A nuclear function for the tumor suppressor BRCA1

Histology and Histopathology

Volumn 15, Issue 1, 2000, Pages 299-307

  Monteiro, Alvaro N A ^a,b   Birge, R B ^c  

^a Strang Cancer Research Laboratory   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Antibody specificity; BRCA1; Breast cancer; Tumor suppressor gene

Indexed keywords

BREAST CANCER; CELLULAR DISTRIBUTION; DNA REPAIR; GENE FUNCTION; GENE LOCATION; GENETIC TRANSCRIPTION; HUMAN; ONCOGENE; OVARY CANCER; PROTEIN INTERACTION; REVIEW; SPINDLE CELL; TUMOR SUPPRESSOR GENE;

BRCA1 PROTEIN; BREAST NEOPLASMS; CELL NUCLEUS; FEMALE; GENES, BRCA1; HUMANS; MUTATION; OVARIAN NEOPLASMS;

EID: 0033963341     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (57)

1. Abel K.J., Xu J., Yin G.-Y., Lyons R.H., Meisler M.H. and Weber B.L. (1995). Mouse Brca1: localization, sequence analysis and identification of evolutionary conserved domains. Hum. Mol. Genet. 4, 2265-2273.
2. Anderson S.F., Schlegel B.P., Nakajima T., Wolpin E.S. and Parvin J.D. (1998). BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nature Genet. 19, 254-256.
3. Aprelikova O., Kuthiala A., Bessho M., Ethier S. and Liu E.T. (1996). BRCA1 protein level is not affected by peptide growth factors in MCF10A cell line. Oncogene 13, 2487-2491.
4. Bennett L.M., Brownlee H.A., Hagavik S. and Wiseman R.W. (1999). Sequence analysis of the rat Brca1 homolog and its promoter region. Mamm. Genome 10, 19-25.
5. Bork P., Hofmann K., Bucher P., Neuwald A.F., Altschul S.F. and Koonin E.V. (1997). A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 11, 68-76.
6. Bradley A. and Sharan S.K. (1996)...and secreted tumor suppressors...Nature Genet. 13, 268-269.
7. Callebaut I. and Mornon J.P. (1997). From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett. 400, 25-30.
8. Chapman M.S. and Verma I.M. (1996). Transcriptional activation by BRCA1. Nature 382, 678-679.
9. Chen Y., Chen C.F., Riley D.J., Allred D.C., Chen P.L., Von Hoff D., Osborne C.K. and Lee W.H. (1995a). Aberrant subcellular localization of BRCA1 in breast cancer cells. Science 270, 789-791.
10. Chen Y., Chen P.L., Riley D.J., Lee W.H., Allred D.C. and Osborne C.K. (1995b). Location of BRCA1 in human breast and ovarian cancer cells: response. Science 272, 125-126.
11. Chen Y., Farmer A.A., Chen C.F., Jones D.C. and Lee W.H. (1996a). BRCA1 is a 220 kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res. 56, 3168-3172.
12. Chen C.F., Li S., Chen Y., Chen P.H., Sharpe Z.D. and Lee W.H. (1996b). The nuclear localization sequences of the BRCA1 protein interact with the importin-α subunit of the nuclear transport signal receptor. J. Biol. Chem. 271, 32863-32868.
13. Chen J., Silver D.P., Walpita D., Cantor S.B., Gazdar A.F., Tomlinsom G., Couch F., Weber B.L., Ashley T., Livingston D.M. and Scully R. (1998). Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2, 317-328.
14. Coene E., Van Oostveldt P., Willems K., van Emmelo J. and De Potter C.R. (1997). BRCA1 is localized in cytoplasmic tube-like invaginations in the nucleus. Nature Genet. 16, 122-124.
15. Connor F., Bertwistle D., Mee P.J., Ross G.M., Swift S., Grigorieva E., Tybulewicz V.L.J. and Ashworth A. (1997). Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nature Genet. 17, 423-430.
16. Easton D.F., Bishop D.T., Ford D., Crockford G.P. and Breast Cancer Linkage Consortium (1993). Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. Am. J. Hum. Genet. 52, 678-701.
17. Futreal P.A., Liu Q., Shattuck-Eidens D., Cochran C., Harshman K., Tavtigian S., Bennett L.M., Haugen-Strano A., Swensen J., Miki Y., Eddington K., McClure M., Frye C., Weaver-Feldhaus J., Ding W., Gholami Z., Soderkvist P., Terry L., Jhanwar S., Berchuck A., Iglehart J.D., Marks J., Ballinger D.G., Barret J.C., Skolnick M.H., Kamb A. and Wiseman R. (1994). BRCA1 mutations in primary breast and ovarian carcinomas. Science 266, 120-122.
