메뉴 건너뛰기




Volumn 16, Issue 3, 2006, Pages 233-252

Functional implications of BRCA1 for early detection, prevention, and treatment of breast cancer

Author keywords

BRCA1; Breast cancer; Early detection; Prevention; Therapy

Indexed keywords

BLEOMYCIN; BRCA1 PROTEIN; BRCA2 PROTEIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIRUBICIN; ESTROGEN RECEPTOR; ETOPOSIDE; FLUOROURACIL; METHOTREXATE; MITOMYCIN C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; ORAL CONTRACEPTIVE AGENT; PACLITAXEL; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SEX HORMONE; TAMOXIFEN; VINCRISTINE;

EID: 33749346363     PISSN: 10454403     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevEukarGeneExpr.v16.i3.30     Document Type: Review
Times cited : (6)

References (215)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0027433563 scopus 로고
    • Genetic linkage analysis in familial breast and ovarian cancer: Results from 214 families
    • The Breast Cancer Linkage Consortium
    • Easton DF, Bishop DT, Ford D, Crockford GP. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium. Am J Hum Genet. 1993;52:678-701.
    • (1993) Am J Hum Genet , vol.52 , pp. 678-701
    • Easton, D.F.1    Bishop, D.T.2    Ford, D.3    Crockford, G.P.4
  • 5
    • 0032953384 scopus 로고    scopus 로고
    • Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas
    • Wilson CA, Ramos L, Villasenor MR, Anders KH, Press MF, Clarke K, et al. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet. 1999;21:236-40.
    • (1999) Nat Genet , vol.21 , pp. 236-240
    • Wilson, C.A.1    Ramos, L.2    Villasenor, M.R.3    Anders, K.H.4    Press, M.F.5    Clarke, K.6
  • 7
    • 0028111802 scopus 로고
    • Has the breast cancer gene been found?
    • Vogelstein B, Kinzler KW. Has the breast cancer gene been found? Cell. 1994;79:1-3.
    • (1994) Cell , vol.79 , pp. 1-3
    • Vogelstein, B.1    Kinzler, K.W.2
  • 9
    • 0029804093 scopus 로고    scopus 로고
    • Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1
    • Smith TM, Lee MK, Szabo CI, Jerome N, McEuen M, Taylor M, et al. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. Genome Res. 1996;6:1029-49.
    • (1996) Genome Res , vol.6 , pp. 1029-1049
    • Smith, T.M.1    Lee, M.K.2    Szabo, C.I.3    Jerome, N.4    McEuen, M.5    Taylor, M.6
  • 10
    • 0035057806 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 and the genetics of breast and ovarian cancer
    • Welcsh PL, King MC. BRCA1 and BRCA2 and the genetics of breast and ovarian cancer. Hum Mol Genet. 2001;10:705-13.
    • (2001) Hum Mol Genet , vol.10 , pp. 705-713
    • Welcsh, P.L.1    King, M.C.2
  • 11
    • 4544374528 scopus 로고    scopus 로고
    • BRCA1 and BRCA2: 1994 and beyond
    • Narod SA, Foulkes WD. BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer. 2004;4:665-76.
    • (2004) Nat Rev Cancer , vol.4 , pp. 665-676
    • Narod, S.A.1    Foulkes, W.D.2
  • 12
    • 0034707053 scopus 로고    scopus 로고
    • In search of the tumour-suppressor functions of BRCA1 and BRCA2
    • Scully R, Livingston D. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature. 2000;408:429-32.
    • (2000) Nature , vol.408 , pp. 429-432
    • Scully, R.1    Livingston, D.2
  • 13
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • Venkitaraman AR. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell. 2002;108:171-82.
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 14
    • 13944281226 scopus 로고    scopus 로고
    • Molecular functions of BRCA1 in the DNA damage response
    • Scully R, Xie A, Nagaraju G. Molecular functions of BRCA1 in the DNA damage response. Cancer Biol Ther. 2004;3:521-7.
    • (2004) Cancer Biol Ther , vol.3 , pp. 521-527
    • Scully, R.1    Xie, A.2    Nagaraju, G.3
  • 15
    • 21644469743 scopus 로고    scopus 로고
    • BRCA1 and transcription
    • Lane TF. BRCA1 and transcription. Cancer Biol Ther. 2004;3:528-33.
    • (2004) Cancer Biol Ther , vol.3 , pp. 528-533
    • Lane, T.F.1
  • 18
    • 0035942190 scopus 로고    scopus 로고
    • Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity
    • Ruffner H, Joazeiro CA, Hemmati D, Hunter T, Verma IM. Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc Natl Acad Sci U S A. 2001;98:5134-9.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5134-5139
    • Ruffner, H.1    Joazeiro, C.A.2    Hemmati, D.3    Hunter, T.4    Verma, I.M.5
  • 19
    • 0036467574 scopus 로고    scopus 로고
    • The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
    • Baer R, Ludwig T. The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity. Curr Opin Genet Dev. 2002;12:86-91.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 86-91
    • Baer, R.1    Ludwig, T.2
  • 20
    • 0042317328 scopus 로고    scopus 로고
    • The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin
    • Wu-Baer F, Lagrazon K, Yuan W, Baer R. The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin. J Biol Chem. 2003;278:34743-6.
    • (2003) J Biol Chem , vol.278 , pp. 34743-34746
    • Wu-Baer, F.1    Lagrazon, K.2    Yuan, W.3    Baer, R.4
  • 22
    • 10544231876 scopus 로고    scopus 로고
    • Identification of a RING protein that can interact in vivo with the BRCA1 gene product
    • Wu LC, Wang ZW, Tsan JT, Spillman MA, Phung A, Xu XL, et al. Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat Genet. 1996;14:430-40.
    • (1996) Nat Genet , vol.14 , pp. 430-440
    • Wu, L.C.1    Wang, Z.W.2    Tsan, J.T.3    Spillman, M.A.4    Phung, A.5    Xu, X.L.6
  • 24
    • 0035805582 scopus 로고    scopus 로고
    • The ring heterodimer brca1-bard1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation
    • Hashizume R, Fukuda M, Maeda I, Nishikawa H, Oyake D, Yabuki Y, et al. The ring heterodimer brca1-bard1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J Biol Chem. 2001;276:14537-40.
    • (2001) J Biol Chem , vol.276 , pp. 14537-14540
    • Hashizume, R.1    Fukuda, M.2    Maeda, I.3    Nishikawa, H.4    Oyake, D.5    Yabuki, Y.6
  • 25
    • 0038237514 scopus 로고    scopus 로고
    • Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein
    • Xia Y, Pao GM, Chen HW, Verma IM, Hunter T. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem. 2003;278:5255-63.
    • (2003) J Biol Chem , vol.278 , pp. 5255-5263
    • Xia, Y.1    Pao, G.M.2    Chen, H.W.3    Verma, I.M.4    Hunter, T.5
  • 26
    • 0034674706 scopus 로고    scopus 로고
    • Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor
    • Yu X, Baer R. Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. J Biol Chem. 2000;275:18541-9.
    • (2000) J Biol Chem , vol.275 , pp. 18541-18549
    • Yu, X.1    Baer, R.2
  • 27
    • 1942517849 scopus 로고    scopus 로고
    • BRCA1: BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair
    • Morris JR, Solomon E. BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair. Hum Mol Genet. 2004;13:807-17.
    • (2004) Hum Mol Genet , vol.13 , pp. 807-817
    • Morris, J.R.1    Solomon, E.2
  • 28
    • 1042278177 scopus 로고    scopus 로고
    • Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase
    • Nishikawa H, Ooka S, Sato K, Arima K, Okamoto J, Klevit RE, et al. Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase. J Biol Chem. 2004;279:3916-24.
    • (2004) J Biol Chem , vol.279 , pp. 3916-3924
    • Nishikawa, H.1    Ooka, S.2    Sato, K.3    Arima, K.4    Okamoto, J.5    Klevit, R.E.6
  • 30
    • 32144463131 scopus 로고    scopus 로고
    • Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility
    • Morris JR, Pangon L, Boutell C, Katagiri T, Keep NH, Solomon E. Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility. Hum Mol Genet. 2006;15:599-606.
    • (2006) Hum Mol Genet , vol.15 , pp. 599-606
    • Morris, J.R.1    Pangon, L.2    Boutell, C.3    Katagiri, T.4    Keep, N.H.5    Solomon, E.6
  • 31
    • 0037048290 scopus 로고    scopus 로고
    • Roles of BRCA1 in centrosome duplication
    • Deng CX. Roles of BRCA1 in centrosome duplication. Oncogene. 2002;21:6222-7.
    • (2002) Oncogene , vol.21 , pp. 6222-6227
    • Deng, C.X.1
  • 32
    • 25444455576 scopus 로고    scopus 로고
    • Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination
    • Sankaran S, Starita LM, Groen AC, Ko MJ, Parvin JD. Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination. Mol Cell Biol. 2005;25:8656-68.
    • (2005) Mol Cell Biol , vol.25 , pp. 8656-8668
    • Sankaran, S.1    Starita, L.M.2    Groen, A.C.3    Ko, M.J.4    Parvin, J.D.5
  • 34
    • 33644684041 scopus 로고    scopus 로고
    • Substrates of the BRCA1-dependent ubiquitin ligase
    • Starita LM, Parvin JD. Substrates of the BRCA1-dependent ubiquitin ligase. Cancer Biol Ther. 2006;5:137-41.
    • (2006) Cancer Biol Ther , vol.5 , pp. 137-141
    • Starita, L.M.1    Parvin, J.D.2
  • 35
    • 3843059160 scopus 로고    scopus 로고
    • Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase
    • Sato K, Hayami R, Wu W, Nishikawa T, Nishikawa H, Okuda Y, et al. Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase. J Biol Chem. 2004;279:30919-22.
    • (2004) J Biol Chem , vol.279 , pp. 30919-30922
    • Sato, K.1    Hayami, R.2    Wu, W.3    Nishikawa, T.4    Nishikawa, H.5    Okuda, Y.6
  • 37
    • 18844407814 scopus 로고    scopus 로고
    • BRCA1/BARD1 inhibition of mRNA 3′ processing involves targeted degradation of RNA polymerase II
    • Kleiman FE, Wu-Baer F, Fonseca D, Kaneko S, Baer R, Manley JL. BRCA1/BARD1 inhibition of mRNA 3′ processing involves targeted degradation of RNA polymerase II. Genes Dev. 2005;19:1227-37.
    • (2005) Genes Dev , vol.19 , pp. 1227-1237
    • Kleiman, F.E.1    Wu-Baer, F.2    Fonseca, D.3    Kaneko, S.4    Baer, R.5    Manley, J.L.6
  • 38
    • 0037076672 scopus 로고    scopus 로고
    • Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase
    • Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ. Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. J Biol Chem. 2002;277:22085-92.
    • (2002) J Biol Chem , vol.277 , pp. 22085-22092
    • Chen, A.1    Kleiman, F.E.2    Manley, J.L.3    Ouchi, T.4    Pan, Z.Q.5
  • 39
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem. 1998;273:5858-68.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 41
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol. 2000;10:886-95.
    • (2000) Curr Biol , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 42
    • 0033963341 scopus 로고    scopus 로고
    • A nuclear function for the tumor suppressor BRCA1
    • Monteiro AN, Birge RB. A nuclear function for the tumor suppressor BRCA1. Histol Histopathol. 2000;15:299-307.
    • (2000) Histol Histopathol , vol.15 , pp. 299-307
    • Monteiro, A.N.1    Birge, R.B.2
  • 43
    • 1842364973 scopus 로고    scopus 로고
    • Localization of BRCA1 and a splice variant identifies the nuclear localization signal
    • Thakur S, Zhang HB, Peng Y, Le H, Carroll B, Ward T, et al. Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol Cell Biol. 1997;17:444-52.
    • (1997) Mol Cell Biol , vol.17 , pp. 444-452
    • Thakur, S.1    Zhang, H.B.2    Peng, Y.3    Le, H.4    Carroll, B.5    Ward, T.6
  • 44
    • 12644270610 scopus 로고    scopus 로고
    • The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor
    • Chen CF, Li S, Chen Y, Chen PL, Sharp ZD, Lee WH. The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor. J Biol Chem. 1996;271:32863-8.
    • (1996) J Biol Chem , vol.271 , pp. 32863-32868
    • Chen, C.F.1    Li, S.2    Chen, Y.3    Chen, P.L.4    Sharp, Z.D.5    Lee, W.H.6
  • 45
    • 0034623941 scopus 로고    scopus 로고
    • Identification of a functional nuclear export sequence in BRCA1
    • Rodriguez JA, Henderson BR. Identification of a functional nuclear export sequence in BRCA1. J Biol Chem. 2000;275:38589-96.
    • (2000) J Biol Chem , vol.275 , pp. 38589-38596
    • Rodriguez, J.A.1    Henderson, B.R.2
  • 48
    • 0034731325 scopus 로고    scopus 로고
    • Characterization of a novel trans-activation domain of BRCA1 that functions in concert with the BRCA1 C-terminal (BRCT) domain
    • Hu YF, Miyake T, Ye Q, Li R. Characterization of a novel trans-activation domain of BRCA1 that functions in concert with the BRCA1 C-terminal (BRCT) domain. J Biol Chem. 2000;275:40910-5.
    • (2000) J Biol Chem , vol.275 , pp. 40910-40915
    • Hu, Y.F.1    Miyake, T.2    Ye, Q.3    Li, R.4
  • 49
    • 0037097982 scopus 로고    scopus 로고
    • JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction
    • Hu YF, Li R. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction. Genes Dev. 2002;16:1509-17.
    • (2002) Genes Dev , vol.16 , pp. 1509-1517
    • Hu, Y.F.1    Li, R.2
  • 50
    • 13444292150 scopus 로고    scopus 로고
    • Classification of BRCA1 missense variants of unknown clinical significance
    • Phelan CM, Dapic V, Tice B, Favis R, Kwan E, Barany F, et al. Classification of BRCA1 missense variants of unknown clinical significance. J Med Genet. 2005;42:138-46.
    • (2005) J Med Genet , vol.42 , pp. 138-146
    • Phelan, C.M.1    Dapic, V.2    Tice, B.3    Favis, R.4    Kwan, E.5    Barany, F.6
  • 51
    • 0033527717 scopus 로고    scopus 로고
    • Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
    • [see comments]
    • Cortez D, Wang Y, Qin J, Elledge SJ. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks [see comments]. Science. 1999;286:1162-6.
    • (1999) Science , vol.286 , pp. 1162-1166
    • Cortez, D.1    Wang, Y.2    Qin, J.3    Elledge, S.J.4
  • 53
    • 0037102275 scopus 로고    scopus 로고
    • Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation
    • Xu B, O'Donnell AH, Kim ST, Kastan MB. Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. Cancer Res. 2002;62:4588-91.
    • (2002) Cancer Res , vol.62 , pp. 4588-4591
    • Xu, B.1    O'Donnell, A.H.2    Kim, S.T.3    Kastan, M.B.4
  • 54
    • 0034624718 scopus 로고    scopus 로고
    • hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
    • Lee JS, Collins KM, Brown AL, Lee CH, Chung JH. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature. 2000;404:201-4.
    • (2000) Nature , vol.404 , pp. 201-204
    • Lee, J.S.1    Collins, K.M.2    Brown, A.L.3    Lee, C.H.4    Chung, J.H.5
  • 55
    • 6344247481 scopus 로고    scopus 로고
    • Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1
    • Kim SS, Cao L, Li C, Xu X, Huber LJ, Chodosh LA, et al. Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1. Mol Cell Biol. 2004;24:9498-507.
    • (2004) Mol Cell Biol , vol.24 , pp. 9498-9507
    • Kim, S.S.1    Cao, L.2    Li, C.3    Xu, X.4    Huber, L.J.5    Chodosh, L.A.6
  • 57
    • 0033637170 scopus 로고    scopus 로고
    • Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
    • Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, et al. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 2000;14:2989-3002.
    • (2000) Genes Dev , vol.14 , pp. 2989-3002
    • Tibbetts, R.S.1    Cortez, D.2    Brumbaugh, K.M.3    Scully, R.4    Livingston, D.5    Elledge, S.J.6
  • 58
    • 0032999336 scopus 로고    scopus 로고
    • BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site
    • Ruffner H, Jiang W, Craig AG, Hunter T, Verma IM. BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. Mol Cell Biol. 1999;19:4843-54.
    • (1999) Mol Cell Biol , vol.19 , pp. 4843-4854
    • Ruffner, H.1    Jiang, W.2    Craig, A.G.3    Hunter, T.4    Verma, I.M.5
  • 59
    • 0034665121 scopus 로고    scopus 로고
    • Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage
    • Chen J. Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. Cancer Res. 2000;60:5037-9.
    • (2000) Cancer Res , vol.60 , pp. 5037-5039
    • Chen, J.1
  • 60
    • 0031046294 scopus 로고    scopus 로고
    • A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins
    • Bork P, Hofmann K, Bucher P, Neuwald AF, Altschul SF, Koonin EV. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 1997;11:68-76.
    • (1997) FASEB J , vol.11 , pp. 68-76
    • Bork, P.1    Hofmann, K.2    Bucher, P.3    Neuwald, A.F.4    Altschul, S.F.5    Koonin, E.V.6
  • 61
    • 0030187780 scopus 로고    scopus 로고
    • BRCA1 protein products... Functional motifs...
