Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

Biochemistry

Volumn 37, Issue 14, 1998, Pages 5010-5019

  Ramachandra, Muralidhara ^a,b   Ambudkar, Suresh V ^a   Chen, David ^a,c   Hrycyna, Christine A ^a   Dey, Saibal ^a   Gottesman, Michael M ^a   Pastan, Ira ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; AZIDOPINE; GLYCOPROTEIN P; N ETHYLMALEIMIDE; PRAZOSIN; VANADIC ACID;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BINDING; DRUG TRANSPORT; GENE; HYDROLYSIS; IMMUNOBLOTTING; LEPIDOPTERA; MULTIDRUG RESISTANCE; NONHUMAN; PHOTOAFFINITY LABELING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CATALYSIS; CELL LINE; CHROMATOGRAPHY, AFFINITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; P-GLYCOPROTEIN; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; RECOMBINANT PROTEINS; SPODOPTERA; VANADATES;

ANIMALIA; LEPIDOPTERA; TRICHOPLUSIA NI; UNIDENTIFIED BACULOVIRUS;

EID: 0032492724     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi973045u     Document Type: Article

References (39)

1. Gottesman, M. M., Hrycyna, C. A., Schoenlein, P. V., Germann, U. A., and Pastan, I. (1995) Annu. Rev. Genet. 29, 607-649.
2. Gottesman, M. M., Pastan, I., and Ambudkar, S. V. (1996) Curr. Opin. Genet. Dev. 6, 610-617.
3. Chen, C.-j., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., and Roninson, I. B. (1986) Cell 47, 381-389.
4. Gottesman, M. M., and Pastan, I. (1993) Annu. Rev. Biochem. 62, 385-427.
5. Beck, W. T., and Qian, X.-D. (1992) Biochem. Pharmacol. 43, 89-93.
6. Cornwell, M. M., Tsuruo, T., Gottesman, M. M., and Pastan, I. (1987) FASEB J. 1, 51-54.
7. Azzaria, M., Schurr, E., and Gros, P. (1989) Mol. Cell. Biol. 9, 5289-5297.
8. Sarkadi, B., Price, E. M., Boucher, R. C., Germann, U. A., and Scarborough, G. A. (1992) J. Biol. Chem. 267, 4854-4858.
9. Ambudkar, S. V., Lelong, I. H., Zhang, J. P., Cardarelli, C. O., Gottesman, M. M., and Pastan, I. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 8472-8476.
10. Doige, C. A., Yu, X. H., and Sharom, F. J. (1992) Biochim. Biophys. Acta 1109, 149-160.
11. Urbatsch, I. L., al-Shawi, M. K., and Senior, A. E. (1994) Biochemistry 33, 7069-7076.
12. Shapiro, A. B., and Ling, V. (1994) J. Biol. Chem. 269, 3745-3754.
13. Ruetz, S., and Gros, P. (1994) J. Biol. Chem. 269, 12277-12284.
14. Ramachandra, M., Ambudkar, S. V., Gottesman, M. M., Pastan, I., and Hrycyna, C. A. (1996) Mol. Biol. Cell 7, 1485-1498.
15. Horio, M., Gottesman, M. M., and Pastan, I. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 3580-3584.
16. Ambudkar, S. V. (1995) J. Bioenerg. Biomembr. 27, 23-29.
17. Sharom, F. J., Yu, X., and Doige, C. A. (1993) J. Biol. Chem. 268, 24197-24202.
18. Shapiro, A. B., and Ling, V. (1995) J. Biol. Chem. 270, 16167-16175.
19. Bruggemann, E. P., Germann, U. A., Gottesman, M. M., and Pastan, I. (1989) J. Biol. Chem. 264, 15483-15488.
20. Dey, S., Ramachandra, M., Pastan, I., Gottesman, M. M., and Ambudkar, S. V. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 10594-10599.
21. Urbatsch, I. L., Sankaran, B., Weber, J., and Senior, A. E. (1995) J. Biol. Chem. 270, 19383-19390.
22. Urbatsch, I. L., Sankaran, B., Bhagat, S., and Senior, A. E. (1995) J. Biol. Chem. 270, 26956-26961.
23. Loo, T. W., and Clarke, D. M. (1995) J. Biol. Chem. 270, 21449-21452.
24. Senior, A. E., al-Shawi, M. K., and Urbatsch, I. L. (1995) FEBS Lett. 377, 285-289.
25. Bailey, J. L. (1967) in Techniques in Protein Chemistry, pp 340-341, Elsevier Publishing Co., New York.
26. Germann, U. A., Chambers, T. C., Ambudkar, S. V., Licht, T., Cardarelli, C. O., Pastan, I., and Gottesman, M. M. (1996) J. Biol. Chem. 271, 1708-1716.
27. Hamada, H., and Tsuruo, T. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 7785-7789.
28. Rao, U. S. (1995) J. Biol. Chem. 270, 6686-6690.
29. Racker, E., Violand, B., O'Neal, S., Alfonzo, M., and Telford, J. (1979) Arch. Biochem. Biophys. 198, 470-477.
30. Nozaki, M., Takeshige, K., Sumimoto, H., and Minakami, S. (1990) Eur. J. Biochem. 187, 335-340.
31. Ambudkar, S. V., Anantharam, V., and Maloney, P. C. (1990) J. Biol. Chem. 265, 12287-12292.
32. Urbatsch, I. L., and Senior, A. E. (1995) Arch. Biochem. Biophys. 316, 135-140.
33. Loo, T. W., and Clarke, D. M. (1996) J. Biol. Chem. 271, 27488-27492.
34. Goodno, C. C., and Taylor, E. W. (1982) Proc. Natl. Acad. Sci. U.S.A. 79, 21-25.
35. Senior, A. E., Al-Shawi, M. K., and Urbatsch, I. L. (1995) J. Bioenerg. Biomembr. 27, 31-36.
36. Rayment, I. (1996) J. Biol. Chem. 271, 15850-15853.
37. Amos, L. A., and Cross, R. A. (1997) Curr. Opin. Struct. Biol. 7, 239-246.
38. Tanford, C. (1983) Annu. Rev. Biochem. 52, 379-409.
39. Spudich, J. A. (1994) Nature 372, 515-518.