Age-related changes in cytokine production by leukocytes in rhesus monkeys

Aging Clinical and Experimental Research

Volumn 13, Issue 2, 2001, Pages 85-94

  Mascarucci, P ^a   Taub, D ^a   Saccani, S ^a   Paloma, M A ^a   Dawson, H ^a   Roth, G S ^a   Ingram, D K ^a   Lane, M A ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

IFN ; IL 1; IL 10; IL 6; PBMCs; Rhesus monkey; TNF

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGENIC AGENT; PHYTOHEMAGGLUTININ; TUMOR NECROSIS FACTOR ALPHA;

AGE; AGED; ANIMAL CELL; ARTICLE; CELL FRACTIONATION; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IN VITRO STUDY; LEUKOCYTE; MACACA; MALE; MONONUCLEAR CELL; NONHUMAN; POLYCLONAL ACTIVATION; POPULATION; PRIMATE; PROTEIN EXPRESSION; RHESUS MONKEY; RODENT; TH1 CELL; TH2 CELL;

AGING; ANIMALS; CYTOKINES; GENE EXPRESSION; INTERFERON TYPE II; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACACA MULATTA; MALE; MITOGENS; RNA, MESSENGER; TH1 CELLS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; MACACA; MACACA MULATTA; PRIMATES; RODENTIA;

EID: 0034991099     PISSN: 03949532     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03351530     Document Type: Article

References (37)

1. In vivo T cell activation, in vitro defective IL-2 secretion, and response to influenza vaccination in elderly women
2. The immune system in the elderly: III. Innate immunity
3. The immune system in the elderly: II. Specific cellular immunity
4. The immune system in the elderly: I. Specific humoral immunity
5. Molecular and cellular basis of immunosenescence
6. Aging and lymphocyte subpopulations: Whole-blood analysis of immune markers in a large population sample of healthy elderly individuals
7. Nutritional influences on immune response in healthy aged persons
8. Dysregulation between TH1 and TH2 T cell subpopulations in the elderly
9. The immunology of ageing
10. Diet modulates Th-1 and Th-2 cytokine production in the peripheral blood of lupus-prone mice
11. Interleukin-6 and aging: Blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction
12. Interleukin-6: A cytokine for gerontologists
13. Monocyte cytokine production in an elderly population: Effect of age and inflammation
14. Age-related impaired proliferation of peripheral blood mononuclear cells is associated with an increase in both IL-10 and IL-12
15. Effect of age on cytokine production in humans
16. The role of nutrition in immunity in the aged
17. Dietary restriction and aging: The initiation of a primate study
18. Direct stimulation of cytokines (IL-1 beta, TNF-alpha, IL-6, IL-2, IFN-gamma and GM-CSF) in whole blood. I. Comparison with isolated PBMC stimulation
19. Dietary restriction in nonhuman primates: Progress report on the NIA study
20. Immunoreactive cytokines within primates
21. A simple and rapid method to analyze specific mRNAs from few cells in a semi-quantitative way using the polymerase chain reaction
22. Comparative sequence analysis of cytokine genes from human and nonhuman primates
23. Immunosenescence: Impact in the young as well as the old?
24. Tumor-induced immune dysfunction
25. Altered cytokine production in the elderly
26. The Th1/Th2 paradigm
27. Th1/Th2 changes in aging
28. Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors
29. Autoantibody production in healthy elderly people is not promoted by interleukin-10 although this cytokine is expressed in them by a peculiar CD8+CD3+ large granular cell subpopulation
30. Production of human alpha- and gamma-interferon is dependent on age and sex and is decreased in rheumatoid arthritis: A simple method for a large-scale assay
31. Age-related alteration of cytokine production profile by T cell subsets in mice: A flow cytometric study
32. Expression of interleukin 2 and the interleukin 2 receptor in aging rats
33. Reduced interferon-gamma (IFN-gamma) secretion with increased IFN-gamma mRNA expression in atopic dermatitis: Evidence for a post-transcriptional defect
34. IL-6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses
35. Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells
36. Aging and food restriction alter some indices of bone metabolism in male rhesus monkeys (Macaca mulatta)