Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis

EMBO Journal

Volumn 23, Issue 24, 2004, Pages 4792-4801

  Lee Hoeflich, Si Tuen ^a   Causing, Carrie G ^b   Podkowa, Monika ^a   Zhao, Xin ^a   Wrana, Jeffrey L ^a,b   Attisano, Liliana ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

BMP; Dendritogenesis; LIM kinase; Neuronal cells

Indexed keywords

ACTIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; LIM KINASE 1; OSTEOGENIC PROTEIN 1; PHOSPHOTRANSFERASE; PROTEIN CDC42; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; CATALYSIS; CYTOSKELETON; DENDRITE; EMBRYO; MOUSE; NERVE FIBER GROWTH; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ACTIN DEPOLYMERIZING FACTORS; ACTINS; ANIMALS; BINDING SITES; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; BONE MORPHOGENETIC PROTEINS; CDC42 GTP-BINDING PROTEIN; CELL LINE; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CEREBRAL CORTEX; COS CELLS; CYTOSKELETON; DENDRITES; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; MICE; MICROFILAMENT PROTEINS; NEURONS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 11244313831     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600418     Document Type: Article

References (43)

1. Aberle H, Haghighi AP, Fetter RD, McCabe BD, Magalhaes TR, Goodman CS (2002) wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila. Neuron 33: 545-558
2. Aizawa H, Wakatsuki S, Ishii A, Moriyama K, Sasaki Y, Ohashi K, Sekine-Aizawa Y, Sehara-Fujisawa A, Mizuno K, Goshima Y, Yahara I (2001) Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Nat Neurosci 4: 367-373
3. Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P (1998) Regulation of actin dynamics through phosphorylation of cofllin by LIM-kinase. Nature 393: 805-809
4. Attisano L, Wrana JL (2002) Signal transduction by the TGF-β superfamily. Science 296: 1646-1647
5. Bernard V, Bohl BP, Bokock GM (1999) Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem 274: 13198-13204
6. Bhowmick NA, Ghiassim M, Bakin A, Aakre M, Lundquist CA, Engel ME, Arteaga CL, Moses HL (2001) Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 12: 27-36
7. da Silva JS, Dotti CG (2002) Breaking the neuronal sphere: regulation of the actin cytoskeleton in neuritogenesis. Nat Rev Neurosci 3: 694-704
8. De Caestecker M, Meyrick B (2001) Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension. Respir Res 2: 193-197
9. Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL (2003) Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol 5: 410-421
10. Dickson BJ (2001) Rho GTPases in growth cone guidance. Curr Opin Neurobiol 11: 103-110
11. Ebendal T, Bengtsson H, Soderstrom S (1998) Bone morphogenetic proteins and their receptors: potential functions in the brain. J Neurosci Res 51: 139-146
12. Edlund S, Landstrom M, Heldin CH, Aspenstrom P (2002) Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell 13: 902-914
13. Edwards DC, Gill GN (1999) Structural features of LIM kinase that control effects on the actin cytoskeleton. J Biol Chem 274: 11352-11361
14. Edwards DC, Sanders LC, Bokoch GM, Gill GN (1999) Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol 1: 253-259
15. Endo M, Ohashi K, Sasaki Y, Goshima Y, Niwa R, Uemura T, Mizuno K (2003) Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. J Neurosci 23: 2527-2537
16. Etienne-Manneville S, Hall A (2002) Rho GTPases in cell biology. Nature 420: 629-635
17. Foletta VC, Lim MA, Soosairaiah J, Kelly AP, Stanley EG, Shannon M, He W, Das S, Massague J, Bernard O (2003) Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. J Cell Biol 162: 1089-1098
18. Gungabissoon RA, Bamburg JR (2003) Regulation of growth cone actin dynamics by ADF/cofilin. J Histochem Cytochem 51: 411-420
19. Higgins D, Burack M, Lein P, Banker G (1997) Mechanisms of neuronal polarity. Curr Opin Neurobiol 7: 599-604
20. Jan Y-N, Jan LY (2001) Dendrites. Genes Dev 15: 2627-2641
21. Labbé E, Letamendia A, Attisano L (2000) Association of Smads with LEF1/TCF mediates cooperative signalling by the TGFβ and Wnt pathways. Proc Natl Acad Sci USA 97: 8358-8363
22. Lane KB, Machado RD, Pauciulo MW, Thomson JR, Phillips III JA, Loyd JE, Nichols WC, Trembath RC (2000) Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. The International PPH Consortium. Nat Genet 26: 81-84
23. Lein P, Johnson M, Guo X, Rueger D, Higgins D (1995) Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons. Neuron 15: 597-605
24. Le Roux P, Behar S, Higgins D, Charette M (1999) OP-1 enhances dendritic growth from cerebral cortical neurons in vitro. Exp Neurol 160: 151-163
25. Liu F, Ventura F, Doody J, Massagué J (1995) Human type II receptor for bone morphogenetic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol 15: 3479-3486
26. Luo L (2002) Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. Annu Rev Cell Dev Biol 18: 601-635
27. Mandell JW, Banker GA (1996) A spatial gradient of Tau protein phosphorylation in nascent axons. J Neurosci 16: 5727-5740
28. Marqués G, Bao H, Haerry TE, Shimell MJ, Ducheck P, Zhang B, O'Connor MB (2002) The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function. Neuron 33: 529-543
29. McCabe BD, Marques G, Haghighi AP, Fetter RD, Crotty ML, Haerry TE, Goodman CS, O'Connor MB (2003) The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. Neuron 39: 241-254
30. Mehler MF, Mabie PC, Zhang D, Kessler JA (1997) Bone morphogenetic proteins in the nervous system. Trends Neurosci 20: 309-317
31. Meng Y, Zhang Y, Tregoubov V, Janus C, Cruz L, Jackson M, Lu WY, MacDonald JF, Wang JY, Falls DL, Jia Z (2002) Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron 35: 121-133
32. Meyer G, Feldman EL (2002) Signaling mechanisms that regulate actin-based motility processes in the nervous system. J Neurochem 83: 490-503
33. Miller FD, Kaplan DR (2003) Signaling mechanisms underlying dendrite formation. Curr Opin Neurobiol 13: 391-398
34. Morris CA, Mervis CB (2000) Williams syndrome and related disorders. Annu Rev Genomics Hum Genet 1: 461-484
35. Munoz-Sanjuan I, Brivanlou AH (2002) Neural induction, the default model and embryonic stem cells. Nat Rev Neurosci 3: 271-280
36. Nagata K, Ohashi K, Yang N, Mizuno K (1999) The N-terminal LIM domain negatively regulates the kinase activity of LIM-kinase 1. Biochem J 343 (Part 1): 99-105
37. Nishihara A, Watabe T, Imamura T, Miyazono K (2002) Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension. Mol Biol Cell 13: 3055-3063
38. Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (2002) Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. Cell 108: 233-246
39. Scott EK, Luo L (2001) How do dendrites take their shape? Nat Neurosci 4: 359-365
40. Threadgill R, Bobb K, Ghosh A (1997) Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42. Neuron 19: 625-634
41. Whitford KL, Dijkhuizen P, Polleux F, Ghosh A (2002) Molecular control of cortical dendrite development. Annu Rev Neurosci 25: 127-149
42. Withers GS, Higgins D, Charette M, Banker G (2000) Bone morphogenetic protein-7 enhances dendritic growth and receptivity to innervation in cultured hippocampal neurons. Eur J Neurosci 12: 106-116
43. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (1998) Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 393: 809-812