin of cancer cells. Science 123:309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warberg, O.1
  • 64
    • 0022786302 scopus 로고
    • Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase
    • Weiss L, Hoffmann GE, Schreiber R, Andres H, Fuchs E, Korber E, Kolb HJ. 1986. Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Biol Chem Hoppe Seyler 367:905-912.
    • (1986) Biol Chem Hoppe Seyler , vol.367 , pp. 905-912
    • Weiss, L.1    Hoffmann, G.E.2    Schreiber, R.3    Andres, H.4    Fuchs, E.5    Korber, E.6    Kolb, H.J.7
  • 66
    • 0036385719 scopus 로고    scopus 로고
    • Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    • Yang YA, Han WF, Morin PJ, Chrest FJ, Pizer ES. 2002. Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp Cell Res 279: 80-90.
    • (2002) Exp Cell Res , vol.279 , pp. 80-90
    • Yang, Y.A.1    Han, W.F.2    Morin, P.J.3    Chrest, F.J.4    Pizer, E.S.5
  • 67
    • 0141894222 scopus 로고    scopus 로고
    • Cloning, expression, characterization and interaction of two components of a human mitochondrial fatty acid synthase: Malonyl transferase and acyl carrier protein
    • in press
    • Zhang L, Joshi AK, Smith S. 2003. Cloning, expression, characterization and interaction of two components of a human mitochondrial fatty acid synthase: Malonyl transferase and acyl carrier protein. J Biol Chem, in press.
    • (2003) J Biol Chem
    • Zhang, L.1    Joshi, A.K.2    Smith, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.