The sulphonylurea glibenclamide inhibits multidrug resistance protein (MPR1) activity in human lung cancer cells

British Journal of Pharmacology

Volumn 132, Issue 3, 2001, Pages 778-784

  Payen, L ^a   Delugin, L ^a   Courtois, A ^a   Trinquart, Y ^a   Guillouzo, A ^a   Fardel, O ^a  

^a INSERM   (France)

Author keywords

Anticancer drug resistance; ATP binding cassette transporters; Glibenclamide; Hepatocytes; Multidrug resistance protein; Sulphonylurea

Indexed keywords

ABC TRANSPORTER; CALCEIN; GLIBENCLAMIDE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PROBENECID; SULFONYLUREA DERIVATIVE; TOLBUTAMIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG; VINCRISTINE;

ANIMAL CELL; ARTICLE; CANCER RESISTANCE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; DRUG UPTAKE; HUMAN; HUMAN CELL; LIVER CELL; LUNG CANCER; MALE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT;

EID: 0035115578     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703863     Document Type: Article

References (44)

1. Biochemical, cellular and pharmcological aspects of the multidrug transporter
2. Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel
3. ATP channels
4. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions
5. ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in Xenopus laevis oocytes
6. The multidrug resistance protein family
7. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
8. Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance
9. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
10. Effect of multidrug reversing agents on transporting activity of human canalicular multispecific organic anion transporter
11. Isolation of biologically active ribonucleic acid from source enriched in ribonuclease
12. Inhibition of multidrug resistance-associated protein (MRP) activity by rifampicin in human multidrug-resistant lung tumor cells
13. Inhibitory effect of the reversal agents V-104, GF120918 and pluronic L61 on MDR1 P-gp-, MRP1- and MRP2-mediated transport
14. Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture
15. ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): No inhibition by intracellular glutathione depletion
16. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
17. P-glycoprotein inhibition by glibenclamide and related compounds
18. Interleukin-1β secretion is impaired by inhibitors of the Atp binding cassette transporter ABC1
19. Probes for for live-cell function
20. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in Eisai hyperbilirubinemic rats
21. Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells
22. Fluorescent cellular indicators are extruded by the multidrug resistance protein
23. Induction of cmrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes
24. Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver
25. Glibenclamide and meglitinide block the transport of low molecular weight solutes into malaria-infected eryhtrocytes
26. Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia
27. Analysis of expression of cMOAT(MRP2), MRP3, MRP4 and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1) in human cancer cell lines
28. Use of the anionic dye carboxy-2′-dichlorofluorescein for sensitive flow cytometric detection of multidrug resistance-associated protein activity
29. Multidrug resistance mediated by the multidrug resistance protein (MRP) gene
30. Growth inhibition, cytokinesis failure and apoptosis of multidrug-resistant leukemia cells after treatment with P-glycoprotein inhibitory agents
31. Inhibitors of MRP1-mediated multidrug resistance
32. ABC1: The gene for Tangier disease and beyond
33. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
34. Characterization and inhibition by a wide range of xenobiotic of organic anion excretion by primary human hepatocytes
35. The multidrug resistance-associated protein (MRP) is over-expressed and functional in rat hepatoma cells
36. Reversal of MRP-mediated multidrug resistance in human lung cancer cells by the antiprogestatin drug RU486
37. The cystic fibrosis transmembrane conductance regulator
38. Concentration effect relations of glibenclamide and its active metabolites in man: Modelling of pharmacokinetics and pharmacodynamics
39. Effects of glibenclamide on glycylsarcosine transport by the rat peptide transporters PEPT1 and PEPT2
40. Mechanism of glibenclamide inhibition of cystic fibrosis transmembrane conductance regulator C1-channels expressed in a routine cell line
41. Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver
42. Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells
43. On the relationship between the probenecid-sensitive transport of daunorubicin or calcein and the glutathione status of cells overexpressing the multidrug resistance-associated protein (MRP)
44. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines