A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2

Journal of Biological Chemistry

Volumn 279, Issue 29, 2004, Pages 30540-30545

  Knowles, Lynn M ^a   Axelrod, Fumiko ^a   Browne, Cecille D ^a   Smith, Jeffrey W ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACIDS; PROTEINS; RNA; TUMORS;

FATTY ACID SYNTHASE (FAS); PROTEOLYSIS;

CELLS;

FATTY ACID; FATTY ACID SYNTHASE; PALMITIC ACID; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; SMALL INTERFERING RNA; TETRAHYDROLIPSTATIN; THIOL ESTER HYDROLASE; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GENE SILENCING; GENE TARGETING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TUMOR CELL; TUMOR CELL CULTURE; UPREGULATION;

AVIDIN; BIOTIN; BLOTTING, WESTERN; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EPITHELIAL CELLS; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; G1 PHASE; HUMANS; LACTONES; LIPASE; OBESITY; PALMITIC ACID; RETINOBLASTOMA PROTEIN; RNA, SMALL INTERFERING; S PHASE; S-PHASE KINASE-ASSOCIATED PROTEINS; SERINE ENDOPEPTIDASES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA; EUKARYOTA;

EID: 3142713030     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M405061200     Document Type: Article

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