Homology-directed DNA repair, mitomycin-C resistance, and chromosome stability is restored with correction of a Brca1 mutation

Cancer Research

Volumn 61, Issue 12, 2001, Pages 4842-4850

  Moynahan, M E ^a   Cui, T Y ^a   Jasin, M ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; GENE PRODUCT; MITOMYCIN C; RAD51 PROTEIN;

ARTICLE; BREAST CANCER; CANCER INHIBITION; CANCER SUSCEPTIBILITY; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DNA METABOLISM; DNA REPAIR; DNA SEQUENCE; GENE MUTATION; GENE TARGETING; GENETIC STABILITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR STABILITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTERACTION; SEQUENCE HOMOLOGY;

ANIMALS; CELL LINE; CHROMOSOME BREAKAGE; CROSS-LINKING REAGENTS; DNA DAMAGE; DNA REPAIR; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION; GENES, BRCA1; GENETIC COMPLEMENTATION TEST; MICE; MITOMYCIN; MUTATION; PHENOTYPE; STEM CELLS; TRANSFECTION; TRANSGENES;

EID: 0035874894     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

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2. Brca1 controls homology-directed DNA repair
3. Genetic analysis of BRCA1 function in a defined tumor cell line
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5. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
6. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
7. The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter
8. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage
9. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
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11. A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability
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13. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
14. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
15. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
16. BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene
17. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin
18. BRCA2 is required for homology-directed repair of chromosomal breaks
19. Loss of heterozygosity induced by a chromosomal double-strand break
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21. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
22. Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination
23. Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells
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25. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages
26. Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells
27. 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
28. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
29. The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells
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36. Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation
37. Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification
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40. PriA-directed replication fork restart in Escherichia coli
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45. Roles of BRCA1 and its interacting proteins
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49. The murin gene p27Kp1 is haplo-insufficient for tumour suppression
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51. Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary gland and ovarian phenotypes in response to diethylstilbestrol
52. Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiae