TGFβ-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein

Molecular Biology of the Cell

Volumn 7, Issue 9, 1996, Pages 1335-1342

  Herrera, Rafael E ^a   Mäkelä, Tomi P ^a   Weinberg, Robert A ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; RETINOBLASTOMA PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL DENSITY; CELL GROWTH; CELL MUTANT; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE;

ANIMALIA;

EID: 0029808318     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.7.9.1335     Document Type: Article

References (47)

1. Arrick, B.A., Lopez, A.R., Elfman, F., Ebner, R., Damsky, C.H., and Derynck, R. (1992). Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1. J. Cell Biol. 118, 715-726.
2. Arteaga, C.L., Carty-Dugger, T., Moses, H.L., Hurd, S.D., and Pietenpol, J.A. (1993a). Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice. Cell Growth Differ. 4, 193-201.
3. Arteaga, C.L., Hurd, S.D., Winnier, A.R., Johnson, M.D., Fendly, B.M., and Forbes, J.T. (1993b). Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression. J. Clin. Invest. 92, 2569-2576.
4. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K. (1993). Current Protocols in Molecular Biology, New York: John Wiley & Sons.
5. Buchkovich, K., Duffy, L.A., and Harlow, E. (1989). The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58, 1097-1105.
6. Chang, H.L., Gillett, N., Figari, I., Lopez, A.R., Palladino, M.A., and Derynck, R. (1993). Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of meth A sarcoma cells. Cancer Res. 53, 4391-4398.
7. Chen, P.L., Scully, P., Shew, J.Y., Wang, J.Y., and Lee, W.H. (1989). Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58, 1193-1198.
8. Datto, M.B., Li, Y., Panus, J.F., Howe, D.J., Xiong, Y., and Wang, X.F. (1995). Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 92, 5545-5549.
9. De Caprio, J.A., Ludlow, J.W., Lynch, D., Furukawa, Y., Griffin, J., Piwnica-Worms, H., Huang, C.M., and Livingston, D.M. (1989). The product of the retinoblastoma susceptibility gene has properties of a cell-cycle regulatory element. Cell 58, 1085-1095.
10. Derynck, R. (1994). TGF-beta-receptor-mediated signaling. Trends Biochem. Sci. 19, 548-553.
11. Ewen, ME., Sluss, H.K., Sherr, C.J., Matsushime, H., Kato, J., and Livingston, D.M. (1993a). Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73, 487-497.
12. Ewen, M.E., Sluss, H.K., Whitehouse, L.L., and Livingston, D.M. (1993b). TGF beta inhibition of CDK4 synthesis is linked to cell-cycle arrest. Cell 74, 1009-1020.
13. Fitzpatrick, D.R., Bielefeldt-Ohmann, H., Himbeck, R.P., Jarnicki, A.G., Marzo, A.L., and Robinson, B.W. (1994). Transforming growth factor-beta: antisense RNA-mediated inhibition affects anchorageindependent growth, tumorigenicity and tumor-infiltrating T-cells in malignant mesothelioma. Growth Factors 11, 29-44.
14. Furukawa, Y., Uenoyama, S., Ohta, M., Tsunoda, A., Griffin, J.D., and Saito, M. (1992). Transforming growth factor-beta inhibits phosphorylation of the retinoblastoma susceptibility gene product in human monocytic leukemia cell line JOSK-I. J. Biol. Chem. 267, 17121-17127.
15. Fynan, T.M., and Reiss, M. (1993). Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis. Crit. Rev. Oncog. 4, 493-540.
16. Geng, Y., Ng-Eaton, E., Pícon, M., Roberts, J.M., Lundberg, A.S., Gifford, A., Sardet, C., and Weinberg, R.A. (1996). Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene 22, 1173-1180.
17. Geng, Y., and Weinberg, R.A. (1993). Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases. Proc. Natl. Acad. Sci. USA 90, 10315-10319.
18. Hannon, G.J., and Beach, D. (1994). p15INK4B is a potential effector of TGF-beta-induced cell-cycle arrest: comments. Nature 372, 257-261.
19. 1 restriction point regulation in Rb-deficient fibroblasts. Mol. Cell. Biol. 16, 2402-2407.
20. Hinds, P.W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S.I., and Weinberg, R.A. (1992). Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70, 993-1006.
21. Huggett, A.C., Ellis, P.A., Ford, C.P., Hampton, L.L., Rimoldi, D., and Thorgeirsson, S.S. (1991). Development of resistance to the growth inhibitory effects of transforming growth factor beta 1 during the spontaneous transformation of rat liver epithelial cells. Cancer Res. 51, 5929-5936.
22. Jacks, T., Fazeli, A., Schmitt, E.M., Bronson, R.T., Goodell, M.A., and Weinberg, R.A. (1992). Effects of an Rb mutation in the mouse: comments. Nature 359, 295-300.
23. Kato, J., Matsushime, H., Hiebert, S.W., Ewen, M.E., and Sherr, C.J. (1993). Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7, 331-342.
24. Koff, A., Ohtsuki, M., Polyak, K., Roberts, J.M., and Massagué, J. (1993). Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science 260, 536-539.
25. Laiho, M., De Caprio, J.A., Ludlow, J.W., Livingston, D.M., and Massagué, J. (1990). Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell 62, 175-185.
26. Li, C.Y., Suardet, L., and Little, J.B. (1995). Potential role of WAF1/ Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. J. Biol. Chem. 270, 4971-4974.
27. Lukas, J., Bartkova, J., Rohde, M., Strauss, M., and Bartek, J. (1995). Cyclin D1 is dispensable for G1 control in retinoblastoma genedeficient cells independently of CDK4 activity. Mol. Cell. Biol. 15, 2600-2611.
28. Mäkelä, T.P., Parvin, J.D., Kim, J., Huber, L.J., Sharp, P.A., and Weinberg, R.A. (1995).A kinase-deficient transcription factor THIIH is functional in basal and activated transcription. Proc. Natl. Acad. Sci. USA 92, 5174-5178.
29. Massagué, J., Cheifetz, S., Laiho, M., Ralph, D.A., Weis, F.M., and Zentella, A. (1992). Transforming growth factor-beta. Cancer Surv. 12, 81-103.
30. Matsushime, H., Quelle, D.E., Shurtleff, S.A., Shibuya, M., Sherr, C.J., and Kato, J.Y. (1994). D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14, 2066-2076.
31. Morton, D.M., and Barrack, E.R. (1995). Modulation of transforming growth factor beta 1 effects on prostate cancer cell proliferation by growth factors and extracellular matrix. Cancer Res. 55, 2596-2602.
32. Moses, H.L. (1992). TGFβ regulation of epithelial cell proliferation. Mol. Reprod. Dev. 32, 179-184.
33. Newman, M.J. (1993). Transforming growth factor beta and the cell surface in tumor progression. Cancer Metastasis Rev. 12, 239-254.
34. Park, K., Kim, S.J., Bang, Y.J., Park, J.G., Kim, N.K., Roberts, A.B., and Sporn, M.B. (1994). Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta. Proc. Natl. Acad. Sci. USA 92, 8772-8776.
35. Polyak, K., Kato, J.Y., Solomon, M.J., Sherr, C.J., Massagué, J., Roberts, J.M., and Koff, A. (1994). p27Kip1, a cyclin-CDK inhibitor, links transforming growth factor-beta and contact inhibition to cell-cycle arrest. Genes Dev. 8, 9-22.
36. Resnitzky, D., and Reed, S.I. (1995). Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol. Cell. Biol. 15, 3463-3469.
37. Reynisdóttir, I., Polyak, K., Iavarone, A., and Massagué, J. (1995). Kip/Cip and Ink4 CDK inhibitors cooperate to induce cell-cycle arrest in response to TGFβ. Genes Dev. 9, 1831-1845.
38. Roberts, A.B., McCune, B.K., and Sporn, M.B. (1992). TGF-beta: regulation of extracellular matrix. Kidney Int. 41, 557-559.
39. Rodeck, U., Bossler, A., Graeven, U., Fox, F.E., Nowell, P.C., Knabbe, C., and Kari, C. (1994). Transforming growth factor beta production and responsiveness in normal human melanocytes and melanoma cells. Cancer Res. 54, 575-581.
40. Serra, R., and Moses, H.L. (1995). pRb is necessary for inhibition of N-myc expression by TGFβ 1 in embryonic lung organ cultures. Development 121, 3057-3066.
41. Smith, R.D. (1994). The anti-proliferative action of transforming growth factor-beta 1 on a rat intestinal epithelial cell line (RIE-1) is dependent on cell population density and culture passage number. Int. J. Biochem. 26, 899-903.
42. Steiner, M.S., and Barrack, E.R. (1992). Transforming growth factorbeta 1 overproduction in prostate cancer, effects on growth in vivo and in vitro. Mol. Endocrinol. 6, 15-25.
43. Suardet, L., Gaide, A.C., Calmes, J.M., Sordat, B., Givel, J.C., Eliason, J.F., and Odartchenko, N. (1992). Responsiveness of three newly established human colorectal cancer cell lines to transforming growth factors beta 1 and beta 2. Cancer Res. 52, 3705-3712.
44. Toyoshima, H., and Hunter, T. (1994). p27, a novel inhibitor of G1 cyclin-CDK protein kinase activity, is related to p21. Cell 78, 67-74.
45. Tsai, L.H., Lees, E., Faha, B., Harlow, E., and Riabowol, K. (1993). The CDK2 kinase is required for the G1-to-S transition in mammalian cells. Oncogene 8, 1593-1602.
46. Ueki, N., Nakazato, M., Ohkawa, T., Ikeda, T., Amuro, Y., Hada, T., and Higashino, K. (1992). Excessive production of transforming growth-factor beta 1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth. Biochim. Biophys. Acta 1137, 189-196.
47. Weinberg, R.A. (1995). The Rb protein and cell-cycle control. Cell 81, 323-330.