Cytokine receptor signalling and aging

Mechanisms of Ageing and Development

Volumn 127, Issue 6, 2006, Pages 526-537

  Fulop, T ^a,b   Larbi, A ^a   Douziech, N ^a   Levesque, I ^a   Varin, A ^b   Herbein, G ^b  

^a Centre de Recherche Sur le Vieillissement   (Canada)

^b IFR133 ^*  (France)

Author keywords

Ageing; Cytokine receptors; IL 2; IL 6; Immunosenescence; JAK STAT; Macrophages; T cells

Indexed keywords

CYTOKINE RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; JANUS KINASE; STAT PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN;

ARTICLE; CELL AGING; CYTOKINE PRODUCTION; DENDRITIC CELL; HEMATOPOIETIC CELL; HUMAN; IMMUNE SYSTEM; IMMUNOMODULATION; IMMUNOSTIMULATION; LIPID RAFT; MACROPHAGE ACTIVATION; MOLECULAR RECOGNITION; MONOCYTE; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; SENESCENCE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

AGED; AGING; ANIMALS; CYTOKINES; HUMANS; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION;

EID: 33646487013     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2006.01.025     Document Type: Article

References (130)

1. Adolfsson O., Huber B.T., and Meydani S.N. Vitamin E-enhanced IL-2 production in old mice: naïve but not memory T cells show increased cell division cycling and IL-2 producing capacity. J. Immunol. 167 (2001) 3809-3817
2. Ahluwalia N., Mastro A.M., Ball R., Miles M.P., Rajendra R., and Handte G. Cytokine production by stimulated mononuclear cells did not change with aging in apparently healthy, well-nourished women. Mech. Ageing Dev. 122 (2001) 1269-1279
3. Akaishi H., Takeda K., Kaisho T., Shineha R., Satomi S., Takeda J., and Akira S. Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes. Int. Immunol. 10 (1998) 1747-1751
4. Albright J.W., Bream J.H., Bere E.W., Young H.A., Winkler-Pickett R., and Ortaldo J.R. Aging of innate immunity: functional comparisons of NK/LAK cells obtained from bulk cultures of young and aged mouse spleen cells in high concentrations of interleukin-2. Exp. Gerontol. 39 (2004) 73-82
5. Alonso M.A., and Millan J. The role of lipid rafts in signalling and membrane trafficking in T lymphocytes. J. Cell Sci. 114 (2001) 3957-3965
6. Aringer M., Cheng A., Nelson J.W., Chen M., Sudarshan C., Zhou Y.J., and O'Shea J.J. Janus kinases and their role in growth and disease. Life Sci. 64 (1999) 2173-2186
7. Auernhammer C.J., and Melmed S. Leukemia-inhibitory factor-neuroimmune modulator of endocrine function. Endocr. Rev. 21 (2000) 313-345
8. Beharka A.A., Meydani M., Wu D., Leka L.S., Meydani A., and Meydani S.N. Interleukin-6 production does not increase with age. J. Gerontol. 56 (2001) B81-B88
9. Bruunsgaard H., and Pedersen B.K. Age-related inflammatory cytokines and disease. Immunol. Allergy Clin. North Am. 23 (2003) 15-39
10. Bruunsgaard H., Pedersen M., and Pedersen B.K. Aging and proinflammatory cytokines. Curr. Opin. Hematol. 8 (2001) 131-136
11. Carrard G., Dieu M., Raes M., Toussaint O., and Friguet B. Impact of ageing on proteasome structure and function in human lymphocytes. Int. J. Biochem. Cell Biol. 35 (2003) 728-739
12. Caruso C., Lio D., Cavallone L., and Franceschi C. Aging, longevity, inflammation, and cancer. Ann. N. Y. Acad. Sci. 1028 (2004) 1-13
13. Castle S.C. Clinical relevance of age-related immune dysfunction. Clin. Infect. Dis. 31 (2000) 578-585
14. Castle S.C., Uyemura K., Crawford W., Wong W., Klaustermeyer W.B., and Makinodan T. Age-related impaired proliferation of peripheral blood mononuclear cells is associated with an increase in both IL-10 and IL-12. Exp. Gerontol. 34 (1999) 243-252
15. Chakravarti B., and Abraham G.N. Aging and T-cell-mediated immunity. Mech. Ageing Dev. 108 (1999) 183-206
16. Chandra R.K. Nutrition and the immune system: an introduction. Am. J. Clin. Nutr. 66 (1999) 460S-463S
17. Chong Z.Z., Li F., and Maiese K. Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease. Brain Res. Brain Res. Rev. 49 (2005) 1-21
18. Chow D., He X., Snow A.L., Rose-John S., and Garcia K.C. Structure of an extracellular gp130 cytokine receptor signaling complex. Science 291 (2001) 2150-2155
19. Chung C.D., Liao J., Liu B., Rao X., Jay P., Berta P., and Shuai K. Specific inhibition of Stat3 signal transduction by PIAS3. Science 278 (1997) 1803-1805
20. Clark J.A., and Peterson T.C. Cytokine production and aging: overproduction of IL-8 in elderly males in response to lipopolysaccharide. Mech. Ageing Dev. 77 (1994) 127-139
21. Dandona P., Aljada A., and Bandyopadhyay A. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol. 25 (2004) 4-7
22. Effros R.B., Cai Z., and Linton P.J. CD8 T cells and aging. Crit. Rev. Immunol. 23 (2003) 45-64
23. Effros R.B., and Pawelec G. Replicative senescence of T lymphocytes: does the Hayflick limit lead to immune exhaustion?. Immunol. Today 18 (1997) 450-454
24. Eicher D.M., Damjanovich S., and Waldmann T.A. Oligomerization of IL-2Ralpha. Cytokine 17 (2002) 82-90
25. Ershler W.B., and Keller E.T. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 51 (2000) 245-270
26. Ershler W.B., Sun W.H., Binkley N., Gravenstein S., Volk M.J., Kamoske G., Klopp R.G., Roecker E.B., Daynes R.A., and Weindruch R. Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res. 12 (1993) 225-230
27. Egwuagu C.E., Yu C.R., Zhang M., Mahdi R.M., Kim S.J., and Gery I. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J Immunol. 168 (2002) 3181-3187
28. Fagiolo U., Cossarizza A., Scala E., Fanales-Belasio E., Ortolani C., Cozzi E., Monti D., Franceschi C., and Paganelli R. Increased cytokine production in mononuclear cells of healthy elderly people. Eur. J. Immunol. 23 (1993) 2375-2378
29. Feng G.S. Shp-2 tyrosine phosphatase: signaling one cell or many. Exp. Cell Res. 253 (1999) 47-54
30. Ferrucci L., Harris T.B., Guralnik J.M., Tracy R.P., Corti M.C., Cohen H.J., Penninx B., Pahor M., Wallace R., and Havlik R.J. Serum IL-6 level and the development of disability in older persons. J. Am. Geriatr. Soc. 47 (1999) 639-646
31. Franceschi C., Bonafe M., Valensin S., Olivieri F., De Luca M., Ottaviani E., and De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. 908 (2000) 244-254
32. Franceschi C., Olivieri F., Marchegiani F., Cardelli M., Cavallone L., Capri M., Salvioli S., Valensin S., De Benedictis G., Di Iorio A., Caruso C., Paolisso G., and Monti D. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech. Ageing Dev. 126 (2005) 351-361
33. Frauwirth K.A., and Thompson C.B. Activation and inhibition of lymphocytes by costimulation. J. Clin. Invest. 109 (2002) 295-299
34. Fujimoto M., Naka T., Nakagawa R., Kawazoe Y., Morita Y., Tateishi A., Okumura K., Narazaki M., and Kishimoto T. Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice. J. Immunol. 165 (2000) 1799-1806
