Importance of glutathione and associated enzymes in drug response

Oncology Research

Volumn 9, Issue 6-7, 1997, Pages 295-302

  Shen, Hongxie ^a   Kauvar, Lawrence ^a   Tew, Kenneth D ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

Adriamycin; Drug resistance; Ethacrynic acid; Gene regulation; Glutathione; Glutathione 5 transferases; Gst inhibitors; MRP; Ter286; Terl99

Indexed keywords

ETACRYNIC ACID; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE;

CELL CULTURE; CELL STRAIN HT29; DRUG EFFECT; DRUG RESISTANCE; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

DRUG RESISTANCE, NEOPLASM; ETHACRYNIC ACID; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HT29 CELLS; HUMANS; TUMOR CELLS, CULTURED;

EID: 0031303391     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Kuzmich, S.; Vanderveer, L. A.; Walsh, E. S.; LaCreta, F. P.; Tew, K. D. Increased levels of glutathione S-lransferase π-transcript as a mechanism of resistance to ethacrynic acid. Biochem. J. 281:219-224; 1992.
2. Ciaccio, P. J.; Shen, H.; Kruh, G. D.; Tew, K. D. Effects of ethacrynic acid exposure on conjugation and MRP mediated efflux in human colon tumor cells. Biochem. Biophys. Res. Commun. 222:111-115; 1996.
3. Ploemen, J. H. T. M.; Van Schanke, A.; van Ommen, B.; van Bladeren, P. J. Reversible conjugation of ethacrynic acid with glutathione and human glutathione S-transferase P1-1. Cancer Res. 54:915-919; 1994.
4. Ciaccio, P. J.; Shen, H.; Jaiswal, A. K.; Lyttle, M. H.; Tew, K. D. Modulation of detoxification gene expression in human colon HT29 cells by glutathione S-transferase inhibitors. Mol. Pharmacol. 48:639-647; 1995.
5. Ciaccio, P. J.; Jaiswal, A. K.; Tew, K. D. Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics. J. Biol. Chem. 269:15558-15562; 1994.
6. LaCreta, F. P.; Brennan, J. M.; Nash, S.; Comis, R. L.; Tew, K. D.; O'Dwyer, P. J. Pharmacokinetics and bioavailability study of ethacrynic acid as a modulator of drug resistance in patients with cancer. J. Pharmacol. Exp. Ther. 270:1186-1191; 1994.
7. Petrini, M.; Conte, A.; Caracciolo, F.; Sabbatini, A.; Grassi, B.; Ronca, G. Reversing of chlorambucil resistance by ethacrynic acid in a B-CLL patient. Br. J. Haematol. 85:409-410; 1993.
8. Lyttle, M. H.; Hocker, M. D.; Hui, H.C.; Caldwell, C. G.; Aaron, D. T.; Engqvist-Goldsteiri, A.; Flatgaard, J. E.; Baeuer, K. E. Isozyme-specific glutathione S-transferase inhibitors: Design and synthesis. J. Med. Chem. 37:189-194; 1994.
9. Flatgaard, J.; Baeur, K. E.; Kauvar, L. M. Isozyme specificity of novel glutathione S-transferase inhibitors. Cancer Chemother. Pharmacol. 33:63-70; 1993.
10. Morgan, A. S.; Ciaccio, P. J.; Tew, K. D.; Kauvar, L. M. Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines. Cancer Chemother. Pharmacol. 37:363-370; 1996.
11. Broxmeyer, H. E.; Cooper, S.; Hague, N.; Morgan, A. S.; Sanderson, P. TER199, a chemically synthesized molecule, has myeloid enhancing activity and synergizes with G-CSF to mobilize myeloid progenitors to the blood. Blood 88:594a; 1996.
12. Morgan, A. S.; Stanboli, A.; Sanderson, P. E. TER199 increases bone marrow (BM) CFU-GM and peripheral platelet and neutrophil counts in myelosuppressed rodents. Blood 88: 134b;1996.
13. Boguski, M. S.; Sikorski, R. S.; Boebl, M. Expanding family. Nature 346:114-120; 1990.
14. Montali, J. A.; Wheatley, J. B.; Schmidt, D. E., Jr. Comparison of GST levels in predicting the efficacy of a novel alkylating agent. Cell. Pharmacol. 2:241-247; 1996.
15. Tew, K. D. Glutathione associated enzymes in anticancer drug
16. resistance. Perspectives in cancer research. Cancer Res. 54: 4313-4320; 1994.
17. Tew, K. D.; Monks, A.; Barone, L.; Rosser, D.; Akerman, G.; Montali, J. A.; Wheatley, J. B.; Schmidt, D. Glutathione associated enzymes in the human cell lines of the National Cancer Institute drug screening program. Mol. Pharmacol. 50:149-159; 1996.
18. Lyttle, M. H.; Satyam, A.; Hocker, M. D.; Bauer, K. E.; Caldwell, C. G.; Hui, H. C.; Morgan, A. S.; Mergia, A.; Kauvar, L. M. Glutathione S-transferase activates novel alkylating agents. J. Med. Chem. 37:1501-1507; 1994.
19. Bolton, M. G.; Hilton, J.; Robertson, K. D.; Streeper, R. T.; Colvin, O. M.; Noe, D. A. Kinetic analysis of the reaction
20. of melphalan with water, phosphate, and glutathione. Drug Metab. Dispos. 21:986-996; 1993.
21. Kauvar, L. M. GST-targeted drug candidates. In: Vermeulen, N. P. E.; Mulder, G. J.; Nieuwenhuyse, H.; Peters, W. H. M.; van Bladeren, P. J., eds. Glutathione S-transferases: Structure, function and clinical implications. London: Taylor and Francis; 1996:187-197.
22. Hartley, D. O.; Cell, D.; Smith, G. C. M.; Zhang, H.; Divecha, N.; Connelly, M. A.; Admon, A.; Lees-Miller, S. P.; Anderson, C. W.; Jackson, S. P. DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3kinase and the ataxia telangiectasis gene product. Cell 82:849-856; 1995.