Structure of the complex between the antibiotic cerulenin and its target, β-ketoacyl-acyl carrier protein synthase

Journal of Biological Chemistry

Volumn 274, Issue 10, 1999, Pages 6031-6034

  Moche, Martin ^a   Schneider, Gunter ^a   Edwards, Patricia ^b   Dehesh, Katayoon ^b   Lindqvist, Ylva ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Calgene Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ANTIBIOTIC AGENT; CERULENIN; MYCOTOXIN;

ARTICLE; CANCER INHIBITION; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME MECHANISM; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; FUNGUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; TUBERCULOSIS;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTIBIOTICS, ANTIFUNGAL; BINDING SITES; CERULENIN; ESCHERICHIA COLI; ISOENZYMES; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 0033525885     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.10.6031     Document Type: Article

References (35)

1. Magnuson, K., Jackowski, S., Rock, C. O., and Cronan, J. E. (1994) Microbiol. Rev. 57, 522-542
2. Somerville, C., and Browse, J. (1991) Science 252, 80-87
3. Hopwood, D. A., and Sherman, D. H. (1990) Annu. Rev. Genet. 24, 37-66
4. Katz, L., and Donadio, S. (1993) Annu. Rev. Microbiol. 47, 875-912
5. Wakil, S. J. (1989) Biochemistry 28, 4523-4530
6. Vance, D. E., Goldberg, I., Mitsuhashi, O., Bloch, K., Omura, S., and Nomura, S. (1972) Biochem. Biophys. Res. Commun. 48, 649-656
7. Huang, W., Jia, J., Edwards, P., Dehesh, K., Schneider, G., and Lindqvist, Y. (1998) EMBO J. 17, 1183-1191
8. Dehesh, K., Edwards, P., Fillatti, J., Slabaugh, M., and Byrne, J. (1998) Plant J. 15, 383-391
9. Pizer, E. S., Wood, F. D., Pasternack, R., and Kuhajda, F. P. (1996) Cancer Res. 56, 745-751
10. Pizer, E. S., Jackisch, C., Wood, F. D., Pasternack, R., Davidson, N. E., and Kuhajda, F. P. (1996) Cancer Res. 56, 2745-2747
11. Rastogi, N., Goh, K. S., Horgen, L., and Barrow, W. W. (1998) FEMS Immunol. Med. Microbiol. 21, 149-157
12. Mdluli, K., Slayden, R. A., Zhu, Y., Ramaswamy, S., Pan, X., Mead, D., Crane, D. D., Musser, J. M., and Barry, C. E., III (1998) Science 280, 1607-1610
13. Kauppinen, S., Siggaard-Andersen, M., and von Wettstein-Knowles, P. (1988) Carlsberg Res. Commun. 53, 357-370
14. Funabashi, H., Kawaguchi, A., Tomoda, H., Omura, S., Okuda, S., and Iwasaki, S. (1989) J. Biochem. (Tokyo)105, 751-755
15. Child, C. J., and Shoolingin-Jordan, P. M. (1998) Biochem. J. 330, 933-937
16. Jaworski, J. G., Clough, R. C., and Barnum, S. R. (1989) Plant Physiol. 90, 41-44
17. Kawaguchi, A., Tomoda, H., Okuda, S., Awaya, J., and Omura, S. (1979) Arch. Biochem. Biophys. 197, 30-35
18. Edwards, P., Sabo Nelsen, J., Metz, J., and Dehesh, K. (1977) FEBS Lett. 402, 62-66
19. Otwinowski, Z. (1993) in Proceedings of the Collaborative Computating Project 4 Study Weekend: Data Collection and Processing (Sawyer, L., Isaacs, N., and Bailey, S. S., eds) pp. 56-62, SERC Daresbury Laboratory, Warrington, UK
20. Collaborative Computating Project 4 (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 760-763
21. Evans, P. R. (1993) in Proceedings of the Collaborative Computating Project 4 Study Weekend: Data Collection and Processing (Sawyer, L., Isaacs, N., and Bailey, S. S., eds) pp. 114-122, SERC Daresbury Laboratory, Warrington, UK
22. Read, R. J. (1986) Acta Crystallogr. Sect. A 42, 140-149
23. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. Sect. D Biol. Crystallogr. 53, 240-253
24. Jones, T. A., Zou, J.-Y., Cowan, S., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A 47, 100-119
25. Kleywegt, G. J., and Jones, T. A. (1996) Acta Crystallogr. Sect. D Biol. Crystallogr. 52, 829-832
26. Laskowski, R. A., McArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 282-291
27. D'Agnolo, G., Rosenfeld, I. S., Awaya, J., Omura, S., and Vagelos, P. R. (1973) Biochim. Biophys. Acta 326, 155-156
28. Morisaki, N., Funabashi, H., Shimazawa, R., Furukawa, J., Kawaguchi, A., Okuda, S., and Iwasaki, S. (1993) Eur. J. Biochem. 211, 111-115
29. Garwin, J. L., Klages, A. L., and Cronan, J. E., Jr. (1980) J. Biol. Chem. 255, 3263-3265
30. Tomoda, H., Kawaguchi, A., Yasuhara, T., Nakajima, T., Omura, S., and Okuda, S. (1984) J. Biochem. (Tokyo) 995, 1712-1723
31. Inokoshi, J., Tomoda, H., Hashimoto, H., Watanabe, A., Takeshima, H., and Omura, S. (1994) Mol. Gen. Genet. 244, 90-96
32. Kraulis, P. (1991) J. Appl. Crystallogr. 24, 946-950
33. Merrit, E. A., and Murphy, M. E. P. (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 869-873
34. Kleywegt, G. J., and Jones, T. A. (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 178-185
35. Esnouf, R. M. (1997) J. Mol. Graph. 15, 133-138