35. Fulop Jr. T., Douziech N., Goulet A.C., Desgeorges S., Linteau A., Lacombe G., and Dupuis G. Cyclodextrin modulation of T lymphocyte signal transduction with aging. Mech. Ageing Dev. 122 (2001) 1413-1430
36. Fülöp Jr. T., Douziech N., Larbi A., and Dupuis G. The role of lipid rafts in T lymphocyte signal transduction with aging. Ann. N. Y. Acad. Sci. 973 (2002) 302-304
37. Fulop T., Larbi A., Douziech N., Fortin C., Guerard K.P., Lesur O., Khalil A., and Dupuis G. Signal transduction and functional changes in neutrophils with aging. Aging Cell. 3 (2004) 217-226
38. Fulop T., Larbi A., Wikby A., Mocchegiani E., Hirokawa K., and Pawelec G. Dysregulation of T cell function in the elderly: scientific basis and clinical implications. Drugs Ageing 22 (2005) 589-603
39. Fulop Jr. T., Utsuyama M., and Hirokawa K. Determination of interleukin 2 receptor number of Con A stimulated human lymphocytes with aging. J. Clin. Lab. Immunol. 34 (1991) 31-36
40. Gillis S., Kozak R., Durante M., and Weksler M.E. Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans. J. Clin. Invest. 67 (1981) 937-942
41. Gisselbrecht S. The CIS/SOCS proteins: a family of cytokine-inducible regulators of signaling. Eur. Cytokine Netw. 10 (1999) 463-470
42. Giuliani N., Sansoni P., Girasole G., Vescovini R., Passeri G., Passeri M., and Pedrazzoni M. Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes. Exp. Gerontol. 36 (2001) 547-557
43. Glaser R., Maccallum R.C., Laskowski B.F., Malarkey W.B., Sheridan J.F., and Kiecott-Glaser J.K. Evidence for a shift in the Th1- and Th2-cytokine response associated with chronic stress and aging. J. Gerontol. 56 (2001) M477-M482
44. Gon Y., Hashimoto S., Hayashi S., Koura T., Matsumoto K., and Horie T. Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly. Clin. Exp. Immunol. 106 (1996) 120-126
45. Grubeck-Loebenstein B., and Wick G. The aging of the immune system. Ann. Rev. Immunol. 80 (2002) 248-290
46. 2+ signaling in T-lymphocytes. Crit. Rev. Immunol. 18 (1998) 419-448
47. Harris T.B., Ferruccim L., Tracy R.P., Corti M.C., Wacholder S., Ettinger Jr. W.H., Heimovitz H., Cohen H.J., and Wallace R. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am. J. Med. 106 (1999) 506-512
48. Harizi H., Grosset C., and Gualde N. Prostaglandin E2 modulates dendritic cell function via EP2 and EP4 receptors subtypes. J. Leukoc. Biol. 73 (2003) 756-763
49. Harizi H., Juzan M., Pitard V., Moreau J.-F., and Gualde N. Cyclooxygenase-2-issued prostaglandin E2 enhances the production of endogenous IL-10, which down-regulates dendritic cell function. J. Immunol. 168 (2002) 2255-2263
50. Hasegawa Y., Sawada M., Ozaki N., Inagaki T., and Suzumura A. Increased soluble tumor necrosis factor receptor levels in the serum of elderly people. Gerontology 46 (2000) 185-188
51. Haynes L., Linto P.J., Eaton S.M., Tonkonogy S.L., and Swain S.L. Interleukin-2, but not other common γ chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naïve T cells of aged mice. J. Exp. Med. 190 (1999) 1013-1024
52. Heim M.H. The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus. J. Recept. Signal Transduct. Res. 19 (1999) 75-120
53. Herbein G., and O'Brien W.A. Tumor necrosis factor (TNF) α and TNF receptors in viral pathogenesis. Proc. Soc. Exp. Biol. Med. 223 (2000) 241-257
54. Hilkens C.M.L., Snijders A., Snijdewint F.G.M., Wierenga E.A., and Kapsenberg M.L. Modulation of T-cell cytokine secretion by accessory cell-derived products. Eur. Resp. J. Suppl. 22 (1996) 90s-94s
55. Hirano T., Nakajima K., and Hibi M. Signaling mechanisms through gp130: a model of the cytokine system. Cytokine Growth Factor Rev. 8 (1997) 241-252
56. Ihle J.N., and Kerr I.M. Jaks and stats in signalling by the cytokine receptor superfamily. Trends Genet. 11 (1995) 69-74
57. Ilangumaran S., Ramanathan S., and Rottapel R. Regulation of the immune system by SOCS family adaptor proteins. Semin. Immunol. 16 (2004) 351-365
58. Jiang H., Harris M.B., and Rothman P. IL-4/IL-13 signaling beyond JAK/STAT. J. Allergy Clin. Immunol. 105 (2000) 1063-1070
59. Joseph C., Kenny A.M., Taxel P., Lorenzo J.A., Duque G., and Kuchel G.A. Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture risk. Mol. Aspects Med. 26 (2005) 181-201
60. Kane L.P., Lin J., and Weiss A. Signal transduction by the TCR for antigen. Curr. Opin. Immunol. 12 (2000) 242-249
61. Khare V., Sodhi A., and Singh S.M. Effect of aging on the tumoricidal functions of murine peritoneal macrophages. Nat. Immunol. 15 (1996) 285-294
62. Kovacs E.J., Grabowski K.A., Duffner L.A., Plackett T.P., and Gergory M.S. Survival and cell mediated immunity after burn injury in aged mice. J. Am. Aging Assoc. 25 (2002) 3-10
63. Krebs D.L., and Hilton D.J. SOCS: physiological suppressors of cytokine signaling. J. Cell Sci. 113 (2000) 2813-2819
64. Larbi A., Douziech N., Dupuis G., Khalil A., Pelletier H., Guerard K.P., and Fulop Jr. T. Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes. J. Leukoc. Biol. 75 (2004) 373-381
65. Larbi A., Dupuis G., Douziech N., Khalil A., and Fulop Jr. T. Low-grade inflammation with aging has consequences for T-lymphocyte signaling. Ann. N. Y. Acad. Sci. 1030 (2004) 125-133
66. Larbi A., Douziech N., Fortin C., Linteau A., Dupuis G., and Fulop Jr. T. The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging. Immun. Ageing. 2 (2005) 6-12
67. Leng S.X., Yangm H., and Walston J.D. Decreased cell proliferation and altered cytokine production in frail older adults. Aging Clin. Exp. Res. 16 (2004) 249-252
68. Lesourd B.M. Nutrition and immunity in the elderly: modification of immune responses with nutritional treatments. Am. J. Clin. Nutr. 66 (1997) 478S-484S
69. Levy D.E., and Lee C.K. What does STAT3 do?. J. Clin. Invest. 109 (2002) 1143-1148
70. Lin J.X., and Leonard W.J. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 19 (2000) 2566-2576
71. Linton P.J., and Dorshkind K. Age-related changes in lymphocyte development and function. Nat. Immunol. 5 (2004) 133-139
72. Liparoto S.F., Myszka D.G., Wu Z., Goldstein B., Laue T.M., and Ciardelli T.L. Analysis of the role of the interleukin-2 receptor gamma chain in ligand binding. Biochemistry 41 (2002) 2543-2551
73. Liu K.D., Gaffen S.L., Goldsmith M.A., and Greene W.C. Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation. Curr. Biol. 7 (1997) 817-826
74. Lloberas J., and Celada A. Effector of aging on macrophage function. Exp. Gerontol. 37 (2002) 1325-1331
75. Maher F.O., Nolan Y., and Lynch M.A. Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat. Neurobiol. Aging 26 (2005) 717-728
76. Mahlknecht U., Will J., Varin A., Hoelzer D., and Herbein G. HDAC3, a class I histone deacetylase, suppresses MAPK11-mediated ATF-2 activation and represses TNF gene expression. J. Immunol. 173 (2004) 3979-3990
77. Mariani E., Pulsatelli L., Neri S., Dolzani P., Meneghetti A., Silvestri T., Ravaglia G., Forti P., Cattini L., and Facchini A. RANTES and MIP-1 alpha production by T lymphocytes, monocytes and NK cells from nonagerian subjects. Exp. Gerontol. 37 (2002) 219-226
78. Mascarucci P., Taub D., Saccani S., Paloma M.A., Dawson H., Roth G.S., Ingram D.K., and Lane M.A. Age-related changes in cytokine production by leukocytes in rhesus monkeys. Aging (Milano) 13 (2001) 85-94
79. Matko J., Bodnar A., Vereb G., Bene L., Vamosi G., Szentesi G., Szollosi J., Gaspar R., Horejsi V., Waldmann T.A., and Damjanovich S. GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines. Eur. J. Biochem. 269 (2002) 1199-1208
80. Matsumoto A., Seki Y., Watanabe R., Hayashi K., Johnston J.A., Harada Y., Abe R., Yoshimura A., and Kubo M. A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production. J. Exp. Med. 197 (2003) 425-436
81. Mazari L., and Lesourd B.M. Nutrition influences on immune responses in healthy aged persons. Mech. Ageing Dev. 104 (1998) 25-40
82. Miller R.A., Garcia G., Kirk C.J., and Witkowski J.M. Early activation defects in lymphocytes from aged mice. Immunol. Rev. 150 (1997) 79-90
83. Minogue A.M., Schmid A.W., Fogarty M.P., Moore A.C., Campbell V.A., Herron C.E., and Lynch M.A. Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta?. J. Biol. Chem. 278 (2003) 27971-27980
84. Mocchegiani E., Bertoni-Freddari C., Marcellini F., and Malavolta M. Brain, aging and neurodegeneration: role of zinc ion availability. Prog. Neurobiol. 75 (2005) 367-390
85. Mocchegiani E., Giacconi R., Cipriano C., Muzzioli M., Gasparini N., Moresi R., Stecconi R., Suzuki H., Cavalieri E., and Mariani E. MtmRNA gene expression, via IL-6 and glucocorticoids, as potential genetic marker of immunosenescence: lessons from very old mice and humans. Exp. Gerontol. 37 (2002) 349-357
86. Mocchegiani E., Giacconi R., Cipriano C., Gasparini N., Orlando F., Stecconi R., Muzzioli M., Isani G., and Carpene E. Metallothioneins (I + II) and thyroid-thymus axis efficiency in old mice: role of corticosterone and zinc supply. Mech. Ageing Dev. 123 (2002) 675-694
87. Mocchegiani E., Giacconi R., Cipriano C., Gasparini N., Bernardini G., Malavolta M., Menegazzi M., Cavalieri E., Muzzioli M., Ciampa A.R., and Suzuki H. The variations during the circadian cycle of liver CD1d-unrestricted NK1.1 + TCR gamma/delta+ cells lead to successful ageing. Role of metallothionein/IL-6/gp130/PARP-1 interplay in very old mice. Exp. Gerontol. 39 (2004) 775-788
88. Mocchegiani E., Marcellini F., and Pawelec G. Nutritional zinc, oxidative stress and immunosenescence: biochemical, genetic, and lifestyle implications for healthy ageing. Biogerontology 5 (2004) 271-273
89. Mocchegiani E., Muzzioli M., and Giacconi R. Zinc and immunoresistance to infection in aging: new biological tools. Trends Pharmacol. Sci. 21 (2000) 205-208
90. Mouat M.F., Greenspan P., Byerley L.O., and Grider A. Zinc uptake into MCF-10A cells is inhibited by cholesterol depletion. J. Nutr. Biochem. 14 (2003) 74-80
91. Murphy K.M., Ouyang W., Farrar J.D., Yang J., Ranganath S., Asnagli H., Afkarian M., and Murphy T.L. Signaling and transcription in T helper development. Annu. Rev. Immunol. 18 (2000) 451-494
92. Mysliwska J., Bryl E., Foerster J., and Mysliwski A. Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status. Mech. Ageing Dev. 100 (1998) 313-328
93. Nathan C.F. Secretory products of macrophages. J. Clin. Invest. 79 (1987) 319-326
94. Nelms K., Keegan A.D., Zamorano J., Ryan J.J., and Paul W.E. The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol. 17 (1999) 701-738
95. Nguyen D.H., Espinoza J.C., and Taub D.D. Cellular cholesterol enrichment impairs T cell activation and chemotaxis. Mech. Ageing Dev. 125 (2004) 641-650
96. Nolan Y., Martin D., Campbell V.A., and Lynch M.A. Evidence of a protective effect of phosphatidylserine-containing liposomes on lipopolysaccharide-induced impairment of long-term potentiation in the rat hippocampus. J. Neuroimmunol. 151 (2004) 12-23
97. Novotny-Diermayr V., Zhang T., Gu L., and Cao X. Protein kinase C delta associates with the interleukin-6 receptor subunit glycoprotein (gp) 130 via Stat3 and enhances Stat3-gp130 interaction. J. Biol. Chem. 277 (2002) 49134-49142
98. O'Donnell E., Vereker E., and Lynch M.A. Age-related impairment in LTP is accompanied by enhanced activity of stress-activated protein kinases: analysis of underlying mechanisms. Eur. J. Neurosci. 12 (2000) 345-352
99. O'Mahony L., Holland J., Jackson J., Feighery C., Hennessy T.P., and Mealy K. Quantitative intracellular cytokine measurement: age-related changes in proinflammatory cytokine production. Clin. Exp. Immunol. 113 (1998) 213-219
100. Pawelec G., Hirokawa K., and Fulop T. Altered T cell signalling in ageing. Mech. Ageing Dev. 122 (2001) 1613-1637
101. Peralta S., Carrascosa J.M., Gallardo N., Ros M., and Arribas C. Ageing increases SOCS-3 expression in rat hypothalamus: effects of food restriction. Biochem. Biophys. Res. Commun. 296 (2002) 425-428
102. Plackett T.P., Schilling E.M., Faunce D.E., Choudhry M.A., Witte P.L., and Kovacs E.J. Aging enhances lymphocyte cytokine defects after injury. FASEB J. 17 (2003) 688-689
103. Rajendran L., and Simons K. Lipid rafts and membrane dynamics. J Cell Sci. 118 (2005) 1099-1102
104. Renshaw M., Rockwell J., Engleman C., Gewirtz A., Katz J., and Sambhara S. Cutting edge: impaired Toll-like receptor expression and function in aging. J. Immunol. 169 (2002) 4697-4701
105. Rieser C., Papesh C., Herold M., Bock G., Ramoner R., Klocker H., Bartsch G., and Thurnher M. Differential deactivation of human dendritic cells by endotoxin desensitization: role for tumor necrosis factor α and prostaglandin E2. Blood 91 (1998) 3112-3117
106. Rodel B., Tavassoli K., Karsunky H., Schmidt T., Bachmann M., Schaper F., Heinrich P., Shuai K., Elsasser H.P., and Moroy T. The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3. EMBO J. 19 (2000) 5845-5855
107. Rose-John S., and Neurath M.F. IL-6 trans-signaling: the heat is on. Immunity 20 (2004) 2-4
108. Sadeghi H.M., Schnelle J.F., Thoma J.K., Nishanian P., and Fahey J.L. Phenotypic and functional characteristics of circulating monocytes of elderly persons. Exp. Gerontol. 34 (1999) 959-970
109. Saito H., Morita Y., Fujimoto M., Narazaki M., Naka T., and Kishimoto T. IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma. J. Immunol. 164 (2000) 5833-5843
110. Saurwein-Teissl M., Blasko L., Zisterer K., Neuman B., Lang B., and Grubeck-Loebenstein B. An imbalance between pro- and anti-inflammatory cytokines, a characteristic feature of old age. Cytokine 12 (2000) 1160-1161
111. Sehgal P.B., Guo G.G., Shah M., Kumar V., and Patel K. Cytokine signaling: STATS in plasma membrane rafts. J. Biol. Chem. 277 (2002) 12067-12074
112. Seki Y., Hayashi K., Matsumoto A., Seki N., Tsukada J., Ransom J., Naka T., Kishimoto T., Yoshimura A., and Kubo M. Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 13003-13008
113. Schuringa J.J., Dekker L.V., Vellenga E., and Kruijer W. Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation. J. Biol. Chem. 276 (2001) 27709-27715
114. Shankar A.H., and Prasad A.S. Zinc and immune function: the biological basis of altered resistance to infection. Am. J. Clin. Nutr. 68 2 Suppl. (1998) 447S-463S
115. Shouda T., Yoshida T., Hanada T., Wakioka T., Oishi M., Miyoshi K., Komiya S., Kosai K., Hanakawa Y., Hashimoto K., Nagata K., and Yoshimura A. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J. Clin. Invest. 108 (2001) 1781-1788
116. Tamir I., Dal Porto J.M., and Cambier J.C. Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction. Curr. Opin. Immunol. 12 (2000) 307-315
117. Toniato E., Chen X.P., Losman J., Flati V., Donahue L., and Rothman P. TRIM8/GERP RING finger protein interacts with SOCS-1. J. Biol. Chem. 277 (2002) 37315-37322
118. Tortorella C., Pisconti A., Piazzolla G., and Antonaci S. APC-dependent impairment of T cell proliferation in aging: role of CD28- and IL-12/IL-15-mediated signaling. Mech. Ageing Dev. 123 (2002) 1389-1402
119. Uyemura K., Castle S.C., and Makinodan T. The frail elderly: role of dendritic cells in the susceptibility to infection. Mech. Ageing Dev. 123 (2002) 955-962
120. Vamosi G., Bodnar A., Vereb G., Jenei A., Goldman C.K., Langowski J., Toth K., Matyus L., Szollosi J., Waldmann T.A., and Damjanovich S. IL-2 and IL-15 receptor alpha-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 11082-11087
121. Vereb G., Matko J., Vamosi G., Ibrahim S.M., Magyar E., Varga S., Szollosi J., Jenei A., Gaspar Jr. R., Waldmann T.A., and Damjanovich S. Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 6013-6018
122. Walk S.F., March M.E., and Ravichandran K.S. Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc. Eur. J. Immunol. 28 (1998) 2265-2275
123. Weissenbach M., Clahsen T., Weber C., Spitzer D., Wirth D., Vestweber D., Heinrich P.C., and Schaper F. Interleukin-6 is a direct mediator of T cell migration. Eur. J. Immunol. 34 (2004) 2895-2906
124. Wick G., Jansen-Dürr P., Berger P., Blasko I., and Grubeck-Loebenstein B. Diseases of aging. Vaccine 18 (2000) 1567-1583
125. Wong H.L., Costa G.L., Lotze M.T., and Wahl S.M. Interleukin (IL) 4 differentially regulates monocyte IL-1 family gene expression and synthesis in vitro and in vivo. J. Exp. Med. 177 (1993) 775-781
126. Woods J.J., Grbic J.T., Rodrick M.L., Jordan A., and Mannick J.A. Suppression of interleukin-2 production in an animal model of thermal injury is related to prostaglandin synthesis. Arch. Surg. 122 (1987) 179-184
127. Wu D., Hayek M.G., and Meydani S. Vitamin E and macrophage cyclooxygenase regulation in the aged. J. Nutr. 131 (2001) 382S-388S
128. Yasukawa H., Sasaki A., and Yoshimura A. Negative regulation of cytokine signaling pathways. Annu. Rev. Immunol. 18 (2000) 143-164
129. Yoon P., Keylock K.T., Hartman M.E., Freund G.G., and Woods J.A. Macrophage hypo-responsiveness to interferon-gamma in aged mice is associated with impaired signaling through Jak-STAT. Mech. Ageing Dev. 125 (2004) 137-143
130. Zhang J.G., Farley A., Nicholson S.E., Willson T.A., Zugaro L.M., Simpson R.J., Moritz R.L., Cary D., Richardson R., Hausmann G., Kile B.J., Kent S.B., Alexander W.S., Metcalf D., Hilton D.J., Nicola N.A., and Baca M. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 2071-2076