The interplay of glutathione-related processes in antioxidant defense

Environmental Toxicology and Pharmacology

Volumn 10, Issue 4, 2001, Pages 141-152

  Cnubben, Nicole H P ^a,b   Rietjens, Ivonne M C M ^b   Wortelboer, Heleen ^a   Van Zanden, Jelmer ^b   Van Bladeren, Peter J ^a,b  

^a TNO   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Antioxidant; Glutathione; Glutathione S transferases; Multidrug resistance associated protein; Oxidative stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN;

ANTIOXIDANT ACTIVITY; CELL PROTECTION; CELL REGENERATION; CHEMICAL STRUCTURE; DETOXIFICATION; ENZYME METABOLISM; HUMAN; MOLECULAR INTERACTION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0034856795     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(01)00077-1     Document Type: Article

References (100)

1. Regulation of JNK signaling by GSTp
2. Role of redox potential and reactive oxygen species in stress signaling
3. Regulatory mechanisms involved in activator-protein (AP-1)-mediated activation of glutathione S-transferase gene expression by chemical agents
4. Glutathione, a vehicle for the transport of chemically reactive metabolites in vivo
5. Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases
6. Detoxication of base propenals and other, α,β-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione S-transferases
7. Identification of cDNAs encoding two human Alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4
8. The multidrug resistance protein family
9. A family of drug transporters: The multidrug resistance-associated proteins
10. Dietary antioxidants and assessment of oxidative stress
11. Multidrug resistance proteins and other drug transport-related resistance to natural product agents
12. Mutagenesis of the putative nucleotide-binding domains of the multidrug resistance associated protein. Analysis of the effect of these mutations on MRP mediated drug resistance and transport
13. Induction of c-fos and c-jun gene expression by phenolic antioxidants
14. Effects of chronic ethacrynic acid exposure on glutathione conjugation and MRP expression in human colon tumor cells
15. Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa-o-quinones
16. Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalyzed by mammalian glutathione S-transferases
17. Mechanisms of aflatoxin carcinogenesis
18. Acetaminophen nephrotoxicity in the CD-1 mouse. II. Protection by probenecid and AT-125 without diminution of renal covalent binding
19. Expression of stably transfected murine glutathione S-transferase A3-3 protects against nucleic acid alkylation and cytotoxicity by aflatoxin B-1 in hamster V79 cells expressing rat cytochrome P450-2B1
20. Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors
21. The kinetics of aflatoxinB1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P4501A2 and 3A4
22. Oxidative stress induced in pathologies: The role of antioxidants
23. Lack of glutathione conjugation to adriamycin in human breast cancer MCF-7/DOX cells
24. Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease
25. Posttranscriptional regulation of MRP/GS-X pump and γ-glutamylcysteine synthetase expression by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea and by cycloheximide in human glioma cells
26. Transient induction of the MRP/GS-X pump and γ-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea in human glioma cells
27. Oxidative stress: Free radical production in neural degeneration
28. Biological and pharmacologic regulation of mammalian glutathione synthesis
29. Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide
30. Glutathione and glutathione-dependent enzymes represent a coordinately regulated defence against oxidative stress
31. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprevention and drug resistance
32. Structural, mechanistic and clinical aspects of MRP1
33. Glutathione metabolism and glutathione S-conjugate export ATPase (MRP1/GS-X pump) activity in cancer. I. Differential expression in human cancer cell lines
34. Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP family
35. Catalytic and regulatory properties of the heavy subunit of rat kidney γ-glutamylcysteine synthetase
36. Human glutathione transferase A4-4: An Alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation
37. The GS-X pump in plant, yeast and animal cells: Structure, function and gene expression
38. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
39. Nrf2 and c-Jun regulation of antioxidant response element (ARE)-mediated expression and induction of γ-glutamylcysteine synthetase heavy subunit gene
40. Glutathione and the response of malignant cells to chemotherapy
41. Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2
42. Transport function and substrate specificity of multidrug resistance protein
43. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2
44. Localization, substrate specificity, and drug resistance conferred by conjugate export pumps of the MRP family
45. Enzymology of cytosolic glutathione S-transferases
46. Immunochemical analysis of quinol-thioether-derived covalent protein adducts in rodent species sensitive and resistant to quinol-thioether-mediated nephrotoxicity
47. Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity and MRP2 mediated drug resistance
