Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc

European Journal of Immunology

Volumn 28, Issue 8, 1998, Pages 2265-2275

  Walk, Scott F ^a   March, Michael E ^a   Ravichandran, Kodimangalam S ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Grb2; Lck; Shc; Syk; ZAP 70

Indexed keywords

PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; BINDING SITE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BINDING SITES; COS CELLS; ENZYME PRECURSORS; GRB2 ADAPTOR PROTEIN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JURKAT CELLS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SON OF SEVENLESS PROTEINS; T-LYMPHOCYTES; TRANSFECTION; TYROSINE; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0031927280     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199808)28:08<2265::AID-IMMU2265>3.0.CO;2-P     Document Type: Article

References (43)

1. Bonfini, L., Migliaccio, E., Pelicci, G., Lafrancone, L. and Pelicci, P., Not all Shc's roads lead to Ras. [Review] Trends Biochem. Sci. 1996. 21: 257-261.
2. Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Nicoletti, I., Pawson, T. and Pelicci, P. G., A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 1992. 70: 93-104.
3. Pawson, T., Protein modules and signaling networks. Nature 1995. 373: 573-580.
4. Blaikie, P., Immanuel, D., Wu, J., Li, N., Yajnik, V. and Margolis, B., A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J. Biol. Chem. 1994. 269: 32031-32034.
5. Kavanaugh, W. and Williams, L., An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Science 1994. 266: 1862-1865.
6. Zhou, M., Harlan, J., Wade, W., Ravichandran, K., Burakoff, S. and Fesik, S., Binding affinities of tyrosinephosphorylated peptides to the COOH-terminal SH2 domain and N-terminal phosphotyrosine binding domains of Shc. J. Biol. Chem. 1995. 271: 31119-31123.
7. Trub, T., Choi, W. E., Wolf, G., Ottinger, E., Chen, Y., Weiss, M. and Shoelson, S. E., Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine. J. Biol. Chem. 1995. 270: 18205-18208.
8. van der Geer, P., Wiley, S., Lai, K., Olivier, J., Gish, G., Stephens, R., Kaplan, D., Shoelson, S. and Pawson, T., A conserved amino-terminal Shc domain binds to activated growth factor receptors and phosphotyrosine-containing peptides. Curr. Biol. 1995. 5: 404-412.
9. Kavanaugh, W., Turck, C. and Williams, L., PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine. Science 1995. 268: 1177-1179.
10. Ravichandran, K. S., Igras, V., Shoelson, S. E., Fesik, S. W. and Burakoff, S. J., Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin-2 signaling. Proc. Natl. Acad. Sci. USA 1996. 93: 5275-5280.
11. Ravichandran, K. S., Lee, K. K., Songyang, Z., Cantley, L. C., Burn, P. and Burakoff, S. J., Interaction of Shc with ζ chain of the T cell receptor upon T cell activation. Science 1993. 262: 902-905.
12. Ravichandran, K. S. and Burakoff, S. J., The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation. J. Biol. Chem. 1994. 269: 1599-1602.
13. Damen, J. E., Liu, L., Cutler, R. L. and Krystal, G., Erythropoeitin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein. Blood 1993. 82: 2296-2303.
14. Cutler, R. L., Liu, L., Damen, J. E. and Krystal, G., Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hematopoietic cells. J. Biol. Chem. 1993. 268: 21463-21465.
15. Inhorn, R. C., Carlesso, N., Durstin, M., Frank, D. A. and Griffin, J. D., Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750. Proc. Natl. Acad. Sci. USA 1995. 92: 8665-8669.
16. shc in T lymphocytes. J. Biol. Chem. 1993. 268: 17659-17661.
17. Lioubin, M. N., Myles, G. M., Carlberg, K., Bowtell, D. and Rohrschneider, L. R., Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells. Mol. Cell. Biol. 1994. 14: 5682-5691.
18. Saxton, T., van Oostveen, I., Bowtell, D., Aebersold, R. and Gold, M., B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, Grb2, mSOS1, and a 145-kDa tyrosinephosphorylated protein. J. Immunol. 1994. 153: 623-636.
19. Rozakis-Adcock, M., McGlade, J., Mbamalu, J., Pelicci, G., Daly, R., Li, W., Batzer, A., Thomas, S., Brugge, J., Pelicci, P. G. and Pawson, T., Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the ras pathway by tyrosine kinases. Nature 1992. 360: 689-692.
20. Margolis, B. and Skolnik, E., Activation of Ras by receptor tyrosine kinases. J. Am. Soc. Nephrol. 1994. 5: 1288-1299.
