Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

Journal of Biological Chemistry

Volumn 276, Issue 15, 2001, Pages 11653-11661

  Sauna, Zuben E ^b   Ambudkar, Suresh V ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CATALYSIS; CELLS; DRUG PRODUCTS; HYDROLYSIS; SUBSTRATES; TUMORS;

MULTIDRUG RESISTANCE; PLASMA MEMBRANES;

BIOCHEMISTRY;

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; GLYCOPROTEIN P; PHOSPHORUS 32; VANADIC ACID; 2',3' O (2,4,6 TRINITRO CYCLOHEXADIENYLIDINE)ADENOSINE 5' TRIPHOSPHATE; 2',3'-O-(2,4,6-TRINITRO-CYCLOHEXADIENYLIDINE)ADENOSINE 5'-TRIPHOSPHATE; 8 AZIDOADENOSINE DIPHOSPHATE; 8-AZIDOADENOSINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE; AZIDE; AZIDOPRAZOSIN; DRUG DERIVATIVE; PRAZOSIN; RADIOACTIVE IODINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; CELL MEMBRANE; CONTROLLED STUDY; ENZYME BINDING; ENZYME KINETICS; ENZYME SUBSTRATE; HUMAN; HYDROLYSIS; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TUMOR CELL; CHEMISTRY; KINETICS; METABOLISM;

ANIMALIA;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AZIDES; CATALYSIS; HUMANS; HYDROLYSIS; IODINE RADIOISOTOPES; KINETICS; P-GLYCOPROTEIN; PRAZOSIN; PROTEIN CONFORMATION;

EID: 0035853686     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011294200     Document Type: Article

References (41)

1. Gottesman, M. M., Pastan, I., and Ambudkar, S. V. (1996) Curr. Opin. Genet. & Dev. 6, 610-617
2. Gottesman, M. M., and Pastan, I. (1993) Annu. Rev. Biochem. 62, 385-427
3. Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I., and Gottesman, M. M. (1999) Annu. Rev. Pharmacol. Toxicol. 39, 361-398
4. Sarkadi, B., Price, E. M., Boucher, R. C., Germann, U. A., and Scarborough, G. A. (1992) J. Biol. Chem. 267, 4854-4858
5. Ambudkar, S. V., Lelong, I. H., Zhang, J., Cardarelli, C. O., Gottesman, M. M., and Pastan, I. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 8472-8476
6. Urbatsch, I. L., al-Shawi, M. K., and Senior, A. E. (1994) Biochemistry 33, 7069-7076
7. Ford, J. M., and Hait, W. N. (1990) Pharmacol. Rev. 42, 155-199
8. Dey, S., Ramachandra, M., Pastan, I., Gottesman, M. M., and Ambudkar, S. V. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 10594-10599
9. Senior, A. E., al-Shawi, M. K., and Urbatsch, I. L. (1995) FEBS Lett. 377, 285-289
10. Sauna, Z. E., and Ambudkar, S. V. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2515-2520
11. Ambudkar, S. V., Cardarelli, C. O., Pashinsky, I., and Stein, W. D. (1997) J. Biol. Chem. 272, 21160-21166
12. Shapiro, A. B., and Ling, V. (1998) Eur. J. Biochem. 254, 189-193
13. Ramachandra, M., Ambudkar, S. V., Chen, D., Hrycyna, C. A., Dey, S., Gottesman, M. M., and Pastan, I. (1998) Biochemistry 37, 5010-5019
14. Schaffner, W., and Weissmann, C. (1973) Anal. Biochem. 56, 502-514
15. al-Shawi, M. K., Urbatsch, I. L., and Senior, A. E. (1994) J. Biol. Chem. 269, 8986-8992
16. Kerr, K. M., Sauna, Z. E., and Ambudkar, S. V. (2001) J. Biol. Chem. 276, 8657-8664
17. Hiratsuka, T., and Uchida, K. (1973) Biochim. Biophys. Acta 320, 635-647
18. Lerner-Marmarosh, N., Gimi, K., Urbatsch, I. L., Gros, P., and Senior, A. E. (1999) J. Biol. Chem. 274, 34711-34718
19. Liu, R., and Sharom, F. J. (1997) Biochemistry 36, 2836-2843
20. Hrycyna, C. A., Ramachandra, M., Germann, U. A., Cheng, P. W., Pastan, I., and Gottesman, M. M. (1999) Biochemistry 38, 13887-13899
21. Loo, T. W., and Clarke, D. M. (1995) J. Biol. Chem. 270, 22957-22961
22. Muller, M., Bakos, E., Welker, E., Varadi, A., Germann, U. A., Gottesman, M. M., Morse, B. S., Roninson, I. B., and Sarkadi, B. (1996) J. Biol. Chem. 271, 1877-1883
23. Loo, T. W., and Clarke, D. M. (1995) J. Biol. Chem. 270, 21449-21452
24. Senior, A. E., and Bhagat, S. (1998) Biochemistry 37, 831-836
25. al-Shawi, M. K., and Senior, A. E. (1993) J. Biol. Chem. 268, 4197-4206
26. Senior, A. E., and Gadsby, D. C. (1997) Semin. Cancer Biol. 8, 143-150
27. Senior, A. E. (1998) Acta Physiol. Scand. Suppl. 643, 213-218
28. Senior, A. E., al-Shawi, M. K., and Urbatsch, I. L. (1995) J. Bioenerg. Biomembr. 27, 31-36
29. Sharom, F. J., Yu, X., Chu, J. W., and Doige, C. A. (1995) Biochem. J. 308, 381-390
30. Scarborough, G. A. (1995) J. Bioenerg. Biomembr. 27, 37-41
31. Urbatsch, I. L., Gimi, K., Wilke-Mounts, S., and Senior, A. E. (2000) Biochemistry 39, 11921-11927
32. Sankaran, B., Bhagat, S., and Senior, A. E. (1997) Biochemistry 36, 6847-6853
33. Urbatsch, I. L., Sankaran, B., Bhagat, S., and Senior, A. E. (1995) J. Biol. Chem. 270, 26956-26961
34. Urbatsch, I. L., Sankaran, B., Weber, J., and Senior, A. E. (1995) J. Biol. Chem. 270, 19383-19390
35. Urbatsch, I. L., Gimi, K., Wilke-Mounts, S., and Senior, A. E. (2000) J. Biol. Chem. 275, 25031-25038
36. Liu, R., and Sharom, F. J. (1996) Biochemistry 35, 11865-11873
37. Zhou, T., Radaev, S., Rosen, B. P., and Gatti, D. L. (2000) EMBO J. 19, 4838-4845
38. Obmolova, G., Ban, C., Hsieh, P., and Yang, W. (2000) Nature 407, 703-710
39. Lamers, M. H., Perrakis, A., Enzlin, J. H., Winterwerp, H. H., de Wind, N. and Sixma, T. K. (2000) Nature 407, 711-717
40. Diederichs, K., Diez, J., Greller, G., Muller, C., Breed, J., Schnell, C., Vonrhein, C., Boos, W., and Welte, W. (2000) EMBO J. 19, 5951-5961
41. Urbatsch, I. L., Beaudet, L., Carrier, I., and Gros, P. (1998) Biochemistry 37, 4592-4602