Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?

Medical Hypotheses

Volumn 64, Issue 2, 2005, Pages 342-349

  Menendez, Javier A ^a,b   Colomer, Ramon ^c   Lupu, Ruth ^a,b  

^a Department of Medicine   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c HOSPITAL JOSEP TRUETA   (Spain)

Author keywords

Fatty acid synthase; Fatty acids; Oncogene

Indexed keywords

ENDOTHELIAL CELL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FATTY ACID; FATTY ACID SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; NEU DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE;

ANGIOGENESIS; CANCER CELL; CANCER GROWTH; CELL SURVIVAL; DIET; ENZYME ACTIVATION; FATTY ACID METABOLISM; HUMAN; LIPOGENESIS; MICROENVIRONMENT; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 11144309582     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.07.022     Document Type: Article

References (80)

1. Y. Tsukamoto, H. Wong, J.S. Mattick, and S.J. Wakil The architecture of the animal fatty acid synthetase complex. IV. Mapping of active centers and model for the mechanism of action J Biol Chem 258 1983 15312 15322
2. S.S. Chirala, A. Jayakumar, Z.W. Gu, and S. Wakil Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer Proc Natl Acad Sci USA 98 2001 3104 3108
3. V.S. Rangan, A.K. Joshi, and S. Smith Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro Biochemistry 40 2001 10792 10799
4. A.K. Joshi, A. Witkowski, and S. Smith Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro Biochemistry 36 1997 2316 2322
5. J.S. Mattick, J. Nickless, M. Mizugaki, C.Y. Yang, S. Uchiyama, and S.J. Wakil The architecture of the animal fatty acid synthetase. I. Proteolytic dissection and peptide mapping J Biol Chem 258 1983 15300 15304
6. S. Wakil Fatty acid synthase, a proficient multifunctional enzyme Biochemistry 28 1989 4523 4530
7. D.A.K. Roncari Mammalian fatty acid synthase. I. Purification and properties of human liver complex Can J Biochem 52 1974 221 230
8. A. Witkowski, V.S. Rangan, Z.I. Randhawa, C.M. Amy, and S. Smith Structural organization of the multifunctional animal fatty acid synthase Int J Biochem 198 1991 571 579
9. B.J. Thompson, and S. Smith Biosynthesis of fatty acids by lactating human breast epithelial cells: an evaluation of the contribution of the overall composition of human milk fat Pediatr Res 19 1985 139 143
10. Z.-X. Xu, W. Stenzel, S.M. Sasic, D.A. Smart, and S.A. Rooney Glucocorticoid regulation of fatty acid synthase gene expression in fetal rat lung Am J Physiol 265 1993 L140 L147
11. L. Weiss, G.E. Hoffmann, R. Schreiber, H. Andres, E. Fuchs, and E. Korber Fatty-acid biosynthesis in man, a pathway of minor importance. Purification optimal assay conditions and organ distribution of fatty-acid synthase Biol. Chem. Hoppe Seyler 367 1986 905 912
12. F.P. Kuhajda Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology Nutrition 16 2000 202 208
13. H.S. Sul, and D. Wang Nutritional and hormonal regulation of enzymes in fat synthesis: studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription Annu Rev Nutr 18 1998 331 351
14. S.D. Clarke Regulation of fatty acid synthase gene expression: an approach for reducing fat accumulation J Anim Sci 71 1993 1957 1965
15. B.A. Clarke, M.K. Armstrong, and D.B. Jump Nutritional control of rat liver fatty acid synthase and S14 mRNA abundance J Nutr 120 1990 218 224
16. A. Katsurada, N. Iritani, H. Fukuda, Y. Matsumara, N. Nishimoto, and T. Noguchi Effects of nutrients and hormones on transcriptional and post-transcriptional regulation of fatty acid synthase in rat liver Eur J Biochem 190 1990 427 433
17. H. Fukuda, N. Iritani, T. Sugimoto, and H. Ikeda Transcriptional regulation of fatty acid synthase by insulin/glucose, polyunsaturated fatty acids and leptin in hepatocytes and adipocytes in normal and genetically obese rats Eur J Biochem 260 1999 505 511
18. M.S. Shurbaji, F.P. Kuhajda, G.R. Pasternack, and T.S. Thurmond Expression of oncogenic antigen 519 (OA-519) in prostate cancer is a potential prognostic indicator Am J Clin Pathol 97 1992 686 691
19. J.I. Epstein, A. Carmichael, and A.W. Partin OA-519 (fatty acid synthase)as an independent predictor of pathologic stage in adenocarcinoma of the prostate Urology 45 1995 81 86
20. J.V. Swinnen, T. Roskams, S. Joniau, H.V. Poppel, R. Oyen, and L. Baert Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer Int J Cancer 98 2002 19 22
21. A. Rashid, E.S. Pizer, M. Moga, L.Z. Milgraum, M. Zahurak, and G.R. Pasternack Elevation of fatty acid synthase expression and fatty acid synthetic activity in colorectal neoplasia Am J Pathol 150 1997 201 208
22. T.S. Gansler, W. Hardman 3rd, D.A. Hunt, S. Schaffel, and R.A. Hennigar Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival Hum Pathol 28 1997 686 692
23. P. Visca, V. Sebastiani, E.S. Pizer, C. Botti, P. De Carli, and S. Filippi Immunohistochemical expression and prognostic significance of FAS and GLUT1 in bladder carcinoma Anticancer Res 23 2003 335 339
24. F.D. Camassei, A. Jenkner, L. Rava, C. Bosman, P. Francalanci, and A. Donfrancesco Expression of the lipogenic enzyme fatty acid synthase (FAS) as a predictor of poor outcome in nephroblastoma: an interinstitutional study Med Pediatr Oncol 40 2003 302 308
25. T. Nemoto, S. Terashima, M. Kogure, Y. Hoshino, T. Kusakabe, and T. Suzuki Overexpression of fatty acid synthase in oesophageal squamous cell dysplasia Pathobiology 69 2001 297 303
26. T. Kusakabe, A. Nashimoto, K. Honma, and T. Suzuki Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach Histopathology 40 2002 71 79
27. E.W. Gabrielson, M.L. Pinn, J.R. Testa, and F.P. Kuhajda Increased fatty acid synthase is a therapeutic target in mesothelioma Clin. Cancer Res. 7 2001 153 157
28. C.J. Piyathilake, A.R. Frost, U. Manne, W.C. Bell, H. Weiss, and D.C. Heimburger The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung Hum Pathol 31 2000 1068 1073
29. H. Krontiras, G.D. Roye, S.E. Beenken, R.B. Myers, M.S. Mayo, and G.E. Peters Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue Head Neck 21 1999 325 329
30. E.S. Pizer, S.F. Lax, F.P. Kuhajda, G.R. Pasternack, and R.J. Kurman Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors Cancer 83 1998 528 537
31. F.P. Kuhajda, A.I. Katumuluwa, and G.R. Pasternack Expression of haptoglobin-related protein and its potential as a tumor antigen Proc Natl Acad Sci USA 86 1989 1188 1192
32. F.P. Kuhajda, S. Piantadosi, and G.P. Pasternack Haptoglobin-related protein epitopes in breast cancer as a predictor of recurrence of the disease N Engl J Med 321 1989 636 641
33. V. Jensen, M. Ladekari, P. Holm-Nielsen, B.S. Flemming, and M. Fleming The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node negative breast cancer J Pathol 176 1995 343 352
34. P.L. Alo, P. Visca, A. Marci, A. Mangoni, C. Botti, and U. Di Tondo Expression of fatty acid (FAS) synthase as a predictor of recurrence in stage I breast carcinoma patients Cancer 77 1996 474 482
35. P.L. Alo, P. Visca, G. Trombetta, A. Mangoni, L. Lenti, S. Monaco, and C. Botti Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas Tumori 85 1999 35 40
36. J.H. Bull, G. Ellison, A. Patel, G. Muir, M. Walker, and M. Underwood Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray Br J Cancer 84 2001 1512 1519
37. P. Visca, P.L. Alo, F. Del Nonno, C. Bottie, G. Trombetta, and F. Marandino Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas and adjacent nonneoplastic mucosa Clin Cancer Res 5 1999 4111 4118
38. L.Z. Milgraum, L.A. Witters, G.R. Pasternack, and F.P. Kuhajda Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma Clin Cancer Res 3 1997 2115 2120
39. P.L. Alo, P. Visca, C. Botti, G.M. Galati, V. Sebastiani, and T. Andreano Immunohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue Am J Clin Pathol 116 2001 129 134
40. T. Takahiro, K. Shinichi, and S. Toshimitsu Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas Clin Cancer Res 9 2003 2204 2212
41. D. Innocenzi, P.L. Alo, A. Balzani, V. Sebastiani, V. Silipo, and G. La Torre Fatty acid synthase expression in melanoma J. Cutan Pathol. 30 2003 23 28
42. S. Omura The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis Bacteriol Rev 40 1976 681 697
43. D. Vance, I. Goldberg, O. Mitsuhashi, and K. Bloch Inhibition of fatty acid synthethases by the antibiotic cerulenin Biochem Biophys Res Commun 48 1972 549 565
44. W.W. Christie, M.L. Hunter, and R.A. Clegg The effects of cerulenin on lipid metabolism in vitro in cellular preparation from the rat Biochim Biophys Acta 666 1981 284 290
45. M. Moche, G. Schneider, P. Edwards, K. Dehesh, and Y. Lindqvist Structure of the complex between the antibiotic cerulenin and its target, β-ketoacyl carrier protein synthase J Biol Chem 274 1999 6031 6034
46. F.P. Kuhajda, K. Jenner, F.D. Wood, R.A. Hennigar, L.B. Jacobs, and J.D. Dick Fatty acid synthesis: a potential selective target for antineoplastic therapy Proc Natl Acad Sci USA 91 1994 6379 6383
47. E.S. Pizer, F.D. Wood, H.S. Heine, F.E. Romantsev, G.R. Pasternack, and F.P. Kuhajda Inhibition of fatty acid synthase delays disease progression in a xenograft model of ovarian cancer Cancer Res. 56 1996 1189 1193
48. E.S. Pizer, C. Jackisch, F.D. Wood, G.R. Pasternack, N.E. Davidson, and F.P. Kuhajda Inhibition of fatty acid synthase induces programmed cell death in human breast cancer cells Cancer Res 56 1996 2745 2747
49. E.S. Pizer, F.J. Chrest, J.A. DiGiuseppe, and W.F. Han Pharmacological inhibition of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines Cancer Res 58 1998 4611 4615
50. F.P. Kuhajda, E.S. Pizer, J.N. Li, N.S. Mani, G.L. Frehywot, and C.A. Townsend Synthesis and anti-tumor activity of a novel inhibitor of fatty acid synthase Proc Natl Acad Sci USA 97 2000 3450 3454
51. E.S. Pizer, J. Thupari, W.F. Han, M.L. Pinn, F.J. Chrest, and G.L. Frehywot Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts Cancer Res 60 2000 213 218
52. J.N. Li, M. Gorospe, F.J. Chrest, T.S. Kumaravel, M.K. Evans, and W.F. Han Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53 Cancer Res 61 2001 1493 1499
53. W. Zhou, P.J. Simpson, J.M. McFadden, C.A. Townsend, S.M. Medghalchi, and A. Vadlamudi Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells Cancer Res 63 2003 7330 7337
54. E. De Schrijver, K. Brusselmans, W. Heyns, G. Verhoeven, and J.V. Swinnen RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells Cancer Res 63 2003 3799 3804
55. J.M. Brown, and A.J. Giaccia The unique physiology of solid tumors: opportunities (and problems) for cancer therapy Cancer Res 58 1998 1408 1416
56. O. Warburg On the origin of cancer cells Science 123 1956 309 314
57. P.W. Hochachka Living without oxygen 1980 Harvard University Press Cambridge, MA p. 1-181
58. P.W. Hochachka, J.L. Rupert, L. Goldenberg, M. Gleave, and P. Kozlowski Going malignant: the hypoxia-cancer connection in the prostate Bioessays 24 2002 749 757
