A BRCA1 mutant alters G2-M cell cycle control in human mammary epithelial cells

Cancer Research

Volumn 57, Issue 16, 1997, Pages 3351-3355

  Larson, Jeffrey S ^a   Tonkinson, John L ^a   Lai, Mei T ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; GROWTH FACTOR;

ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL CYCLE G2 PHASE; DNA REPLICATION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOSIS; OVARY CANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS;

BRCA1 PROTEIN; BREAST; CELL DIVISION; CELL LINE; EPIDERMAL GROWTH FACTOR; FEMALE; FLOW CYTOMETRY; G1 PHASE; G2 PHASE; GENES, BRCA1; HUMANS; MITOSIS; PHOSPHORYLATION; TRANSFECTION;

EID: 0030800325     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Ford, D., and Easton, D. F. The genetics of breast and ovarian cancer. Br. J. Cancer, 72: 805-812, 1995.
2. Jacobs, I. J., Smith, S. A., Wiseman, R. W., Futreal, P. A., Harrington, T., Osborne, R. J., Leech, V., Molyneux, A., Berchuk, A., Ponder, B. A. J., and Bast, R. C., Jr. A deletion unit on chromosome 17q in epithelial ovarian tumors distal to the familial breast/ovarian cancer locus. Cancer Res., 53: 1218-1221, 1993.
3. Cornelis, R. S., Devilee, P., Van Vliet, M., Kuipersdij, K., Shoorn, N., Kersenmaeker, A., Bardoel, A., Khan, P. M., and Cornelisse, C. J. Allele loss patterns on chromosome 17q in 109 breast carcinomas indicate at least two distinct target regions. Oncogene, 8: 781-785, 1993.
4. Chen, Y., Chen, C-F., Riley, D. J., Allred, D. C., Chen, P-L., Von Hoff, D., Osborne, C. K., and Lee, W-H. Aberrant subcellular localization of BRCA1 in breast cancer. Science (Washington DC), 270: 789-791, 1995.
5. Thompson, M. E., Jensen, R. A., Obermiller, P. S., Page, D. L., and Holt, J. T. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat. Genet., 9: 444-450, 1995.
6. Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P. A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., Bell, R., Rosenthal, J., Hussey, C., Tran, T., McClure, M., Frye, C., Hattier, T., Phelps, R., Haugen-Strano, A., Katcher, H., Yakumo, K., Gholami, Z., Shaffer, D., Stone, S., Bayer., S., Wray, C., Bogden, R., Dayananth, P., Ward, J., Tonin, P., Narod, S., Bristow, P. K., Norris, F. H., Helvering, L., Morrison, P., Rosteck, P., Lai, M., Barrett, J. C., Lewis, C., Neuhausen, S., Cannon-Albright, L., Goldgar, D., Wiseman, R., Kamb, A., and Skolnick, M. H. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science (Washington DC), 266: 66-71, 1994.
7. Grade, K., Jandrig, B., and Scherneck, S. BRCA1 mutation update and analysis. J. Cancer Res. Clin. Oncol., 122: 702-706, 1996.
8. Szabo, C. I., Wagner, L. A., Francisco, L. V., Roach, J. C., Argonza, R., King, M-C., and Ostrander, E. A. Human, canine and murine BRCA1 genes: sequence comparison among species. Hum. Mol. Genet., 5: 1289-1298, 1996.
9. Monteiro, A. N. A., August, A., and Hanafusa, H. Evidence for a transcription activation function of BRCA1 c-terminal region. Proc. Natl. Acad. Sci. USA, 93: 13595-13599, 1996.
10. Chapman, M. S., and Verma, I. M. Transcriptional activation by BRCA1. Nature (Lond.), 382: 678-679, 1996.
11. Holt, J. T., Thompson, M. E., Szabo, C., Rohinson-Benion, C., Arteaga, C. L., King, M-C., and Jensen, R. A. Growth retardation and tumor inhibition by BRCA1. Nat. Genet., 12: 298-302, 1996.
12. Stampfer, M. R., and Bartley, J. C. Induction of transformation and continuous cell lines from normal mammary epithelial cells after exposure to benzo[a]pyrene. Proc. Natl. Acad. Sci. USA, 82: 2394-2398, 1985.
13. Thomas, J. E., Smith, M., Rubinfeld, B., Gutowski, M., Beckmann, R. P., and Polakis, P. Subcellular localization and analysis of apparent 180-kDa and 220-kDa proteins of the breast cancer susceptibility gene, BRCA1. J. Biol. Chem., 271: 28630-28635, 1996.
14. Tonkinson, J. L., Marder, P., Andis, S. L., Schultz, R. M., Gossett, L. S., Shih, C., and Mendelsohn, L. G. Cell cycle effects of antifolate antimetabolites: implications for cytotoxicity and cytostasis. Cancer Chemother. Pharmacol., 39: 521-531, 1997.
15. Clark, R., Stampfer, M. R., Milley, R., O'Rourke, E., Walen, K. H., Kriegler, M., Kopplin, J., and McCormick, F. Transformation of human mammary epithelial cells by oncogenic retroviruses. Cancer Res., 48: 4689-4694, 1988.
16. Rao, V. N., Shao, N., Ahmad, M., and Reddy, E. S. P. Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts. Oncogene, 12: 523-528, 1996.
17. Chen, Y., Farmer, A. A., Chen, C-F., Jones, D. C., Chen, P-L., and Lee, W-H. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res., 56: 3168-3172, 1996.
18. Thomas, J. E., Smith, M., Tonkinson, J. L., Rubinfeld, B., and Polakis, P. Induction of phosphorylation on BRCA1 during the cell cycle and following DNA damage. Cell Growth & Differ., 8: 801-809, 1997.
19. Callebaut, I., and Mornon. J-P. From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEES Lett., 400: 25-30, 1997.
20. Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., and Livingston, D. M. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell, 88: 265-275, 1997.