Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture risk

Molecular Aspects of Medicine

Volumn 26, Issue 3, 2005, Pages 181-201

  Joseph, Cherian ^a   Kenny, Anne M ^a   Taxel, Pamela ^a   Lorenzo, Joseph A ^a   Duque, Gustavo ^b   Kuchel, George A ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Androgen; Bone; Cytokines; Estrogen; Hormones; Inflammation; Mobility; Muscle

Indexed keywords

CYTOKINE; SEX HORMONE; SOMATOMEDIN BINDING PROTEIN;

AGE DISTRIBUTION; BONE DENSITY; COFFEE; DISEASE ASSOCIATION; ENDOCRINE DISEASE; FRACTURE; HUMAN; HYPERTHYROIDISM; IMMUNOPATHOLOGY; MUSCLE ATROPHY; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOPOROSIS; PROPHYLAXIS; REVIEW; RISK ASSESSMENT; RISK FACTOR; VISUAL DISORDER;

EID: 16244413269     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mam.2005.01.004     Document Type: Review

References (127)

1. S. Acharyya, K.J. Ladner, L.L. Nelsen, J. Damrauer, P.J. Reiser, S. Swoap, and D.C. Guttridge Cancer cachexia is regulated by selective targeting of skeletal muscle gene products J. Clin. Invest. 114 3 2004 370 378
2. B.B. Aggarwal Signalling pathways of the TNF superfamily: a double-edged sword Nat. Rev. Immunol. 3 9 2003 745 756
3. J. An, R.C. Ribeiro, P. Webb, J.A. Gustafsson, P.J. Kushner, J.D. Baxter, and D.C. Leitman Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators Proc. Natl. Acad Sci. USA 96 26 1999 15161 15166
4. G.S. Ashcroft, S.J. Mills, K. Lei, L. Gibbons, M.J. Jeong, M. Taniguchi, M. Burow, M.A. Horan, S.M. Wahl, and T. Nakayama Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor J. Clin. Invest. 111 9 2003 1309 1318
5. P.B. Baltes, and J. Smith New frontiers in the future of aging: from successful aging of the young old to the dilemmas of the fourth age Gerontology 49 2 2003 123 135
6. J. Bargonetti, and J.J. Manfredi Multiple roles of the tumor suppressor p53 Curr. Opin. Oncol. 14 1 2002 86 91
7. R. Basu, A. Basu, and K.S. Nair Muscle changes in aging J. Nutr. Health Aging 6 5 2002 336 341
8. R.N. Baumgartner, P.M. Stauber, K.M. Koehler, L. Romero, and P.J. Garry Associations of fat and muscle masses with bone mineral in elderly men and women Am. J. Clin. Nutr. 63 3 1996 365 372
9. T. Bellido, R.L. Jilka, B.F. Boyce, G. Girasole, H. Broxmeyer, S.A. Dalrymple, R. Murray, and S.C. Manolagas Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor J. Clin. Invest. 95 6 1995 2886 2895
10. K. Bhagat, and P. Vallance Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo Circulation 96 9 1997 3042 3047
11. S. Bord, A. Horner, S. Beavan, and J. Compston Estrogen receptors alpha and beta are differentially expressed in developing human bone J. Clin. Endocrinol. Metab. 86 5 2001 2309 2314
12. S.E. Borst The role of TNF-alpha in insulin resistance Endocrine 23 2-3 2004 177 182
13. S. Bovenkerk, N. Lanciloti, and N. Chandar Induction of p53 expression and function by estrogen in osteoblasts Calcif. Tissue Int. 73 3 2003 274 280
14. B.F. Boyce, L. Xing, G. Franzoso, and U. Siebenlist Required and nonessential functions of nuclear factor-kappa B in bone cells Bone 25 1 1999 137 139
15. M. Cacquevel, N. Lebeurrier, S. Cheenne, and D. Vivien Cytokines in neuroinflammation and Alzheimer's disease Curr. Drug Targets 5 6 2004 529 534
16. A.J. Campbell, W.J. Busby, M.C. Robertson, C.L. Lum, J.A. Langlois, and F.C. Morgan Disease, impairment, disability and social handicap: a community based study of people aged 70 years and over Disabil. Rehab. 16 2 1994 72 79
17. A.R. Cappola, K. Bandeen-Roche, G.S. Wand, S. Volpato, and L.P. Fried Association of IGF-I levels with muscle strength and mobility in older women J. Clin. Endocrinol. Metab. 86 9 2001 4139 4146
18. A.R. Cappola, Q.L. Xue, L. Ferrucci, J.M. Guralnik, S. Volpato, and L.P. Fried Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women J. Clin. Endocrinol. Metab. 88 5 2003 2019 2025
19. J.A. Cauley, J. Robbins, Z. Chen, S.R. Cummings, R.D. Jackson, A.Z. LaCroix, M. LeBoff, C.E. Lewis, J. McGowan, J. Neuner, M. Pettinger, M.L. Stefanick, J. Wactawski-Wende, and N.B. Watts Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial JAMA 290 13 2003 1729 1738
20. C.A. Cefalu Is bone mineral density predictive of fracture risk reduction Curr. Med. Res. Opin. 20 3 2004 341 349
21. M. Centrella, M.C. Horowitz, J.M. Wozney, and T.L. McCarthy Transforming growth factor-beta gene family members and bone Endocr. Rev. 15 1 1994 27 39
22. N. Chandar, D. Logan, A. Szajkovics, and W. Harmston Gene expression changes accompanying p53 activity during estrogen treatment of osteoblasts Life Sci. 75 17 2004 2045 2055
23. M.C. Cohen, and S. Cohen Cytokine function: a study in biologic diversity Am. J. Clin. Pathol. 105 5 1996 589 598
24. H.J. Cohen, T. Harris, and C.F. Pieper Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly Am. J. Med. 114 3 2003 180 187
25. D.S. Colvard, E.F. Eriksen, P.E. Keeting, E.M. Wilson, D.B. Lubahn, F.S. French, B.L. Riggs, and T.C. Spelsberg Identification of androgen receptors in normal human osteoblast-like cells Proc. Natl. Acad. Sci. USA 86 3 1989 854 857
26. C. Cooper, E.J. Atkinson, S.J. Jacobsen, W.M. O'Fallon, and L.J. Melton III Population-based study of survival after osteoporotic fractures Am. J. Epidemiol. 137 9 1993 1001 1005
27. S.R. Cummings, and L.J. Melton Epidemiology and outcomes of osteoporotic fractures Lancet 359 9319 2002 1761 1767
28. S.R. Cummings, M.C. Nevitt, W.S. Browner, K. Stone, K.M. Fox, K.E. Ensrud, J. Cauley, D. Black, and T.M. Vogt Risk factors for hip fracture in white women N. Engl. J. Med. 332 1995 767 773
29. P. Dargent-Molina, A.M. Schott, D. Hans, F. Favier, H. Grandjean, C. Baudoin, P.J. Meunier, and G. Breart Separate and combined value of bone mass and gait speed measurements in screening for hip fracture risk: results from the EPIDOS study. Epidemiologie de l'Osteoporose Osteoporos. Int. 9 2 1999 188 192
30. F. De Benedetti, T. Alonzi, A. Moretta, D. Lazzaro, P. Costa, V. Poli, A. Martini, G. Ciliberto, and E. Fattori Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation J. Clin. Invest. 99 4 1997 643 650
31. F.E. Dewhirst, J.M. Ago, W.J. Peros, and P. Stashenko Synergism between parathyroid hormone and interleukin 1 in stimulating bone resorption in organ culture J. Bone Miner. Res. 2 2 1987 127 134
32. A.S. Dobs, T. Nguyen, C. Pace, and C.P. Roberts Differential effects of oral estrogen versus oral estrogen-androgen replacement therapy on body composition in postmenopausal women J. Clin. Endocrinol. Metab. 87 4 2002 1509 1516
33. V. Elliot-Gibson, E.R. Bogoch, S.A. Jamal, and D.E. Beaton Practice patterns in the diagnosis and treatment of osteoporosis after a fragility fracture: a systematic review Osteoporos. Int. 15 10 2004 767 778
34. K.E. Ensrud, J. Cauley, R. Lipschutz, and S.R. Cummings Weight change and fractures in older women. Study of Osteoporotic Fractures Research Group Arch. Intern. Med. 157 8 1997 857 863
35. K.E. Ensrud, S.K. Ewing, K.L. Stone, J.A. Cauley, P.J. Bowman, and S.R. Cummings Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women J. Am. Geriatr. Soc. 51 12 2003 1740 1747
36. W.B. Ershler, and E.T. Keller Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty Annu. Rev. Med. 51 2000 245 270
37. W.H. Ettinger, M.A. Davis, J.M. Neuhaus, and K.P. Mallon Long-term physical functioning in persons with knee osteoarthritis from NHANES. I. Effects of comorbid medical conditions J. Clin. Epidemiol. 47 7 1994 809 815
38. M.A. Febbraio, and B.K. Pedersen Muscle-derived interleukin-6: mechanisms for activation and possible biological roles FASEB J. 16 11 2002 1335 1347
39. K.R. Feingold, and C. Grunfeld Role of cytokines in inducing hyperlipidemia Diabetes 41 Suppl 2 1992 97 101
40. H.A. Feldman, C. Longcope, C.A. Derby, C.B. Johannes, A.B. Araujo, A.D. Coviello, W.J. Bremner, and J.B. McKinlay Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study J. Clin. Endocrinol. Metab. 87 2 2002 589 598
41. S.L. Ferrari, L. Ahn-Luong, P. Garnero, S.E. Humphries, and S.L. Greenspan Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women J. Clin. Endocrinol. Metab. 88 1 2003 255 259
42. L. Ferrucci, J.M. Guralnik, M. Pahor, M.C. Corti, and R.J. Havlik Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled JAMA 277 9 1997 728 734
43. L. Ferrucci, B.W. Penninx, S. Volpato, T.B. Harris, K. Bandeen-Roche, J. Balfour, S.G. Leveille, L.P. Fried, and J.M. Md Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels J. Am. Geriatr. Soc. 50 12 2002 1947 1954
44. L. Ferrucci, J.M. Guralnik, S. Studenski, L.P. Fried, G.B. Cutler, and J.D. Jr Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report J. Am. Geriatr. Soc. 52 4 2004 625 634
45. M.A. Fiatarone, E.F. O'Neill, N.D. Ryan, K.M. Clements, G.R. Solares, M.E. Nelson, S.B. Roberts, J.J. Kehayias, L.A. Lipsitz, and W.J. Evans Exercise training and nutritional supplementation for physical frailty in very elderly people N. Engl. J. Med. 330 1994 1769 1775
46. L.P. Fried, K. Bandeen-Roche, J.D. Kasper, and J.M. Guralnik Association of comorbidity with disability in older women: the Women's Health and Aging Study J. Clin. Epidemiol. 52 1 1999 27 37
47. L.P. Fried, C.M. Tangen, J. Walston, A.B. Newman, C. Hirsch, J. Gottdiener, T. Seeman, R. Tracy, W.J. Kop, G. Burke, and M.A. McBurnie Frailty in older adults: evidence for a phenotype J. Gerontol. A Biol. Sci. Med. Sci. 56 3 2001 M146 M156
48. N. Furuyama, and Y. Fujisawa Regulation of collagenolytic protease secretion through c-Src in osteoclasts Biochem. Biophys. Res. Commun. 272 1 2000 116 124
49. P. Gerdhem, K.A. Ringsberg, H. Magnusson, K.J. Obrant, and K. Akesson Bone mass cannot be predicted by estimations of frailty in elderly ambulatory women Gerontology 49 3 2003 168 172
50. J.A. Grisso, J.L. Kelsey, B.L. Strom, G.Y. Chiu, G. Maislin, L.A. O'Brien, S. Hoffman, and F. Kaplan Risk factors for falls as a cause of hip fracture in women. The Northeast Hip Fracture Study Group N. Engl. J. Med. 324 19 1991 1326 1331
51. J.M. Guralnik, A.Z. LaCroix, R.D. Abbott, L.F. Berkman, S. Satterfield, D.A. Evans, and R.B. Wallace Maintaining mobility in late life. I. Demographic characteristics and chronic conditions Am. J. Epidemiol. 137 8 1993 845 857
52. L.C. Hofbauer, R.M. Ten, and S. Khosla The anti-androgen hydroxyflutamide and androgens inhibit interleukin-6 production by an androgen-responsive human osteoblastic cell line J. Bone Miner. Res. 14 8 1999 1330 1337
53. L.C. Hofbauer, S. Khosla, C.R. Dunstan, D.L. Lacey, T.C. Spelsberg, and B.L. Riggs Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells Endocrinology 140 9 1999 4367 4370
54. D.M. Huber, A.C. Bendixen, P. Pathrose, S. Srivastava, K.M. Dienger, N.K. Shevde, and J.W. Pike Androgens suppress osteoclast formation induced by RANKL and macrophage-colony stimulating factor Endocrinology 142 9 2001 3800 3808
55. M. Iannuzzi-Sucich, K.M. Prestwood, and A.M. Kenny Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women J. Gerontol. A Biol. Sci. Med. Sci. 57 12 2002 M772 M777
56. R.L. Jilka, G. Hangoc, G. Girasole, G. Passeri, D.C. Williams, J.S. Abrams, B. Boyce, H. Broxmeyer, and S.C. Manolagas Increased osteoclast development after estrogen loss: mediation by interleukin-6 Science 257 1992 88 91
57. C. Kasperk, A. Helmboldt, I. Borcsok, S. Heuthe, O. Cloos, F. Niethard, and R. Ziegler Skeletal site-dependent expression of the androgen receptor in human osteoblastic cell populations Calcif. Tissue Int. 61 6 1997 464 473
58. V. Katavic, D. Grcevic, S.K. Lee, J. Kalinowski, S. Jastrzebski, W. Dougall, D. Anderson, L. Puddington, H.L. Aguila, and J.A. Lorenzo The surface antigen CD45R identifies a population of estrogen-regulated murine marrow cells that contain osteoclast precursors Bone 32 6 2003 581 590
59. S. Khosla, E.J. Atkinson, C.R. Dunstan, and W.M. O'Fallon Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men J. Clin. Endocrinol. Metab. 87 4 2002 1550 1554
60. P.W. Kincade, K.L. Medina, and G. Smithson Sex hormones as negative regulators of lymphopoiesis Immunol. Rev. 137 1994 119 134
61. Y. Koshihara, A. Suematsu, D. Feng, R. Okawara, H. Ishibashi, and S. Yamamoto Osteoclastogenic potential of bone marrow cells increases with age in elderly women with fracture Mech. Ageing Dev. 123 2002 1321 1331
62. S. Kousteni, T. Bellido, L.I. Plotkin, C.A. O'Brien, D.L. Bodenner, L. Han, K. Han, G.B. DiGregorio, J.A. Katzenellenbogen, B.S. Katzenellenbogen, P.K. Roberson, R.S. Weinstein, R.L. Jilka, and S.C. Manolagas Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity Cell 104 5 2001 719 730
63. S. Kousteni, J.R. Chen, T. Bellido, L. Han, A.A. Ali, C.A. O'Brien, L. Plotkin, Q. Fu, A.T. Mancino, Y. Wen, A.M. Vertino, C.C. Powers, S.A. Stewart, R. Ebert, A.M. Parfitt, R.S. Weinstein, R.L. Jilka, and S.C. Manolagas Reversal of bone loss in mice by nongenotropic signaling of sex steroids Science 298 5594 2002 843 846
64. G.A. Kuchel, C. Tannenbaum, S.L. Greenspan, and N.M. Resnick Can variability in the hormonal status of elderly women assist in the decision to administer estrogens J. Womens Health Gend. Based Med. 10 2 2001 109 116
65. N. Kurihara, D. Bertolini, T. Suda, Y. Akiyama, and G.D. Roodman IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release J. Immunol. 144 11 1990 4226 4230
66. D.L. Lacey, E. Timms, H.L. Tan, M.J. Kelley, C.R. Dunstan, T. Burgess, R. Elliott, A. Colombero, G. Elliott, S. Scully, H. Hsu, J. Sullivan, N. Hawkins, E. Davy, C. Capparelli, A. Eli, Y.X. Qian, S. Kaufman, I. Sarosi, V. Shalhoub, G. Senaldi, J. Guo, J. Delaney, and W.J. Boyle Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation Cell 93 2 1998 165 176
67. K.C. Lambert, E.M. Curran, B.M. Judy, D.B. Lubahn, and D.M. Estes Estrogen receptor-alpha deficiency promotes increased TNF-alpha secretion and bacterial killing by murine macrophages in response to microbial stimuli in vitro J. Leukoc. Biol. 75 6 2004 1166 1172
68. J.A. Langlois, T. Harris, A.C. Looker, and J. Madans Weight change between age 50 years and old age is associated with risk of hipfracture in white women aged 67 years and older Arch. Intern. Med. 156 1996 989 994
69. J.A. Langlois, M. Visser, L.S. Davidovic, S. Maggi, G. Li, and T.B. Harris Hip fracture risk in older white men is associated with change in body weight from age 50 years to old age Arch. Intern. Med. 158 9 1998 990 996
70. J.A. Langlois, M.E. Mussolino, M. Visser, A.C. Looker, T. Harris, and J. Madans Weight loss from maximum body weight among middle-aged and older white women and the risk of hip fracture: the NHANES I epidemiologic follow-up study Osteoporos. Int. 12 9 2001 763 768
71. A. Lelbach, J.G. Scharf, and G. Ramadori Regulation of insulin-like growth factor-I and of insulin-like growth factor binding protein-1, -3 and -4 in cocultures of rat hepatocytes and Kupffer cells by interleukin-6 J. Hepatol. 35 5 2001 558 567
72. S.G. Leveille Musculoskeletal aging Curr. Opin. Rheumatol. 16 2 2004 114 118
73. Y.P. Li, and M.B. Reid NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes Am. J. Physiol. Regul Integr. Comp. Physiol. 279 4 2000 R1165 R1170
74. J.T. Lin, and J.M. Lane Osteoporosis: a review Clin. Orthop. 425 2004 126 134
75. S.C. Lin, T. Yamate, Y. Taguchi, V.Z. Borba, G. Girasole, C.A. O'Brien, T. Bellido, E. Abe, and S.C. Manolagas Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow J. Clin. Invest. 100 8 1997 1980 1990
76. S.C. Manolagas, S. Kousteni, and R.L. Jilka Sex steroids and bone Recent Prog. Horm. Res. 57 2002 385 409
77. S.C. Manolagas Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis Endocr. Rev. 21 2 2000 115 137
78. C.J. March, B. Mosley, A. Larsen, D.P. Cerretti, G. Braedt, V. Price, S. Gillis, C.S. Henney, S.R. Kronheim, and K. Grabstein Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs Nature 315 6021 1985 641 647
79. R.A. Marottoli, L.F. Berkman, and L.M. Cooney Jr. Decline in physical function following hip fracture J. Am. Geriatr. Soc. 40 1992 861 866
80. T. Masuzawa, C. Miyaura, Y. Onoe, K. Kusano, H. Ohta, S. Nozawa, and T. Suda Estrogen deficiency stimulates B lymphopoiesis in mouse bone marrow J. Clin. Invest. 94 3 1994 1090 1097
81. C. Menaa, N. Kurihara, and G.D. Roodman CFU-GM-derived cells form osteoclasts at a very high efficiency Biochem. Biophys. Res. Commun. 267 3 2000 943 946
82. V. Mor, J. Murphy, S. Masterson-Allen, C. Willey, A. Razmpour, M.E. Jackson, D. Greer, and S. Katz Risk of functional decline among well elders J. Clin. Epidemiol. 42 9 1989 895 904
83. M.E. Mussolino, A.C. Looker, J.H. Madans, J.A. Langlois, and E.S. Orwoll Risk factors for hip fracture in white men: the NHANES I Epidemiologic Follow-up Study J. Bone Miner. Res. 13 6 1998 918 924
84. T. Nguyen, P. Sambrook, P. Kelly, G. Jones, S. Lord, J. Freund, and J. Eisman Prediction of osteoporotic fractures by postural instability and bone density BMJ 307 6912 1993 1111 1115
85. R. Nuti, G. Martini, and C. Gennari Age-related changes of whole skeleton and body composition in healthy men Calcif. Tissue Int. 57 5 1995 336 339
86. Y. Onoe, C. Miyaura, H. Ohta, S. Nozawa, and T. Suda Expression of estrogen receptor beta in rat bone Endocrinology 138 10 1997 4509 4512
87. K. Ostrowski, T. Rohde, M. Zacho, S. Asp, and B.K. Pedersen Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running J. Physiol. 508 Pt 3 1998 949 953
88. M.J. Oursler, L. Pederson, J. Pyfferoen, P. Osdoby, L. Fitzpatrick, and T.C. Spelsberg Estrogen modulation of avian osteoclast lysosomal gene expression Endocrinology 132 3 1993 1373 1380
89. H. Payette, R. Roubenoff, P.F. Jacques, C.A. Dinarello, P.W. Wilson, L.W. Abad, and T. Harris Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study J. Am. Geriatr. Soc. 51 9 2003 1237 1243
90. B.K. Pedersen, and L. Hoffman-Goetz Exercise and the immune system: regulation, integration, and adaptation Physiol. Rev. 80 3 2000 1055 1081
91. B.K. Pedersen, A. Steensberg, and P. Schjerling Muscle-derived interleukin-6: possible biological effects J. Physiol. 536 Pt 2 2001 329 337
92. M. Pedersen, H. Bruunsgaard, N. Weis, H.W. Hendel, B.U. Andreassen, E. Eldrup, F. Dela, and B.K. Pedersen Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes Mech. Ageing Dev. 124 4 2003 495 502
93. L. Pederson, M. Kremer, J. Judd, D. Pascoe, T.C. Spelsberg, B.L. Riggs, and M.J. Oursler Androgens regulate bone resorption activity of isolated osteoclasts in vitro Proc. Natl. Acad. Sci. USA 96 2 1999 505 510
94. H.M. Perry III, D.K. Miller, P. Patrick, and J.E. Morley Testosterone and leptin in older African-American men: relationship to age, strength, function, and season Metabolism 49 8 2000 1085 1091
95. J.C. Prior Progesterone as a bone-trophic hormone Endocr. Rev. 11 2 1990 386 398
96. L.G. Raisz Local and systemic factors in the pathogenesis of osteoporosis N. Engl. J. Med. 318 13 1988 818 828
97. P.B. Rapuri, J.C. Gallagher, and G. Haynatzki Endogenous levels of serum estradiol and sex hormone binding globulin determine bone mineral density, bone remodeling, the rate of bone loss, and response to treatment with estrogen in elderly women J. Clin. Endocrinol. Metab. 89 2004 4954 4962
98. G. Ravaglia, P. Forti, F. Maioli, B. Nesi, L. Pratelli, D. Cucinotta, L. Bastagli, and G. Cavalli Body composition, sex steroids, IGF-1, and bone mineral status in aging men J. Gerontol. A Biol. Sci. Med. Sci. 55 9 2000 M516 M521
99. N.F. Ray, J.K. Chan, M. Thamer, and L.J. Melton III Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation J. Bone Miner. Res. 12 1 1997 24 35
100. Regulation of Bone Cell Function by Estrogens, second ed. Academic Press, San Diego, 2001
101. N.M. Resnick, and S.L. Greenspan 'Senile' Osteoporosis Reconsidered JAMA 261 7 1989 1025 1029
102. D.B. Reuben, A.I. Cheh, T.B. Harris, L. Ferrucci, J.W. Rowe, R.P. Tracy, and T.E. Seeman Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons J. Am. Geriatr. Soc. 50 4 2002 638 644
103. B.L. Riggs, S. Khosla, and L.J. Melton III Sex steroids and the construction and conservation of the adult skeleton Endocr. Rev. 23 3 2002 279 302
104. R. Roubenoff, H. Parise, H.A. Payette, L.W. Abad, R. D'Agostino, P.F. Jacques, P.W. Wilson, C.A. Dinarello, and T.B. Harris Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study Am. J. Med. 115 6 2003 429 435
105. C. Scheidt-Nave, H. Bismar, G. Leidig-Bruckner, H. Woitge, M.J. Seibel, R. Ziegler, and J. Pfeilschifter Serum interleukin 6 is a major predictor of bone loss in women specific to the first decade past menopause J. Clin. Endocrinol. Metab. 86 5 2001 2032 2042
106. G. Schett, S. Kiechl, K. Redlich, F. Oberhollenzer, S. Weger, G. Egger, A. Mayr, J. Jocher, Q. Xu, P. Pietschmann, S. Teitelbaum, J. Smolen, and J. Willeit Soluble RANKL and risk of nontraumatic fracture JAMA 291 9 2004 1108 1113
107. G. Sesmilo, K.K. Miller, D. Hayden, and A. Klibanski Inflammatory cardiovascular risk markers in women with hypopituitarism J. Clin. Endocrinol. Metab. 86 12 2001 5774 5781
108. R. Sharma, and S.D. Anker Cytokines, apoptosis and cachexia: the potential for TNF antagonism Int. J. Cardiol. 85 1 2002 161 171
109. N.K. Shevde, A.C. Bendixen, K.M. Dienger, and J.W. Pike Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression Proc. Natl. Acad Sci. USA 97 14 2000 7829 7834
110. E.S. Siris, J.P. Bilezikian, M.R. Rubin, D.M. Black, R.S. Bockman, H.G. Bone, M.C. Hochberg, M.R. McClung, and T.J. Schnitzer Pins and plaster aren't enough: a call for the evaluation and treatment of patients with osteoporotic fractures J. Clin. Endocrinol. Metab. 88 8 2003 3482 3486
111. T.C. Spelsberg, M. Subramaniam, B.L. Riggs, and S. Khosla The actions and interactions of sex steroids and growth factors/cytokines on the skeleton Mol. Endocrinol. 13 6 1999 819 828
112. E.R. Stanley, K.L. Berg, D.B. Einstein, P.S. Lee, F.J. Pixley, Y. Wang, and Y.G. Yeung Biology and action of colony - stimulating factor-1 Mol. Reprod. Dev. 46 1 1997 4 10
113. A. Steensberg, A.D. Toft, P. Schjerling, J. Halkjaer-Kristensen, and B.K. Pedersen Plasma interleukin-6 during strenuous exercise: role of epinephrine Am. J. Physiol. Cell Physiol. 281 3 2001 C1001 C1004
114. B. Stein, and M.X. Yang Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta Mol. Cell Biol. 15 9 1995 4971 4979
115. T. Suda, N. Takahashi, N. Udagawa, E. Jimi, M.T. Gillespie, and T.J. Martin Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families Endocr. Rev. 20 3 1999 345 357
116. W.H. Sun, E.T. Keller, B.S. Stebler, and W.B. Ershler Estrogen inhibits phorbol ester-induced I kappa B alpha transcription and protein degradation Biochem. Biophys. Res. Commun. 244 3 1998 691 695
117. S.S. Tabibzadeh, D. Poubouridis, L.T. May, and P.B. Sehgal Interleukin-6 immunoreactivity in human tumors Am. J. Pathol. 135 3 1989 427 433
118. S.L. Teitelbaum Bone resorption by osteoclasts Science 289 5484 2000 1504 1508
119. A.W. van den Beld, F.H. De Jong, D.E. Grobbee, H.A. Pols, and S.W. Lamberts Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men J. Clin. Endocrinol. Metab. 85 9 2000 3276 3282
120. M. van den Akker, F. Buntinx, J.F. Metsemakers, S. Roos, and J.A. Knottnerus Multimorbidity in general practice: prevalence, incidence, and determinants of co-occurring chronic and recurrent diseases J. Clin. Epidemiol. 51 5 1998 367 375
121. D. Vanderschueren, L. Vandenput, S. Boonen, M.K. Lindberg, R. Bouillon, and C. Ohlsson Androgens and bone Endocr. Rev. 25 3 2004 389 425
122. M. Visser, M. Pahor, D.R. Taaffe, B.H. Goodpaster, E.M. Simonsick, A.B. Newman, M. Nevitt, and T.B. Harris Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study J. Gerontol. A Biol. Sci. Med. Sci. 57 5 2002 M326 M332
123. R.S. Weinstein, R.L. Jilka, A.M. Parfitt, and S.C. Manolagas The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage Endocrinology 138 9 1997 4013 4021
124. S.X. Yang, and G.A. Kuchel Estrogen, cerebrovascular system and dementia R.H. Paul R.A. Cohen B.R. Ott Vascular dementia: cerebrovascular mechanisms and clinical management 2004 Humana Press Tatowa, NJ
125. H. Yoshida, S. Hayashi, T. Kunisada, M. Ogawa, S. Nishikawa, H. Okamura, T. Sudo, L.D. Shultz, and S. Nishikawa The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene Nature 345 6274 1990 442 444
126. J. Zhang, T.D. Pugh, B. Stebler, W.B. Ershler, and E.T. Keller Orchiectomy increases bone marrow interleukin-6 levels in mice Calcif. Tissue Int. 62 3 1998 219 226
127. B. Zubrowski, W.A. Mohler, G.A. Kuchel, and A.M. Kenny Correlation of clinical outcomes with high resolution muscle imaging in adults with early frailty Am. Geriatr. Soc. Ref Type: Abstract 52 4 2004 5119