Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer

Cancer Research

Volumn 56, Issue 6, 1996, Pages 1189-1193

  Pizer, Ellen S ^a   Wood, Fawn D ^a   Heine, Henry S ^a   Romantsev, Fedor E ^a   Pasternack, Gary R ^a   Kuhajda, Francis P ^a,b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID SYNTHASE;

ARTICLE; ASCITES; CANCER GRAFT; CANCER MODEL; CONTROLLED STUDY; DISEASE COURSE; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NUDE MOUSE; OVARY CANCER; PRIORITY JOURNAL; XENOGRAFT;

ANIMALS; ANTIBIOTICS, ANTIFUNGAL; ASCITES; CERULENIN; DISEASE PROGRESSION; DRUG RESISTANCE, MULTIPLE; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; FEMALE; HUMANS; INJECTIONS, INTRAPERITONEAL; MICE; MICE, NUDE; OVARIAN NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0029971427     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Greenstein, J. P Biochemistry of Cancer, pp. 1-653. New York: Academic Press, Inc , 1954.
2. Medes, G., Thomas, A., and Weinhouse, S. Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res., 13: 27-29, 1953
3. Hardman, W., Gansler, T. Schaffel, S., and Hennigar, R. OA-519 immunostaining portends poor prognosis in ovarian cancer (Abstract). Mod. Pathol. 8: 90A, 1995.
4. Pizer, E. S., Wood, F. D., Pasternack, G. R., and Kuhajda, F. P. Altered fatty acid biosynthesis in endometrial carcinoma (Abstract). Mod. Pathol. 8: 95A, 1995.
5. Rashid, A., Milgraum, L. Z., Pasternack, G. R., Kuhajda, F P and Hamilton, S. R. Expression of Fatty Acid Synthase in colorectal cancer. Mod. Pathol. 8: 67A, 1995. (Abstract)
6. Epstein, J I , CarMichael, M., and Partin, A. W. OA-519 (fatty acid synthase) as an independent predictor of pathologic stage in adenocarcinoma of the prostate. Urology, 45: 81-86, 1995
7. Jensen, V , Ladekari, M., Holm-Nielsen, P., Flemming, B. S , and Flemming, M. The prognostic value of oncogenic antigen 519 (OA519) expression and proliferative activity detected by antibody MIB-I in node negative breast cancer. J. Pathol., 176: 343-352, 1995
8. Weiss, L., Hoffmann, G E. Schreiber, R., Andres, H., Fuchs, E., Korber, E. and Kolb, H. J. Fatty-acid biosynthesis in man, a pathway of minor importance. Biol Chem Hoppe-Seyler. 367: 905-912, 1986
9. Kuhajda, F. P., Jenner, K., Wood, F D , Hennigar, R A., Jacobs, L. B., Dick, J D., and Pasternack, G. R. Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc. Natl. Acad. Sci. USA, 91: 6379-6383, 1994.
10. Pizer, E. S , Wood, F D , Pasternack, G. R., and Kuhajda, F. P. Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells. Cancer Res., 56 745-751, 1996
11. Hamilton, T. C., Young, R. C., Louie, K. G., Behrens, B. C., McKoy, W. M., Grotzinger, K. R., and Ozols, R. F Characterization of a xenograft model of human ovarian carcinoma which produces ascites and intraabdominal carcinomatosis in mice Cancer Res., 44: 5286-5290, 1984
12. Young, R. C , Perez, C. A., and Hoskins, W J. Cancer of the ovary In: V. T. DeVita, Jr., S Hellman, and S. A Rosenberg (eds.), Cancer: Principles and Practice of Oncology. Philadelphia: J. B. Lippincott Co., 1993
13. Folch, J , Lees, M., and Sloane Stanley, G. H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem., 226: 497-509, 1957.
14. Omura, S. The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis. Bacteriol. Rev., 40: 681-697, 1976.
15. Funabashi, H., Kawaguchi, A, Tomoda, H., Omura, S , Okuda, S., and Iwasaki, S. Binding site of cerulenin in fatty acid synthetase. J. Biochem , 105: 751-755, 1989.
16. Wakil, S Fatty acid synthase, a proficient multifunctional enzyme Biochemistry, 28. 4523-4530, 1989.
17. The Merck Index. An Encyclopedia of Chemicals. Drugs and Biologicals. Ed. 10. In: M. Windholz (ed.). Rahway, NJ. Merck and Co., Inc., 1983.
18. Hardie, D. G. Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase. Biochim. Biophys Acta, 1123: 231-238, 1992.