    • [letter]
    • Koonin EV, Altschul SF, Bork P. BRCA1 protein products ... Functional motifs... [letter]. Nat Genet. 1996;13:266-8.
    • (1996) Nat Genet , vol.13 , pp. 266-268
    • Koonin, E.V.1    Altschul, S.F.2    Bork, P.3
  • 62
    • 0031031787 scopus 로고    scopus 로고
    • From BRCA1 to RAP1: A widespread BRCT module closely associated with DNA repair
    • Callebaut I, Mornon JP. From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett. 1997;400:25-30.
    • (1997) FEBS Lett , vol.400 , pp. 25-30
    • Callebaut, I.1    Mornon, J.P.2
  • 63
    • 3142608985 scopus 로고    scopus 로고
    • Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains
    • Botuyan MV, Nomine Y, Yu X, Juranic N, Macura S, Chen J, et al. Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure. 2004;12:1137-46.
    • (2004) Structure , vol.12 , pp. 1137-1146
    • Botuyan, M.V.1    Nomine, Y.2    Yu, X.3    Juranic, N.4    Macura, S.5    Chen, J.6
  • 64
    • 2542490186 scopus 로고    scopus 로고
    • Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
    • Williams RS, Lee MS, Hau DD, Glover JN. Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1. Nat Struct Mol Biol. 2004;11:519-25.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 519-525
    • Williams, R.S.1    Lee, M.S.2    Hau, D.D.3    Glover, J.N.4
  • 65
    • 2542489188 scopus 로고    scopus 로고
    • Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
    • Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, et al. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol. 2004;11:512-8.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 512-518
    • Clapperton, J.A.1    Manke, I.A.2    Lowery, D.M.3    Ho, T.4    Haire, L.F.5    Yaffe, M.B.6
  • 66
    • 2342484423 scopus 로고    scopus 로고
    • Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: Implications for signaling
    • Shiozaki EN, Gu L, Yan N, Shi Y. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Mol Cell. 2004;14:405-12.
    • (2004) Mol Cell , vol.14 , pp. 405-412
    • Shiozaki, E.N.1    Gu, L.2    Yan, N.3    Shi, Y.4
  • 67
    • 0346101743 scopus 로고    scopus 로고
    • Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains
    • Rodriguez M, Yu X, Chen J, Songyang Z. Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J Biol Chem. 2003;278:52914-8.
    • (2003) J Biol Chem , vol.278 , pp. 52914-52918
    • Rodriguez, M.1    Yu, X.2    Chen, J.3    Songyang, Z.4
  • 68
    • 0142240342 scopus 로고    scopus 로고
    • BRCT repeats as phosphopeptide-binding modules involved in protein targeting
    • Manke IA, Lowery DM, Nguyen A, Yaffe MB. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science. 2003;302:636-9.
    • (2003) Science , vol.302 , pp. 636-639
    • Manke, I.A.1    Lowery, D.M.2    Nguyen, A.3    Yaffe, M.B.4
  • 69
    • 0028034348 scopus 로고
    • Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families
    • Friedman LS, Ostermeyer EA, Szabo CI, Dowd P, Lynch ED, Rowell SE, et al. Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families. Nat Genet. 1994;8:399-404.
    • (1994) Nat Genet , vol.8 , pp. 399-404
    • Friedman, L.S.1    Ostermeyer, E.A.2    Szabo, C.I.3    Dowd, P.4    Lynch, E.D.5    Rowell, S.E.6
  • 70
    • 0030474170 scopus 로고    scopus 로고
    • Evidence for a transcriptional activation function of BRCA1 Cterminal region
    • Monteiro AN, August A, Hanafusa H. Evidence for a transcriptional activation function of BRCA1 Cterminal region. Proc Natl Acad Sci U S A. 1996;93:13595-9.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13595-13599
    • Monteiro, A.N.1    August, A.2    Hanafusa, H.3
  • 71
    • 0029830051 scopus 로고    scopus 로고
    • Transcriptional activation by BRCA1
    • [letter; comment]
    • Chapman MS, Verma IM. Transcriptional activation by BRCA1 [letter; comment]. Nature. 1996;382:678-9.
    • (1996) Nature , vol.382 , pp. 678-679
    • Chapman, M.S.1    Verma, I.M.2
  • 73
    • 0031830844 scopus 로고    scopus 로고
    • BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A
    • Anderson SF, Schlegel BP, Nakajima T, Wolpin ES, Parvin JD. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat Genet. 1998;19:254-6.
    • (1998) Nat Genet , vol.19 , pp. 254-256
    • Anderson, S.F.1    Schlegel, B.P.2    Nakajima, T.3    Wolpin, E.S.4    Parvin, J.D.5
  • 74
    • 0034306456 scopus 로고    scopus 로고
    • BRCA1: Exploring the links to transcription
    • Monteiro AN. BRCA1: exploring the links to transcription. Trends Biochem Sci. 2000;25:469-74.
    • (2000) Trends Biochem Sci , vol.25 , pp. 469-474
    • Monteiro, A.N.1
  • 75
    • 0036682183 scopus 로고    scopus 로고
    • The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme
    • Chiba N, Parvin JD. The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme. Cancer Res. 2002;62:4222-8.
    • (2002) Cancer Res , vol.62 , pp. 4222-4228
    • Chiba, N.1    Parvin, J.D.2
  • 76
    • 0032532543 scopus 로고    scopus 로고
    • BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells
    • Wang Q, Zhang H, Kajino K, Greene MI. BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells. Oncogene. 1998;17:1939-48.
    • (1998) Oncogene , vol.17 , pp. 1939-1948
    • Wang, Q.1    Zhang, H.2    Kajino, K.3    Greene, M.I.4
  • 78
    • 0034697973 scopus 로고    scopus 로고
    • BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer
    • Bochar DA, Wang L, Beniya H, Kinev A, Xue Y, Lane WS, et al. BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell. 2000;102:257-65.
    • (2000) Cell , vol.102 , pp. 257-265
    • Bochar, D.A.1    Wang, L.2    Beniya, H.3    Kinev, A.4    Xue, Y.5    Lane, W.S.6
  • 79
    • 0033609057 scopus 로고    scopus 로고
    • BRCA1 interacts with components of the histone deacetylase complex
    • Yarden RI, Brody LC. BRCA1 interacts with components of the histone deacetylase complex. Proc Natl Acad Sci U S A. 1999;96:4983-8.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 4983-4988
    • Yarden, R.I.1    Brody, L.C.2
  • 80
    • 0033591295 scopus 로고    scopus 로고
    • BRCA1 inhibition of estrogen receptor signaling in transfected cells
    • Fan S, Wang J, Yuan R, Ma Y, Meng Q, Erdos MR, et al. BRCA1 inhibition of estrogen receptor signaling in transfected cells. Science. 1999;284:1354-6.
    • (1999) Science , vol.284 , pp. 1354-1356
    • Fan, S.1    Wang, J.2    Yuan, R.3    Ma, Y.4    Meng, Q.5    Erdos, M.R.6
  • 82
    • 0001221269 scopus 로고    scopus 로고
    • Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50
    • Kleiman FE, Manley JL. Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. Science. 1999;285:1576-9.
    • (1999) Science , vol.285 , pp. 1576-1579
    • Kleiman, F.E.1    Manley, J.L.2
  • 85
    • 0036490136 scopus 로고    scopus 로고
    • Participation of BRCA1 in the DNA repair response...via transcription
    • Monteiro AN. Participation of BRCA1 in the DNA repair response...via transcription. Cancer Biol Ther. 2002;1:187-8.
    • (2002) Cancer Biol Ther , vol.1 , pp. 187-188
    • Monteiro, A.N.1
  • 86
    • 0034723347 scopus 로고    scopus 로고
    • BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression
    • [In Process Citation]
    • MacLachlan TK, Somasundaram K, Sgagias M, Shifman Y, Muschel RJ, Cowan KH, et al. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression [In Process Citation]. J Biol Chem. 2000;275:2777-85.
    • (2000) J Biol Chem , vol.275 , pp. 2777-2785
    • MacLachlan, T.K.1    Somasundaram, K.2    Sgagias, M.3    Shifman, Y.4    Muschel, R.J.5    Cowan, K.H.6
  • 87
    • 0036261733 scopus 로고    scopus 로고
    • BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets
    • MacLachlan TK, Takimoto R, El-Deiry WS. BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets. Mol Cell Biol. 2002;22:4280-92.
    • (2002) Mol Cell Biol , vol.22 , pp. 4280-4292
    • MacLachlan, T.K.1    Takimoto, R.2    El-Deiry, W.S.3
  • 88
    • 0030759895 scopus 로고    scopus 로고
    • Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1
    • Somasundaram K, Zhang H, Zeng YX, Houvras Y, Peng Y, Zhang H, et al. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1. Nature. 1997;389:187-90.
    • (1997) Nature , vol.389 , pp. 187-190
    • Somasundaram, K.1    Zhang, H.2    Zeng, Y.X.3    Houvras, Y.4    Peng, Y.5    Zhang, H.6
  • 89
    • 0036490983 scopus 로고    scopus 로고
    • BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation
    • Takimoto R, MacLachlan TK, Dicker DT, Niitsu Y, Mori T, El Deiry WS. BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation. Cancer Biol Ther. 2002;1:177-86.
    • (2002) Cancer Biol Ther , vol.1 , pp. 177-186
    • Takimoto, R.1    MacLachlan, T.K.2    Dicker, D.T.3    Niitsu, Y.4    Mori, T.5    El Deiry, W.S.6
  • 90
    • 0032473879 scopus 로고    scopus 로고
    • BRCA1 physically associates with p53 and stimulates its transcriptional activity
    • Zhang H, Somasundaram K, Peng Y, Tian H, Zhang H, Bi D, et al. BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene. 1998;16:1713-21.
    • (1998) Oncogene , vol.16 , pp. 1713-1721
    • Zhang, H.1    Somasundaram, K.2    Peng, Y.3    Tian, H.4    Zhang, H.5    Bi, D.6
  • 91
    • 0345276495 scopus 로고    scopus 로고
    • Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair
    • Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, et al. Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell. 2003;12:1087-99.
    • (2003) Mol Cell , vol.12 , pp. 1087-1099
    • Dong, Y.1    Hakimi, M.A.2    Chen, X.3    Kumaraswamy, E.4    Cooch, N.S.5    Godwin, A.K.6
  • 93
    • 0035874894 scopus 로고    scopus 로고
    • Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation
    • Moynahan ME, Cui TY, Jasin M. Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation. Cancer Res. 2001;61:4842-50.
    • (2001) Cancer Res , vol.61 , pp. 4842-4850
    • Moynahan, M.E.1    Cui, T.Y.2    Jasin, M.3
  • 95
    • 0031472370 scopus 로고    scopus 로고
    • Association of BRCA1 with Rad51 in mitotic and meiotic cells
    • Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell. 1997;88:265-75.
    • (1997) Cell , vol.88 , pp. 265-275
    • Scully, R.1    Chen, J.2    Plug, A.3    Xiao, Y.4    Weaver, D.5    Feunteun, J.6
  • 96
    • 0033590171 scopus 로고    scopus 로고
    • BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene
    • Snouwaert JN, Gowen LC, Latour AM, Mohn AR, Xiao A, DiBiase L, et al. BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene. Oncogene. 1999;18:7900-7.
    • (1999) Oncogene , vol.18 , pp. 7900-7907
    • Snouwaert, J.N.1    Gowen, L.C.2    Latour, A.M.3    Mohn, A.R.4    Xiao, A.5    DiBiase, L.6
  • 97
    • 0034604716 scopus 로고    scopus 로고
    • The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin
    • Bhattacharyya A, Ear US, Koller BH, Weichselbaum RR, Bishop DK. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin. J Biol Chem. 2000;275:23899-903.
    • (2000) J Biol Chem , vol.275 , pp. 23899-23903
    • Bhattacharyya, A.1    Ear, U.S.2    Koller, B.H.3    Weichselbaum, R.R.4    Bishop, D.K.5
  • 98
    • 0033603440 scopus 로고    scopus 로고
    • BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair
    • Abbott DW, Thompson ME, Robinson-Benion C, Tomlinson G, Jensen RA, Holt JT. BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair. J Biol Chem. 1999;274:18808-12.
    • (1999) J Biol Chem , vol.274 , pp. 18808-18812
    • Abbott, D.W.1    Thompson, M.E.2    Robinson-Benion, C.3    Tomlinson, G.4    Jensen, R.A.5    Holt, J.T.6
  • 99
    • 0037099520 scopus 로고    scopus 로고
    • Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts
    • Zhong Q, Boyer TG, Chen PL, Lee WH. Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res. 2002;62:3966-70.
    • (2002) Cancer Res , vol.62 , pp. 3966-3970
    • Zhong, Q.1    Boyer, T.G.2    Chen, P.L.3    Lee, W.H.4
  • 100
    • 0035136283 scopus 로고    scopus 로고
    • Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2
    • Wang H, Zeng ZC, Bui TA, DiBiase SJ, Qin W, Xia F, et al. Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2. Cancer Res. 2001;61:270-7.
    • (2001) Cancer Res , vol.61 , pp. 270-277
    • Wang, H.1    Zeng, Z.C.2    Bui, T.A.3    DiBiase, S.J.4    Qin, W.5    Xia, F.6
  • 101
    • 23644445483 scopus 로고    scopus 로고
    • Oh what a tangled web it weaves: BRCA1 and DNA decatenation
    • Ashworth A. Oh what a tangled web it weaves: BRCA1 and DNA decatenation. Cancer Cell. 2005;8:95-7.
    • (2005) Cancer Cell , vol.8 , pp. 95-97
    • Ashworth, A.1
  • 103
    • 33645003172 scopus 로고    scopus 로고
    • BRCA1: Cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution
    • Deng CX. BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res. 2006;34:1416-26.
    • (2006) Nucleic Acids Res , vol.34 , pp. 1416-1426
    • Deng, C.X.1
  • 104
    • 0035032649 scopus 로고    scopus 로고
    • Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation
    • Xu B, Kim S, Kastan MB. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol. 2001;21:3445-50.
    • (2001) Mol Cell Biol , vol.21 , pp. 3445-3450
    • Xu, B.1    Kim, S.2    Kastan, M.B.3
  • 105
    • 0030800325 scopus 로고    scopus 로고
    • A BRCA1 mutant alters G2-M cell cycle control in human mammary epithelial cells
    • Larson JS, Tonkinson JL, Lai MT. A BRCA1 mutant alters G2-M cell cycle control in human mammary epithelial cells. Cancer Res. 1997;57:3351-5.
    • (1997) Cancer Res , vol.57 , pp. 3351-3355
    • Larson, J.S.1    Tonkinson, J.L.2    Lai, M.T.3
  • 106
    • 0035959804 scopus 로고    scopus 로고
    • BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents
    • Mullan PB, Quinn JE, Gilmore PM, McWilliams S, Andrews H, Gervin C, et al. BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents. Oncogene. 2001;20:6123-31.
    • (2001) Oncogene , vol.20 , pp. 6123-6131
    • Mullan, P.B.1    Quinn, J.E.2    Gilmore, P.M.3    McWilliams, S.4    Andrews, H.5    Gervin, C.6
  • 107
    • 0033106326 scopus 로고    scopus 로고
    • Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
    • Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, et al. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell. 1999;3:389-95.
    • (1999) Mol Cell , vol.3 , pp. 389-395
    • Xu, X.1    Weaver, Z.2    Linke, S.P.3    Li, C.4    Gotay, J.5    Wang, X.W.6
  • 108
    • 0030910022 scopus 로고    scopus 로고
    • The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews
    • Struewing JP, Hartge P, Wacholder S, Baker SM, Berlin M, McAdams M, et al. The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med. 1997;336:1401-8.
    • (1997) N Engl J Med , vol.336 , pp. 1401-1408
    • Struewing, J.P.1    Hartge, P.2    Wacholder, S.3    Baker, S.M.4    Berlin, M.5    McAdams, M.6
  • 109
    • 0037087536 scopus 로고    scopus 로고
    • Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: Analysis of 10,000 individuals
    • Frank TS, Deffenbaugh AM, Reid JE, Hulick M, Ward BE, Lingenfelter B, et al. Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals. J Clin Oncol. 2002;20:1480-90.
    • (2002) J Clin Oncol , vol.20 , pp. 1480-1490
    • Frank, T.S.1    Deffenbaugh, A.M.2    Reid, J.E.3    Hulick, M.4    Ward, B.E.5    Lingenfelter, B.6
  • 110
    • 27544483543 scopus 로고    scopus 로고
    • Application of embryonic lethal or other obvious phenotypes to characterize the clinical significance of genetic variants found in trans with known deleterious mutations
    • Judkins T, Hendrickson BC, Deffenbaugh AM, Eliason K, Leclair B, Norton MJ, et al. Application of embryonic lethal or other obvious phenotypes to characterize the clinical significance of genetic variants found in trans with known deleterious mutations. Cancer Res. 2005;65:10096-103.
