Practical, catalytic, asymmetric synthesis of β-lactones via a sequential ketene dimerization/hydrogenation process: Inhibitors of the thioesterase domain of fatty acid synthase

Journal of Organic Chemistry

Volumn 71, Issue 12, 2006, Pages 4549-4558

  Purohit, Vikram C ^a   Richardson, Robyn D ^b   Smith, Jeffrey W ^b   Romo, Daniel ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID SYNTHASE (FAS); KETENE FORMATION; LACTONES;

CATALYSIS; DIMERIZATION; FATTY ACIDS; HYDROGENATION; OPTICAL MATERIALS; SYNTHESIS (CHEMICAL);

ORGANIC COMPOUNDS;

ACID; ACID CHLORIDE; ANTIOBESITY AGENT; BETA LACTONE; CHLORIDE; DIMER; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; KETENE DERIVATIVE; LACTONE; RECOMBINANT ENZYME; TETRAHYDROLIPSTATIN; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

ACYLATION; ALKYLATION; ARTICLE; ASYMMETRIC SYNTHESIS; CALTER DIMERIZATION; CANCER CELL; CATALYSIS; CHROMATOGRAPHY; COMPETITIVE INHIBITION; DEVICE; DIMERIZATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; EPIMERIZATION; FLUORESCENCE; HYDROGENATION; INFRARED SPECTROSCOPY; INHIBITION KINETICS; METABOLITE; OPTICAL ROTATION; PROTEIN DOMAIN; REACTION ANALYSIS; REACTIVE INTERMEDIATE;

ALKENES; CATALYSIS; DIMERIZATION; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; HYDROGENATION; KETONES; LACTONES; PALMITOYL-COA HYDROLASE;

EID: 33744898777     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo060392d     Document Type: Article

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