Replicative senescence of T cells: Does the Hayflick Limit lead to immune exhaustion?

Immunology Today

Volumn 18, Issue 9, 1997, Pages 450-454

  Effros, Rita B ^a   Pawelec, Graham ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN EXPRESSION; CELL DIVISION; CLONE; FIBROBLAST; GENE EXPRESSION REGULATION; GROWTH REGULATION; HUMAN; LIFESPAN; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; REVIEW; SENESCENCE; T LYMPHOCYTE;

EID: 0030823184     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(97)01079-7     Document Type: Review

References (47)

1. Hayflick, L. and Moorhead, P.S. (1961) Exp. Cell Res. 25, 585-621
2. Adibzadeh, M., Mariani, E., Bartoloni, C. et al. (1996) Mech. Ageing Dev. 91, 145-154
3. Smith, J.R. and Pereira-Smith, O.M. (1996) Science 273, 63-67
4. Morgan, D.A., Ruscetti, F.W. and Gallo, R.C. (1976) Science 193, 1007-1008
5. Johnson, J.P., Cianfriglia, M., Glasebrook, A.L. and Nabholz, M. (1982) in Isolation, Characterisation, and Utilisation of T Lymphocyte Clones (Fathman, C.G. and Fitch, F.W., eds), pp. 183-191, Academic Press
6. Kaltoft, K., Pedersen, C.B., Hansen, B.H. and Thestrup-Petersen, K. (1995) Cancer Genet. Cytogenet. 81, 13-16
7. Perillo, N.L., Walford, R.L., Newman, M.A. and Effros, R.B. (1989) Exp. Gerontol. 24, 177-187
8. Adibzadeh, M., Pohla, H., Rehbein, A. and Pawelec, G. (1995) Mech. Ageing Dev. 83, 171-183
9. Pawelec, G., Sansom, D., Rehbein, A., Adibzadeh, M. and Beckman, I. (1996) Exp. Gerontol. 31, 655-668
10. Grubeck-Loebenstein, B., Lechner, H. and Trieb, K. (1994) Int. Arch. Allergy Immunol. 104, 232-239
11. McCarron, M., Osborne, Y., Story, C., Dempsey, J.L., Turner, R. and Moreley, A. (1987) Mech. Ageing Dev. 41, 211-218
12. Weng, N.P., Levine, B.L., June, C.H. and Hodes, R.J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11091-11094
13. Perillo, N.L., Naeim, F., Walford, R.L. and Effros, R.B. (1993) Mech. Ageing Dev. 67, 173-185
14. Pawelec, G., Schneider, E.M. and Wernet, P. (1986) J. Immunol. 136, 402-411
15. Pawelec, G., Fernandez, N., Brocker, T., Schneider, E.M., Festenstein, H. and Wernet, P. (1988) J. Exp. Med. 167, 243-261
16. Pawelec, G., Brocker, T., Busch, F.W. et al. (1988) J. Mol. Cell. Immunol. 4, 21-34
17. Beverly, B., Kang, S.M., Lenardo, M.J. and Schwartz, R.H. (1992) Int. Immunol. 4, 661-671
18. Effros, R.B., Zhu, X. and Walford, R.L. (1994) J. Gerontol. 49, B65-B70
19. Effros, R.B., Boucher, N., Porter, V. et al. (1994) Exp. Gerontol. 29, 601-609
20. Olovnikov, A.M. (1971) Doklady Biochem. 201, 394-397
21. Fairweather, S., Fox, M. and Margison, G.P. (1987) Exp. Cell Res. 168, 153-159
22. Allsopp, R.C. (1996) Exp. Gerontol. 31, 235-243
23. Watson, J.D. (1972) Nat. New Biol. 239, 197-201
24. Vaziri, H., Schachter, F., Uchida, I. et al. (1993) Am. J. Hum. Genet. 52, 661-667
25. Allsopp, R.C., Chang, E., Kashefia-Azam, M. et al. (1995) Exp. Cell Res. 220, 194-200
26. Shay, J.W. and Wright, W.E. (1996) Curr. Opin. Oncol. 8, 66-71
27. Weng, N.P., Levine, B.L., June, C.H. and Hodes, R.J. (1996) J. Exp. Med. 183, 2471-2479
28. Bodnar, A.G., Kim, N.W., Effros, R.B. and Chiu, C-P. (1996) Exp. Cell Res. 228, 58-64
29. Bryan, T.M., Englezou, A., Gupta, J., Bacchetti, S. and Reddel, R.R. (1995) EMBO J. 14, 4240-4248
30. Shay, J.W., Wright, W.E. and Werbin, H. (1993) Int. J. Oncol. 3, 559-563
31. Chang, E. and Harley, C.B. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11190-11194
32. Dimri, G.P., Lee, X.H., Basile, G. et al. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 9363-9367
33. Effros, R.B., Allsopp, R., Chiu, C.P. et al. (1996) AIDS 10, F17-F22
34. Dutra, W.O., Martins, O.A., Cancado, J.R. et al (1996) Scand. J. Immunol. 43, 88-93
35. Rossi, E., Matutes, E., Morilla, R., Owusu-Ankomah, K., Heffernan, A.M. and Catovsky, D. (1996) Leukemia 10, 494-497
36. Schmidt, D., Goronzy, J.J. and Weyand, C.M. (1996) J. Clin. Invest. 97, 2027-2037
37. Roman, L.I., Manzano, L., De la Hera, A. et al. (1996) Gastroenterology 110, 1008-1019
38. Doherty, P.C., Hou, S. and Tripp, R.A. (1994) Curr. Opin. Immunol. 6, 545-552
39. Carmichael, A., Jin, X., Sissons, P. and Borysiewicz, L. (1993) J. Exp. Med. 177, 249-256
40. Morley, J.K., Batiwala, F.M., Hingorani, R. and Gregersen, P.K. (1995) J. Immunol. 154, 6182-6190
41. Grunewald, J. and Wigzell, H. (1996) Immunologist 4, 99-103
42. Bruno, L., Kirberg, J. and Von Boehmer, H. (1995) Immunity 2, 37-43
43. McLean, A.R. and Michie, C.A. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 3707-3711
44. Chen, Q., Fischer, A., Reagan, J.D., Yan, L.J. and Ames, B. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 4337-4341
45. Keogh, B.P., Tresini, M., Crisofalo, V.J. and Allen, R.G. (1996) Mech. Ageing Dev. 86, 151-160
46. Hara, E., Tsuri, H., Shinozaki, S. and Oda, K. (1991) Biochem. Biophys. Res. Commun. 179, 528-534
47. Wright, W.E., Brasiskyte, D., Piatyszek, M.A. and Shay, J.W. (1996) EMBO J. 15, 1734-1741