18. Gowen L.C., Avrutskaya A.V., Latour A.M., Koller B.H. and Leadon S.A. (1998). BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science 281, 1009-1012.
19. Gudas J.M., Nguyen H., Li T. and Cowan K.H. (1995). Hormone-dependent regulation of BRCA1 in human breast cancer cells. Cancer Res. 55, 4561-4565.
20. Hsu L.C., and White R.L. (1998). BRCA1 is associated with the centrosome during mitosis. Proc. Natl. Acad. Sci. USA 95, 12983-12988.
21. Jensen R.A., Thompson M.E., Jetton T.L., Szabo C.I., van der Meer R., Helou B., Tronick S.R., Page D.L., King M.-C. and Holt J.T. (1996a). BRCA1 is secreted and exhibits properties of a granin. Nature Genet. 12, 303-308.
22. Jensen R.A., Thompson M.E., Jetton T.L., van der Meer R., Helou B., Arteaga C.L., Page D.L., Holt J.T., Tronick S.R., Gown A.M., Skelly M., Ostermeyer B., Schieltz D., Szabo C.I. and King M.-C. (1996b). BRCA1 protein products: antibody specificity. Nature Genet. 13, 269-272.
23. Jensen D.E., Proctor M., Marquis S.T., Gardner H.P., Ha S.I., Chodosh L.A., Ishov A.M., Tommerup N., Vissing H., Sekido Y., Minna J., Borodovsky A., Schultz D.C., Wilkinson K.D., Maul G.G., Barlev N., Berger S.L., Prendergast G.C. and Rascher III F.J. (1998). BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated growth suppression. Oncogene 16, 1097-1112.
24. Jin Y., Xu X.L., Yang M.C.W., Wei F., Ayi T.C., Bowcock A.M. and Baer R. (1997). Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains. Proc. Natl. Acad. Sci. USA 94, 12075-12080.
25. Koonin E.V., Altschul S.F. and Bork P. (1996). Functional motifs. Nat. Genet. 13, 266-267.
26. Lane T.F., Deng C., Elson A., Lyu M.S., Kozak C.A. and Leder P. (1995). Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermaly derived tissues in mice. Gene. Dev. 9, 2712-2722.
27. Mazoyer S., Dunning A.M., Serova O., Dearden J., Puget N., Healey C.S., Gayther S.A., Mangion J., Stratton M.R., Lynch H.T., Goldgar D.E. and Ponder B.A. (1996). A polymorphic stop codon in BRCA2. Nature Genet. 14, 253-254.
28. Miki Y., Swensen J., Shattuck-Eidens D., Futreal P.A., Harshman K., Tavtigian S., Liu Q., Cochran C., Bennett L.M., Ding W., Bell R., Rosenthal J., Hussey C., Tran T., McClure M., Frye C., Hattier T., Phelps R., Haugen-Strano A., Katcher H., Yakumo K., Gholami Z., Shaffer D., Stone S., Bayer S., Wray C., Bogden R., Dayananth P., Ward J., Tonin P., Narod S., Bristow P.K., Norris F.H., Helvering L., Morrisson P., Rostek P., Lai M., Barret J.C., Lewis C., Neuhausen S., Cannon-Albright L., Goldgar D., Wiseman R., Kamb A. and Skolnick M.H. (1994). A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71.
29. Monteiro A.N.A., August A. and Hanafusa H. (1996). Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl. Acad. Sci. USA 93, 13595-13599.
30. Monteiro A.N.A., August A. and Hanafusa H. (1997). Common variants of BRCA1 and transcription activation. Am. J. Hum. Genet. 61, 761-762.
31. Ouchi T., Monteiro A.N.A., August A., Aaronson S.A. and Hanafusa H. (1998). BRCA1 regulates p53-dependent gene expression. Proc. Natl. Acad. Sci. USA 95, 2302-2306.
32. Ozawa H. and Takata K. (1995). The granin family-its role in sorting and secretory granule formation. Cell Struct. Funct. 20, 415-420.
33. Patel K.J., Yu V.P.C.C., Lee H., Corcoran A., Thistlethwaite F.C., Evans M.J., Colledge W.H., Friedman L.S., Ponder B.A.J. and Venkitaraman A.R. (1998). Involvement of Brca2 in DNA repair. Mol. Cell 1, 347-357.
34. Rao V.N., Shao N., Ahmad M. and Reddy E.S.P. (1996). Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts. Oncogene 12, 523-528.
35. Ruffner H. and Verma I.M. (1997). BRCA1 is a cell cycle-regulated nuclear phosphoprotein. Proc. Natl. Acad. Sci. USA 94, 7138-7143.
36. Saurin A.J., Borden K.L.B., Boddy M.N. and Freemont P.S. (1996). Does this have a familiar RING? Trends Biochem. Sci. 21, 208-214.
