Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells

Oncogene

Volumn 23, Issue 28, 2004, Pages 4945-4958

  Menendez, Javier A ^a,b   Oza, Bharvi P ^a   Atlas, Ella ^a,b   Verma, Vishal A ^a   Mehmi, Inderjit ^a   Lupu, Ruth ^a,b  

^a Evanston NW Hlthcare Res Institute ^*  (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Apoptosis; C75; Cerulenin; Endometrial cancer; Estradiol; Estrogen receptor; Fatty acid synthase; RNA interference; Small interfering RNA; Tamoxifen

Indexed keywords

ALKALINE PHOSPHATASE; ANTIESTROGEN; C 75; CELL CYCLE PROTEIN; CERULENIN; CYCLIN DEPENDENT KINASE INHIBITOR; DNA FRAGMENT; ENZYME INHIBITOR; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; GENE PRODUCT; LUCIFERASE; MYCOTOXIN; PROGESTERONE RECEPTOR; PROTEIN; PROTEIN P21; PROTEIN P27; RNA; TAMOXIFEN; TUMOR ASSOCIATED FATTY ACID SYNTHASE; UNCLASSIFIED DRUG; FATTY ACID SYNTHASE;

AGONIST; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASSAY; BINDING AFFINITY; CANCER CELL; CELL DEATH; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG RESPONSE; DRUG SCREENING; DRUG SELECTIVITY; ENDOMETRIUM CARCINOMA; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ESTROGEN RESPONSIVE ELEMENT; EVALUATION; FATTY ACID SYNTHASE GENE; GENE; GENE EXPRESSION; GENE SEQUENCE; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO CULTURE; INHIBITION KINETICS; MODEL; MONITORING; ONCOGENE NEU; PRIORITY JOURNAL; PROTEIN EXPRESSION; RELIABILITY; RNA INTERFERENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STIMULATION; TRANSCRIPTION INITIATION; ADENOCARCINOMA; DRUG ANTAGONISM; ENDOMETRIUM TUMOR; FEMALE; GENETICS; TRANSACTIVATION; TUMOR CELL LINE;

ADENOCARCINOMA; CELL LINE, TUMOR; ENDOMETRIAL NEOPLASMS; ESTRADIOL; FATTY ACID SYNTHETASE COMPLEX; FEMALE; HUMANS; RECEPTORS, ESTROGEN; TAMOXIFEN; TRANS-ACTIVATION (GENETICS);

EID: 3042723614     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207476     Document Type: Article

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