BRCA1: Exploring the links to transcription

Trends in Biochemical Sciences

Volumn 25, Issue 10, 2000, Pages 469-474

  Monteiro, Alvaro N A ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b STRANG CANCER PREVENTION CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; PROTEIN P53; RNA POLYMERASE; TRANSCRIPTION FACTOR;

CARCINOGENESIS; DNA REPAIR; GENE DISRUPTION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; ONCOGENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 0034306456     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01632-7     Document Type: Note

References (44)

1. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium
2. Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome
3. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1
4. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression
5. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
6. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins
7. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
8. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
9. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability
10. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
11. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
12. Association of BRCA1 with Rad51 in mitotic and meiotic cells
13. Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2
14. Brca1 controls homology-directed DNA repair
15. Transcriptional activation by recruitment
16. Evidence for a transcriptional activation function of BRCA1 C-terminal region
17. Transcriptional activation by BRCA1
18. Common BRCA1 variants and transcriptional activation
19. Functional assay for BRCA1: mutagenesis of C-terminal region reveals critical residues for transcriptional activation
20. BRCA1 is a component of the RNA polymerase II holoenzyme
21. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A
22. Activation of transcription in vitro by the BRCA1 carboxy-terminal domain
23. BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPBα in activated transcription
24. CBP/p300 interact with and function as transcriptional coactivators of BRCA1
25. BRCA1 regulates p53-dependent gene expression
26. BRCA1 physically associates with p53 and stimulates its transcriptional activity
27. Collaboration of STAT1 and BRCA1 in differential regulation of IFN-γ target genes
28. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1
29. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK
30. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression
31. BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells
32. BRCA1 interacts with components of the histone deacetylase complex
33. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
34. Characterization of a carboxy-terminal BRCA1 interacting protein
35. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage
36. BRCA1 inhibition of estrogen receptor signaling in transfected cells
37. Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50
38. BRCA1 required for transcription-coupled repair of oxidative DNA damage
39. BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair
40. Transcription-coupled repair and human disease
41. Genetic analysis of BRCA1 function in a defined tumor cell line
42. Structure of an XRCC1 BRCT domain: a new protein-protein interaction module
43. Selective use of TBP and TFIIB revealed by a TATA-TBP-TFIIB array with altered specificity
44. Identification of a RING protein that can interact in vivo with the BRCA1 gene product