59. A. Baron, T. Migita, D. Tang, and M. Loda Fatty acid synthase: a metabolic oncogene in prostate cancer? J Cell Biochem 91 2004 47 53
60. J.A. Menendez, I. Mehmi, E. Atlas, R. Colomer, and R. Lupu Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: role of exogenous dietary fatty acids p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB Int J Oncol 24 2004 591 608
61. Y.A. Yang, W.F. Han, P.J. Morin, F.J. Chrest, and E.S. Pizer Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase Exp Cell Res 279 2002 80 90
62. T. Van de Sande, E. De Schrijver, W. Heyns, G. Verhoeven, and J.V. Swinnen Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells Cancer Res 62 2002 642 646
63. C. Kumar-Sinha, K.W. Ignatoski, M.E. Lippman, S.P. Ethier, and A.M. Chinnaiyan Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis Cancer Res 63 2003 132 139
64. J.V. Swinnen, H. Heemers, L. Deboel, F. Foufelle, W. Heyns, and G. Verhoeven Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway Oncogene 19 2000 5173 5181
65. D. Wang, and H.S. Sul Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt J Biol Chem 273 1998 25420 25426
66. J.V. Swinnen, W. Ulrix, W. Heyns, and G. Verhoeven Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins Proc Natl Acad Sci USA 94 1997 12975 12980
67. J.N. Li, M.A. Mahmoud, W.F. Han, M. Ripple, and E.S. Pizer Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia Exp Cell Res 261 2000 159 165
68. H. Heemers, B. Maes, F. Foufelle, W. Heyns, G. Verhoeven, and J.V. Swinnen Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway Mol Endocrinol 15 2001 1817 1828
69. Y.A. Yang, P.J. Morin, W.F. Han, T. Chen, D.M. Bornman, and E.W. Gabrielson Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c Exp Cell Res 282 2003 132 137
70. J.B. Kim, P. Sarraf, M. Wright, K.M. Yao, E. Mueller, and G. Solanes Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1 J Clin Invest 101 1998 1 9
71. M.M. Magana, and T.F. Osborne Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter J Biol Chem 271 1996 32689 32694
72. H. Shimano, N. Yahagi, M. Amemiya-Kudo, A.H. Hasty, J. Osuga, and Y. Tamura Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes J Biol Chem 274 1999 35832 35839
73. S. Kersten Mechanisms of nutritional and hormonal regulation of lipogenesis EMBO Rep 2 2001 282 286
74. J. Kotzka, D. Muller-Wieland, G. Roth, L. Kremer, M. Munck, and S. Schurmann Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade J Lipid Res 41 2000 99 108
75. M. Fleischmann, and P.B. Iynedjian Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt Biochem J 349 2000 13 17
76. J.A. Menendez, S. Ropero, I. Mehmi, E. Atlas, R. Colomer, and R. Lupu Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis Int J Oncol 24 2004 1369 1383
77. X. Deng, L.M. Cagen, H.G. Wilcox, E.A. Park, R. Raghow, and M.B. Elam Regulation of the rat SREBP-1c promoter in primary rat hepatocytes Biochem Biophys Res Commun 290 2002 256 262
78. P. Bougnoux, S. Koscielny, V. Chajes, P. Descamps, C. Couet, and G. Calais G alpha-Linolenic acid content of adipose breast tissue: a host determinant of the risk of early metastasis in breast cancer Br J Cancer 70 1994 330 334
79. V. Klein, V. Chajes, E. Germain, G. Schulgen, M. Pinault, and D. Malvy Low alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer Eur. J. Cancer 36 2000 335 340
80. V. Maillard, P. Bougnoux, P. Ferrari, M.L. Jourdan, M. Pinault, and F. Lavillonniere N-3 and N-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case-control study in Tours, France Int. J. Cancer 98 2002 78 83