Brain, aging and neurodegeneration: Role of zinc ion availability

Progress in Neurobiology

Volumn 75, Issue 6, 2005, Pages 367-390

  Mocchegiani, Eugenio ^a   Bertoni Freddari, Carlo ^a   Marcellini, Fiorella ^a   Malavolta, Marco ^a  

^a INRCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; AMYLOID BETA PROTEIN; BINDING PROTEIN; CLIOQUINOL; GLUCOCORTICOID; ISOPROTEIN; METALLOTHIONEIN; NEUROTROPHIC FACTOR; XENOBIOTIC AGENT; ZINC ION;

AGING; ALZHEIMER DISEASE; APOPTOSIS; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN TISSUE; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; DNA DAMAGE; DNA REPAIR; HOMEOSTASIS; HUMAN; MENTAL PERFORMANCE; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROFILAMENT; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SEIZURE; STRESS; SUBACUTE MYELOOPTIC NEUROPATHY; SYNAPSE; SYNAPSE VESICLE; ZINC METABOLISM;

AGING; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; DIETARY SUPPLEMENTS; HUMANS; METALLOTHIONEIN; NEURODEGENERATIVE DISEASES; NEURONS; ZINC;

EID: 20444447595     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2005.04.005     Document Type: Review

References (309)

1. A.B. Abdel-Mageed, and K.C. Agrawal Activation of nuclear factor kappaB: potential role in metallothionein-mediated mitogenic response Cancer Res. 58 1998 2335 2338
2. S. Altunbasak, F. Biatmakoui, V. Baytok, O. Herguner, H.R. Burgt, and L. Kayrin Serum and hair zinc levels in epileptic children taking valproic acid Biol. Trace Elem. Res. 58 1997 117 125
3. F. Amenta, A.L. Jaton, and A. Ricci Effect of long term hydergine treatment on the age dependent loss of mossy fibers and of granule cells in the rat hippocampus Arch. Gerontol. Geriatr. 10 1990 287 296
4. R. Ammendola, M. Mesuraca, T. Russo, and F. Cimino Sp1 DNA binding efficiency is highly reduced in nuclear extracts from aged rat tissues J. Biol. Chem. 267 1992 17944 17948
5. M.C. Amoureux, D. Van Gool, M.T. Herrero, R. Dom, F.C. Colpaert, and P.J. Pauwels Regulation of metallothionein-III (GIF) mRNA in the brain of patients with Alzheimer disease is not impaired Mol. Chem. Neuropathol. 32 1997 101 121
6. W.L. An, R.F. Cowburn, L. Li, H. Braak, I. Alafuzoff, K. Iqbal, I.G. Iqbal, B. Winblad, and J.J. Pei Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease Am. J. Pathol. 163 2003 591 607
7. E. Andrasi, E. Farkas, D. Gawlik, U. Rosick, and P. Bratter Brain iron and zinc contents of german patients with alzheimer disease J. Alzheimers Dis. 2 2000 17 26
8. A. Ashworth, S.S. Morris, P.I. Lira, and S.M. Grantham-McGregor Zinc supplementation, mental development and behaviour in low birth weight term infants in northeast Brazil Eur. J. Clin. Nutr. 52 1998 223 227
9. S. Attucci, G.V. Clodfelter, O. Thibault, J. Staton, F. Moroni, P.W. Landfield, and N.M. Porter Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity Neuroscience 112 2002 183 194
10. B. Bao, A.S. Prasad, F.W. Beck, and M. Godmere Zinc modulates mRNA levels of cytokines Am. J. Physiol. Endocrinol. Metab. 285 2003 E1095 E1102
11. C. Barcia, A. Fernandez Barreiro, M. Poza, and M.T. Herrero Parkinson's disease and inflammatory changes Neurotox. Res. 5 2003 411 418
12. A. Baskys, J.N. Reynolds, and P.L. Carlen NMDA depolarizations and long-term potentiation are reduced in the aged rat neocortex Brain. Res. 530 1990 142 146
13. C. Beaulieu, R. Dyck, and M. Cynader Enrichment of glutamate in zinc-containing terminals of the cat visual cortex Neuroreport 3 1992 861 864
14. R. Beneke, C. Geisen, B. Zevnik, T. Bauch, W.U. Muller, J.H. Kupper, and T. Moroy DNA excision repair and DNA damage-induced apoptosis are linked to poly(ADP-ribosyl)ation but have different requirements for p53 Mol. Cell. Biol. 20 2000 6695 6703
15. C. Bertoni-Freddari, P. Fattoretti, M. Solazzi, B. Giorgetti, G. Di Stefano, T. Casoli, and W. Meier-Ruge Neuronal death versus synaptic pathology in Alzheimer's disease Ann. N.Y. Acad. Sci. 1010 2003 635 638
16. C. Bertoni-Freddari, C. Giuli, C. Pieri, D. Paci, and A. Dravid A modulating effect of Hygergine on the synaptic plasticity of old rats J. Pharmacol. 16 Suppl. 3 1985 33 38
17. P. Bhaskaram, and P. Hemalatha Zinc status of Indian children Indian J. Med. Res. 102 1995 210 215
18. S. Bhatnagar, and S. Taneja Zinc and cognitive development Br. J. Nutr. 85 2001 S139 S145
19. A. Birinyi, D. Parker, M. Antal, and O. Shupliakov Zinc co-localizes with GABA and glycine in synapses in the lamprey spinal cord J. Comp. Neurol. 433 2001 208 221
20. M.M. Black, S. Sazawal, R.E. Black, S. Khosla, J. Kumar, and V. Menon Cognitive and motor development among small-for-gestational-age infants: impact of zinc supplementation, birth weight, and caregiving practices Pediatrics 113 2004 1297 1305
21. J.R. Blair-West, D.A. Denton, A.P. Gibson, and M.J. McKinely Opening the blood-brain barrier to zinc Brain Res. 507 1990 6 10
22. E.M. Blalock, J.W. Geddes, K.C. Chen, N.M. Porter, W.R. Markesbery, and P.W. Landfield Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses Proc. Natl. Acad. Sci. U.S.A. 101 2004 2173 2178
23. M.E. Boerrigter, J.Y. Wei, and J. Vijg DNA repair and Alzheimer's disease J. Gerontol. 47 1992 B177 B184
24. C.E. Brown, and R.H. Dyck Experience-dependent regulation of synaptic zinc is impaired in the cortex of aged mice Neuroscience 119 2003 795 801
25. H.H. Bruhl, J. Foni, Y.H. Lee, and A. Madow Plasma concentrations of magnesium, lead, lithium, copper, and zinc in mentally retarded persons Am. J. Ment. Defic. 92 1987 103 111
26. S.C. Burdette, and S.J. Lippard Meeting of the minds: metalloneurochemistry Proc. Natl. Acad. Sci. U.S.A. 100 2003 3605 3610
27. A. Bush, and N. Beail Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis Am. J. Ment. Retard. 109 2004 83 97
28. A.I. Bush, and R.E. Tanzi The galvanization of beta-amyloid in Alzheimer's disease Proc. Natl. Acad. Sci. U.S.A. 99 2002 7317 7319
29. A.I. Bush, W.H. Pettingell, G. Multhaup, M. dParadis, J.P. Vonsattel, J.F. Gusella, K. Beyreuther, C.L. Masters, and R.E. Tanzi Rapid induction of Alzheimer A beta amyloid formation by zinc Science 265 1994 1464 1467
30. D.A. Butterfield, and C.B. Pocernich The glutamatergic system and Alzheimer's disease: therapeutic implications CNS Drugs 17 2003 641 652
31. C. Cady, M.S. Evans, and G.J. Brewer Age-related differences in NMDA responses in cultured rat hippocampal neurons Brain Res. 921 2001 1 11
32. J. Carrasco, M. Giralt, A. Molinero, M. Penkowa, T. Moos, and J. Hidalgo Metallothionein (MT)-III: generation of polyclonal antibodies, comparison with MT-I + II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains J. Neurotraum. 16 1999 1115 1129
33. D.M. Caspary, T.M. Holder, L.F. Hughes, J.C. Milbrandt, R.M. McKernan, and D.K. Naritoku Age-related changes in GABA(A) receptor subunit composition and function in rat auditory system Neuroscience 93 1999 307 312
