Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells

Cancer Research

Volumn 56, Issue 12, 1996, Pages 2745-2747

  Pizer, Ellen S ^a   Jackisch, Christian ^a   Wood, Fawn D ^a   Pasternack, Gary R ^a   Davidson, Nancy E ^a   Kuhajda, Francis P ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERULENIN; DNA FRAGMENT; FATTY ACID; FATTY ACID SYNTHASE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CELL DEATH; ETIOLOGY; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; METABOLIC INHIBITION; PRIORITY JOURNAL;

ANTIBIOTICS, ANTIFUNGAL; APOPTOSIS; BREAST NEOPLASMS; CERULENIN; DNA, NEOPLASM; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; FEMALE; HUMANS; TUMOR CELLS, CULTURED;

EID: 0029949512     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Greenstein, J P. Biochemistry of Cancer, pp. 1-683 New York: Academic Press, Inc., 1954
2. Medes, G , Thomas, A., and Weinhouse, S. Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res., 13: 27-29, 1953.
3. Pizer, E. S. Wood, F. D., Pasternack, G R., and Kuhajda, F. P. Altered fatty acid biosynthesis in endometrial carcinoma. Mod. Pathol., 8: 95A, 1995
4. Bobrow, L. G., Happerfield, L. C., Pasternack, G. R., Smith, P., and Owens, A. H. The expression of fatty acid synthase in primary breast cancer: is it an independent prognostic indicator? Breast Cancer Res. Treat., 27, 159, 1993.
5. Jensen, V., Ladekari, M , Holm-Nielsen, P., Flemming, B S , and Flemming, M. The prognostic value of oncogenic antigen 519 (OA519) expression and proliferative activity detected by antibody MIB-1 in node negative breast cancer. J. Pathol., 176: 343-352, 1995.
6. Hardman, W. Gansler, T , Schaffel, S. and Hennigar, R OA-519 immunostaining portends poor prognosis in ovarian cancer. Mod. Pathol., 8: 90A, 1995.
7. Shurbaji, M. S., Kuhajda, F. P., Pasternack, G. R., and Thurmond, T. S. Expression of oncogenic antigen 519 (OA-519) in prostate cancer is a potential progressive indicator. Am J. Clin. Pathol., 97: 686-691, 1992.
8. Redston, M. S., Kern, S. E., Vogelstein, B., and Hamilton, S. R. Expression of OA519 (haptoglobin-related protein epitopes) in colorectal carcinomas: comparison with molecular genetic alterations and metastasis. Mod. Pathol , 5: 47A, 1992.
9. Rashid, A., Milgraum, L. Z , Pasternack, G. R , Kuhajda, F. P., and Hamilton, S. R Expression of fatty acid synthase in colorectal cancer. Mod. Pathol., 8: 67A, 1995.
10. Epstein, J. I., CarMichael, M., and Partin, A. W. OA-519 (Fatty acid synthase) as an independent predictor of pathologic stage in adenocarcinoma of the prostate. Urology, 45: 81-86, 1995.
11. Omura, S. The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis Bacteriol. Rev., 40: 681-697, 1976.
12. Funabashi, H., Kawaguchi, A. Tomoda, H., Omura, S., Okuda, S., and Iwasaki, S Binding site of cerulenin in fatty acid synthetase. J Biochem., 105: 751-755, 1989.
13. Kuhajda, F. P. Jenner, K., Wood, F D., Hennigar, R A., Jacobs, L. B., Dick, J. D., and Pasternack, G R. Fatty acid synthesis: a potential selective target for antineoplastic therapy Proc Natl Acad. Sci. USA, 91: 6379-6383, 1994.
14. Pizer, E S , Wood, F. D., Pasternack, G. R , and Kuhajda, F. P. Fatty acid synthase (FAS), a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells. Cancer Res., 56: 745-751, 1996.
15. Pizer, E. S , Wood, F D., Heine, H. S., Romantsev, F. R., Pasternack, G. R., and Kuhajda, F. P Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res., 56: 1189-1193, 1996.
16. McCloskey, D. E., Casero, Jr , R A , Woster, P. M , and Davidson, N E. Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue. Cancer Res., 55: 3233-3236, 1995
17. Pizer, E. S , Kurman, R. J., Pasternack, G. R., and Kuhajda, F. P Expression of fatty acid synthase is closely linked to proliferation and decidualization in cycling endometrium. Int J Gynecol. Pathol , in press, 1995.
18. 2+-ATPase mRNA expression in NIH 3T3 cells. Biochem. Biophys. Res. Commun, 197, 1483-1491, 1993