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Volumn 22, Issue 1, 1999, Pages 37-43

Conditional mutation of Brca 1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CHROMOSOME 11; CHROMOSOME REARRANGEMENT; EXON; GENE MUTATION; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; ALLELE; ANIMAL; APOPTOSIS; CELL LINE; EPITHELIUM CELL; EXPERIMENTAL NEOPLASM; FEMALE; GENE TRANSLOCATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOUSE STRAIN; MUTATION; PATHOLOGY; UDDER;

EID: 0032587877     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/8743     Document Type: Article
Times cited : (645)

References (44)
  • 1
    • 0030806561 scopus 로고    scopus 로고
    • Epidemiology, prevention, and early detection of breast cancer
    • Alberg, A.J. & Helzlsouer, K.J. Epidemiology, prevention, and early detection of breast cancer. Curr Opin. Oncol. 9, 505-511 (1997).
    • (1997) Curr Opin. Oncol. , vol.9 , pp. 505-511
    • Alberg, A.J.1    Helzlsouer, K.J.2
  • 3
    • 0028113345 scopus 로고
    • A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
    • Miki, Y. et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71 (1994).
    • (1994) Science , vol.266 , pp. 66-71
    • Miki, Y.1
  • 4
    • 0030970137 scopus 로고    scopus 로고
    • The BRCA1 and BRCA2 breast cancer genes
    • Casey, G. The BRCA1 and BRCA2 breast cancer genes. Curr. Opin. Oncol. 9, 88-93 (1997).
    • (1997) Curr. Opin. Oncol. , vol.9 , pp. 88-93
    • Casey, G.1
  • 5
    • 0029987651 scopus 로고    scopus 로고
    • BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner
    • Chen, Y. et al. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res. 56, 3168-3172 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 3168-3172
    • Chen, Y.1
  • 6
    • 0031958724 scopus 로고    scopus 로고
    • Differential transcriptional activation by the N-terminal region of BRCA1 splice variants BRCA1a and BRCA1b
    • Cui, J.Q., Wang, H., Reddy, E.S. & Rao, V.N. Differential transcriptional activation by the N-terminal region of BRCA1 splice variants BRCA1a and BRCA1b. Oncol. Rep. 5, 585-589 (1998).
    • (1998) Oncol. Rep. , vol.5 , pp. 585-589
    • Cui, J.Q.1    Wang, H.2    Reddy, E.S.3    Rao, V.N.4
  • 7
    • 1842364973 scopus 로고    scopus 로고
    • Localization of BRCA1 and a splice variant identifies the nuclear localization signal
    • Thakur, S. et al. Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol. Cell. Biol. 17, 444-452 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 444-452
    • Thakur, S.1
  • 8
    • 8044257697 scopus 로고    scopus 로고
    • Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-δ11b
    • Wilson, C.A. et al. Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-δ11b. Oncogene 14, 1-16 (1997).
    • (1997) Oncogene , vol.14 , pp. 1-16
    • Wilson, C.A.1
  • 9
    • 0028863788 scopus 로고
    • Isolation of the mouse homologue of BRCA1 and genetic mapping to mouse chromosome 11
    • Bennett, L.M. et al. Isolation of the mouse homologue of BRCA1 and genetic mapping to mouse chromosome 11. Genomics 29, 576-581 (1995).
    • (1995) Genomics , vol.29 , pp. 576-581
    • Bennett, L.M.1
  • 10
    • 0027383402 scopus 로고
    • Cloning the RAD51 homologue of Schizosaccharomyces pombe
    • Muris, D.F. et al. Cloning the RAD51 homologue of Schizosaccharomyces pombe. Nucleic Acids Res 21, 4586-4591 (1993).
    • (1993) Nucleic Acids Res , vol.21 , pp. 4586-4591
    • Muris, D.F.1
  • 11
    • 0026751113 scopus 로고
    • Rad51 protein involved in repair and recombination in S. Cerevisiae is a RecA-like protein
    • Shinohara, A., Ogawa, H. & Ogawa, T. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell 69, 457-470 (1992).
    • (1992) Cell , vol.69 , pp. 457-470
    • Shinohara, A.1    Ogawa, H.2    Ogawa, T.3
  • 12
    • 0027325816 scopus 로고
    • Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA
    • Shinohara, A. et al. Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. Nature Genet 4, 239-243 (1993).
    • (1993) Nature Genet , vol.4 , pp. 239-243
    • Shinohara, A.1
  • 13
    • 0031472370 scopus 로고    scopus 로고
    • Association of BRCA1 with Rad51 in mitotic and meiotic cells
    • Scully, R. et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265-275 (1997).
    • (1997) Cell , vol.88 , pp. 265-275
    • Scully, R.1
  • 14
    • 12644270610 scopus 로고    scopus 로고
    • The nuclear localization sequences of the BRCA1 protein interact with the importin-α subunit of the nuclear transport signal receptor
    • Chen, C.F. et al. The nuclear localization sequences of the BRCA1 protein interact with the importin-α subunit of the nuclear transport signal receptor. J. Biol. Chem. 271, 32863-32868 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 32863-32868
    • Chen, C.F.1
  • 15
    • 0032473879 scopus 로고    scopus 로고
    • BRCA1 physically associates with p53 and stimulates its transcriptional activity
    • Zhang, H. et al. BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene 16, 1713-1721 (1998).
