Early activation defects in T lymphocytes from aged mice

Immunological Reviews

Volumn 160, Issue , 1997, Pages 79-90

  Miller, Richard A ^a,d   Garcia, Gonzalo ^a   Kirk, Christopher J ^b   Witkowski, Jacek M ^c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c MEDICAL UNIVERSITY OF GDANSK   (Poland)

^d UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CALCIUM ION; CD3 ANTIGEN; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOPROTEIN; PROTEIN KINASE; RAF PROTEIN;

AGING; ENZYME ACTIVATION; ENZYME ACTIVITY; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; AGING; ANIMALS; ANTIGENS, CD3; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; LYMPHOCYTE ACTIVATION; MAP KINASE KINASE KINASE 1; MICE; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0031449597     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1997.tb01029.x     Document Type: Review

References (34)

1. Wange RL, Samelson LE. Complex complexes: signaling at the TCR. Immunity 1996;5:197-205.
2. Chan AC, Desai DM, Weiss A. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu Rev Immunol 1994;12:555-592.
3. Philosophe B, Miller RA. Diminished calcium signal generation in subsets of T lymphocytes that predominate in old mice. J Gerontol A Biol Sci Med Sci 1990;45: B87-B93.
4. Rajasekar R, Augustin A. Antigen-dependent selection of T cells that are able to efficiently regulate free cytoplasmic calcium levels. J Immunol 1994;153:1037-1045.
5. Grossmann A, Ledbetter JA, Rabinovitch PS. Aging-related deficiency in intracellular calcium response to anti-CD3 or concanavalin A in murine T-cell subsets. J Gerontol A Biol Sci Med Sci 1990;45: B81-B86.
6. Miller RA. Calcium signals in T lymphocytes from old mice. Life Sci 1996;59:469-475.
7. Miller RA, Jacobson B, Weil G, Simons ER. Diminished calcium influx in lectin-stimulated T cells from old mice. J Cell Physiol 1987;132:337-342.
8. Miller RA, Philosophe B, Ginis I, Weil G, Jacobson B. Defective control of cytoplasmic calcium concentration in T lymphocytes from old mice. J Cell Physiol 1989;138:175-182.
9. Negoro S, Hara H. The effect of taurine on the age-related decline of the immune response in mice: the restorative effect on the T cell proliferative response to costimulation with ionomycin and phorbol myristate acetate. Adv Exp Med Biol 1992;315:229-239.
10. Lerner A, Philosophe B, Miller RA. Defective calcium influx and preserved inositol phosphate generation in T cells from old mice. Aging Immunol Infect Dis 1988;1:149-157.
11. 2+ and not recruitment from internal stores is essential for T lymphocyte proliferation. Eur J Immunol 1988;18:917-922.
12. Philosophe B, Miller RA. T lymphocyte heterogeneity in old and young mice: functional defects in T cells selected for poor calcium signal generation. Eur J Immunol 1989;19:695-699.
13. Miller RA, Flurkey K, Molloy M, Luby T, Stadecker MJ. Differential sensitivity of virgin and memory T lymphocytes to calcium ionophores suggests a bouyant density separation method and a model for memory cell hyporesponsiveness to Con A. J Immunol 1991;147:3080-3086.
14. Witkowski JM, Miller RA. Increased function of P-glycoprotein in T lymphocytes of aging mice. J Immunol 1993;150:1296-1306.
15. Bining N, Miller RA. Cytokine production by subsets of CD4 memory T cells differing in P-glycoprotein expression: effects of aging. J Gerontol A Biol Sci Med Sci 1997;52A: B137-B145.
16. Linton PJ, Haynes L, Klinman NR, Swain SL. Antigen-independent changes in naive CD4 T cells with aging. J Exp Med 1996;184:1891-1900.
17. Patel HR, Miller RA. Analysis of protein phosphorylation patterns reveals unanticipated complexity in T lymphocyte activation pathways. J Immunol 1991;146:3332-3339.
18. Patel HR, Miller RA. Age-associated changes in mitogen-induced protein phosphorylation in murine T lymphocytes. Eur J Immunol 1992;22:253-260.
19. Fulop T Jr., Leblanc C, Lacombe G, Dupuis G. Cellular distribution of protein kinase C isozymes in CD3-mediated stimulation of human T lymphocytes with aging. FEBS Lett 1995;375:69-74.
20. Monks CR, Kupfer H, Tamir I, Barlow A, Kupfer A. Selective modulation of protein kinase C-theta during T-cell activation. Nature 1997;385:83-86.
21. Shi J, Miller RA. Tyrosine-specific protein phosphorylation in response to anti-CD3 antibody is diminished in old mice. J Gerontol A Biol Sci Med Sci 1992;47: B147-B153.
22. Shi J, Miller RA. Differential tyrosine-specific protein phosphorylation in mouse T lymphocyte subsets. Effect of age. J Immunol 1993;151:730-739.
23. Chan AC, Irving BA, Fraser JD, Weiss A. The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc Natl Acad Sci USA 1991;88:9166-9170.
24. van Oers NS, Killeen N, Weiss A. ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells. Immunity 1994;1:675-685.
25. Garcia GG, Miller RA. Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: effect of age. Cell Immunol 1997;175:51-57.
26. Sancho J, et al. Coupling of GTP-binding to the T cell receptor (TCR) zeta-chain with TCR-mediated signal transduction. J Immunol 1993;150:3230-3242.
27. van Oers NS, Killeen N, Weiss A. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. J Exp Med 1996;183:1053-1062.
28. Miller RA. Aging and the immune response. In: Schneider EL, Rowe JW, eds. Handbook of the biology of aging. San Diego, CA: Academic Press; 1996. p.355-392.
29. Gorgas G, Butch ER, Guan KL, Miller RA. Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice. Mech Ageing Dev 1997;91:74-83.
30. mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complex. Cell Immunol 1996;168:201-210.
31. Ghosh J, Miller RA. Rapid tyrosine phosphorylation of Grb2 and Shc in T cells exposed to anti-CD3, anti-CD4, and anti-CD45 stimuli: differential effects of aging. Mech Ageing Dev 1995;80:171-187.
32. Osman N, Lucas SC, Turner H, Cantrell D. A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor zeta chain tyrosine-based activation motif. J Biol Chem 1995;270:13981-13986.
33. Ravichandran KS, Lorenz U, Shoelson SE, Burakoff SJ. Interaction of Shc with Grb2 regulates association of Grb2 with mSOS. Mol Cell Biol 1995;15:593-600.
34. Dianzani U, et al. Molecular associations on the T cell surface correlate with immunological memory. Eur J Immunol 1990;20:2249-2257.