Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

Molecular Cell

Volumn 19, Issue 3, 2005, Pages 297-308

  Ogunjimi, Abiodun A ^a   Briant, Douglas J ^a   Pece Barbara, Nadia ^a   Le Roy, Christine ^a   Di Guglielmo, Gianni M ^a   Kavsak, Peter ^a   Rasmussen, Richele K ^a   Seet, Bruce T ^a,b   Sicheri, Frank ^a,b   Wrana, Jeffrey L ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; PROTEIN; SMAD7 PROTEIN; SMURF2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN E2 LIGASE; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONJUGATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOLECULAR RECOGNITION; MUTAGENESIS; PROTEIN DOMAIN; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STIMULATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TRANS-ACTIVATORS; TRANSFECTION; UBIQUITIN; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES;

EID: 23044505285     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2005.06.028     Document Type: Article

References (20)

1. L. Attisano, and J.L. Wrana Signal transduction by the TGF-beta superfamily Science 296 2002 1646 1647
2. G.M. Di Guglielmo, C. Le Roy, A.F. Goodfellow, and J.L. Wrana Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover Nat. Cell Biol. 5 2003 410 421
3. T. Ebisawa, M. Fukuchi, G. Murakami, T. Chiba, K. Tanaka, T. Imamura, and K. Miyazono Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation J. Biol. Chem. 276 2001 12477 12480
4. M.H. Glickman, and A. Ciechanover The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction Physiol. Rev. 82 2002 373 428
5. E. Gronroos, U. Hellman, C.H. Heldin, and J. Ericsson Control of Smad7 stability by competition between acetylation and ubiquitination Mol. Cell 10 2002 483 493
6. A. Hanyu, Y. Ishidou, T. Ebisawa, T. Shimanuki, T. Imamura, and K. Miyazono The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling J. Cell Biol. 155 2001 1017 1027
7. K.F. Harvey, and S. Kumar Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions Trends Cell Biol. 9 1999 166 169
8. H. Hayashi, S. Abdollah, Y. Qiu, J. Cai, Y.Y. Xu, B.W. Grinnell, M.A. Richardson, J.N. Topper, M.A. Gimbrone Jr., J.L. Wrana, and D. Falb The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling Cell 89 1997 1165 1173
9. A. Hershko, and A. Ciechanover The ubiquitin system Annu. Rev. Biochem. 67 1998 425 479
10. L. Huang, E. Kinnucan, G. Wang, S. Beaudenon, P.M. Howley, J.M. Huibregtse, and N.P. Pavletich Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade Science 286 1999 1321 1326
11. L. Izzi, and L. Attisano Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation Oncogene 23 2004 2071 2078
12. P. Kavsak, R.K. Rasmussen, C.G. Causing, S. Bonni, H. Zhu, G.H. Thomsen, and J.L. Wrana Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation Mol. Cell 6 2000 1365 1375
13. M. Macias-Silva, S. Abdollah, P.A. Hoodless, R. Pirone, L. Attisano, and J.L. Wrana MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling Cell 87 1996 1215 1224
14. S. Orlicky, X. Tang, A. Willems, M. Tyers, and F. Sicheri Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase Cell 112 2003 243 256
15. C.M. Pickart Mechanisms underlying ubiquitination Annu. Rev. Biochem. 70 2001 503 533
16. A.B. Roberts TGF-beta signaling from receptors to the nucleus Microbes Infect. 1 1999 1265 1273
17. C. Suzuki, G. Murakami, M. Fukuchi, T. Shimanuki, Y. Shikauchi, T. Imamura, and K. Miyazono Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane J. Biol. Chem. 277 2002 39919 39925
18. M.A. Verdecia, C.A. Joazeiro, N.J. Wells, J.L. Ferrer, M.E. Bowman, T. Hunter, and J.P. Noel Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase Mol. Cell 11 2003 249 259
19. H. Zhu, P. Kavsak, S. Abdollah, J.L. Wrana, and G.H. Thomsen A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation Nature 400 1999 687 693
20. H.J. Zhu, J. Iaria, and A.M. Sizeland Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways J. Biol. Chem. 274 1999 32258 32264