    • (2005) Cancer Res , vol.65 , pp. 10096-10103
    • Judkins, T.1    Hendrickson, B.C.2    Deffenbaugh, A.M.3    Eliason, K.4    Leclair, B.5    Norton, M.J.6
  • 111
    • 24644490720 scopus 로고    scopus 로고
    • Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: Systematic evidence review for the U.S. Preventive Services Task Force
    • Nelson HD, Huffman LH, Fu R, Harris EL. Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med. 2005;143:362-79.
    • (2005) Ann Intern Med , vol.143 , pp. 362-379
    • Nelson, H.D.1    Huffman, L.H.2    Fu, R.3    Harris, E.L.4
  • 112
    • 15544381256 scopus 로고    scopus 로고
    • Prevention and management of hereditary breast cancer
    • Narod SA, Offit K. Prevention and management of hereditary breast cancer. J Clin Oncol. 2005;23:1656-63.
    • (2005) J Clin Oncol , vol.23 , pp. 1656-1663
    • Narod, S.A.1    Offit, K.2
  • 113
    • 33644875778 scopus 로고    scopus 로고
    • Evaluation and management of women with BRCA1/2 mutations
    • (Williston Park)
    • Peshkin BN, Isaacs C. Evaluation and management of women with BRCA1/2 mutations. Oncology (Williston Park). 2005;19:1451-9.
    • (2005) Oncology , vol.19 , pp. 1451-1459
    • Peshkin, B.N.1    Isaacs, C.2
  • 114
    • 0035880897 scopus 로고    scopus 로고
    • Family history of breast and ovarian cancers and BRCA1 and BRCA2 mutations in a population-based series of early-onset breast cancer
    • Loman N, Johannsson O, Kristoffersson U, Olsson H, Borg A. Family history of breast and ovarian cancers and BRCA1 and BRCA2 mutations in a population-based series of early-onset breast cancer. J Natl Cancer Inst. 2001;93:1215-23.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1215-1223
    • Loman, N.1    Johannsson, O.2    Kristoffersson, U.3    Olsson, H.4    Borg, A.5
  • 115
    • 33645119502 scopus 로고    scopus 로고
    • Genetic risk assessment and BRCA mutation testing
    • Eisinger F, Horsman DE. Genetic risk assessment and BRCA mutation testing. Ann Intern Med. 2006;144:376-7.
    • (2006) Ann Intern Med , vol.144 , pp. 376-377
    • Eisinger, F.1    Horsman, D.E.2
  • 118
    • 0033799478 scopus 로고    scopus 로고
    • Screening for genomic rearrangements in families with breast and ovarian cancer identifies BRCA1 mutations previously missed by conformation-sensitive gel electrophoresis or sequencing
    • Unger MA, Nathanson KL, Calzone K, Antin-Ozerkis D, Shih HA, Martin AM, et al. Screening for genomic rearrangements in families with breast and ovarian cancer identifies BRCA1 mutations previously missed by conformation-sensitive gel electrophoresis or sequencing. Am J Hum Genet. 2000;67:841-50.
    • (2000) Am J Hum Genet , vol.67 , pp. 841-850
    • Unger, M.A.1    Nathanson, K.L.2    Calzone, K.3    Antin-Ozerkis, D.4    Shih, H.A.5    Martin, A.M.6
  • 119
    • 0033556051 scopus 로고    scopus 로고
    • Screening for germline rearrangements and regulatory mutations in BRCA1 led to the identification of four new deletions
    • Puget N, Stoppa-Lyonnet D, Sinilnikova OM, Pages S, Lynch HT, Lenoir GM, et al. Screening for germline rearrangements and regulatory mutations in BRCA1 led to the identification of four new deletions. Cancer Res. 1999;59:455-61.
    • (1999) Cancer Res , vol.59 , pp. 455-461
    • Puget, N.1    Stoppa-Lyonnet, D.2    Sinilnikova, O.M.3    Pages, S.4    Lynch, H.T.5    Lenoir, G.M.6
  • 120
    • 33645084562 scopus 로고    scopus 로고
    • Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer
    • Walsh T, Casadei S, Coats KH, Swisher E, Stray SM, Higgins J, et al. Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. JAMA. 2006;295:1379-88.
    • (2006) JAMA , vol.295 , pp. 1379-1388
    • Walsh, T.1    Casadei, S.2    Coats, K.H.3    Swisher, E.4    Stray, S.M.5    Higgins, J.6
  • 122
    • 0031946411 scopus 로고    scopus 로고
    • Yeast-based assays for detection and characterization of mutations in BRCA1
    • Monteiro AN, Humphrey JS. Yeast-based assays for detection and characterization of mutations in BRCA1. Breast Dis. 1998;10:61-70.
    • (1998) Breast Dis , vol.10 , pp. 61-70
    • Monteiro, A.N.1    Humphrey, J.S.2
  • 124
    • 0346101739 scopus 로고    scopus 로고
    • Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations
    • Williams RS, Chasman DI, Hau DD, Hui B, Lau AY, Glover JN. Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations. J Biol Chem. 2003;278:53007-16.
    • (2003) J Biol Chem , vol.278 , pp. 53007-53016
    • Williams, R.S.1    Chasman, D.I.2    Hau, D.D.3    Hui, B.4    Lau, A.Y.5    Glover, J.N.6
  • 125
    • 2542543477 scopus 로고    scopus 로고
    • Structure-based assessment of missense mutations in human BRCA1: Implications for breast and ovarian cancer predisposition
    • Mirkovic N, Marti-Renom MA, Weber BL, Sali A, Monteiro AN. Structure-based assessment of missense mutations in human BRCA1: implications for breast and ovarian cancer predisposition. Cancer Res. 2004;64:3790-7.
    • (2004) Cancer Res , vol.64 , pp. 3790-3797
    • Mirkovic, N.1    Marti-Renom, M.A.2    Weber, B.L.3    Sali, A.4    Monteiro, A.N.5
  • 127
    • 0035570037 scopus 로고    scopus 로고
    • Psychosocial issues following a positive result of genetic testing for BRCA1 and BRCA2 mutations: Findings from a focus group and a needs-assessment survey
    • Di Prospero LS, Seminsky M, Honeyford J, Doan B, Franssen E, Meschino W, et al. Psychosocial issues following a positive result of genetic testing for BRCA1 and BRCA2 mutations: findings from a focus group and a needs-assessment survey. CMAJ. 2001;164:1005-9.
    • (2001) CMAJ , vol.164 , pp. 1005-1009
    • Di Prospero, L.S.1    Seminsky, M.2    Honeyford, J.3    Doan, B.4    Franssen, E.5    Meschino, W.6
  • 128
    • 21244483991 scopus 로고    scopus 로고
    • Measurement of psychological factors associated with genetic testing for hereditary breast, ovarian and colon cancers
    • Vadaparampil ST, Ropka M, Stefanek ME. Measurement of psychological factors associated with genetic testing for hereditary breast, ovarian and colon cancers. Fam Cancer. 2005;4:195-206.
    • (2005) Fam Cancer , vol.4 , pp. 195-206
    • Vadaparampil, S.T.1    Ropka, M.2    Stefanek, M.E.3
  • 129
    • 0038474022 scopus 로고    scopus 로고
    • Use of genetic testing and prophylactic mastectomy and oophorectomy in women with breast or ovarian cancer from families with a BRCA1 or BRCA2 mutation
    • Meijers-Heijboer H, Brekelmans CT, Menke-Pluymers M, Seynaeve C, Baalbergen A, Burger C, et al. Use of genetic testing and prophylactic mastectomy and oophorectomy in women with breast or ovarian cancer from families with a BRCA1 or BRCA2 mutation. J Clin Oncol. 2003;21:1675-81.
    • (2003) J Clin Oncol , vol.21 , pp. 1675-1681
    • Meijers-Heijboer, H.1    Brekelmans, C.T.2    Menke-Pluymers, M.3    Seynaeve, C.4    Baalbergen, A.5    Burger, C.6
  • 131
    • 0028843102 scopus 로고
    • Breast and ovarian cancer incidence in BRCA1-mutation carriers
    • Breast Cancer Linkage Consortium
    • Easton DF, Ford D, Bishop DT. Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Am J Hum Genet. 1995;56:265-71.
    • (1995) Am J Hum Genet , vol.56 , pp. 265-271
    • Easton, D.F.1    Ford, D.2    Bishop, D.T.3
  • 133
    • 0030893779 scopus 로고    scopus 로고
    • Recommendations for follow-up care of individuals with an inherited predisposition to cancer. II. BRCA1 and BRCA2
    • Cancer Genetics Studies Consortium
    • Burke W, Daly M, Garber J, Botkin J, Kahn MJ, Lynch P, et al. Recommendations for follow-up care of individuals with an inherited predisposition to cancer. II. BRCA1 and BRCA2. Cancer Genetics Studies Consortium. JAMA. 1997;277:997-1003.
