Metabolism of ATP-binding cassette drug transporter inhibitors: Complicating factor for multidrug resistance

Expert Opinion on Drug Metabolism and Toxicology

Volumn 1, Issue 2, 2005, Pages 219-232

  Cnubben, Nicole H P ^a   Wortelboer, Heleen M ^a   Van Zanden, Jelmer J ^b   Rietjens, Ivonne M C M ^b   Van Bladeren, Peter J ^b,c  

^a TNO   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

BCRP; drug transport; inhibitors; MDR; MDR1 P glycoprotein; metabolism; modulators; MRP1; MRP2

Indexed keywords

ABC TRANSPORTER; CYCLOSPORIN DERIVATIVE; DIBENZO[A,D]CYCLOHEPTENE DERIVATIVE; GLYCOPROTEIN P; QUINOLINE DERIVATIVE; VALSPODAR; ZOSUQUIDAR;

DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MULTIDRUG RESISTANCE; REVIEW; RNA INTERFERENCE; TRANSPORT AT THE CELLULAR LEVEL;

ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CYCLOSPORINS; DIBENZOCYCLOHEPTENES; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; HUMANS; P-GLYCOPROTEINS; QUINOLINES; RNA INTERFERENCE;

EID: 33748892510     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.1.2.219     Document Type: Review

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