34. R.C. Casper, B. Kirschner, H.H. Sandstead, R.A. Jacob, and J.M. Davis An evaluation of trace metals, vitamins, and taste function in anorexia nervosa Am. J. Clin. Nutr. 33 1980 1801 1808
35. K.R. Cavan, R.S. Gibson, C.F. Grazioso, A.M. Isalgue, M. Ruz, and N.W. Solomons Growth and body composition of periurban Guatemalan children in relation to zinc status: a cross-sectional study Am. J. Clin. Nutr. 57 1993 334 343
36. J. Chan, Z. Huang, M.E. Merrifield, M.T. Salgado, and M.J. Stillman Studies of metal binding reactions in metallothioneins by spectroscopic, molecular biology, and molecular modeling techniques Coord. Chem. Rev. 233-234 2002 319 339
37. H.P. Chase, K.M. Hambidge, S.E. Barnett, M.J. Houts-Jacobs, K. Lenz, and J. Gillespie Low vitamine A and zinc concentrations in Mexican-American migrant children with growth retardation Am. J. Clin. Nutr. 33 1980 2346 2349
38. Y. Chen, Y. Irie, W.M. Keung, and W. Maret S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein 3 through transnitrosation Biochemistry 41 2002 8360 8367
39. X.C. Chen, T.A. Yin, J.S. He, Q.Y. Ma, Z.M. Han, and L.X. Li Low levels of zinc in hair and blood, pica, anorexia, and poor growth in Chinese preschool children Am. J. Clin. Nutr. 42 1985 694 700
40. C. Cheng, and I.J. Reynolds Calcium-sensitive fluorescent dyes can report increases in intracellular free zinc concentration in cultured forebrain neurons J. Neurochem. 71 1998 210 2401
41. D.W. Choi, M. Yokoyama, and J. Koh Zinc neurotoxicity in cortical cell culture Neuroscience 24 1988 67 79
42. S.S. Chou, M.S. Clegg, T.Y. Momma, B.J. Niles, J.Y. Duffy, G.P. Daston, and C.L. Keen Alterations in protein kinase C activity and processing during zinc deficiency-induced cell death Biochem. J. 383 2004 63 71
43. Y. Christen Oxidative stress and Alzheimer disease Am. J. Clin. Nutr. 71 2000 621S 629S
44. G. Cikim, H. Canatan, M.F. Gursu, F. Gulcu, G. Baydas, and A.E. Kilicoglu Levels of zinc and lipid peroxidation in acute coronary syndrome Biol. Trace Elem. Res. 96 2003 61 69
45. J. Clausen, S.A. Nielsen, and M. Kristensen Biochemical and clinical effects of an antioxidative supplementation of geriatric patients. A double blind study Biol. Trace Elem. Res. 20 1989 135 151
46. A. Clements, D. Allsop, D.M. Walsh, and C.H. Williams Aggregation and metal-binding properties of mutant forms of the amyloid A beta peptide of Alzheimer's disease J. Neurochem. 66 1996 740 747
47. V. Colangelo, J. Schurr, M.J. Ball, R.P. Pelaez, N.G. Bazan, and W.J. Lukiw Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling J. Neurosci. Res. 70 2002 462 473
48. T.B. Cole, H.J. Wenzel, K.E. Kafer, P.A. Schwartzkroin, and R.D. Palmiter Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene Proc. Natl. Acad. Sci. U.S.A. 96 1999 1716 1721
49. R.A. Colvin, N. Davis, R.W. Nipper, and P.A. Carter Zinc transport in the brain: routes of zinc influx and efflux in neurons J. Nutr. 130 5S Suppl. 2000 1484S 1487S
50. J. Constantinidis The hypothesis of zinc deficiency in the pathogenesis of neurofibrillary tangles Med. Hypotheses 35 1991 319 323
51. J. Constantinidis, J. Richard, and R. Tissot Pick's disease and zinc metabolism Rev. Neurol. (Paris) 133 1977 685 696
52. C.R. Cornett, W.R. Markesbery, and W.D. Ehmann Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain Neurotoxicology 19 1998 339 345
53. F.M. Corrigan, G.P. Reynolds, and N.I. Ward Hippocampal tin, aluminum, and zinc in Alzheimer's disease Biometals 6 1993 149 154
54. C. Corsi, A. Melani, L. Bianchi, G. Pepeu, and F. Pedata Effect of adenosine A2A receptor stimulation on GABA release from the striatum of young and aged rats in vivo Neuroreport 10 1999 3933 3937
55. L.C. Costello, Z. Guan, R.B. Franklin, and P. Feng Metallothionein can function as a chaperone for zinc uptake transport into prostate and liver mitochondria J. Inorg. Biochem. 98 2004 664 666
56. S. Couillard-Despres, Q. Zhu, P.C. Wong, D.L. Price, D.W. Cleveland, and J.P. Julien Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase Proc. Natl. Acad. Sci. U.S.A. 95 1998 9626 9630
57. R.J. Cousins, and R.J. McMahon Integrative aspects of zinc transporters J. Nutr. 130 5S Suppl. 2000 1384S 1387S
58. J.P. Crow, J.B. Sampson, Y. Zhuang, J.A. Thompson, and J.S. Beckman Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite J. Neurochem. 69 1997 1936 1944
59. M.P. Cuajungco, and K.Y. Faget Zinc takes the center stage: its paradoxical role in Alzheimer's disease Brain Res. Brain Res. Rev. 41 2003 44 56
60. M.P. Cuajungco, L.E. Goldstein, A. Nunomura, M.A. Smith, J.T. Lim, C.S. Atwood, X. Huang, Y.W. Farrag, G. Perry, and A.I. Bush Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc J. Biol. Chem. 275 2000 19439 19442
61. M.P. Cuajungco, and G.J. Lees Zinc and Alzheimer's disease: is there a direct link? Brain Res. Rev. 23 1997 219 236
62. M.P. Cuajungco, and G.J. Lees Zinc metabolism in the brain: relevance to human neurodegenerative disorders Neurobiol. Dis. 4 1997 137 169
63. J.L. Cummings Alzheimer's disease N. Engl. J. Med. 351 2004 56 67
64. C.A. Curcio, and J.W. Hinds Stability of synaptic density and spine volume in dentate gyrus of aged rats Neurobiol. Aging 4 1983 77 87
65. D.E. Danford, J.C. Smith Jr., and A.M. Huber Pica and mineral status in the mentally retarded Am. J. Clin. Nutr. 35 1982 958 967
66. G. Danscher, S.M. Jo, E. Varea, Z. Wang, T.B. Cole, and H.D. Schroder Inhibitory zinc-enriched terminals in mouse spinal cord Neuroscience 105 2001 941 947
67. G. Danscher, K.B. Jensen, C.J. Frederickson, K. Kemp, A. Andreasen, S. Juhl, M. Stoltenberg, and R. Ravid Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material J. Neurosci. Meth. 76 1997 53 59
68. G. Danscher, M. Stoltenberg, and S. Juhl How to detect gold, silver and mercury in human brain and other tissues by autometallographic silver amplification Neuropathol. Appl. Neurobiol. 20 1994 454 467
69. D.L. Davidson, and N.I. Ward Abnormal aluminium, cobalt, manganese, strontium and zinc concentrations in untreated epilepsy Epilepsy Res. 2 1988 323 330
70. M.A. Deibel, W.D. Ehmann, and W.R. Markesbery Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress J. Neurol. Sci. 143 1996 137 142
71. S. Devergnas, F. Chimienti, N. Naud, A. Pennequin, Y. Coquerel, J. Chantegrel, A. Favier, and M. Seve Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study Biochem. Pharmacol. 68 2004 699 709
72. D.T. Dexter, A. Carayon, F. Javoy-Agid, Y. Agid, F.R. Wells, S.E. Daniel, A.J. Lees, P. Jenner, and C.D. Marsden Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia Brain 114 1991 1953 1975
73. P.M. Doraiswamy, and A.E. Finefrock Metals in our minds: therapeutic implications for neurodegenerative disorders Lancet Neurol. 3 2004 431 434
74. J.G. Dorea, M.R. Horner, V.L. Bezerra, M.G. Pereira, and J.B. Salomon Hair zinc levels and nutritional status in urban children from Ilheus, Bahia, Brazil Hum. Nutr. Appl. Nutr. 36 1982 63 67
75. P. Dore-Duffy, F. Catalanotto, J.O. Donaldson, K.M. Ostrom, and M.A. Testa Zinc in multiple sclerosis Ann. Neurol. 14 1983 450 454
76. J. Dorszewska, and Z. Adamczewska-Goncerzewicz Oxidative damage to DNA, p53 gene expression and p53 protein level in the process of aging in rat brain Respir. Physiol. Neurobiol. 139 2004 227 236
77. J. Dorszewska, Z. Adamczewska-Goncerzewicz, and J. Szczech Apoptotic proteins in the course of aging of central nervous system in the rat Respir. Physiol. Neurobiol. 139 2004 145 155
78. I.E. Dreosti, and A. MacLennan Maternal plasma zinc levels and first trimester abortion Early Hum. Dev. 21 1990 141 142
79. Y. Du, K.R. Bales, R.C. Dodel, X. Liu, M.A. Glinn, J.W. Horn, S.P. Little, and S.M. Paul Alpha2-macroglobulin attenuates beta-amyloid peptide 1-40 fibril formation and associated neurotoxicity of cultured fetal rat cortical neurons J. Neurochem. 70 1998 1182 1188
80. Y. Du, B. Ni, M. Glinn, R.C. Dodel, K.R. Bales, Z. Zhang, P.A. Hyslop, and S.M. Paul alpha2-Macroglobulin as a beta-amyloid peptide-binding plasma protein J. Neurochem. 69 1997 299 305
81. M.F. Dunn, S.E. Pattison, M.C. Storm, and E. Quiel Comparison of the zinc binding domains in the 7S nerve growth factor and the zinc-insulin hexamer Biochemistry 19 1980 718 725
82. M. Ebadi, and S.K. Sharma Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson's disease Antioxid. Redox Signal 5 2003 319 335
83. M. Ebadi, M.V. Ramana Kumari, M. Hiramatsu, R. Hao, R.F. Pfeiffer, and P. Rojas Metallothionein, neurotrophins and selegiline in providing neuroprotection in Parkinson's disease Restor. Neurol. Neurosci. 12 1998 103 111
84. M. Ebadi, R.F. Pfeiffer, L.C. Murrin, and H. Shiraga Metallothionein and oxidation reactions in Parkinson's disease Proc. West. Pharmacol. Soc. 34 1991 285 290
85. M. Ebadi, L.C. Murrin, and R.F. Pfeiffer Hippocampal zinc thionein and pyridoxal phosphate modulate synaptic functions Ann. N.Y. Acad. Sci. 585 1990 189 201
86. W.D. Ehmann, M. Alauddin, T.I. Hossain, and W.R. Markesbery Brain trace elements in Pick's disease Ann. Neurol. 15 1984 102 104
87. J.C. Erickson, G. Hollopeter, S.A. Thomas, G.J. Froelick, and R.D. Palmiter Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures J. Neurosci. 17 1997 1271 1281
88. N. Fabris, and E. Mocchegiani Arginine-containing compounds and thymic endocrine activity Thymus 19 1992 S21 S30
89. N. Fabris, E. Mocchegiani, L. Amadio, M. Zannotti, F. Licastro, and C. Franceschi Thymic hormone deficiency in normal aging and Down's syndrome: is there a primary failure of the thymus? Lancet 1 1984 983 986
90. A.E. Favier Hormonal effects of zinc on growth in children Biol. Trace Elem. Res. 32 1992 383 398
91. L. Felici, E. Bronzetti, and F. Amenta Enzyme histochemistry of glutamate dehydrogenase in aging rat cerebellar cortex Mech. Aging Dev. 47 1989 199 205
92. R.A. Floyd, and K. Hensley Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases Neurobiol. Aging 23 2002 795 807
93. L. Forsleff, A.G. Schauss, I.D. Bier, and S. Stuart Evidence of functional zinc deficiency in Parkinson's disease J. Altern. Complem. Med. 5 1999 57 64
94. T.C. Foster, and A. Kumar Calcium dysregulation in the aging brain Neuroscientist 8 2002 297 301
95. P.J. Fraker, and W.G. Telford A reappraisal of the role of zinc in life and death decisions of cells Proc. Soc. Exp. Biol. Med. 215 1997 229 236
96. C.J. Frederickson, W. Maret, and M.P. Cuajungco Zinc and excitotoxic brain injury: a new model Neuroscientist 10 2004 18 25
97. C.J. Frederickson, S.W. Suh, D. Silva, C.J. Frederickson, and R.B. Thompson Importance of zinc in the central nervous system: the zinc-containing neuron J. Nutr. 130 5S Suppl. 2000 1471S 1483S
98. C.J. Frederickson, and D.W. Moncrieff Zinc-containing neurons Biol. Signals 3 1994 127 139
99. C.J. Frederickson, M.D. Hernandez, and J.F. McGinty Translocation of zinc may contribute to seizure-induced death of neurons Brain Res. 480 1989 317 321
100. K.M. Frick, L.A. Burlingame, S.S. Delaney, and J. Berger-Sweeney Sex differences in neurochemical markers that correlate with behavior in aging mice Neurobiol. Aging 23 2002 145 158
101. N. Fukuda, M. Ichihara, T. Morinaga, K. Kawai, H. Hayashi, Y. Murakumo, S. Matsuo, and M. Takahashi Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis J. Biol. Chem. 278 2003 50386 50392
102. C. Jeandel, M.B. Nicolas, F. Dubois, F. Nabet-Belleville, F. Penin, and G. Cuny Lipid peroxidation and free radical scavengers in Alzheimer's disease Gerontology 35 1989 275 282
103. Y. Geinisman, O. Ganeshina, R. Yoshida, R.W. Berry, J.F. Disterhoft, and M. Gallagher Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum Neurobiol. Aging 25 2004 407 416
104. R. Giacconi, C. Cipriano, M. Muzzioli, N. Gasparini, F. Orlando, and E. Mocchegiani Interrelationships among brain, endocrine and immune response in aging and successful aging: role of metallothionein III isoform Mech. Aging Dev. 124 2003 371 378
105. R.S. Gibson, P.D. Vanderkooy, A.C. MacDonald, A. Goldman, B.A. Ryan, and M. Berry A growth-limiting, mild zinc-deficiency syndrome in some southern Ontario boys with low height percentiles Am. J. Clin. Nutr. 49 1989 1266 1273
106. P. Gil Gregorio, S.P. Ramirez Diaz, and J.M. Ribera Casado Dementia and Nutrition. Intervention study in institutionalized patients with Alzheimer disease J. Nutr. Health Aging 7 2003 304 308
107. J.C. Gillin, W.T. Carpenter, K.M. Hambidge, R.J. Wyatt, and R.I. Henkin Zinc and copper in patients with schizophrenia Encephale 8 1982 435 444
108. J.P. Godbout, and R.W. Johnson Interleukin-6 in the aging brain J. Neuroimmunol. 147 2004 141 144
109. H.J. Goldberg, and E.M. Sheehy Fifth day fits: an acute zinc deficiency syndrome? Arch. Dis. Child 57 1982 633 635
110. M.S. Golub, P.T. Takeuchi, C.L. Keen, M.E. Gershwin, A.G. Hendrickx, and B. Lonnerdal Modulation of behavioral performance of prepubertal monkeys by moderate dietary zinc deprivation Am. J. Clin. Nutr. 60 1994 238 243
111. C. Gonzalez, T. Martin, J. Cacho, M.T. Brenas, T. Arroyo, B. Garcia-Berrocal, J.A. Navajo, and J.M. Gonzalez-Buitrago Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers Eur. J. Clin. Invest. 29 1999 637 642
112. P. Grammas, P. Moore, T. Botchlet, O. Hanson-Painton, D.R. Cooper, M.J. Ball, and A. Roher Cerebral microvessels in Alzheimer's have reduced protein kinase C activity Neurobiol. Aging 16 1995 563 569
113. I. Gronek, and M. Kolomaznik Serum zinc levels in various mental disorders Zh. Nevropatol. Psikhiatr. Im. S. S. Korsakova. 89 1989 126 127
114. Z. Guan, B. Kukoyi, P. Feng, M.C. Kennedy, R.B. Franklin, and L.C. Costello Kinetic identification of a mitochondrial zinc uptake transport process in prostate cells J. Inorg. Biochem. 97 2003 199 206
115. D. Guidolin, P. Polato, G. Venturin, A. Zanotti, E. Mocchegiani, N. Fabris, and M.G. Nunzi Correlation between zinc level in hippocampal mossy fibers and spatial memory in aged rats Ann. N.Y. Acad. Sci. 673 1992 187 193
116. H. Haase, and D. Beyersmann Intracellular zinc distribution and transport in C6 rat glioma cells Biochem. Biophys. Res. Commun. 296 2002 923 928
117. E.S. Halas, C.D. Hunt, and M.J. Eberhardt Learning and memory disabilities in young adult rats from mildly zinc deficient dams Physiol. Behav. 37 1986 451 458
118. E.S. Halas, and H.H. Sandstead Malnutrition and behavior: the performance versus learning problem revisited J. Nutr. 110 1980 1858 1864
119. J.A. Halsted, H.A. Ronaghy, P. Abadi, M. Haghshenass, G.H. Amirhakemi, R.M. Barakat, and J.G. Reinhold Zinc deficiency in man. The Shiraz experiment Am. J. Med. 53 1972 277 284
120. E. Ho, and B.N. Ames Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line Proc. Natl. Acad. Sci. U.S.A. 99 2002 16770 16775
121. L.H. Ho, R.N. Ratnaike, and P.D. Zalewski Involvement of intracellular labile zinc in suppression of DEVD-caspase activity in human neuroblastoma cells Biochem. Biophys. Res. Commun. 268 2000 148 154
122. S.Y. Ho, F.A. Catalanotto, R.P. Lisak, and P. Dore-Duffy Zinc in multiple sclerosis. II: Correlation with disease activity and elevated plasma membrane-bound zinc in erythrocytes from patients with multiple sclerosis Ann. Neurol. 20 1986 712 715
123. P.R. Hof, and J.H. Morrison The aging brain: morphomolecular senescence of cortical circuits Trends Neurosci. 27 2004 607 613
124. J. Huang, Y. Yao, J. Lin, Y.H. Ye, W.Y. Sun, and W.X. Tang Dagger The solution structure of rat Abeta-(1-28) and its interaction with zinc ion: insights into the scarcity of amyloid deposition in aged rat brain J. Biol. Inorg. Chem. 9 2004 627 635
125. X. Huang, M.P. Cuajungco, C.S. Atwood, R.D. Moir, R.E. Tanzi, and A.I. Bush Alzheimer's disease, beta-amyloid protein and zinc J. Nutr. 130 5S Suppl. 2000 1488S 1492S
126. X. Huang, C.S. Atwood, R.D. Moir, M.A. Hartshorn, J.P. Vonsattel, R.E. Tanzi, and A.I. Bush Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors J. Biol. Chem. 272 1997 26464 26470
127. R.P. Hullin Serum zinc in psychiatric patients Prog. Clin. Biol. Res. 129 1983 197 206
128. L. Humphries, B. Vivian, M. Stuart, and C.J. McClain Zinc deficiency and eating disorders J. Clin. Psychiatry 50 1989 456 459
129. C. Ikonomidou, and L. Turski Neurodegenerative disorders: clues from glutamate and energy metabolism Crit. Rev. Neurobiol. 10 1996 239 263
130. G.W. Intano, E.J. Cho, C.A. McMahan, and C.A. Walter Age-related base excision repair activity in mouse brain and liver nuclear extracts J. Gerontol. A: Biol. Sci. Med. Sci. 58 2003 205 211
131. M.J. Jackson, and P.J. Garrod Plasma zinc, copper, and amino acid levels in the blood of autistic children J. Autism. Child. Schizophr. 8 1978 203 208
132. C. Jacob, W. Maret, and B.L. Vallee Control of zinc transfer between thionein, metallothionein, and zinc proteins Proc. Natl. Acad. Sci. U.S.A. 95 1998 3489 3494
133. K.A. Jellinger General aspects of neurodegeneration J. Neural. Transm. Suppl. 65 2003 101 144
134. P. Jenner, A.H. Schapira, and C.D. Marsden New insights into the cause of Parkinson's disease Neurology 42 1992 2241 2250
135. Y. Jia, J.M. Jeng, S.L. Sensi, and J.H. Weiss Zn2+ currents are mediated by calcium-permeable AMPA/kainate channels in cultured murine hippocampal neurones J. Physiol. 543 2002 35 48
136. D. Jiang, P.G. Sullivan, S.L. Sensi, O. Steward, and J.H. Weiss Zn(2+) induces permeability transition pore opening and release of proapoptotic peptides from neuronal mitochondria J. Biol. Chem. 276 2001 47524 47529
137. F.J. Jimenez-Jimenez, J.A. Molina, M.V. Aguilar, I. Meseguer, C.J. Mateos-Vega, M.J. Gonzalez-Munoz, F. de Bustos, A. Martinez-Salio, M. Orti-Pareja, M. Zurdo, and M.C. Martinez-Para Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease J. Neural. Transm. 105 1998 497 505
138. F.J. Jimenez-Jimenez, P. Fernandez-Calle, M. Martinez-Vanaclocha, E. Herrero, J.A. Molina, A. Vazquez, and R. Codoceo Serum levels of zinc and copper in patients with Parkinson's disease J. Neurol. Sci. 112 1992 30 33
139. J. Kadrabova, A. Madaric, M. Sustrova, and E. Ginter Changed serum trace element profile in Down's syndrome Biol. Trace Elem. Res. 54 1996 201 206
140. E. Kapaki, C. Zournas, G. Kanias, T. Zambelis, A. Kakami, and C. Papageorgiou Essential trace element alterations in amyotrophic lateral sclerosis J. Neurol. Sci. 47 1997 171 175
141. J. Kapur, and R.L. Macdonald Rapid seizure-induced reduction of benzodiazepine and Zn2+ sensitivity of hippocampal dentate granule cell GABAA receptors J. Neurosci. 17 1997 7532 7540
142. R.L. Katz, C.L. Keen, I.F. Litt, L.S. Hurley, K.M. Kellams-Harrison, and L.J. Glader Zinc deficiency in anorexia nervosa J. Adolesc. Health Care 8 1987 400 406
143. R.G. Kay, C. Tasman-Jones, J. Pybus, R. Whiting, and H. Black A syndrome of acute zinc deficiency during total parenteral alimentation in man Ann. Surg. 183 1976 331 340
144. K.A. Keller, A. Grider, and J.A. Coffield Age-dependent influence of dietary zinc restriction on short-term memory in male rats Physiol. Behav. 72 2001 339 348
145. C. Kenn, and E. Gibb The role of zinc in senile dementia Br. J. Psychiatry 149 1986 221 223
146. E.Y. Kim, J.Y. Koh, Y.H. Kim, S. Sohn, E. Joe, and B.J. Gwag Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures Eur. J. Neurosci. 11 1999 327 334
147. C.P. Kirschke, and L. Huang ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus J. Biol. Chem. 278 2003 4096 4102
148. M. Knipp, G. Meloni, B. Roschitzki, and M. Vasak Zn(7)Metallothionein-3 and the synaptic vesicle cycle: interaction of metallothionein-3 with the small GTPase Rab3A Biochemistry 44 2005 3159 3165
149. J.Y. Koh Zinc and disease of the brain Mol. Neurobiol. 24 2001 99 106
150. J.Y. Koh, and D.W. Choi Zinc toxicity on cultured cortical neurons: involvement of N-methyl-d-aspartate receptors Neuroscience 60 1994 1049 1057
151. J.Y. Koh, S.W. Suh, B.J. Gwag, Y.Y. He, C.Y. Hsu, and D.W. Choi The role of zinc in selective neuronal death after transient global cerebral ischemia Science 272 1996 1013 1016
152. D.M. Kovacs alpha2-macroglobulin in late-onset Alzheimer's disease Exp. Gerontol. 35 2000 473 479
153. K. Kretschmannova, I. Svobodova, and H. Zemkova Day-night variations in zinc sensitivity of GABAA receptor-channels in rat suprachiasmatic nucleus Brain Res. Mol. Brain Res. 120 2003 46 51
154. B. Lask, A. Fosson, U. Rolfe, and S. Thomas Zinc deficiency and childhood-onset anorexia nervosa J. Clin. Psychiatry 54 1993 63 66
155. 2+: a synergistic interplay between presynaptic P2X2 and postsynaptic glycine receptors Eur. J. Neurosci. 16 2002 1025 1036
156. W. Law, E.E. Kelland, P. Sharp, and N.J. Toms Characterisation of zinc uptake into rat cultured cerebrocortical oligodendrocyte progenitor cells Neurosci. Lett. 352 2003 113 116
157. J.Y. Lee, J.H. Kim, R.D. Palmiter, and J.Y. Koh Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury Exp. Neurol. 184 2003 337 347
158. J.Y. Lee, T.B. Cole, R.D. Palmiter, S.W. Suh, and J.Y. Koh Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice Proc. Natl. Acad. Sci. U.S.A. 99 2002 7705 7710
159. J.Y. Lee, T.B. Cole, R.D. Palmiter, and J.Y. Koh Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin J. Neurosci. 20 RC79 2000 1 5
160. H.M. Lehmann, B.B. Brothwell, L.P. Volak, and D.J. Bobilya Zinc status influences zinc transport by porcine brain capillary endothelial cells J. Nutr. 132 2002 2763 2768
161. J.B. Leverenz, and M.A. Raskind Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis Exp. Neurol. 150 1998 296 304
162. Y.V. Li, C.J. Hough, and J.M. Sarvey Do we need zinc to think? Sci. STKE 182 2003 pe19
163. Y. Li, C.J. Hough, C.J. Frederickson, and J.M. Sarvey Induction of mossy fiber → Ca3 long-term potentiation requires translocation of synaptically released Zn2+ J. Neurosci. 21 2001 8015 8025
164. F. Licastro, R.A. Mariani, G. Faldella, E. Carpene, G. Guidicini, A. Rangoni, T. Grilli, and G. Bazzocchi Immune-endocrine status and coeliac disease in children with Down's syndrome: relationships with zinc and cognitive efficiency Brain Res. Bull. 55 2001 313 317
165. F. Licastro, L.J. Davis, E. Mocchegiani, and N. Fabris Impaired peripheral zinc metabolism in patients with senile dementia of probable Alzheimer's type as shown by low plasma concentrations of thymulin Biol. Trace Elem. Res. 51 1996 55 62
166. F. Licastro, E. Mocchegiani, M. Masi, and N. Fabris Modulation of the neuroendocrine system and immune functions by zinc supplementation in children with Down's syndrome J. Trace Elem. Electrolytes Health Dis. 7 1993 237 239
167. F. Licastro, G. Savorani, G. Sarti, A. Salsi, F. Cavazzuti, L. Zanichelli, G. Tucci, E. Mocchegiani, and N. Fabris Zinc and thymic hormone-dependent immunity in normal aging and in patients with senile dementia of the Alzheimer type J. Neuroimmunol. 27 1990 201 208
168. J.P. Liuzzi, and R.J. Cousins Mammalian zinc transporters Annu. Rev. Nutr. 24 2004 151 172
169. M.A. Lovell, C. Xie, and W.R. Markesbery Protection against amyloid beta peptide toxicity by zinc Brain Res. 823 1999 88 95
170. M.A. Lovell, J.D. Robertson, W.J. Teesdale, J.L. Campbell, and W.R. Markesbery Copper, iron and zinc in Alzheimer's disease senile plaques J. Neurol. Sci. 158 1998 47 52
171. T. Lu, Y. Pan, S.Y. Kao, C. Li, I. Kohane, J. Chan, and B.A. Yankner Gene regulation and DNA damage in the aging human brain Nature 429 2004 883 891
172. A.M. Lynch, and M.A. Lynch The age-related increase in IL-1 type I receptor in rat hippocampus is coupled with an increase in caspase-3 activation Eur. J. Neurosci. 15 2002 1779 1788
173. N.J. Macdonald, F. Decorti, T.C. Pappas, and G. Taglialatela Cytokine/neurotrophin interaction in the aged central nervous system J. Anat. 197 2000 543 551
174. M. Maes, N. DeVos, A. Wauters, P. Demedts, V.W. Maurits, H. Neels, E. Bosmans, C. Altamura, A. Lin, C. Song, M. Vandenbroucke, and S. Scharpe Inflammatory markers in younger vs elderly normal volunteers and in patients with Alzheimer's disease J. Psychiatr. Res. 33 1999 397 405
175. M. Maes, E. Vandoolaeghe, H. Neels, P. Demedts, A. Wauters, H.Y. Meltzer, C. Altamura, and R. Desnyder Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflamatory response in that illness Biol. Psychiatry 42 1997 349 358
176. J. Magistretti, L. Castelli, V. Taglietti, and F. Tanzi Dual effect of Zn2+ on multiple types of voltage-dependent Ca2+ currents in rat palaeocortical neurons Neuroscience 117 2003 249 264
177. C.M. Maier, and P.H. Chan Role of superoxide dismutases in oxidative damage and neurodegenerative disorders Neuroscientist 8 2002 323 334
178. M. Mancini, A. Ricci, and F. Amenta Age-related changes in sulfide-silver staining in the rat neostriatum: a quantitative histochemical study Neurobiol. Aging 13 1992 501 504
179. W. Maret, and B.L. Vallee Thiolate ligands in metallothionein confer
180. D.S. Martin, P.E. Lonergan, B. Boland, M.P. Fogarty, M. Brady, D.F. Horrobin, V.A. Campbell, and M.A. Lynch Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid J. Biol. Chem. 277 2002 34239 34246
181. T.F. Massaro, M. Mohs, and G. Fosmire Effects of moderate zinc deficiency on cognitive performance in young adult rats Physiol. Behav. 29 1982 117 121
182. B.A. Masters, C.J. Quaife, J.C. Erickson, E.J. Kelly, G.J. Froelick, B.P. Zambrowicz, R.L. Brinster, and R.D. Palmiter Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles J. Neurosci. 14 1994 5844 5857
183. C.J. McClain, M.A. Stuart, B. Vivian, M. McClain, R. Talwalker, L. Snelling, and L. Humphries Zinc status before and after zinc supplementation of eating disorder patients J. Am. Coll. Nutr. 11 1992 694 700
184. W.J. McEntee, and T.H. Crook Age-associated memory impairment: a role for catecholamines Neurology 40 1990 526 530
185. P.L. McGeer, and E.G. McGeer Local neuroinflammation and the progression of Alzheimer's disease J. Neurovirol. 8 2002 529 538
186. R.N. McLay, S.M. Freeman, R.E. Harlan, C.F. Ide, A.J. Kastin, and J.E. Zadina Aging in the hippocampus: interrelated actions of neurotrophins and glucocorticoids Neurosci. Biobehav. Rev. 21 1997 615 629
187. C.A. McLean, R.A. Cherny, F.W. Fraser, S.J. Fuller, M.J. Smith, K. Beyreuther, A.I. Bush, and C.L. Masters Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease Ann. Neurol. 46 1999 860 866
188. I.J. Mcloughlin, and J.S. Hodje Zinc in depressive disorder Acta Psychiatr. Scand. 82 1990 451 453
189. P. Mecocci, A. Cherubini, E. Mariani, C. Ruggiero, and U. Senin Depression in the elderly: new concepts and therapeutic approaches Aging Clin. Exp. Res. 16 2004 176 189
190. W. Meier-Ruge, P. Iwangoff, and K. Reichlmeier Neurochemical enzyme changes in Alzheimer's and Pick's disease Arch. Gerontol. Geriatr. 3 1984 161 165
191. C. Meplan, M.J. Richard, and P. Hainaut Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells Oncogene 19 2000 5227 5236
192. M. Mira, P.M. Stewart, and S.F. Abraham Vitamin and trace element status of women with disordered eating Am. J. Clin. Nutr. 50 1989 904 940
193. M. Miyamoto Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10 Exp. Gerontol. 32 1997 139 148
194. I. Miyazaki, M. Asanuma, Y. Higashi, C.A. Sogawa, K. Tanaka, and N. Ogawa Age-related changes in expression of metallothionein-III in rat brain Neurosci. Res. 43 2002 323 333
195. E. Mocchegiani, R. Giacconi, C. Cipriano, E. Muti, N. Gasparini, and M. Malavolta Are zinc-bound metallothionein isoforms (I + II and III) involved in impaired thymulin production and thymic involution during aging? Immun. Aging 1 2004 5 16
196. E. Mocchegiani, R. Giacconi, C. Cipriano, N. Gasparini, G. Bernardini, M. Malavolta, M. Menegazzi, E. Cavalieri, M. Muzzioli, A.R. Ciampa, and H. Suzuki The variations during the circadian cycle of liver CD1d-unrestricted NK1.1 + TCR gamma/delta + cells lead to successful aging. Role of metallothionein/IL-6/ gp130/PARP-1 interplay in very old mice Exp. Gerontol. 39 2004 775 788
197. E. Mocchegiani, R. Giacconi, P. Fattoretti, T. Casoli, C. Cipriano, E. Muti, M. Malavolta, G. DiStefano, and C. Bertoni-Freddari Metallothionein isoforms (I + II and III) and interleukin-6 in the hippocampus of old rats: may their concomitant increments lead to neurodegeneration? Brain Res. Bull. 63 2004 133 142
198. E. Mocchegiani, M. Muzzioli, R. Giacconi, T. Casoli, G. DiStefano, and P. Fattoretti Zinc, brain and aging P. Zatta Metal Ions and Neurodegenerative Diseases 2004 World Scientific Publishing Singapore 139 181
199. E. Mocchegiani, R. Giacconi, E. Muti, M. Muzzioli, and C. Cipriano Plasticity of neuroemdocrine-thymus interactions during ontogeny and aging: role of zinc R.H. Straub E. Mocchegiani The Neuroendocrine Immune Network in Aging 2004 Elsevier Amsterdam 307 329
200. E. Mocchegiani, M. Muzzioli, R. Giacconi, C. Cipriano, N. Gasparini, C. Franceschi, R. Gaetti, E. Cavalieri, and H. Suzuki Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply Mech. Aging Dev. 124 2003 459 468
201. E. Mocchegiani, R. Giacconi, C. Cipriano, M. Muzzioli, N. Gasparini, R. Moresi, R. Stecconi, H. Suzuki, E. Cavalieri, and E. Mariani MtmRNA gene expression, via IL-6 and glucocorticoids, as potential genetic marker of immunosenescence: lessons from very old mice and humans Exp. Gerontol. 37 2002 349 357
202. E. Mocchegiani, R. Giacconi, C. Cipriano, M. Muzzioli, P. Fattoretti, C. Bertoni-Freddari, G. Isani, P. Zambenedetti, and P. Zatta Zinc-bound metallothioneins as potential biological markers of aging Brain Res. Bull. 55 2001 147 153
203. E. Mocchegiani, M. Muzzioli, and R. Giacconi Zinc and immunoresistance to infection in aging: new biological tools Trends Pharmacol. Sci. 21 2000 205 208
204. E. Mocchegiani, M. Muzzioli, and R. Giacconi Zinc, metallothioneins, immune responses, survival and aging Biogerontology 1 2000 133 143
205. E. Mocchegiani, A. Ciavattini, L. Santarelli, A. Ribaldi, M. Muzzioli, P. Bonazzi, R. Giacconi, N. Fabris, and G.G. Garretti Role of zinc and alpha2 macroglobulin on thymic endocrine activity and on peripheral immune efficiency (natural killer activity and interleukin 2) in cervical carcinoma Br. J. Cancer 79 1999 244 250
206. E. Mocchegiani, M. Muzzioli, C. Cipriano, and R. Giacconi Zinc, T-cell pathways, aging: role of metallothioneins Mech. Aging Dev. 106 1998 183 204
207. J.H. Morrison, and P.R. Hof Life and death of neurons in the aging brain Science 278 1997 412 419
208. R.E. Mrak, S.T. Griffin, and D.I. Graham Aging-associated changes in human brain J. Neuropathol. Exp. Neurol. 56 1997 1269 1275
209. Y. Nakamura Isolation of p53-target genes and their functional analysis Cancer Sci. 95 2004 7 11
210. P. Murphy, I. Wadiwala, D.E. Sharland, and G.S. Rai Copper and zinc levels in "healthy" and "sick" elderly J. Am. Geriatr. Soc. 33 1985 847 849
211. H. Nagata, S. Miyata, S. Nakamura, M. Kameyama, and Y. Katsui Heavy metal concentrations in blood cells in patients with amyotrophic lateral sclerosis J. Neurol. Sci. 67 1985 173 178
212. M.M. Nicolle, M. Gallagher, and M. McKinney No loss of synaptic proteins in the hippocampus of aged, behaviorally impaired rats Neurobiol. Aging 20 1999 343 348
213. R.L. Noble, and R.P. Warren Analysis of blood cell populations, plasma zinc and natural killer cell activity in young children with Down's syndrome J. Ment. Defic. Res. 32 1988 193 201
214. R. Palm, and G. Hallmans Zinc and copper in multiple sclerosis J. Neurol. Neurosurg. Psychiatry 45 1982 691 698
215. R.D. Palmiter The elusive function of metallothioneins Proc. Natl. Acad. Sci. U.S.A. 95 1998 8428 8430
216. R.D. Palmiter, T.B. Cole, C.J. Quaife, and S.D. Findley ZnT-3, a putative transporter of zinc into synaptic vesicles Proc. Natl. Acad. Sci. U.S.A. 93 1996 14934 14939
217. A.E. Panayi, N.M. Spyrou, B.S. Iversen, M.A. White, and P. Part Determination of cadmium and zinc in Alzheimer's brain tissue using inductively coupled plasma mass spectrometry J. Neurol. Sci. 195 2002 1 10
218. Z.P. Pang, D.S. Wang, T.L. Xu, and J.S. Li Zn2+ depresses GABAA receptor mediated responses in acutely dissociated sacral dorsal commissural neurons Sheng Li Xue Bao. 50 1998 649 655
219. A. Pascale, S. Govoni, and F. Battaini Age-related alteration of PKC, a key enzyme in memory processes: physiological and pathological examples Mol. Neurobiol. 16 1998 49 62
220. L. Patrick Eating disorders: a review of the literature with emphasis on medical complications and clinical nutrition Altern. Med. Rev. 7 2002 184 202
221. M. Penkowa, S. Florit, M. Giralt, A. Quintana, A. Molinero, J. Carrasco, and J. Hidalgo Metallothionein reduces central nervous system inflammation, neurodegeneration, and cell death following kainic acid-induced epileptic seizures J. Neurosci. Res. 79 2005 522 534
222. M. Penkowa, H. Nielsen, J. Hidalgo, and N. Bernth Moos T. Distribution of metallothionein I + II and vesicular zinc in the developing central nervous system: correlative study in the rat J. Comp. Neurol. 412 1999 303 318
223. J. Penland, H. Sanstead, N. Egger, H. Dayal, N. Alcock, R. Plotkin, C. Rocco, and A. Zavaleta Zinc, iron and micronutrient supplementation effects on cognitive and psychomotor function of Mexican-American school children FASEB J. 13 1999 921
224. J.G. Penland, H.H. Sandstead, N.W. Alcock, H.H. Dayal, X.C. Chen, J.S. Li, F. Zhao, and J.J. Yang A preliminary report: effects of zinc and micronutrients repletion on growth and neuropsychological function of urban Chinese children J. Am. Coll. Nutr. 16 1997 268 272
225. T. Pepersack, P. Rotsaert, F. Benoit, D. Willems, M. Fuss, P. Bourdoux, and J. Duchateau Prevalence of zinc deficiency and its clinical relevance among hospitalised elderly Arch. Gerontol. Geriatr. 33 2001 243 253
226. J. Perez-Clausell, and G. Danscher Intravesicular localization of zinc in rat telencephalic boutons. A histochemical study Brain Res. 337 1985 91 98
227. A. Persechini, K. McMillan, and B.S. Masters Inhibition of nitric oxide synthase activity by Zn2+ ion Biochemistry 34 1995 15091 15095
228. C.C. Pfeiffer, and U. Ilier A study of zinc deficiency and copper excess in the schizophrenias Int. Rev. Neurobiol. (Suppl.) 1 1972 141 165
229. M. Planas, M. Conde, S. Audivert, C. Perez-Portabella, R. Burgos, P. Chacon, J. Rossello, M. Boada, and L.L. Tarraga Micronutrient supplementation in mild Alzheimer disease patients Clin. Nutr. 23 2004 265 272
230. M. Pollack, S. Phaneuf, A. Dirks, and C. Leeuwenburgh The role of apoptosis in the normal aging brain, skeletal muscle, and heart Ann. N.Y. Acad. Sci. 959 2002 93 107
231. A.S. Prasad, J.A. Halsted, and M. Nadimi Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia Am. J. Med. 31 1961 532 546
232. C.W. Pratt, and S.V. Pizzo The effect of zinc and other divalent cations on the structure and function of human alpha 2-macroglobulin Biochim. Biophys. Acta 791 1984 123 130
233. C.J. Quaife, E.J. Kelly, B.A. Masters, R.L. Brinster, and R.D. Palmiter Ectopic expression of metallothionein-III causes pancreatic acinar cell necrosis in transgenic mice Toxicol. Appl. Pharmacol. 148 1998 148 157
234. R. Rahil-Khazen, B.J. Bolann, A. Myking, and R.J. Ulvik Multi-element analysis of trace element levels in human autopsy tissues by using inductively coupled atomic emission spectrometry technique (ICP-AES) J. Trace Elem. Med. Biol. 16 2002 15 25
235. T.S. Rajeswari, and E. Radha Metabolism of the glutamate group of amino acids in rat brain as a function of age Mech. Aging Dev. 24 1984 139 149
236. F.A. Rassendren, P. Lory, J.P. Pin, and J. Nargeot Zinc has opposite effects on NMDA and non-NMDA receptors expressed in Xenopus oocytes Neuron 4 1990 733 740
237. A. Ricci, M.T. Ramacci, O. Ghirardi, and F. Amenta Age-related changes of the mossy fibre system in rat hippocampus: effect of long term acetyl-l-carnitine treatment Arch. Gerontol. Geriatr. 8 1989 63 71
238. H.P. Rieder, G. Schoettli, and H. Seiler Trace elements in whole blood of multiple sclerosis Eur. Neurol. 22 1983 85 92
239. C.W. Ritchie, A.I. Bush, and C.L. Masters Metal-protein attenuating compounds and Alzheimer's disease Expert Opin. Investig. Drugs 13 2004 1585 1592
240. C.W. Ritchie, A.I. Bush, A. Mackinnon, S. Macfarlane, M. Mastwyk, L. MacGregor, L. Kiers, R. Cherny, Q.X. Li, A. Tammer, D. Carrington, C. Mavros, I. Volitakis, M. Xilinas, D. Ames, S. Davis, K. Beyreuther, R.E. Tanzi, and C.L. Masters Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial Arch. Neurol. 60 2003 1685 1691
241. A. Rolfs, and M.A. Hediger Metal ion transporters in mammals: structure, function and pathological implications J. Physiol. 518 1999 1 12
242. L.L. Rulon, J.D. Robertson, M.A. Lovell, M.A. Deibel, W.D. Ehmann, and W.R. Markesber Serum zinc levels and Alzheimer's disease Biol. Trace Elem. Res. 75 2000 79 85
243. R.J. Rylett, and L.R. Williams Role of neurotrophins in cholinergic-neurone function in the adult and aged CNS Trends Neurosci. 17 1994 486 490
244. T. Saito, K. Takahashi, N. Nakagawa, T. Hosokawa, M. Kurasaki, O. Yamanoshita, Y. Yamamoto, H. Sasaki, K. Nagashima, and H. Fujita Deficiencies of hippocampal Zn and ZnT3 accelerate brain aging of rat Biochem. Biophys. Res. Commun. 279 2000 505 511
245. D.L. Samudralwar, C.C. Diprete, B.F. Ni, W.D. Ehmann, and W.R. Markesbery Elemental imbalances in the olfactory pathway in Alzheimer's disease J. Neurol. Sci. 130 1995 139 145
246. P.S. Sastry, and K.S. Rao Apoptosis and the nervous system J. Neurochem. 74 2000 1 20
247. S. Sazawal, M. Bentley, R.E. Black, P. Dhingra, S. George, and M.K. Bhan Effect of zinc supplementation on observed activity in low socioeconomic Indian preschool children Pediatrics 98 1996 1132 1137
248. S.W. Scheff, K.J. Anderson, and S.T. DeKosky Strain comparison of syn-aptic density in hippocampal CA1 of aged rats Neurobiol. Aging 6 1985 29 34
249. G. Segovia, A. Porrai, A. Del Arco, and F. Mora Glutamatergic neurotransmission in aging: a critical perspective Mech. Aging Dev. 122 2001 1 29
250. S.L. Sensi, and J.M. Jeng Rethinking the excitotoxic ionic milieu: the emerging role of Zn(2+) in ischemic neuronal injury Curr. Mol. Med. 4 2004 87 111
251. S.L. Sensi, D. Ton-That, and J.H. Weiss Mitochondrial sequestration and Ca(2+)-dependent release of cytosolic Zn(2+) loads in cortical neurons Neurobiol. Dis. 10 2002 100 108
252. M. Seve, F. Chimienti, S. Devergnas, and A. Favier In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression BMC Genom. 5 2004 32 36
253. C.T. Sheline, H. Wang, A.L. Cai, V.L. Dawson, and D.W. Choi Involvement of poly ADP ribosyl polymerase-1 in acute but not chronic zinc toxicity Eur. J. Neurosci. 18 2003 1402 1409
254. D. Shore, R.I. Henkin, N.R. Nelson, R.P. Agarwal, and R.J. Wyatt Hair and serum copper, zinc, calcium, and magnesium concentrations in Alzheimer-type dementia J. Am. Geriatr. Soc. 32 1984 892 895
255. D.M. Skovronsky, D.B. Moore, M.E. Milla, R.W. Doms, and V.M. Lee Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network J. Biol. Chem. 275 2000 2568 2575
256. L. Slomianka Neurons of origin of zinc-containing pathways and the distribution of zinc-containing boutons in the hippocampal region of the rat Neuroscience 48 1992 325 352
257. T.G. Smart, X. Xie, and B.J. Krishek Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc Prog. Neurobiol. 42 1994 341 393
258. D.K. Smith, E.B. Feldman, and D.S. Feldman Trace element status in multiple sclerosis Am. J. Clin. Nutr. 50 1989 136 140
259. V.A. Soldatenkov, and V.N. Potaman DNA-binding properties of poly(ADP-ribose) polymerase: a target for anticancer therapy Curr. Drug Targets 5 2004 357 365
260. J.C. Sorensen, B. Mattsson, A. Andreasen, and B.B. Johansson Rapid disappearance of zinc positive terminals in focal brain ischemia Brain Res. 812 1998 265 269
261. L. Sottrup-Jensen, O. Sand, L. Kristensen, and G.H. Fey The alpha-macroglobulin bait region. Sequence diversity and localization of cleavage sites for proteinases in five mammalian alpha-macroglobulins J. Biol. Chem. 264 1989 15781 15789
262. D.U. Spahl, D. Berendji-Grun, C.V. Suschek, V. Kolb-Bachofen, and K.D. Kroncke Regulation of zinc homeostasis by inducible NO synthase-derived NO: nuclear metallothionein translocation and intranuclear Zn2+ release Proc. Natl. Acad. Sci. U.S.A. 100 2003 13952 13957
263. P.C. Stanley, and V.C. Wakwe Toxic trace metals in the mentally ill patients Niger. Postgrad. Med. J. 9 2002 199 204
264. C.M. St Croix, K.J. Wasserloos, K.E. Dineley, I.J. Reynolds, E.S. Levitan, and B.R. Pitt Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein Am. J. Physiol. Lung Cell Mol. Physiol. 282 2002 L185 L192
265. G.R. Stewart, C.J. Frederickson, G.A. Howell, and F.H. Gage Cholinergic denervation-induced increase of chelatable zinc in mossy-fiber region of the hippocampal formation Brain Res. 290 1984 43 51
266. J.B. Strosznajder, H. Jesko, and R.P. Strosznajder Age-related alteration of poly(ADP-ribose) polymerase activity in different parts of the brain Acta Biochim. Pol. 47 2000 331 337
267. F.M. Sturtevant Zinc deficiency, acrodermatitis enteropathica, optic atrophy, subacute myelo-optic neuropathy, and 5,7-dihalo-8-quinolinols Pediatrics 65 1980 610 613
268. S.W. Suh, J.W. Chen, M. Motamedi, B. Bell, K. Listiak, N.F. Pons, G. Danscher, and C.J. Frederickson Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury Brain Res. 852 2000 268 273
269. S.W. Suh, K.B. Jensen, M.S. Jensen, D.S. Silva, P.J. Kesslak, G. Danscher, and C.J. Frederickson Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains Brain Res. 852 2000 274 278
270. P.A. Szweda, B. Friguet, and L.I. Szweda Proteolysis, free radicals, and aging Free Radic. Biol. Med. 33 2002 29 36
271. S. Takahashi, I. Takahashi, H. Sato, Y. Kubota, S. Yoshida, and Y. Muramatsu Age-related changes in the concentrations of major and trace elements in the brain of rats and mice Biol. Trace Elem. Res. 80 2001 145 158
272. A. Takeda, A. Minami, Y. Seki, and N. Oku Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus J. Neurosi. Res. 75 2004 225 229
273. A. Takeda, M. Hirate, H. Tamano, and N. Oku Release of glutamate and GABA in the hippocampus under zinc deficiency J. Neurosci. Res. 72 2003 537 542
274. A. Takeda, M. Suzuki, and N. Oku Possible involvement of plasma histidine in differential brain permeability to zinc and cadmium Biometals 15 2002 371 375
275. A. Takeda Zinc homeostasis and functions of zinc in the brain Biometals 14 2001 343 351
276. A. Takeda Movement of zinc and its functional significance in the brain Brain Res. Brain Res. Rev. 34 2000 137 148
277. D.R. Thomas, R. Hailwood, B. Harris, P.A. Williams, M.F. Scanlon, and R. John Thyroid status in senile dementia of the Alzheimer type (SDAT) Acta Psychiatr. Scand. 76 1987 158 163
278. R.B. Thompson, D. Peterson, W. Mahoney, M. Cramer, B.P. Maliwal, S.W. Suh, C. Frederickson, C. Fierke, and P. Herman Fluorescent zinc indicators for neurobiology J. Neurosci. Meth. 118 2002 63 75
279. C.M. Thompson, W.R. Markesbery, W.D. Ehmann, Y.-X. Mao, and D.E. Vance Regional brain trace element studies in Alzheimer's disease Neurotoxicology 9 1988 1 7
280. N. Tonder, F.F. Johansen, C.J. Frederickson, J. Zimmer, and N.H. Diemer Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat Neurosci. Lett. 109 1990 247 252
281. L. Tong, T. Toliver-Kinsky, M. Edwards, D.K. Rassin, K. Werrbach-Perez, and J.R. Perez-Polo Attenuated transcriptional responses to oxidative stress in the aged rat brain J. Neurosi. Res. 70 2002 318 326
282. A.Q. Truong-Tran, J. Carter, R.E. Ruffin, and P.D. Zalewski The role of zinc in caspase activation and apoptotic cell death Biometals 14 2001 315 330
283. H.J. Tsay, P. Wang, S.L. Wang, and H.H. Ku Age-associated changes of superoxide dismutase and catalase activities in the rat brain J. Biomed. Sci. 7 2000 466 474
284. Y. Uchida, K. Takio, K. Titani, Y. Ihara, and M. Tomonaga The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein Neuron 7 1991 337 347
285. C.J. Van Binsbergen, J. Odink, H. Van den Berg, H. Koppeschaar, and H.J. Coelingh Bennink Nutritional status in anorexia nervosa: clinical chemistry, vitamins, iron and zinc Eur. J. Clin. Nutr. 42 1988 929 937
286. M.P. Vaquero Magnesium and trace elements in the elderly: intake, status and recommendations J. Nutr. Health Aging 6 2002 147 153
287. A.V. Vener, M.V. Aksenova, and G.Sh. Burbaeva Drastic reduction of the zinc- and magnesium-stimulated protein tyrosine kinase activities in Alzheimer's disease hippocampus FEBS Lett. 328 1993 6 8
288. M. Vinceti, M. Bergomi, G. Nacci, V. Pietrini, A. Ferrari, K. Fortini, D. Guidetti, P. Sola, E. Rocchi, D. Mancia, and G. Vivoli Erythrocyte zinc, copper, and copper/zinc superoxide dismutase and risk of sporadic amyotrophic lateral sclerosis: a population-based case-control study Amyotroph. Lateral. Scler. Other. Motor. Neuron. Disord. 3 2002 208 214
289. W.J. Walsh, A. Usman, and J. Tarpey Disordered metal metabolism in a large autism population Proceedings of the American Psychiatric Association. New Research: Abstract NR109 New Orleans, USA 2001
290. Z. Wang, G. Danscher, Y.K. Kim, A. Dahlström, and S.M. Jo Inhibitory zinc-enriched terminals in the mouse cerebellum: double-immunohistochemistry for zinc transporter 3 and glutamate decarboxylase Neurosci. Lett. 321 2002 37 40
291. Z. Wang, G. Danscher, S.M. Jo, Y. Shi, Daa, and H. Schrøder Retrograde tracing of zinc-enriched (ZEN) neuronal somata in rat spinal cord Brain Res. 900 2001 80 87
292. Z. Wang, J.Y. Li, A. Dahlström, and Danscher G Zinc-enriched GABAergic terminals in mouse spinal cord Brain Res. 921 2001 165 172
293. W. Watjen, H. Haase, M. Biagioli, and D. Beyersmann Induction of apoptosis in mammalian cells by cadmium and zinc Environ. Health Perspect. 110 Suppl. 5 2002 865 867
294. X. Wei, Y. Zhang, and J. Zhou Alzheimer's disease-related gene expression in the brain of senescence accelerated mouse Neurosci. Lett. 268 1999 139 142
295. J.H. Weiss, S.L. Sensi, and J.Y. Koh Zn(2+): a novel ionic mediator of neural injury in brain disease Trends Pharmacol. Sci. 21 2000 395 401
296. P. Widlak, and W.T. Garrard Ionic and cofactor requirements for the activity of the apoptotic endonuclease DFF40/CAD Mol. Cell Biochem. 218 2001 125 130
297. K. Williams Separating dual effects of zinc at recombinant N-methyl-d-aspartate receptors Neurosci. Lett. 215 1996 9 12
298. R.J. Williams, J.P. Spencer, F.M. Goni, and C.A. Rice-Evans Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage Neurosci. Lett. 371 2004 106 110
299. T.L. Williamson, L.I. Bruijn, Q. Zhu, K.L. Anderson, S.D. Anderson, J.P. Julien, and D.W. Cleveland Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant Proc. Natl. Acad. Sci. U.S.A. 95 1998 9631 9636
300. G. Wolf, and W. Schmidt Zinc and glutamate dehydrogenase in putative glutamatergic brain structures Acta Histochem. 72 1983 15 23
301. B.S. Wong, S.G. Chen, M. Colucci, Z. Xie, T. Pan, T. Liu, R. Li, P. Gambetti, M.S. Sy, and D.R. Brown Aberrant metal binding by prion protein in human prion disease J. Neurochem. 78 2001 1400 1408
302. X. Xie, U. Gerber, B.H. Gahwiler, and T.G. Smart Interaction of zinc with ionotropic and metabotropic glutamate receptors in rat hippocampal slices Neurosci. Lett. 159 1993 46 50
303. S. Yajima, C.H. Lammers, S.H. Lee, Y. Hara, K. Mizuno, and M.M. Mouradian Cloning and characterization of murine glial cell-derived neurotrophic factor inducible transcription factor (MGIF) J. Neurosci. 17 1997 8657 8666
304. M. Yanik, A. Kocyigit, H. Tutkun, H. Vural, and H. Herken Plasma manganese, selenium, zinc, copper, and iron concentrations in patients with schizophrenia Biol. Trace Elem. Res. 98 2004 109 117
305. A.B. Young, L.G. Ott, D. Beard, R.J. Dempsey, P.A. Tibbs, and C.J. McClain The acute-phase response of the brain-injured patient J. Neurosurg. 69 1988 375 380
306. W.H. Yu, W.J. Lukiw, C. Bergeron, H.B. Niznik, and P.E. Fraser Metallothionein III is reduced in Alzheimer's disease Brain Res. 894 2001 37 45
307. P.D. Zalewski, I.J. Forbes, and W.H. Betts Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p- toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II) Biochem. J. 296 1993 403 408
308. P. Zambenedetti, R. Giordano, and P. Zatta Metallothioneins are highly expressed in astrocytes and microcapillaries in Alzheimer's disease J. Chem. Neuroanat. 15 1998 21 26
309. J. Zeng, R. Heuchel, W. Schaffner, and J.H. Kagi Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Sp1 FEBS Lett. 279 1991 310 312