    • (1997) JAMA , vol.277 , pp. 997-1003
    • Burke, W.1    Daly, M.2    Garber, J.3    Botkin, J.4    Kahn, M.J.5    Lynch, P.6
  • 134
    • 0036837238 scopus 로고    scopus 로고
    • A BRCA1/2 mutation, high breast density and prominent pushing margins of a tumor independently contribute to a frequent false-negative mammography
    • Tilanus-Linthorst M, Verhoog L, Obdeijn IM, Bartels K, Menke-Pluymers M, Eggermont A, et al. A BRCA1/2 mutation, high breast density and prominent pushing margins of a tumor independently contribute to a frequent false-negative mammography. Int J Cancer. 2002;102:91-5.
    • (2002) Int J Cancer , vol.102 , pp. 91-95
    • Tilanus-Linthorst, M.1    Verhoog, L.2    Obdeijn, I.M.3    Bartels, K.4    Menke-Pluymers, M.5    Eggermont, A.6
  • 136
    • 0033869841 scopus 로고    scopus 로고
    • Association of mammographically defined percent breast density with epidemiologic risk factors for breast cancer (United States)
    • Vachon CM, Kuni CC, Anderson K, Anderson VE, Sellers TA. Association of mammographically defined percent breast density with epidemiologic risk factors for breast cancer (United States). Cancer Causes Control. 2000;11:653-62.
    • (2000) Cancer Causes Control , vol.11 , pp. 653-662
    • Vachon, C.M.1    Kuni, C.C.2    Anderson, K.3    Anderson, V.E.4    Sellers, T.A.5
  • 138
    • 32944479344 scopus 로고    scopus 로고
    • Mammographic density and breast cancer risk in BRCA1 and BRCA2 mutation carriers
    • Mitchell G, Antoniou AC, Warren R, Peock S, Brown J, Davies R, et al. Mammographic density and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Res. 2006;66:1866-72.
    • (2006) Cancer Res , vol.66 , pp. 1866-1872
    • Mitchell, G.1    Antoniou, A.C.2    Warren, R.3    Peock, S.4    Brown, J.5    Davies, R.6
  • 139
    • 11144245099 scopus 로고    scopus 로고
    • Utilization of screening and preventive surgery among unaffected carriers of a BRCA1 or BRCA2 gene mutation
    • Wainberg S, Husted J. Utilization of screening and preventive surgery among unaffected carriers of a BRCA1 or BRCA2 gene mutation. Cancer Epidemiol Biomarkers Prev. 2004;13:1989-95.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 1989-1995
    • Wainberg, S.1    Husted, J.2
  • 140
    • 4544230001 scopus 로고    scopus 로고
    • Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination
    • Warner E, Plewes DB, Hill KA, Causer PA, Zubovits JT, Jong RA, et al. Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination. JAMA. 2004;292:1317-25.
    • (2004) JAMA , vol.292 , pp. 1317-1325
    • Warner, E.1    Plewes, D.B.2    Hill, K.A.3    Causer, P.A.4    Zubovits, J.T.5    Jong, R.A.6
  • 142
    • 0035680432 scopus 로고    scopus 로고
    • Hormonal prevention of hereditary breast cancer
    • Narod SA. Hormonal prevention of hereditary breast cancer. Ann N Y Acad Sci. 2001;952:36-43.
    • (2001) Ann N Y Acad Sci , vol.952 , pp. 36-43
    • Narod, S.A.1
  • 143
    • 0033610723 scopus 로고    scopus 로고
    • Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2
    • Jernstrom H, Lerman C, Ghadirian P, Lynch HT, Weber B, Garber J, et al. Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2. Lancet. 1999;354:1846-50.
    • (1999) Lancet , vol.354 , pp. 1846-1850
    • Jernstrom, H.1    Lerman, C.2    Ghadirian, P.3    Lynch, H.T.4    Weber, B.5    Garber, J.6
  • 145
    • 0142178215 scopus 로고    scopus 로고
    • Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2
    • King MC, Marks JH, Mandell JB. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science. 2003;302:643-6.
    • (2003) Science , vol.302 , pp. 643-646
    • King, M.C.1    Marks, J.H.2    Mandell, J.B.3
  • 146
    • 0032587877 scopus 로고    scopus 로고
    • Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
    • [see comments]
    • Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, et al. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation [see comments]. Nat Genet. 1999;22:37-43.
    • (1999) Nat Genet , vol.22 , pp. 37-43
    • Xu, X.1    Wagner, K.U.2    Larson, D.3    Weaver, Z.4    Li, C.5    Ried, T.6
  • 147
    • 0023490467 scopus 로고
    • Influence of pregnancy and lactation on serum and breast fluid estrogen levels: Implications for breast cancer risk
    • Petrakis NL, Wrensch MR, Ernster VL, Miike R, Murai J, Simberg N, et al. Influence of pregnancy and lactation on serum and breast fluid estrogen levels: implications for breast cancer risk. Int J Cancer. 1987;40:587-91.
    • (1987) Int J Cancer , vol.40 , pp. 587-591
    • Petrakis, N.L.1    Wrensch, M.R.2    Ernster, V.L.3    Miike, R.4    Murai, J.5    Simberg, N.6
  • 149
    • 0034686619 scopus 로고    scopus 로고
    • Genetic and hormonal risk factors in breast cancer
    • Martin AM, Weber BL. Genetic and hormonal risk factors in breast cancer. J Natl Cancer Inst. 2000;92:1126-35.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1126-1135
    • Martin, A.M.1    Weber, B.L.2
  • 150
    • 0242390079 scopus 로고    scopus 로고
    • Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies
    • Collaborative Group on Hormonal Factors in Breast Cancer
    • Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Lancet. 1996;347:1713-27.
    • (1996) Lancet , vol.347 , pp. 1713-1727
  • 151
    • 0036952821 scopus 로고    scopus 로고
    • Oral contraceptives and risk of familial breast cancer
    • Heimdal K, Skovlund E, Moller P. Oral contraceptives and risk of familial breast cancer. Cancer Detect Prev. 2002;26:23-7.
    • (2002) Cancer Detect Prev , vol.26 , pp. 23-27
    • Heimdal, K.1    Skovlund, E.2    Moller, P.3
  • 153
    • 20944437355 scopus 로고    scopus 로고
    • Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations
    • Milne RL, Knight JA, John EM, Dite GS, Balbuena R, Ziogas A, et al. Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations. Cancer Epidemiol Biomarkers Prev. 2005;14:350-6.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 350-356
    • Milne, R.L.1    Knight, J.A.2    John, E.M.3    Dite, G.S.4    Balbuena, R.5    Ziogas, A.6
  • 154
    • 0030865837 scopus 로고    scopus 로고
    • Does oral contraceptive use increase the risk of breast cancer in women with BRCA1/BRCA2 mutations more than in other women?
    • Ursin G, Henderson BE, Haile RW, Pike MC, Zhou N, Diep A, et al. Does oral contraceptive use increase the risk of breast cancer in women with BRCA1/BRCA2 mutations more than in other women? Cancer Res. 1997;57:3678-81.
    • (1997) Cancer Res , vol.57 , pp. 3678-3681
    • Ursin, G.1    Henderson, B.E.2    Haile, R.W.3    Pike, M.C.4    Zhou, N.5    Diep, A.6
  • 156
    • 0027761905 scopus 로고
    • Elective ovarian removal and estrogen replacement therapy - Effects on sexual life, psychological well-being and androgen status
    • Nathorst-Boos J, von SB, Carlstrom K. Elective ovarian removal and estrogen replacement therapy - effects on sexual life, psychological well-being and androgen status. J Psychosom Obstet Gynaecol. 1993;14:283-93.
    • (1993) J Psychosom Obstet Gynaecol , vol.14 , pp. 283-293
    • Nathorst-Boos, J.1    Von, S.B.2    Carlstrom, K.3
  • 157
    • 30944463691 scopus 로고    scopus 로고
    • Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: The PROSE Study Group
    • Rebbeck TR, Friebel T, Wagner T, Lynch HT, Garber JE, Daly MB, et al. Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group. J Clin Oncol. 2005;23:7804-10.
    • (2005) J Clin Oncol , vol.23 , pp. 7804-7810
    • Rebbeck, T.R.1    Friebel, T.2    Wagner, T.3    Lynch, H.T.4    Garber, J.E.5    Daly, M.B.6
  • 158
    • 0033574030 scopus 로고    scopus 로고
    • Effects of estrogen and estrogen-progestin on mammographic parenchymal density
    • Postmenopausal Estrogen/Progestin Interventions (PEPI) Investigators
    • Greendale GA, Reboussin BA, Sie A, Singh HR, Olson LK, Gatewood O, et al. Effects of estrogen and estrogen-progestin on mammographic parenchymal density. Postmenopausal Estrogen/Progestin Interventions (PEPI) Investigators. Ann Intern Med. 1999;130:262-9.
