Green tea epigallocatechin gallate: A natural inhibitor of fatty-acid synthase

Biochemical and Biophysical Research Communications

Volumn 288, Issue 5, 2001, Pages 1200-1206

  Wang, Xuan ^a   Tian, Weixi ^a  

^a UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

C75; Epigallocatechin gallate (EGCG); Fatty acid synthase (FAS); Inhibition kinetics; Inhibitor

Indexed keywords

ENZYME INHIBITOR; EPIGALLOCATECHIN GALLATE; FATTY ACID SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CHICKEN; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISSOCIATION; DRUG MECHANISM; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; REDUCTION; TEA;

GALLUS GALLUS;

EID: 0035900577     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5923     Document Type: Article

References (17)

1. The animal fatty acid synthase: One gene, one polypeptide, even enzymes
2. Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology
3. Synthesis and antitumor activity of an inhibitor of fatty-acid synthase
4. Reduced food intake and body weight in mice treated with fatty-acid synthase inhibitors
5. Inhibition of food intake by inhibitors of fatty-acid synthase
6. Flavanol digallates in green tea leaf
7. Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols
8. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate
9. Studies on the reactivity of the essential sulfhydryl groups as a conformational probe for the fatty-acid synthetase of chicken liver. Inactivation by 5,5′-dithiobis-(2-nitrobenzoic acid) and intersubunit cross-linking of the inactivated enzyme
10. The denaturation and inactivation of fatty-acid synthase from duck liver in guanidine hydrochloride
11. Comparative studies of the pigeon liver fatty-acid synthetase complex and its subunits. Kinetics of partial reactions and the number of binding sites for acetyl and malonyl groups
12. The loading site of carboxyl anion on condensation center of fatty acid synthase
13. Inhibition of β-ketoacyl-acyl carrier protein synthase by thiolactomycin and ceyulenin
14. The inhibition effect of carboxylates on fatty acid synthetase
15. Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase
16. Test of chronic toxicity of TPP in rats