Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells

Cancer Chemotherapy and Pharmacology

Volumn 40, Issue 2, 1997, Pages 150-158

  Gollapudi, Sastry ^a   Kim, Choong H ^a   Tran, Bich Ngoc ^a   Sangha, Soni ^a   Gupta, Sudhir ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Drug transport; MRP; Multidrug resistance; P glycoprotein; Subcellular drug distribution

Indexed keywords

CARRIER PROTEIN; DAUNORUBICIN; GLYCOPROTEIN P; PROBENECID; VINCRISTINE;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STRAIN HL 60; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG SENSITIVITY; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA P 388; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; SCINTILLATION SPECTROMETRY; STAINING;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; DAUNORUBICIN; DRUG RESISTANCE, MULTIPLE; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; LEUKEMIA P388; MICE; MICROSCOPY, CONFOCAL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; PROBENECID; VINCRISTINE;

EID: 0030953774     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050640     Document Type: Article

References (42)

1. Ueda K, Carderelli C, Gottesman MM, Pastan I (1987) Expression of a full length cDNA for the human MDR1 gene confers resistance to colchicine, doxorubin and vinblastine. Proc Natl Acad Sci USA 84:3004-3008
2. Endicott J, Ling V (1989) The biochemistry of P-glycoprotein mediated multidrug resistance. Annu Rev Biochem 58:131-171
3. Grant CE, Valdimarsson G, Hipfner DR, Almiquist KC, Cole SPC, Deeley RG (1994) Overexpression of multidrug resistance associated protein (MRP) increases resistance to natural product drugs. Cancer Res 54:357-361
4. Juranka PF, Zastawny RL, Ling V (1989) P-glycoprotein: multidrug resistance and a superfamily of membrane associated transport proteins. FASEB J 3:2583-2592
5. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz AU, Duncan AM, Deeley RG (1992) Overexpression of a transporter gene in a multidrug resistant human cancer cell line. Science 258:1650-1654
6. Zaman GJR, Flens MJ, Van Leusden MR, De Haas M, Mulder HS, Lankelma J, Pinedo HM, Scheper RJ, Bass F, Broxterman HJ, Borst P (1994) The human multidrug resistance asociated protein MRP is a plasma membrane drug efflux pump. Proc Natl Acad Sci USA 91:8822-8826
7. Barrand MA, Rhodes T, Center MS, Twentyman PR (1992) Chemosensitisation and drug accumulation effects of cyclosporin A, PSC833 and verapamil in human MDR large cell lung cancer cells expressing a 190-KD membrane distinct from P-glycoprotein. Eur J Cancer 29A:408-415
8. Marquardt D, Center MS (1992) Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: evidence for nuclear drug accumulation and redistribution in resistant cells. Cancer Res 52:3157-3163
9. Hindenburg AA, Gervasoni JE, Krishna S, Stewart VJ, Rosado M, Lutzky J, Bhalla K, Baker MA, Taub RN (1989) Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and -resistant HL60 cells. Cancer Res 49: 4607-4614
10. Gervasoni JE, Fields SJ, Krishna S, Baker MA, Rosado M, Thuraisamy K, Hindenburg AA, Taub RN (1991) Subcellular distribution of daunorubicin in P-glycoprotein positive and -negative drug resistant cell lines using laser assisted-confocal microscopy. Cancer Res 51:4955-4963
11. Tsuruo T, Iido H, Tsukagoshi SH, Sakurai Y (1981) Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 41:1667-1672
12. Zamora JM, Beck WT (1986) Chloroquine enhancement of anticancer drug cytotoxicity in multiple drug resistant human leukemic cells. Biochem Pharmacol 35:4303-4310
13. Slater LM, Sweet P, Stupecky M, Gupta S (1986) Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro. J Clin Invest 77:1405-1408
14. Gupta S, Kim J, Gollapudi S (1991) Reversal of daunorubicin resistance in P388/ADR cells by itraconozole. J Clin Invest 87:1467-1469
15. Ford JM, Hait WN (1990) Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol. Rev 42:155-199
16. Safa AR, Glover CJ, Sewell JL, Meyers MB, Biedler JL, Felsted RL (1987) Identification of the multidrug resistance related membrane glycoprotein as an acceptor for calcium channel blockers. J Biol Chem 262:7884-7888
17. Cornwell MM, Pastan I, Gottesman MM (1987) Certain calcium channel blockers bind specifically to multidrug resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J Biol Chem 262:2166-2170
18. Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T (1993) Human P-glycoprotein transports cyclosporin A and FK-506. J Biol Chem 268:6077-6080
19. Gollapudi S, Gupta S (1992) Lack of reversal of daunorubicin resistance in HL60/AR cells by cyclosporin A. Anticancer Res 12:2127-2132
20. Cole SPC (1992) Multidrug resistance in small lung cancer. Can J Physiol Pharmacol 70:313-329
21. Cole SP, Downes HF, Slovak ML (1989) Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumor cell lines which do not overexpress P-glycoprotein. Br J Cancer 59:42-46
22. Versantvoort CHM, Schuurhuis GJ, Pinedo HM, Eakman CA, Kuiper CM, Lankelma J, Broxterman HJ (1993) Genestein modulates the decreased drug accumulation in non-P-glycoprotein-mediated multidrug resistant tumor cells. Br J Cancer 68:939-946
23. Zaman GJ, Lankelma J, Van Tellingen O, Beijnen J, Dekker H, Paulusma C, Oude Elferink RP, Baas F, Borst P (1995) Role of glutathione in the exports of compounds from the cells by the multidrug resistance associated protein. Proc Natl AcadSci (USA) 92:7690-7694
24. Lutzky A, Astor MB,Taub RN, Baker MA, Bhalla K, Gervosani JR, Rosado MR, Stewart M, Krishna S, Hindenburg AA (1989) Role of glutathione and dependent enzymes in anthracycline resistant HI60/AR cells. Cancer Res 49:4120-4125
25. Leier I, Jedlitscky G, Buchholz U, Cole SP, Deeley RG, Keppler D (1994) The MRP gene encodes an ATP dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem 264:27807-27810
26. Feller N, Broxterman HJ, Wahrer DCR, Pinedo HM (1995) ATP-dependent efflux of calcein by multidrug resistance protein (MRP). No inhibition by intracelluar glutathione depletion. FEBS Lett 368:385-388
27. Leier I, Jedlitscky G, Buchholz U, Keppler D (1994) Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells. Eur J Biochem 220:599-606
28. Lam BK, Xu K, Atkins MB, Austen KF (1992) Leukotriene C4 uses a probenecid sensitive export carrier that does not recognize leukotriene B4. Proc Natl Acad Sci USA 89:11598-11602
29. Krishnamachary N, Center MS (1993) The MRP gene associated with a non P-glycoprotein multidrug resistance encodes a 190 KDa membrane bound glycoprotein. Cancer Res 53:3658-3661
30. Gollapudi S, Thadepalli F, Kim CH, Gupta S (1995) Difloxacin reverses multidrug resistance in HL60/AR cells that overexpress multidrug resistance related protein (MRP) gene. Oncol Res 7:73-85
31. Bhalla K, Huang Y, Tang C, Self S, Ray S, Mahoney M, Bonnathpur V, Tourkina E, Ibrado A, Bullock G, Willingham MC (1994) Characterization of human myeloid leukemia cell line highly resistant to taxol. Leukemia 8:465-475
32. Mirski SEL, Gerlach JH, Cole SPC (1987) Multidrug resistance in a small cell lung cancer cell line selected in adriamycin. Cancer Res 47:2594-2598
33. Mossman T (1983) Rapid colorometric assay for cellular growth and survival. Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63
34. Gilman AG, Rall TW, Nies AS, Taylor P (eds) (1990) The pharmacological basis of therapeutics (8th edn). Pergamon Press, New York, p 1703
35. Cole SPC, Sparks KE, Fraser K, Loe DW, Grant CE, Wilson GM, Deeley RG (1994) Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res 54:5902-5910
36. Evers R, Zaman GJR, Van Deemeter L, Jansen H, Calafat J, Oomen LCJM, Oude Elferink RPJ, Borst P, Schinkel AH (1996) Basolateral localization of export activity of the multidrug resistance associated protein in polarized pig kidney cells. J Clin Invest 97:1211-1218
37. Gekeler V, Ise W, Sanders KH, Ulrich W, Beck J (1995) The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP-associated multidrug resistance. Biochem Biophys Res Comm 208:345-352
38. Manzano RG, Wright KA, Twentyman PR (1996) Modulation by acrolein and chloroacetaldehyde of multidrug resisatnce mediated by the multidrug resisatnce associated protein. Clin Cancer Res 2:1321-1326
39. Rhodes T, Barrand MA, Twentyman PR (1994) Modification by brefeldin A, bafilomycin A1 and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole (NBD) of cellular accumulation and intracellular distribution of anthracyclines in the non-P-glycoprotein mediated multidrug resistatant cell line COR-L23/R. Brit J Cancer 70:60-66
40. Cole SPC, Chanda ER, Dickie FP, Gerlach JH, Mirski SEL (1991) Non-P-glycoprotein mediated multidrug resistance in small cell lung cancer cell lines: evidence for a decreased susceptibilty to drug induced DNA damage and reduced levels of topoisomerase II. Cancer Res 51:3345-3352
41. Cole SPC, Pinkoski MJ, Bhardwaj G, Deeley RG (1992) Elevated expression of annexin (lipocortin II, p36) in a multidrug resistant small cell lung cancer cell line. Br J Cancer 65:498-502
42. Schneider E, Altenberg GA, Cowan KH (1994) Increased intracellular pH as a possible mechanism of MRP mediated multidrug resistance in the human mammary carcinoma cell line MCF7/VP (abstract). Proc Am Assoc Can Res 36:325