    • (1999) Ann Intern Med , vol.130 , pp. 262-269
    • Greendale, G.A.1    Reboussin, B.A.2    Sie, A.3    Singh, H.R.4    Olson, L.K.5    Gatewood, O.6
  • 162
    • 0038744296 scopus 로고    scopus 로고
    • Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: A combined analysis of 22 studies
    • Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet. 2003;72:1117-30.
    • (2003) Am J Hum Genet , vol.72 , pp. 1117-1130
    • Antoniou, A.1    Pharoah, P.D.2    Narod, S.3    Risch, H.A.4    Eyfjord, J.E.5    Hopper, J.L.6
  • 164
    • 0034597916 scopus 로고    scopus 로고
    • Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: A case-control study
    • Hereditary Breast Cancer Clinical Study Group
    • Narod SA, Brunet JS, Ghadirian P, Robson M, Heimdal K, Neuhausen SL, et al. Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Hereditary Breast Cancer Clinical Study Group. Lancet. 2000;356:1876-81.
    • (2000) Lancet , vol.356 , pp. 1876-1881
    • Narod, S.A.1    Brunet, J.S.2    Ghadirian, P.3    Robson, M.4    Heimdal, K.5    Neuhausen, S.L.6
  • 165
    • 0035861037 scopus 로고    scopus 로고
    • Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial
    • King MC, Wieand S, Hale K, Lee M, Walsh T, Owens K, et al. Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial. JAMA. 2001;286:2251-6.
    • (2001) JAMA , vol.286 , pp. 2251-2256
    • King, M.C.1    Wieand, S.2    Hale, K.3    Lee, M.4    Walsh, T.5    Owens, K.6
  • 166
    • 0036569877 scopus 로고    scopus 로고
    • The pathology of familial breast cancer: Predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2
    • Lakhani SR, van de Vijver MJ, Jacquemier J, Anderson TJ, Osin PP, McGuffog L, et al. The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2. J Clin Oncol. 2002;20:2310-8.
    • (2002) J Clin Oncol , vol.20 , pp. 2310-2318
    • Lakhani, S.R.1    Van De Vijver, M.J.2    Jacquemier, J.3    Anderson, T.J.4    Osin, P.P.5    McGuffog, L.6
  • 167
    • 33645675556 scopus 로고    scopus 로고
    • Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: An update
    • Gronwald J, Tung N, Foulkes WD, Offit K, Gershoni R, Daly M, et al. Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: an update. Int J Cancer. 2006;118:2281-4.
    • (2006) Int J Cancer , vol.118 , pp. 2281-2284
    • Gronwald, J.1    Tung, N.2    Foulkes, W.D.3    Offit, K.4    Gershoni, R.5    Daly, M.6
  • 168
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 1998;90:1371-88.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1371-1388
    • Fisher, B.1    Costantino, J.P.2    Wickerham, D.L.3    Redmond, C.K.4    Kavanah, M.5    Cronin, W.M.6
  • 169
    • 0035804228 scopus 로고    scopus 로고
    • Role of direct interaction in BRCA1 inhibition of estrogen receptor activity
    • Fan S, Ma YX, Wang C, Yuan RQ, Meng Q, Wang JA, et al. Role of direct interaction in BRCA1 inhibition of estrogen receptor activity. Oncogene. 2001;20:77-87.
    • (2001) Oncogene , vol.20 , pp. 77-87
    • Fan, S.1    Ma, Y.X.2    Wang, C.3    Yuan, R.Q.4    Meng, Q.5    Wang, J.A.6
  • 170
    • 0035859823 scopus 로고    scopus 로고
    • BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor
    • Zheng L, Annab LA, Afshari CA, Lee WH, Boyer TG. BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor. Proc Natl Acad Sci U S A. 2001;98:9587-92.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9587-9592
    • Zheng, L.1    Annab, L.A.2    Afshari, C.A.3    Lee, W.H.4    Boyer, T.G.5
  • 171
    • 0032918850 scopus 로고    scopus 로고
    • Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines
    • Ferlini C, Scambia G, Marone M, Distefano M, Gaggini C, Ferrandina G, et al. Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines. Br J Cancer. 1999;79:257-63.
    • (1999) Br J Cancer , vol.79 , pp. 257-263
    • Ferlini, C.1    Scambia, G.2    Marone, M.3    Distefano, M.4    Gaggini, C.5    Ferrandina, G.6
  • 172
    • 12144290945 scopus 로고    scopus 로고
    • Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: Influence of age, grade, and histological type
    • Foulkes WD, Metcalfe K, Sun P, Hanna WM, Lynch HT, Ghadirian P, et al. Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: influence of age, grade, and histological type. Clin Cancer Res. 2004;10:2029-34.
    • (2004) Clin Cancer Res , vol.10 , pp. 2029-2034
    • Foulkes, W.D.1    Metcalfe, K.2    Sun, P.3    Hanna, W.M.4    Lynch, H.T.5    Ghadirian, P.6
  • 173
    • 18044394762 scopus 로고    scopus 로고
    • Preferences of Women Evaluating Risks of Tamoxifen (POWER) study of preferences for tamoxifen for breast cancer risk reduction
    • Melnikow J, Paterniti D, Azari R, Kuenneth C, Birch S, Kuppermann M, et al. Preferences of Women Evaluating Risks of Tamoxifen (POWER) study of preferences for tamoxifen for breast cancer risk reduction. Cancer. 2005;103:1996-2005.
    • (2005) Cancer , vol.103 , pp. 1996-2005
    • Melnikow, J.1    Paterniti, D.2    Azari, R.3    Kuenneth, C.4    Birch, S.5    Kuppermann, M.6
  • 174
    • 0033581212 scopus 로고    scopus 로고
    • Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: Results from a 3-year randomized clinical trial
    • Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators
    • Ettinger B, Black DM, Mitlak BH, Knickerbocker RK, Nickelsen T, Genant HK, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. JAMA. 1999;282:637-45.
    • (1999) JAMA , vol.282 , pp. 637-645
    • Ettinger, B.1    Black, D.M.2    Mitlak, B.H.3    Knickerbocker, R.K.4    Nickelsen, T.5    Genant, H.K.6
  • 175
    • 0033575083 scopus 로고    scopus 로고
    • The effect of raloxifene on risk of breast cancer in postmenopausal women: Results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation
    • Cummings SR, Eckert S, Krueger KA, Grady D, Powles TJ, Cauley JA, et al. The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. JAMA. 1999;281:2189-97.
    • (1999) JAMA , vol.281 , pp. 2189-2197
    • Cummings, S.R.1    Eckert, S.2    Krueger, K.A.3    Grady, D.4    Powles, T.J.5    Cauley, J.A.6
  • 176
    • 0035687124 scopus 로고    scopus 로고
    • The MORE trial: Multiple outcomes for raloxifene evaluation - Breast
    • Dickler MN, Norton L. The MORE trial: multiple outcomes for raloxifene evaluation - breast cancer as a secondary end point: implications for prevention. Ann N Y Acad Sci. 2001;949:134-42.
    • (2001) Ann N Y Acad Sci , vol.949 , pp. 134-142
    • Dickler, M.N.1    Norton, L.2
  • 177
    • 33745249570 scopus 로고    scopus 로고
    • Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial
    • Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA. 2006;295:2727-41.
    • (2006) JAMA , vol.295 , pp. 2727-2741
    • Vogel, V.G.1    Costantino, J.P.2    Wickerham, D.L.3    Cronin, W.M.4    Cecchini, R.S.5    Atkins, J.N.6
  • 178
    • 0141762745 scopus 로고    scopus 로고
    • Aromatase inhibitors: Mechanism of action and role in the treatment of breast cancer
    • Miller WR. Aromatase inhibitors: mechanism of action and role in the treatment of breast cancer. Semin Oncol. 2003;30:3-11.
    • (2003) Semin Oncol , vol.30 , pp. 3-11
    • Miller, W.R.1
  • 179
    • 1842505162 scopus 로고    scopus 로고
    • Aromatase inhibitors for breast cancer in postmenopausal women
    • Campos SM. Aromatase inhibitors for breast cancer in postmenopausal women. Oncologist. 2004;9:126-36.
    • (2004) Oncologist , vol.9 , pp. 126-136
    • Campos, S.M.1
  • 180
    • 10044258794 scopus 로고    scopus 로고
    • A phase I study of the pharmacokinetics, pharmacodynamics, and safety of single- and multiple-dose anastrozole in healthy, premenopausal female volunteers
    • Tredway DR, Buraglio M, Hemsey G, Denton G. A phase I study of the pharmacokinetics, pharmacodynamics, and safety of single- and multiple-dose anastrozole in healthy, premenopausal female volunteers. Fertil Steril. 2004;82:1587-93.
