Glutathione-dependent biotransformation of the alkylating drug thiotepa and transport of its metabolite monoglutathionylthiotepa in human MCF-7 breast cancer cells

Cancer Research

Volumn 58, Issue 20, 1998, Pages 4616-4623

  Cnubben, Nicole H P ^a   Rommens, Angela J M ^a   Oudshoorn, Martin J ^a   Van Bladeren, Peter J ^a  

^a TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BUTHIONINE SULFOXIMINE; DRUG METABOLITE; ETACRYNIC ACID; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLUTATHIONYLTHIOTEPA; PROBENECID; THIOTEPA; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG TRANSFORMATION; DRUG TRANSPORT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANTINEOPLASTIC AGENTS, ALKYLATING; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BIOTRANSFORMATION; BREAST NEOPLASMS; CELL DIVISION; FEMALE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; THIOTEPA;

EID: 0032532339     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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