Influences of glutathione on anionic substrate efflux in tumour cells expressing the multidrug resistance-associated protein, MRP1

Biochemical Pharmacology

Volumn 62, Issue 2, 2001, Pages 199-206

  Bagrij, Tanya ^a   Klokouzas, Antonios ^a   Hladky, Stephen B ^a   Barrand, Margery A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

2 ,7 (2 carboxyethyl) 5 (and 6) carboxyfluorescein; BCECF; Buthionine sulfoximine; Calcein; Glutathione; Methylfluorescein glutathione; Multidrug resistance associated protein

Indexed keywords

2',7' BIS(2 CARBOXYETHYL) 5 CARBOXYFLUORESCEIN; 2',7' BIS(2 CARBOXYETHYL) 6 CARBOXYFLUORESCEIN; ADENOSINE TRIPHOSPHATE; BUTHIONINE SULFOXIMINE; CALCEIN; DINITROPHENYLGLUTATHIONE; FLUORESCEIN DERIVATIVE; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLUTATHIONE DISULFIDE; INDOMETACIN; METHYLFLUORESCEIN GLUTATHIONE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN ANTIBODY QCRL 3; PROBENECID; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; VERLUKAST; VINCRISTINE;

ANION TRANSPORT; ARTICLE; CELL LEVEL; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; DRUG TRANSPORT; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; TUMOR RESISTANCE;

ANIONS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; GLUTATHIONE; GLUTATHIONE DISULFIDE; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; TUMOR CELLS, CULTURED;

EID: 0035879951     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00660-8     Document Type: Article

References (39)

1. Biology of the multidrug resistance-associated protein, MRP
2. Pharmacological characterization of multidrug-resistant MRP-transfected human tumor cells
3. Reduced arsenate V accumulation in a human lung tumour cell line overexpressing the multidrug resistance-association protein (MRP)
4. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
5. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump
6. Active efflux of the free acid form of the fluorescent dye 2′,7′-bis(2-carboxyethyl)-5-(6)-carboxyfluorescein in multidrug- resistance-protein-overexpressing murine and human leukemia cells
7. Indomethacin-mediated reversal of multidrug resistance and drug efflux in human and murine cell lines overexpressing MRP, but not P-glycoprotein
8. Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells
9. Transport of glutathione conjugates into secretory vesicles is mediated by the multidrug-resistance protein 1
10. Modulation of multidrug resistance protein expression in porcine brain capillary endothelial cells in vitro
11. ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): No inhibition by intracellular glutathione depletion
12. Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells
13. Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients
14. On the relationship between the probenecid-sensitive transport of daunorubicin or calcein and the glutathione status of cells overexpressing the multidrug resistance-associated protein
15. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein
16. Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural produce toxins
17. Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): Evidence for cotransport with reduced glutathione
18. ATP-dependent transport of reduced glutathione on YCF1, the yeast orthologue of mammalian multidrug resistance-associated proteins
19. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates
20. Fluorimetric analysis of multidrug resistance-associated protein activity and reduced glutathione levels in small numbers of adherent cells
21. Characteristics of drug uptake into vesicles containing the multidrug resistance-associated protein, MRP
22. Calcein transport and distribution following alterations to reduced glutathione (GSH) levels in lung tumour cells expressing the multidrug resistance-associated protein (MRP)
23. MRP1-mediated transport of 2,4-dinitrophenyl-S-glutathione (DNP-SG) in membrane vesicles prepared from human erythrocytes and COR-L23/R lung tumour cells
24. Pharmacology of L-660,711 (MK-571): A novel potent and selective leukotriene D4 receptor antagonist
25. A 190k protein overexpressed in non-P-glycoprotein containing MDR cells and its relation to the MRP gene
26. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
27. ATP/Mg2+-dependent cardiac transport system for glutathione S-conjugates. A study using rat heart sarcolemma vesicles
28. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein
29. Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein
30. Use of membrane vesicles to investigate drug interactions with transporter proteins, P-glycoprotein and multidrug resistance-associated protein
31. ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump
32. Kinetic analysis of calcein and calcein-acetoxymethylester efflux mediated by the multidrug resistance protein and P-glycoprotein
33. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions
34. Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export
35. Measurement of intracellular pH using BCECF in cells containing organic anion transporters
36. Anti-cancer drugs and glutathione stimulate vanadate-induced trapping of nucleotide in multidrug resistance-associated protein (MRP)
37. The multidrug resistance protein family
38. Multidrug resistance-associated protein (MRP)-mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles
39. Characteristics of reduced glutathione efflux from human lung tumour cells containing different amounts of multidrug resistance-associated protein, MRP1