Evidence for a shift in the Th-1 to Th-2 cytokine response associated with chronic stress and aging

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 56, Issue 8, 2001, Pages M477-M482

  Glaser, Ronald ^a,b,c   MacCallum, Robert C ^b,c   Laskowski, Bryon F ^a   Malarkey, William B ^a,b,c   Sheridan, John F ^a,b,c   Kiecolt Glaser, Janice K ^b,c  

^a Department of Molecular Virology ^*  (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2;

ADULT; AGED; AGING; ARTICLE; CAREGIVER; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMENTIA; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MENTAL STRESS; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

AGED; AGED, 80 AND OVER; AGING; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CAREGIVERS; CASE-CONTROL STUDIES; CD4-CD8 RATIO; CHRONIC DISEASE; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNE SYSTEM; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; LONGITUDINAL STUDIES; MALE; PROTO-ONCOGENE PROTEINS; REFERENCE VALUES; REGRESSION ANALYSIS; SENSITIVITY AND SPECIFICITY; STRESS, PSYCHOLOGICAL;

EID: 0034888332     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/56.8.M477     Document Type: Article

References (27)

1. Spousal caregivers of dementia victims: Longitudinal changes in immunity and health
2. Electroencephalographic sleep and natural killer activity in depressed patients and control subjects
3. Psychosocial modulation of cytokine-induced natural killer cell activity in older adults
4. Slowing of wound healing by psychological stress
5. Chronic stress alters the immune response to influenza virus vaccine in older adults
6. Efficacy of an influenza hemagglutinin-diphtheria toxoid conjugate vaccine in elderly nursing home subjects during an influenza outbreak
7. Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination
8. Stress-induced immunomodulation: Implications for infection diseases?
9. The influence of psychological stress on the immune response to vaccines
10. Chronic stress associated with spousal caregiving of patients with Alzheimer's dementia is associated with down-regulation of B-lymphocyte GH mRNA
11. The expanding universe of T-cell subsets: Th1, Th2 and more
12. Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: Clinical implications
13. Neuroendocrine regulation of cytokine production during experimental influenza viral infection: Effects of restraint stress-induced elevation in endogenous corticosterone
14. Methodological issues in behavioral immunology research with humans
15. Physical activity assessment for epidemiologic research: The utility of two simplified approaches
16. The MOS 36-item-short-form health survey (SF-36): I. Conceptual framework and item selection
17. Effect of aging on serum albumin
18. Cytokine dysregulation associated with exam stress in healthy medical students
19. + T cell subsets
20. Detection of altered T Helper 1 and T Helper 2 cytokine production by peripheral blood mononuclear cells in patients with multiple sclerosis utilizing intracellular cytokine detection by flow cytometry and surface marker analysis
21. Shaking up immunity: Psychological and immunological changes after a natural disaster
22. Caregiver depression after bereavement: Chronic stress isn't over when it's over
23. Stress depresses interferon production by leukocytes concomitant with a decrease in natural killer cell activity
24. Stress hormones, Th1/Th2-patterns, pro/anti-inflammatory cytokines and susceptibility to disease
25. Glucocorticoid induced type-1/type-2 cytokine alterations in humans: A model for stress-related immune dysfunction