    • (1998) Oncogene , vol.16 , pp. 1713-1721
    • Zhang, H.1
  • 17
    • 0029115660 scopus 로고
    • The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues
    • Marquis, S.T. et al. The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Nature Genet. 11, 17-26 (1995).
    • (1995) Nature Genet. , vol.11 , pp. 17-26
    • Marquis, S.T.1
  • 18
    • 0028828673 scopus 로고
    • Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice
    • Lane, T.F. et al. Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev. 9, 2712-2722 (1995).
    • (1995) Genes Dev. , vol.9 , pp. 2712-2722
    • Lane, T.F.1
  • 19
    • 15844371372 scopus 로고    scopus 로고
    • The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
    • Hakem, R. et al. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85, 1009-1023 (1996).
    • (1996) Cell , vol.85 , pp. 1009-1023
    • Hakem, R.1
  • 20
    • 0029784528 scopus 로고    scopus 로고
    • Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
    • Liu, C.Y., Flesken-Nikitin, A., Li, S., Zeng, Y. & Lee, W.H. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev. 10, 1835-1843 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 1835-1843
    • Liu, C.Y.1    Flesken-Nikitin, A.2    Li, S.3    Zeng, Y.4    Lee, W.H.5
  • 21
    • 0030051903 scopus 로고    scopus 로고
    • Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
    • Gowen, L.C., Johnson, B.L., Latour, A.M., Sulik, K.K. & Koller, B.H. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nature Genet. 12, 191-194 (1996).
    • (1996) Nature Genet. , vol.12 , pp. 191-194
    • Gowen, L.C.1    Johnson, B.L.2    Latour, A.M.3    Sulik, K.K.4    Koller, B.H.5
  • 22
    • 0032542216 scopus 로고    scopus 로고
    • A targeted disruption of the murine Brca1 gene causes γ-radiation hypersensitivity and genetic instability
    • Shen, S.X. et al. A targeted disruption of the murine Brca1 gene causes γ-radiation hypersensitivity and genetic instability. Oncogene 17, 3115-3124 (1998).
    • (1998) Oncogene , vol.17 , pp. 3115-3124
    • Shen, S.X.1
  • 23
    • 0030924656 scopus 로고    scopus 로고
    • Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
    • Ludwig, T., Chapman, D.L., Papaioannou, V.E. & Efstratiadis, A. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 11, 1226-1241 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 1226-1241
    • Ludwig, T.1    Chapman, D.L.2    Papaioannou, V.E.3    Efstratiadis, A.4
  • 24
    • 0031717379 scopus 로고    scopus 로고
    • Inducible gene targeting in mice using the Cre/lox system
    • Sauer, B. Inducible gene targeting in mice using the Cre/lox system. Methods 14, 381-392 (1998).
    • (1998) Methods , vol.14 , pp. 381-392
    • Sauer, B.1
  • 25
    • 0030658840 scopus 로고    scopus 로고
    • Cre-mediated gene deletion in the mammary gland
    • Wagner, K.U. et al. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res. 25, 4323-4330 (1997).
    • (1997) Nucleic Acids Res. , vol.25 , pp. 4323-4330
    • Wagner, K.U.1
  • 26
    • 0032519554 scopus 로고    scopus 로고
    • Think globally, act locally: The making of a mouse mammary gland
    • Hennighausen, L. & Robinson, G.W. Think globally, act locally: the making of a mouse mammary gland. Genes Dev. 12, 449-455 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 449-455
    • Hennighausen, L.1    Robinson, G.W.2
  • 27
    • 0021360314 scopus 로고
    • Chromosomal assignment of the murine gene encoding the transformation-related protein p53
    • Rotter, V., Wolf, D., Pravtcheva, D. & Ruddle, F.H. Chromosomal assignment of the murine gene encoding the transformation-related protein p53. Mol. Cell. Biol. 4, 383-385 (1984).
    • (1984) Mol. Cell. Biol. , vol.4 , pp. 383-385
    • Rotter, V.1    Wolf, D.2    Pravtcheva, D.3    Ruddle, F.H.4
  • 28
    • 0030067067 scopus 로고    scopus 로고
    • The murine homolog of the human breast and ovarian cancer susceptibility gene Brca1 maps to mouse chromosome 11D
    • Schrock, E. et al. The murine homolog of the human breast and ovarian cancer susceptibility gene Brca1 maps to mouse chromosome 11D. Hum. Genet. 97, 256-259 (1996).
    • (1996) Hum. Genet. , vol.97 , pp. 256-259
    • Schrock, E.1
  • 29
    • 0033106326 scopus 로고    scopus 로고
    • Centrosome amplification and a defective G2-M checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
    • Xu, X. et al. Centrosome amplification and a defective G2-M checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell 3, 389-396 (1999).
    • (1999) Mol. Cell , vol.3 , pp. 389-396
    • Xu, X.1
  • 30
  • 31
    • 7844247959 scopus 로고    scopus 로고
    • P53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours
    • Crook, T. et al. p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1-and BRCA2-associated breast tumours. Oncogene 17, 1681-1689 (1998).
    • (1998) Oncogene , vol.17 , pp. 1681-1689
    • Crook, T.1
  • 32
    • 0030910037 scopus 로고    scopus 로고
    • P53 and ATM: Cell cycle, cell death, and cancer
    • Morgan, S.E. & Kastan, M.B. p53 and ATM: cell cycle, cell death, and cancer. Adv. Cancer Res. 71, 1-25 (1997).
    • (1997) Adv. Cancer Res. , vol.71 , pp. 1-25
    • Morgan, S.E.1    Kastan, M.B.2
  • 33
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower, LA. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221 (1992).
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1
  • 34
    • 0031804961 scopus 로고    scopus 로고
    • DNA mismatch repair and cancer
    • Prolla, T.A. DNA mismatch repair and cancer. Curr. Opin. Cell Biol. 10, 311-316 (1998).
    • (1998) Curr. Opin. Cell Biol. , vol.10 , pp. 311-316
    • Prolla, T.A.1
  • 35
    • 0030932869 scopus 로고    scopus 로고
    • Cancer-susceptibility genes. Gatekeepers and caretakers
    • Kinzler, K.W. & Vogelstein, B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 386, 761-763 (1997).
    • (1997) Nature , vol.386 , pp. 761-763
    • Kinzler, K.W.1    Vogelstein, B.2
  • 36
    • 0033055841 scopus 로고    scopus 로고
    • Mammary tumor formation in p53- and BRCA1-deficient mice
    • Cressman, V.L. et al. Mammary tumor formation in p53-and BRCA1-deficient mice. Cell Growth Differ. 10, 1-10 (1999).
    • (1999) Cell Growth Differ. , vol.10 , pp. 1-10
    • Cressman, V.L.1
  • 37
    • 0030694274 scopus 로고    scopus 로고
    • Allelic loss at BRCA1, BRCA2, and adjacent loci in relation to TP53 abnormality in breast cancer
    • Tseng, S.L. et al. Allelic loss at BRCA1, BRCA2, and adjacent loci in relation to TP53 abnormality in breast cancer. Genes Chromosomes Cancer 20, 377-382 (1997).
    • (1997) Genes Chromosomes Cancer , vol.20 , pp. 377-382
    • Tseng, S.L.1
  • 38
    • 0032584068 scopus 로고    scopus 로고
    • The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
    • Yang, X., Li, C., Xu, X. & Deng, C. The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad. Sci. USA 95, 3667-3672 (1998).
    • (1998) Proc Natl Acad. Sci. USA , vol.95 , pp. 3667-3672
    • Yang, X.1    Li, C.2    Xu, X.3    Deng, C.4
  • 39
    • 0029917507 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 is a negative regulator of bone growth
    • Deng, C., Wynshaw-Boris, A., Zhou, F., Kuo, A. & Leder, P. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84, 911-921 (1996).
    • (1996) Cell , vol.84 , pp. 911-921
    • Deng, C.1    Wynshaw-Boris, A.2    Zhou, F.3    Kuo, A.4    Leder, P.5
  • 40
    • 0028598814 scopus 로고
    • Murine FGFR-1 is required for early postimplantation growth and axial organization
    • Deng, C.X. et al. Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev. 8, 3045-3057 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 3045-3057
    • Deng, C.X.1
  • 41
    • 0028059099 scopus 로고
    • Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting
    • Gu, H., Marth, J.D., Orban, P.C., Mossmann, H. & Rajewsky, K. Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting. Science 265, 103-106 (1994).
    • (1994) Science , vol.265 , pp. 103-106
    • Gu, H.1    Marth, J.D.2    Orban, P.C.3    Mossmann, H.4    Rajewsky, K.5
  • 42
    • 0030873168 scopus 로고    scopus 로고
    • Inhibins and activins regulate mammary epithelial cell differentiation through mesenchymal-epithelial interactions
    • Robinson, G.W. & Hennighausen, L. Inhibins and activins regulate mammary epithelial cell differentiation through mesenchymal-epithelial interactions. Development 124, 2701-2708 (1997).
    • (1997) Development , vol.124 , pp. 2701-2708
    • Robinson, G.W.1    Hennighausen, L.2
  • 43
    • 0030008349 scopus 로고    scopus 로고
    • Efficient in vivo manipulation of mouse genomic sequences at the zygote stage
    • Lakso, M. et al. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc. Natl Acad. Sci. USA 93, 5860-5865 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 5860-5865
    • Lakso, M.1
  • 44
    • 0025976209 scopus 로고
    • Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells
    • Johnson, P., Gray, D., Mowat, M. & Benchimol, S. Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells. Mol. Cell. Biol. 11, 1-11 (1991).
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 1-11
    • Johnson, P.1    Gray, D.2    Mowat, M.3    Benchimol, S.4


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