Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21(WAF1/CIP1)

Nature

Volumn 389, Issue 6647, 1997, Pages 187-190

  Somasundaram, Kumaravel ^a   Zhang, Hongbing ^a   Zeng, Yi Xin ^a   Mouvras, Yariv ^b   Peng, Yi ^a   Zhang, Hongxiang ^a   Wu, Gen Sheng ^a   Licht, Jonathan D ^b   Weber, Barbara L ^a   El Deiry, Wafik S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; NUCLEAR PROTEIN; PROTEIN P21; PROTEIN P53;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; GENETIC PREDISPOSITION; HELA CELL; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANIMALS; BRCA1 PROTEIN; CELL CYCLE; COS CELLS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LUMINESCENT PROTEINS; MICE; MUTATION; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030759895     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/38291     Document Type: Article

References (25)

1. Miki, Y. et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71 (1994).
2. Futreal, P. A. et al. BRCA1 mutations in primary breast and ovarian carcinomas. Science 266, 120-122 (1994).
3. Easton, D. F., Ford, D. & Bishop, D. T. Breast and ovarian cancer incidence in BRCA1-mutation carriers. Am. J. Hum. Genet 56, 265-271 (1995).
4. Chen, Y. et al. Aberrant subcellular localization of BRCA1 in breast cancer. Science 270, 789-791 (1995).
5. Scully, R. et al Location of BRCA1 in human breast and ovarian cancer cells. Science 272, 123-125 (1996).
6. Chapman, M. S. & Verma, I. M. Transcriptional activation by BRCA1. Nature 382, 678-679 (1996).
7. Monteiro, A. N., August, A, & Hanafusa, H. Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl Acad. Sci, USA 93, 13595-13599 (1996).
8. Scully, R. et al Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265-275 (1997).
9. Gowen, L. C. et al. Brcal deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nature Genet. 12, 191-194 (1996).
10. Hakem, R. et al. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85, 1009-1023 (1996).
11. Sherr, C. J. & Roberts, J. M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9, 1149-1163 (1995).
12. Zeng, Y.-X., Somasundaram, K., Prabhu, N. S., Krishnadasan, R. & El-Deiry, W. S. Detection and analysis of living, growth-inhibited mammalian cells following transfection. Biotechniques 23, 88-94 (1997).
13. El-Deiry, W. S. et al. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825 (1993).
14. Zhang, W. et al. p53-independent induction of WAF1/CIP1 in human leukeumia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation. Cancer Res. 55, 668-674 (1995).
15. Waldman, T., Kinzler, K. W. & Vogelstein, B. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 55, 5187-5190 (1995).
16. Vaughn, J. P. et al. BRCA1 expression is induced before DNA synthesis in both normal and tumor- derived breast cells. Cell Growth Differ. 7, 711-715 (1996).
17. Gudas, J. M. et al. Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells. Cell Growth Differ. 7, 717-723 (1996).
18. Chen, Y. et al. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res. 56, 3168-3172 (1996).
19. Humphrey, J. S. et al. Human BRCA1 inhibits growth in yeast: Potential use in diagnostic testing. Proc. Natl Acad. Sci. USA 94, 5820-5825 (1997).
20. Scully, R. et al. BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl Acad. Sci. USA 94, 5605-5610 (1997).
21. WAFI/CIPI expression Nature Genet. 15, 78-82 (1997).
22. WAFI/CIPI expression in normal and neoplastic tissues. Cancer Res. 55, 2910-2919 (1995).
23. Thakur, S. et al. Localization of BRCA1 and a splice variant identifies the nuclear localization signal Mol. Cell. Biol. 17, 444-452 (1997).
24. Meyuhas, O. & Perry, R. P. Construction and identification of cDNA clones for mouse ribosomal proteins: application for the study of r-protein gene expression. Gene 10, 113-129 (1980).
25. Somasundaram, K. & El-Deiry, W. S. Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region. Oncogene 14, 1047-1057 (1997).