21. Ravichandran, K. S., Lorenz, U., Shoelson, S. and Burakoff, S. J., Interaction of Shc with Grb2 regulates association of Grb2 with mSOS. Mol. Cell. Biol. 1995. 15: 593-600.
22. Li,N., Batzer, A., Daly, R., Yajnik, V., Skolnik, E., Chardin, P., Bar-Sagi, D., Margolis, B. and Schlessinger, J., Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature 1993. 363: 85-88.
23. Baumann, G., Maier, D., Freuler, F., Tschopp, C., Baudisch, K. and Wienands, J., In vitro characterization of major ligands for Src homology 2 domains derived from protein tyrosine kinases, from the adaptor protein SHC and from GTPase-activating protein in Ramos B cells. Eur. J. Immunol. 1994. 24: 1799-1807.
24. Marengere, L. E. M., Waterhouse, P., Duncan, G. S., Mittrucker, H., Feng, G. and Mak, T. W., Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 1996. 272: 1170-1173.
25. Koretzky, G. A., The role of Grb2-associated proteins in T-cell activation [Review]. Immunol. Today 1997. 18: 401-406.
26. Ravichandran, K. S., Pratt, J. C., Sawasdikosol, S., Irie, H. Y. and Burakoff, S. J., Coreceptors and adapter proteins in T cell signaling. Ann. N. Y. Acad. Sci. 1995. 766: 117-133.
27. Lin, K. and Abraham, K. M., Targets of p56Lck activity in immature thymoblasts-stimulation of the Ras/Raf/ MAP kinase pathway. Int. Immunol. 1997. 9: 291-306.
28. Gotoh, N., Tojo, A. and Shibuya, M., A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3. EMBO J. 1996. 15: 6197-6204.
29. Weiss, A. and Littman, D. R., Signal transduction by lymphocyte antigen receptors. Cell 1994. 76: 263-274.
30. van Oers, N., Lowin-Kropf, B., Finlay, D., Connolly, K. and Weiss, A., Alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity 1996. 5: 429-436.
31. Gotoh, N., Toyoda, M. and Shibuya, M., Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen activated protein kinase activation. Mol. Cell. Biol. 1997. 17: 1824-1831.
32. van der Geer, P., Wiley, S., Gish, G. and Pawson, T., The Shc adaptor protein is highly phosphorylated at conserved twin tyrosine residues (Y239/240) that mediate protein-protein interactions. Curr. Biol. 1996. 6: 1435-1444.
33. McGlade, J., Cheng, A., Pelicci, G., Pelicci, P. G. and Pawson, T., Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases. Proc. Natl. Acad. Sci. USA 1992. 89: 8869-8873.
34. Ravichandran, K. S. and Burakoff, S. J., Evidence for differential intracellular signaling via CD4 and CD8 molecules. J. Exp. Med. 1994. 179: 727-732.
35. Lamkin, T. D., Walk, S. W., Liu, L., Damen, J. E., Krystal, G. and Ravichandran, K. S., Shc interaction with SHIP in vivo requires the Shc-PTB domain and two specific tyrosines on SHIP. J. Biol. Chem. 1997. 272: 10396-10401.
36. Kurosaki, T., Molecular mechanisms in B cell antigen receptor signaling. Curr. Opin. Immunol. 1997. 9: 309-318.
37. Chu, D., Spits, H., Peyron, J., Rowley, J., Bolen, J. and Weiss, A., The syk protein tyrosine kinase can function independently of CD45 or Ick in T cell antigen receptor signaling. EMBO J. 1996. 15: 6251-6261.
38. Ravichandran, K., Zhou, M., Pratt, J., Walk, S., Harlan, J., Fesik, S. and Burakoff, S., Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine binding domain in vivo. Mol. Cell. Biol. 1997. 17: 5540-5549.
39. Pratt, J. C., Weiss, M., Sieff, C., Shoelson, S., Burakoff, S. J. and Ravichandran, K. S., Evidence for a physical association between the Shc-PTB domain and the be chain of the granulocyte-macrophage colony stimulating factor receptor. J. Biol. Chem. 1996. 271: 12137-12140.
40. Iwashima, M., Irving, B. A., Vanoers, N. S. C., Chan, A. C. and Weiss, A., Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 1994. 263: 1136-1139.
41. Cooke, M. P., Abraham, K. M., Forbush, K. A., and Perlmutter, R. M., Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). Cell 1991. 65: 281-291.
42. Harmer, S. and DeFranco, A. L., Shc possesses two Grb2 binding sites needed for the efficient formation of complexes with SOS in B lymphocytes. Mol. Cell. Biol. 1997. 16: 4087-4095.
43. Hahn, W. C., Menzin E., Saito, T., Germain, R. N. and Bierer, B. E., The complete sequences of pFNeo and pMH-Neo: convenient expression vectors for high level expression of eukaryotic genes in hematopoietic cell lines. Gene 1993. 127: 267-268.