37. Scully R., Ganesan S., Brown M., De Caprio J.A., Cannistra S.A, Feunteun J., Schnitt S. and Livingston D.M. (1996). Location of BRCA1 in human breast and ovarian cancer cells. Science 272, 123-125.
38. Scully R., Anderson S.F., Chao D.M., Wei W., Ye L., Young R.A., Livingston D.M. and Parvin J.D. (1997a). BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. USA 94, 5605-5610.
39. Scully R., Chen J., Plug A., Xiao Y., Weaver D., Feunteun J., Ashley T. and Livingston D.M. (1997b). Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265-275.
40. Scully R., Chen J., Ochs R.L., Keegan K., Hoekstra M., Feunteun J. and Livingston D.M. (1997c). Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90, 425-435.
41. Sharan S.K., Wims M. and Bradley A. (1995). Murine Brca1: sequence and significance for human missense mutations. Hum. Mol. Genet. 4, 2275-2278.
42. Sharan S.K., Morimatsu M., Albrecht U., Lim D.S., Regel E., Dinh C., Sands A., Eichele G., Hasty P. and Bradley A. (1997). Embryonic lethality and radiation sensitivity mediated by Rad51 in mice lacking Brca2. Nature 386, 804-810.
43. Shen S.X., Weaver Z., Xu X., Li C., Weinstein M., Chen L., Guan X.Y., Ried T. and Deng C.X. (1998). A targeted disruption of the murine BRCA1 gene causes y-irradiation hypersensitivity and genetic instability. Oncogene 17, 3115-3124.
44. Waf1/CiP1. Nature 389, 187-190.
45. Szabo C.I., Wagner L.A., Francisco L.V., Roach J.C., Argonza R., King M.-C. and Ostrander E.A. (1996). Human, canine and murine BRCA1 genes: sequence comparison among species. Hum. Mol. Genet. 5, 1289-1298.
46. Thakur S., Zhang H.B., Peng Y., Le H., Carrol B., Ward T., Yao J., Farid L.M., Couch F.J., Wilson R.B. and Weber B.L. (1997). Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol. Cell. Biol. 17, 444-452.
47. Thomas J.E., Smith M., Rubinfeld B., Gutowski M., Beckmann R.P. and Polakis P. (1996). Subcellular localization and analysis of apparent 180 kDa and 220 kDa proteins of the breast cancer susceptibility gene, BRCA1. J. Biol. Chem. 45, 28630-28635.
48. Thomas J.E., Smith M., Tonkinson J.L., Rubinfeld B. and Polakis P. (1997) Induction of phosphorylation on BRCA1 during the cell cycle and after DNA damage. Cell Growth Diff. 8, 801-809.
49. Wang Q., Zhang H., Kajino K. and Greene M.I. (1998). BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells. Oncogene 17, 1939-1947.
50. Wilson C.A., Payton M.N., Pekar S.K., Zhang K., Pacifici R.E., Gudas J.L., Thukral S., Calzone F.J., Reese D.M. and Slamon D.I (1996). BRCA1 protein products: Antibody specificity. Nature Genet. 13, 264-265.
51. Wilson C.A., Payton M.N., Elliot G.S., Buaas F.W., Cajulis E.E., Grosshans D., Ramos L., Reese D.M., Slamon D.J. and Calzone F.J. (1997). Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b. Oncogene 14, 1-16.
52. Wilson C.A., Ramos L., Villasenor M.R., Anders K.H., Press M.F., Clarke K., Karlan B., Chen J.J., Scully R., Livingston D., Zuch R.H., Kanter M.H., Cohen S., Calzone F.J. and Slamon D.J. (1999). Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nature Genet. 21, 236-240.
53. Wong A.K.C., Ormonde P.A., Pero R., Chen Y., Lian L., Salada G., Berry S., Lawrence Q., Dayananth P., Ha P., Tavtigian S.V., Teng D.H.F. and Bartel P.L. (1998). Characterization of a carboxy-terminal BRCA1 interacting protein. Oncogene 17, 2279-2285.
54. Wu L.C., Wang Z.W., Tsan J.T., Spillman, M.A., Phung A., Xu X.L., Yang M.C., Hwang L.Y., Bowcock A.M. and Baer R. (1996). Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nature Genet. 14, 430-440.
55. Yu X., Wu L.C., Bowcock A.M., Aronheim A. and Baer R. (1998). The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. J. Biol. Chem. 273, 25388-25392.
56. BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells. Oncogene 14, 2863-2869.
57. Zhang H., Somasundaram K., Peng Y., Tian H., Zhang H., Bi D., Weber B.L. and El-Deiry W.S. (1998). BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene 16, 1713-1721.