Sequential Activation of Rac-1, SEK-1/MKK-4, and Protein Kinase Cδ is Required for Interleukin-6-induced STAT3 Ser-727 Phosphorylation and Transactivation

Journal of Biological Chemistry

Volumn 276, Issue 29, 2001, Pages 27709-27715

  Schuringa, Jan Jacob ^a,b   Dekker, Lodewijk V ^c   Vellenga, Edo ^a,b   Kruijer, Wiebe ^a  

^a University of Groningen Center of Biological Sciences Haren   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISSOCIATION; ENZYMES;

TRANSCRIPTION;

BIOCHEMISTRY;

INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PROTEIN KINASE C DELTA; RAC PROTEIN; RAC1 PROTEIN; ROTTLERIN; SERINE; STAT3 PROTEIN; TYROSINE; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ISOENZYME; MAP2K4 PROTEIN, HUMAN; PRIMER DNA; PRKCD PROTEIN, HUMAN; PROTEIN KINASE C; STAT3 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME ACTIVATION; ENZYME LOCALIZATION; FLUORESCENCE MICROSCOPY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INHIBITION KINETICS; NUCLEAR IMPORT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSACTIVATION; WESTERN BLOTTING; CELL CULTURE; CHEMISTRY; METABOLISM; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION;

BASE SEQUENCE; DNA PRIMERS; DNA-BINDING PROTEINS; HUMANS; INTERLEUKIN-6; ISOENZYMES; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; RAC1 GTP-BINDING PROTEIN; SERINE; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0035920174     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009821200     Document Type: Article

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