SOCS: Physiological suppressors of cytokine signaling

Journal of Cell Science

Volumn 113, Issue 16, 2000, Pages 2813-2819

  Krebs, D L ^a   Hilton, D J ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Cytokine; JAK; Signal transduction; SOCS; STAT

Indexed keywords

CYTOKINE; ERYTHROPOIETIN; GAMMA INTERFERON; PROTEIN; PROTEIN TYROSINE KINASE; STAT PROTEIN; SUPPRESSORS OF CYTOKINE SIGNALING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CONTROLLED STUDY; EMBRYO; ERYTHROPOIESIS; FETUS LIVER; GENE TARGETING; LYMPHOCYTE DIFFERENTIATION; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMAL; CARRIER PROTEINS; CYTOKINES; PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033828672     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
2. Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: Evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis
3. Identification of SOCS-3 as a potential mediator of central leptin resistance
4. Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor
5. The role of SOCS-3 in leptin signaling and leptin resistance
6. Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor
7. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
8. STATs and gene regulation
9. STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver
10. Socs1 binds to multiple signalling proteins and suppresses Steel factor-dependent proliferation
11. Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-1 receptor
12. A new protein containing an SH2 domain that inhibits JAK kinases
13. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor critical for STAT5 activation
14. Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice
15. Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins
16. The ubiquitin system
17. Twenty proteins containing a C-terminal SOCS box form five structural classes
18. Negative regulators of cytokine signal transduction
19. Requirement for Stat5 in thymic stromal lymphopoietinmediated signal transduction
20. Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma-induced genes by suppressing tyrosine phosphorylation of STAT1
21. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
22. Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5
23. SOCS-1 is a potent inhibitor of IL-4 signal transduction
24. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
25. SOCS3 is essential in the regulation of fetal liver erythropoiesis
26. Cloning and characterization of novel CIS family genes
27. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation
28. Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice
29. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs
30. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
31. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: Role of Stat5 in proliferation
32. Structure and function of a new STAT-induced STAT inhibitor
33. Accelerated apoptosis in lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice
34. Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling
35. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
36. An introduction to the cytokines
37. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
38. SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase
39. Jak2 is essential for signaling through a variety of cytokine receptors
40. Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling
41. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
42. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
43. A family of cytokine-inducible inhibitors of signalling
44. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
45. Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma
46. CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells
47. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
48. SWiP-1: Novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development
49. Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein
50. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
51. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
52. Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation
53. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation