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Volumn 49, Issue 3, 2002, Pages 187-193

Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells

(4) Liu, Binqiu a Wang, Yingqiang a Fillgrove, Kerry L a Anderson, Vernon E a

a CASE WESTERN RESERVE UNIVERSITY (United States)

Author keywords

Breast cancer; Cell culture; Enoyl reductase; Enzyme inhibition; Fatty acid synthase; Triclosan

Indexed keywords

ENOYL REDUCTASE; FATTY ACID SYNTHASE; OXIDOREDUCTASE; TRICLOSAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING ASSAY; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL STRAIN MCF 7; CELL VIABILITY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG BINDING; DRUG EFFECT; DRUG POTENCY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; GOOSE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL SURVIVAL; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); FATTY ACID SYNTHETASE COMPLEX; FEMALE; HUMANS; KINETICS; OXIDOREDUCTASES; TRICLOSAN; TUMOR CELLS, CULTURED;

EID: 0036185911 PISSN: 03445704 EISSN: None Source Type: Journal
DOI: 10.1007/s00280-001-0399-x Document Type: Article

Times cited : (103)

References (33)

1
- 0025183708
- Basic local alignment search tool
- (1990) J Mol Biol , vol.215 , pp. 403
- Altschul, S.F.¹ Gish, W.² Miller, W.³ Myers, E.W.⁴ Lipman, D.J.⁵

2
- 0024603513
- Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase
- (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 3114
- Amy, C.M.¹ Witkowski, A.² Naggert, J.³ Williams, B.⁴ Randhawa, Z.⁵ Smith, S.⁶

3
- 0029901844
- Triclosan: Applications and safety
- (1996) Am J Infect Control , vol.24 , pp. 209
- Bhargava, H.N.¹ Leonard, P.A.²

4
- 0017134664
- One-step purification and properties of a two-peptide fatty acid synthetase from the uropygial gland of the goose
- (1976) Biochemistry , vol.15 , pp. 1948
- Buckner, J.S.¹ Kolattukudy, P.E.²

5
- 0024853921
- Homology analysis of the protein sequences of fatty acid synthases from chicken liver, rat mammary gland, and yeast
- (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 8373
- Chang, S.I.¹ Hammes, G.G.²

6
- 0030940841
- Animal fatty acid synthase: Functional mapping and cloning and expression of the domain I constituent activities
- (1997) Proc Nati Acad Sci U S A , vol.94 , pp. 5588
- Chirala, S.S.¹ Huang, W.Y.² Jayakumar, A.³ Sakai, K.⁴ Wakil, S.J.⁵

7
- 0024332260
- Binding site of cerulenin in fatty aced synthetase
- (1989) J Biochem , vol.105 , pp. 751
- Funabashi, H.¹ Kawaguchi, A.² Tomoda, H.³ Omura, S.⁴ Okuda, S.⁵ Iwasaki, S.⁶

8
- 0032515066
- Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis
- (1998) J Biol Chem , vol.273 , pp. 30316
- Heath, R.I.¹ Yu, Y.T.² Shapiro, M.A.³ Olsun, E.⁴ Rock, C.O.⁵

9
- 0032550730
- Characterization of fatty acid synthase in cell lines derived from experimental mammary tumors
- (1998) Biochim Biophys Acta , vol.1392 , pp. 85
- Hennigar, R.A.¹ Pochet, M.² Hunt, D.A.³ Lukacher, A.E.⁴ Venema, V.J.⁵ Seal, E.⁶ Marrero, M.B.⁷

10
- 0029051666
- Human fatty acid synthase: Properties and molecular cloning
- (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 8695
- Jayakumar, A.¹ Tai, M.H.² Huang, W.Y.³ Al-Feel, W.⁴ Hsu, M.⁵ Abu-Elhcega, L.⁶ Chirala, S.S.⁷ Wakil, S.J.⁸

11
- 0031050460
- Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro
- (1997) Biochemistry , vol.36 , pp. 2316
- Joshi, A.K.¹ Witkowski, A.² Smith, S.³

12
- 4243508040
- United States Patent no. 5,759,837
- (1998) Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway
- Kuhajda, F.P.¹ Pasternack, G.R.²

13
- 0028301959
- Fatty acid synthesis: A potential selective target for antineoplastic therapy
- (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6379
- Kuhajda, F.P.¹ Jenner, K.² Wood, F.D.³ Hennigar, R.A.⁴ Jacobs, L.B.⁵ Dick, J.D.⁶ Pasternack, G.R.⁷

14
- 0034724397
- Synthesis and antitumor activity of an inhibitor of fatty acid synthase
- (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 3450
- Kuhajda, F.P.¹ Pizer, E.S.² Li, J.N.³ Mani, N.S.⁴ Frehywot, G.L.⁵ Townsend, C.A.⁶

15
- 0033518174
- Structure-activity studies of cerulenin analogues as protein palmitoylation inhibitors
- (1999) J Med Chem , vol.42 , pp. 4932
- Lawrence, D.S.¹ Zilfou, J.T.² Smith, C.D.³

16
- 2042431646
- Patent no. WO 99/37800
- (1999) Enoyl-ACP (acyl carrier protein) reductase-interacting substances in antimicrobial screening
- Levy, S.B.¹ McMurry, L.M.²

17
- 0032490937
- Triclosan targets lipid synthesis
- (1998) Nature , vol.394 , pp. 531
- McMurry, L.M.¹ Oethinger, M.² Levy, S.B.³

18
- 0034272404
- Coenzyme A analogues and derivatives: Synthesis and applications as mechanistic probes of coenzyme-A ester-utilizing enzymes
- (2000) Chem Rev , vol.100 , pp. 3283
- Mishra, P.K.¹ Drueckhammer, D.G.²

19
- 0033525885
- Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase
- (1999) J Biol Chem , vol.274 , pp. 6031
- Moche, M.¹ Schneider, G.² Edwards, P.³ Dehesh, K.⁴ Lindqvist, Y.⁵

20
- 0023728105
- The behavior and significance of slow-binding enzyme-inhibitors
- (1988) Adv Enzymol Relat Areas Mol Biol , vol.61 , pp. 201
- Morrison, J.F.¹ Walsh, C.T.²

21
- 0016114668
- Mechanism of action of CM-55, a synthetic analogue of the antilipogenic antibiotic cerulenin
- (1974) Antimicrob Agents Chemother , vol.6 , pp. 387
- Ohno, T.¹ Awaya, J.² Kesado, T.³ Nomura, S.⁴ Omura, S.⁵

22
- 0029949512
- Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells
- (1996) Cancer Res , vol.56 , pp. 2745
- Pizer, E.S.¹ Jackisch, C.² Wood, F.D.³ Pasternack, G.R.⁴ Davidson, N.E.⁵ Kuhajda, F.P.⁶

23
- 0029971427
- Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer
- (1996) Cancer Res , vol.56 , pp. 1189
- Pizer, E.S.¹ Wood, F.D.² Heine, H.S.³ Romantsev, F.E.⁴ Pastemack, G.R.⁵ Kuhajda, F.P.⁶

24
- 0032721424
- Molecular basis for triclosan activity involves a flipping loop in the active site
- (1999) Protein Sci , vol.8 , pp. 2529
- Qiu, X.¹ Janson, C.A.² Court, R.I.³ Smyth, M.G.⁴ Payne, D.J.⁵ Abdel-Meguld, S.S.⁶

25
- 0035845638
- Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro
- (2001) Biochemistry , vol.40 , pp. 10792
- Rangan, V.S.¹ Joshi, A.K.² Smith, S.³

26
- 0033607650
- Crystallographic analysis of triclosan bound to enoyl reductase
- (1999) J Mol Biol , vol.294 , pp. 527
- Roujeinikova, A.¹ Levy, C.W.² Rowsell, S.³ Sedeinikova, S.⁴ Baker, P.J.⁵ Minshull, C.A.⁶ Mistry, A.⁷ Colls, J.G.⁸ Camble, R.⁹ Stuitje, A.R.¹⁰ Slabas, A.R.¹¹ Rafferty, J.B.¹² Pauptit, R.A.¹³ Viner, R.¹⁴ Rice, D.W.¹⁵

27
- 0027054628
- Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum
- (1992) Biochem J , vol.288 , pp. 839
- Spencer, J.B.¹ Jordan, P.M.²

28
- 0032775211
- Structural basis and mechanism of enoyl reductase inhibition by triclosan
- (1999) J Mol Biol , vol.290 , pp. 859
- Stewart, M.J.¹ Parikh, S.² Xiao, G.³ Tonge, P.J.⁴ Kisker, C.⁵

29
- 0019888073
- Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits
- (1981) J Biol Chem , vol.256 , pp. 5128
- Stoops, J.K.¹ Wakil, S.J.²

30
- 0019951235
- Lack of coordinated regulation of lipogenic enzymes in a human breast cell line, SKBr3
- (1982) Biochim Biophys Acta , vol.712 , pp. 217
- Thompson, B.J.¹ Smith, S.²

31
- 0033592365
- Kinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan
- (1999) Biochemistry , vol.38 , pp. 12514
- Ward, W.H.¹ Holdgate, G.A.² Rowsell, S.³ McLean, E.G.⁴ Pauptit, R.A.⁵ Clayton, E.⁶ Nichols, W.W.⁷ Colls, J.G.⁸ Minshull, C.A.⁹ Jude, D.A.¹⁰ Mistry, A.¹¹ Timms, D.¹² Camble, R.¹³ Hales, N.J.¹⁴ Britton, C.J.¹⁵ Taylor, I.W.¹⁶

32
- 0022786302
- Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty- acid synthase
- (1986) Biol Chem Hoppe Seyler , vol.367 , pp. 905
- Weiss, L.¹ Hoffmann, G.E.² Sehreiber, R.³ Andres, H.⁴ Fuchs, E.⁵ Korber, E.⁶ Kolb, H.J.⁷

33
- 0021112850
- The architecture of the animal fatty acid synthetase. III. Isolation and characterization of beta-ketoacyl reductase
- (1983) J Biol Chem , vol.258 , pp. 15305
- Wong, H.¹ Mattick, J.S.² Wakil, S.J.³

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