48. Analysis of expression of cMOAT (MRP2), MRP3, MRP4 and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1) in human cancer cell lines
49. Frequent coordinated overexpression of the MRP/GS-X pump and γ-glutamylcysteine synthetase genes in human colorectal cancers
50. Frequent overexpression of MRP/GS-X pump and γ-glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells, and normal mouse tissues
51. Coordinate expression of drug resistance genes
52. ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump
53. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates
54. The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump
55. Characterization of vincristine transport by the Mr 190,000 multidrug resistance protein (MRP): Evidence for cotransport with reduced glutathione
56. 1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene
57. Regulation of glutathione synthesis
58. Nomenclature for human glutathione transferases
59. Glutathione and glutathione-dependent enzymes in cancer drug resistance
60. Overexpression of seleno-glutathione peroxidase by gene transfer enhances the resistance of T47D human breast cancer cells to clastogenic oxidants
61. An electrophile responsive element (EpRE) regulates α,β-naphthoflavone induction of the human γ-glutamylcysteine synthetase regulatory subunit gene
62. The pharmacology and toxicology of polyphenolic glutathione conjugates
63. Membrane-bound glutathione transferases
64. Identification of a putative antioxidant responsive element in the 5′-flanking region of the human γ-glutamylcysteine synthetase heavy subunit gene
65. Constitutive and α,β-naphthoflavone induced expression of the human γ-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence
66. Coordinated overexpression of the MRP and γ-glutamylcysteine synthetase genes, but not MDR1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines
67. Expression of γ-glutamylcysteine synthetase (γ-GCS) and multidrug resistance-associated protein (MRP), but not human canalicular multispecific organic anion transporter (cMOAT) genes correlated with exposure of human lung cancers to platinum drugs
68. Reactive oxygen species and antioxidants in signal transduction and gene expression
69. Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione
70. Redox signalling and the control of cell growth and death
71. Doxorubicin and daunorubicin glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump
72. Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins
73. From vacuolar GS-X pumps to multispecific ABC transporters
74. ATP-dependent transport of reduced glutathione on YCF1, the yeast orthologue of mammalian multidrug resistance associated proteins
75. Multidrug resistance protein MRP1 protects against the toxicity of the major lipid peroxidation product 4-hydroxynonenal
76. Glutathione S-transferases - A review
77. MRP4; a previously unidentified factor in resistance to nucleoside-based antiviral drugs
78. Glutathione, oxidative stress and neurodegeneration
79. Human class Mu glutathione transferases, in particular isoenzyme M2-2, catalyze detoxication of the dopamine metabolite aminochrome
80. Antioxidant and redox regulation of gene transcription
81. Importance of glutathione and associated enzymes in drug response
82. Oxidative metabolites of 5-S-cysteinyldopamine inhibit the α-ketoglutarate dehydrogenase complex: Possible relevance to the pathogenesis of Parkinson's disease
83. Induction of glutathione S-transferase hGST 5.8 is an early response to oxidative stress in RPE cells
84. Several closely related glutathione S-transferase isozymes catalyzing conjugation of 4-hydroxynonenal are differentially expressed in human tissues
85. Glutathione-associated enzymes in anticancer drug resistance
86. Coordinate changes in expression of protective genes in drug-resistant cells
87. GST function in drug and stress response
88. Formation and export of the glutathione conjugate of 4-hydroxy-2,3-E-nonenal in hepatoma cells
89. Glutathione conjugation as bioactivation reaction
90. Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes
91. On the relationship between the probenecid-sensitive transport of daunorubicin or calcein and the glutathione status of cells overexpressing the multidrug resistance-associated protein
92. Multidrug resistance and its reversal
93. Transcriptional activation mediated by the yeast AP-1 protein is required for normal cadmium tolerance
94. Regulation of γ-glutamylcysteine synthetase subunit gene expression: Insights into transcriptional control of antioxidant defenses
95. The organization of the human GSTP1-1 gene promotor and its response to retinoic acid and cellular redox status
96. Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other; evidence of signaling across the dimer interface
97. Expression of multidrug resistance protein/GS-X pump and γ-glutamylcysteine synthetase genes is regulated by oxidative stress
98. Role of glutathione in the export of compounds from cells by the multidrug resistance-associated protein
99. Transport of amphipathic anions by human multidrug resistance protein 3
100. Cloning and sequence analysis of the promoter region of the MRP gene of HL60 cells isolated for resistance to Adriamycin