    • (2004) Fertil Steril , vol.82 , pp. 1587-1593
    • Tredway, D.R.1    Buraglio, M.2    Hemsey, G.3    Denton, G.4
  • 181
    • 85028126732 scopus 로고    scopus 로고
    • Reducing breast cancer incidence in familial breast cancer: Overlooking the present panorama
    • Marchetti P, Di Rocco CZ, Ricevuto E, Bisegna R, Cianci G, Calista F, et al. Reducing breast cancer incidence in familial breast cancer: overlooking the present panorama. Ann Oncol. 2004;15 Suppl 1:127-34.
    • (2004) Ann Oncol , vol.15 , Issue.1 SUPPL. , pp. 127-134
    • Marchetti, P.1    Di Rocco, C.Z.2    Ricevuto, E.3    Bisegna, R.4    Cianci, G.5    Calista, F.6
  • 183
    • 1842614292 scopus 로고    scopus 로고
    • Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: The PROSE Study Group
    • Rebbeck TR, Friebel T, Lynch HT, Neuhausen SL, van't Veer L, Garber JE, et al. Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group. J Clin Oncol. 2004;22:1055-62.
    • (2004) J Clin Oncol , vol.22 , pp. 1055-1062
    • Rebbeck, T.R.1    Friebel, T.2    Lynch, H.T.3    Neuhausen, S.L.4    Van't Veer, L.5    Garber, J.E.6
  • 187
    • 33645740288 scopus 로고    scopus 로고
    • Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis
    • Smolen GA, Muir B, Mohapatra G, Barmettler A, Kim WJ, Rivera MN, et al. Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis. Cancer Res. 2006;66:3452-5.
    • (2006) Cancer Res , vol.66 , pp. 3452-3455
    • Smolen, G.A.1    Muir, B.2    Mohapatra, G.3    Barmettler, A.4    Kim, W.J.5    Rivera, M.N.6
  • 188
    • 0030860404 scopus 로고    scopus 로고
    • p53 mutations in BRCA1-associated familial breast cancer
    • [letter] [see comments]
    • Crook T, Crossland S, Crompton MR, Osin P, Gusterson BA. p53 mutations in BRCA1-associated familial breast cancer [letter] [see comments]. Lancet. 1997;350:638-9.
    • (1997) Lancet , vol.350 , pp. 638-639
    • Crook, T.1    Crossland, S.2    Crompton, M.R.3    Osin, P.4    Gusterson, B.A.5
  • 192
    • 10744231591 scopus 로고    scopus 로고
    • Gene expression profiling after radiation-induced DNA damage is strongly predictive of BRCA1 mutation carrier status
    • Kote-Jarai Z, Williams RD, Cattini N, Copeland M, Giddings I, Wooster R, et al. Gene expression profiling after radiation-induced DNA damage is strongly predictive of BRCA1 mutation carrier status. Clin Cancer Res. 2004;10:958-63.
    • (2004) Clin Cancer Res , vol.10 , pp. 958-963
    • Kote-Jarai, Z.1    Williams, R.D.2    Cattini, N.3    Copeland, M.4    Giddings, I.5    Wooster, R.6
  • 194
    • 10544220023 scopus 로고    scopus 로고
    • Clinical and pathological features of ovarian cancer in women with germline mutations of BRCA1
    • Rubin SC, Benjamin I, Behbakht K, Takahashi H, Morgan MA, LiVolsi VA, et al. Clinical and pathological features of ovarian cancer in women with germline mutations of BRCA1. N Engl J Med. 1996;335: 1413-6.
    • (1996) N Engl J Med , vol.335 , pp. 1413-1416
    • Rubin, S.C.1    Benjamin, I.2    Behbakht, K.3    Takahashi, H.4    Morgan, M.A.5    LiVolsi, V.A.6
  • 198
    • 0033518603 scopus 로고    scopus 로고
    • Survival after breast cancer in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers
    • [see comments]
    • Lee JS, Wacholder S, Struewing JP, McAdams M, Pee D, Brody LC, et al. Survival after breast cancer in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers [see comments]. J Natl Cancer Inst. 1999;91:259-63.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 259-263
    • Lee, J.S.1    Wacholder, S.2    Struewing, J.P.3    McAdams, M.4    Pee, D.5    Brody, L.C.6
  • 202
    • 0037303255 scopus 로고    scopus 로고
    • Impact of germline BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma: 10-Year follow up data
    • Goffin JR, Chappuis PO, Begin LR, Wong N, Brunet JS, Hamel N, et al. Impact of germline BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma: 10-year follow up data. Cancer. 2003;97:527-36.
    • (2003) Cancer , vol.97 , pp. 527-536
    • Goffin, J.R.1    Chappuis, P.O.2    Begin, L.R.3    Wong, N.4    Brunet, J.S.5    Hamel, N.6
  • 203
    • 0035807219 scopus 로고    scopus 로고
    • Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway
    • Lafarge S, Sylvain V, Ferrara M, Bignon YJ. Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway. Oncogene. 2001;20:6597-606.
    • (2001) Oncogene , vol.20 , pp. 6597-6606
    • Lafarge, S.1    Sylvain, V.2    Ferrara, M.3    Bignon, Y.J.4
  • 204
    • 33646409883 scopus 로고    scopus 로고
    • BRCA1 Downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance
    • Chabalier C, Lamare C, Racca C, Privat M, Valette A, Larminat F. BRCA1 Downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance. Cell Cycle. 2006;5:1001-7.
    • (2006) Cell Cycle , vol.5 , pp. 1001-1007
    • Chabalier, C.1    Lamare, C.2    Racca, C.3    Privat, M.4    Valette, A.5    Larminat, F.6
  • 206
    • 0030584084 scopus 로고    scopus 로고
    • Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro
    • Baumann P, Benson FE, West SC. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell. 1996;87:757-66.
    • (1996) Cell , vol.87 , pp. 757-766
    • Baumann, P.1    Benson, F.E.2    West, S.C.3
  • 207
    • 25144498670 scopus 로고    scopus 로고
    • The carboxyl-terminal of BRCA1 is required for subnuclear assembly of RAD51 after treatment with cisplatin but not ionizing radiation in human breast and ovarian cancer cells
    • Zhou C, Huang P, Liu J. The carboxyl-terminal of BRCA1 is required for subnuclear assembly of RAD51 after treatment with cisplatin but not ionizing radiation in human breast and ovarian cancer cells. Biochem Biophys Res Commun. 2005;336:952-60.
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 952-960
    • Zhou, C.1    Huang, P.2    Liu, J.3
  • 208
    • 31444432285 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for early breast cancer: Optimal use of epirubicin
    • Gluck S. Adjuvant chemotherapy for early breast cancer: optimal use of epirubicin. Oncologist. 2005;10:780-91.
    • (2005) Oncologist , vol.10 , pp. 780-791
    • Gluck, S.1
  • 209
    • 0043130465 scopus 로고    scopus 로고
    • The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells
    • Fedier A, Steiner RA, Schwarz VA, Lenherr L, Haller U, Fink D. The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells. Int J Oncol. 2003;22:1169-73.
    • (2003) Int J Oncol , vol.22 , pp. 1169-1173
    • Fedier, A.1    Steiner, R.A.2    Schwarz, V.A.3    Lenherr, L.4    Haller, U.5    Fink, D.6
  • 210
    • 0038147067 scopus 로고    scopus 로고
    • BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells
    • Tassone P, Tagliaferri P, Perricelli A, Blotta S, Quaresima B, Martelli ML, et al. BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells. Br J Cancer. 2003;88:1285-91.
    • (2003) Br J Cancer , vol.88 , pp. 1285-1291
    • Tassone, P.1    Tagliaferri, P.2    Perricelli, A.3    Blotta, S.4    Quaresima, B.5    Martelli, M.L.6
  • 212
    • 0034721885 scopus 로고    scopus 로고
    • BRCA1 facilitates stress-induced apoptosis in breast and ovarian cancer cell lines
    • Thangaraju M, Kaufmann SH, Couch FJ. BRCA1 facilitates stress-induced apoptosis in breast and ovarian cancer cell lines. J Biol Chem. 2000;275:33487-96.
    • (2000) J Biol Chem , vol.275 , pp. 33487-33496
    • Thangaraju, M.1    Kaufmann, S.H.2    Couch, F.J.3
  • 214
    • 25444497278 scopus 로고    scopus 로고
    • The concept of synthetic lethality in the context of anticancer therapy
    • Kaelin WG Jr. The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer. 2005;5:689-98.
    • (2005) Nat Rev Cancer , vol.5 , pp. 689-698
    • Kaelin Jr., W.G.1
  • 215
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005;434:917-21.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3    Tutt, A.N.4    Johnson, D.A.5    Richardson, T.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.