The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3

EMBO Journal

Volumn 19, Issue 21, 2000, Pages 5845-5855

  Rödel, Bernd ^a   Tavassoli, Kamiab ^a   Karsunky, Holger ^a   Schmidt, Thorsten ^b   Bachmann, Malte ^a   Schaper, Fred ^c   Heinrich, Peter ^c   Shuai, Ke ^d   Elsässer, Hans Peter ^e   Möröy, Tarik ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b BAYER AG   (Germany)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Cytokine signaling; Gfi 1; Nuclear dots; STAT3; T cell proliferation

Indexed keywords

BETA GALACTOSIDASE; CYTOKINE RECEPTOR; INTERLEUKIN 6; PROTEIN INHIBITOR; STAT3 PROTEIN; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL NUCLEUS; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LYMPHOCYTE PROLIFERATION; MALIGNANT TRANSFORMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTO ONCOGENE; REPORTER GENE; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSACTIVATION; TRANSGENIC MOUSE; YEAST;

EID: 0034329453     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.21.5845     Document Type: Article

References (42)

1. Defective IL-2-mediated IL-2 receptor α chain expression in Stat3-deficient T lymphocytes
2. Stat3 as an oncogene
3. Constitutive activation of STAT3 signaling confers resistance to apoptosis in human U266 myeloma cells
4. Specific inhibition of Stat3 signal transduction by PIAS3
5. STATs and gene regulation
6. A new protein containing an SH2 domain that inhibits JAK kinases
7. Interleukin 2 signaling involves the phosphorylation of Stat proteins
8. Structure and erythroid cell-restricted expression of a chicken cDNA encoding a novel zinc finger protein of the Cys + His class
9. Signaling through the interleukin 2 receptor β chain activates an STAT-5-like DNA-binding activity
10. Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
11. Cutting edge: TCR stimulation by antibody and bacterial superantigen induces Stat3 activation in human T cells
12. Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein
13. Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes
14. Requirement of STAT3 but not STAT1 activation for epidermal growth factor receptor mediated cell growth in vitro
15. 1 arrest induced by interleukin-2 withdrawal
16. Mutual requirement of CDK4 and Myc in malignant transformation: Evidence for cyclin D1/CDK4 and p16INK4A as upstream regulators of Myc
17. Interleukin-6-type cytokine signalling throug the gp130/Jak/STAT pathway
18. Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors
19. Identification of a new family of tissue specific helix-loop-helix proteins with a two hybrid system
20. STATs: Signal transducers and activators of transcription
21. 1-antichymotrypsin expression in human cortical astrocytes
22. Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor
23. Inhibition of Stat 1-mediated gene activation by PIAS 1
24. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
25. Expression of a pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in 1pr/1pr mice
26. Structure and function of a new STAT-induced STAT inhibitor
27. STAT3 is a serine kinase target in T lymphocytes. Interleukin 2 and T cell antigen receptor signals converge upon serine 727
28. Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of STAT3 in human T-lymphocytes
29. The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases
30. Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice
31. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
32. MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene
33. Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis
34. The STAT family of proteins in cytokine signaling
35. A family of cytokine-inducible inhibitors of signaling
36. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice
37. The Gfi-1B protooncoprotein represses p21(waf1) and inhibits myeloid cell differentiation
38. Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice
39. 2+ fluxes
40. Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2
41. Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor