Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract

Physiology of the Gastrointestinal Tract

Volumn 1, Issue , 2006, Pages 685-725

  Beyak, Michael J ^a,b   Bulmer, David C E ^b   Jiang, Wen ^b   Keating, C ^b   Rong, Weifang ^b   Grundy, David ^b  

^a QUEEN S UNIVERSITY   (Canada)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33646181531     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088394-3/50028-3     Document Type: Chapter

References (447)

1. Sengupta JN, Gebhart GF Gastrointestinal afferent fibers and sensation. Physiology of the gastrointestinal tract 1994, 483-520. Raven Press, New York. 3rd ed. L.R. Johnson (Ed.).
2. Le Douarin NM, Kaleheim C, Teillet M-A The cellular and molecular basis of early sensory ganglion development. Sensory neurons: diversity, development and plasticity 1992, 143-170. Oxford University Press, New York. S.A. Scott (Ed.).
3. Yu S, Kollarik M, Lacy BE, Undem BJ Subtypes of the capsaicin-sensitive vagal C-fibers in guinea pig esophagus. Gastroenterology 2004, 126:1424.
4. Undem BJ, Chuaychoo B, Lee MG, Weinreich D, Myers AC, Kollarik M Two distinct phenotypes of vagal afferent C-fibers innervating the lungs. J Physiol 2004, 556:905-917.
5. Sang Q, Young HM The origin and development of the vagal and spinal innervation of the external muscle of the mouse esophagus. Brain Res 1998, 809:253-268.
6. Ratcliffe ER, Setru SU, Chen JJ, D'Autreaux F, Gershon MD Enteric netrins are chemoattractants for deleted in colorectal cancer (DCC)-expressing vagal sensory axons in the fetal gut. Gastroenterology 2004, 126:A17.
7. Lawson SN, Biscoe TJ Development of mouse dorsal root ganglia: an autoradiographic and quantitative study. J Neurocytol 1979, 8:265-274.
8. Ma Q, Fode C, Guillemot F, Anderson DJ Neurogenini and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia. Genes Dev 1999, 13:1717-1728.
9. Davies AM Intrinsic differences in the growth rate of early nerve fibers related to target distance. Nature 1989, 337:553-555.
10. Kennedy TE, Tessier-Lavigne M Guidance and induction of branch formation in developing axons by target-derived diffusible factors. Curr Opin Neurobiol 1995, 5:83-90.
11. Lewin GR, Barde YA Physiology of the neurotrophins. Annu Rev Neurosci 1996, 19:289-317.
12. Young HM, Anderson RB, Anderson CR Guidance cues involved in the development of the peripheral autonomic nervous system. Auton Neurosci 2004, 112:1-14.
13. Anderson CN, Ohta K, Quick MM, Fleming A, Keynes R, Tannahill D Molecular analysis of axon repulsion by the notochord. Development 2003, 130:1123-1133.
14. De Bellard ME, Rao Y, Bronner-Fraser M Dual function of Slit2 in repulsion and enhanced migration of trunk, but not vagal, neural crest cells. J Cell Biol 2003, 162:269-279.
15. Krull CE, Lansford R, Gale NW, Collazo A, Marcelle C, Yancopoulos GD, Fraser SE, Bronner-Fraser M Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration. Curr Biol 1997, 7:571-580.
16. Dickson BJ, Keleman K Netrins. Curr Biol 2002, 12:R154-R155.
17. Jiang Y, Liu MT, Gershon MD Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas. Dev Biol 2003, 258:364-384.
18. Levi-Montalcini R The nerve growth factor 35 years later. Science 1987, 237:1154-1162.
19. Markus A, Patel TD, Snider WD Neurotrophic factors and axonal growth. Curr Opin Neurobiol 2002, 12:523-531.
20. Forgie A, Kuehnel F, Wyatt S, Davies AM In vivo survival requirement of a subset of nodose ganglion neurons for nerve growth factor. Eur J Neurosci 2000, 12:670-676.
21. Bennett DL, Averill S, Clary DO, Priestley JV, McMahon SB Postnatal changes in the expression of the trkA high-affinity NGF receptor in primary sensory neurons. Eur J Neurosci 1996, 8:2204-2208.
22. Beyak MJ, Ramji N, Krol KM, Kawaja MD, Vanner SJ Two TTX-resistant sodium currents in mouse colonic dorsal root ganglia neurons and their role in colitis induced hyperexcitability. Am J Physiol Gastrointest Liver Physiol 2004, 287:G845-G855.
23. Robinson DR, McNaughton PA, Evans ML, Hicks GA Characterization of the primary spinal afferent innervation of the mouse colon using retrograde labelling. Neurogastroenterol Motil 2004, 16:113-124.
24. Brady R, Zaidi SI, Mayer C, Katz DM BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons. J Neurosci 1999, 19:2131-2142.
25. Buchman VL, Davies AM Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons. Development 1993, 118:989-1001.
26. ElShamy WM, Ernfors P Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 complement and cooperate with each other sequentially during visceral neuron development. J Neurosci 1997, 17:8667-8675.
27. Fox EA, Phillips RJ, Baronowsky EA, Byerly MS, Jones S, Powley TL Neurotrophin-4 deficient mice have a loss of vagal intraganglionic mechanoreceptors from the small intestine and a disruption of short-term satiety. J Neurosci 2001, 21:8602-8615.
28. Newgreen D, Young HM Enteric nervous system: development and developmental disturbances-part 2. Pediatr Dev Pathol 2002, 5:329-349.
29. Forgie A, Doxakis E, Buj-Bello A, Wyatt S, Davies AM Differences and developmental changes in the responsiveness of PNS neurons to GDNF and neurturin. Mol Cell Neurosci 1999, 13:430-440.
30. Wank M, Neuhuber WL Local differences in vagal afferent innervation of the rat esophagus are reflected by neurochemical differences at the level of the sensory ganglia and by dif brainstem projections. J Comp Neurol 2001, 435:41-59.
31. Yoshida Y, Tanaka Y, Hirano M, Nakashima T Sensory innervation of the pharynx and larynx. Am J Med 2000, 108(suppl 4a):51S-61S.
32. Powley TL, Prechtl JC, Fox EA, Berthoud HR Anatomical considerations for surgery of the rat abdominal vagus: distribution, paraganglia and regeneration. J Auton Nerv Syst 1983, 9:79-97.
33. Prechtl JC, Powley TL Organization and distribution of the rat subdi-aphragmatic vagus and associated paraganglia. J Comp Neurol 1985, 235:182-195.
34. Berthoud HR, Carlson NR, Powley TL Topography of efferent vagal innervation of the rat gastrointestinal tract. Am J Physiol 1991, 260:R200-R207.
35. Berthoud HR, Powley TL Vagal afferent innervation of the rat fundic stomach: morphological characterization of the gastric tension receptor. J Comp Neurol 1992, 319:261-276.
36. Phillips RJ, Powley TL Gastric volume detection after selective vagotomies in rats. Am J Physiol 1998, 274:R1626-R1638.
37. Berthoud HR, Kressel M, Neuhuber WL An anterograde tracing study of the vagal innervation of rat liver, portal vein and biliary system. Anat Embryol (Berl) 1992, 186:431-442.
38. Phillips RJ, Baronowsky EA, Powley TL Afferent innervation of gastrointestinal tract smooth muscle by the hepatic branch of the vagus. J Comp Neurol 1997, 384:248-270.
39. Zhang X, Renehan WE, Fogel R Vagal innervation of the rat duodenum. J Auton Nerv Syst 2000, 79:8-18.
40. Altschuler SM, Escardo J, Lynn RB, Miselis RR The central organization of the vagus nerve innervating the colon of the rat. Gastroenterology 1993, 104:502-509.
41. Berthoud HR, Neuhuber WL Functional and chemical anatomy of the afferent vagal system. Auton Neurosci 2000, 85:1-17.
42. Berthoud HR, Blackshaw LA, Brookes SJ, Grundy D Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract. Neurogastroenterol Motil 2004, 16(suppl 1):28-33.
43. Cervero F Sensory innervation of the viscera: peripheral basis of visceral pain. Physiol Rev 1994, 74:95-138.
44. Gillis RA, Quest JA, Pagani FD, Norman WP Control centres in the central nervous system for regulating gastrointestinal motility. Physiology of the gastrointestinal tract 1994, 621-683. Raven Press, New York. 3rd ed. J. LR (Ed.).
45. Cervero F, Foreman RD Sensory innervation of the viscera. Central regulation of autonomie functions 1990, 104-125. Oxford University Press, New York. A.D. Loewy, K.M. Spyer (Eds.).
46. Ma RC, Szurszewski JH Modulation by opioid peptides of mechanosensory pathways supplying the guinea-pig inferior mesenteric ganglion. J Physiol 1996, 491:435-445. pt 2.
47. Cervero F, Connell LA Distribution of somatic and visceral primary afferent fibers within the thoracic spinal cord of the cat. J Comp Neurol 1984, 230:88-98.
48. Morgan C, Nadelhaft I, de Groat WC The distribution of visceral primary afferents from the pelvic nerve to Lissauer's tract and the spinal gray matter and its relationship to the sacral parasympathetic nucleus. J Comp Neurol 1981, 201:415-440.
49. Nadelhaft I, Booth AM The location and morphology of preganglionic neurons and the distribution of visceral afferents from the rat pelvic nerve: a horseradish peroxidase study. J Comp Neurol 1984, 226:238-245.
50. Vizzard MA, Brisson M, de Groat WC Transneuronal labeling of neurons in the adult rat central nervous system following inoculation of pseudorabies virus into the colon. Cell Tissue Res 2000, 299:9-26.
51. Costa M, Brookes SH, Zagorodnyuk V How many kinds of visceral afferents?. Gut 2004, 53:111-114. suppl 2.
52. Grundy D, Scratcherd T Sensory afferents from the gastrointestinal tract. The gastrointestinal system 1989, Vol. 1:593-620. MD: American Physiological Society, Bethesda. J.D. Wood (Ed.).
53. Powley TL, Phillips RJ Musings on the wanderer: what's new in our understanding of vago-vagal reflexes? I. Morphology and topography of vagal afferents innervating the GI tract. Am J Physiol Gastrointest Liver Physiol 2002, 283:G1217-G1225.
54. Berthoud HR, Kressel M, Raybould HE, Neuhuber WL Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by in vivo Dil-tracing. Anat Embryol (Berl) 1995, 191:203-212.
55. Berthoud HR, Patterson LM Anatomical relationship between vagal afferent fibers and CCK-immunoreactive entero-endocrine cells in the rat small intestinal mucosa. Acta Anat (Basel) 1996, 156:123-131.
56. Wang FB, Powley TL Topographic inventories of vagal afferents in gastrointestinal muscle. J Comp Neurol 2000, 421:302-324.
57. Neuhuber WL, Kressel M, Stark A, Berthoud HR Vagal efferent and afferent innervation of the rat esophagus as demonstrated by antero-grade Dil and DiA tracing: focus on myenteric ganglia. J Auton Nerv Syst 1998, 70:92-102.
58. Brierley SM, Jones RC III, Gebhart GF, Blackshaw LA Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice. Gastroenterology 2004, 127:166-178.
59. Hicks GA, Coldwell JR, Schindler M, Ward PA, Jenkins D, Lynn PA, Humphrey PP, Blackshaw LA Excitation of rat colonic afferent fibers by 5-HT (3) receptors. J Physiol 2002, 544:861-869.
60. Lynn PA, Blackshaw LA In vitro recordings of afferent fibers with receptive fields in the serosa, muscle and mucosa of rat colon. J Physiol 1999, 518:271-282. ptl.
61. Aldskogius H, Elfvin LG, Forsman CA Primary sensory afferents in the inferior mesenteric ganglion related nerves of the guinea pig. An experimental study with anterogradely transported wheat germ agglutinin-horseradish peroxidase conjugate. J Auton Nerv Syst 1986, 15:179-190.
62. Blackshaw LA, Gebhart GF The pharmacology of gastrointestinal nociceptive pathways. Curr Opin Pharmacol 2002, 2:642-649.
63. Mazzia C, Clerc N Ultrastructural relationships of spinal primary afferent fibers with neuronal and non-neuronal cells in the myenteric plexus of the cat oesophago-gastric junc. Neuroscience 1997, 80:925-937.
64. Mazzia C, Clerc N Ultrastructural analysis of spinal primary afferent fibers within the circular muscle of the cat lower esophageal sphincter. Histochem CellBiol 2000, 113:235-239.
65. Lynn PA, Olsson C, Zagorodnyuk V, Costa M, Brookes SJ Rectal intra-ganglionic laminar endings are transduction sites of extrinsic mechanore-ceptors in the guinea pig rectum. Gastroenterology 2003, 125:786-794.
66. Olsson C, Costa M, Brookes SJ Neurochemical characterization of extrinsic innervation of the guinea pig rectum. J Comp Neurol 2004, 470:357-371.
67. Fox EA, Phillips RJ, Martinson FA, Baronowsky EA, Powley TL Vagal afferent innervation of smooth muscle in the stomach and duodenum of the mouse: morphology and topography. J Comp Neurol 2000, 428:558-576.
68. Nonidez JF Afferent nerve endings in the ganglia of the intermuscular plexus of the dog's esophagus. J Comp Neurol 1946, 85:177-189.
69. Rodrigo J, Hernandez J, Vidal MA, Pedrosa JA Vegetative innervation of the esophagus. II. Intraganglionic laminar endings. ActaAnat (Basel) 1975, 92:79-100.
70. Zagorodnyuk VP, Brookes SJ Transduction sites of vagal mechanore-ceptors in the guinea pig esophagus. J Neurosci 2000, 20:6249-6255.
71. Zagorodnyuk VP, Chen BN, Brookes SJ Intraganglionic laminar endings are mechano-transduction sites of vagal tension receptors in the guinea-pig stomach. J Physiol 2001, 534:255-268.
72. Berthoud HR, Patterson LM, Neumann F, Neuhuber WL Distribution and structure of vagal afferent intraganglionic laminar endings (IGLEs) in the rat gastrointestinal tract. Anat Embryol (Berl) 1997, 195:183-191.
73. Castelucci P, Robbins HL, Furness JB P2X (2) purine receptor immunoreactivity of intraganglionic laminar endings in the mouse gastrointestinal tract. Cell Tissue Res 2003, 312:167-174.
74. Fox EA, Phillips RJ, Byerly MS, Baronowsky EA, Chi MM, Powley TL Selective loss of vagal intramuscular mechanoreceptors in mice mutant for steel factor, the c-Kit receptor ligand. Anat Embryol (Berl) 2002, 205:325-342.
75. Fox EA, Phillips RJ, Martinson FA, Baronowsky EA, Powley TL C-Kit mutant mice have a selective loss of vagal intramuscular mechanore-ceptors in the forestomach. Anat Embryol (Berl) 2001, 204:11-26.
76. Berthoud HR, Lynn PA, Blackshaw LA Vagal and spinal mechanosen-sors in the rat stomach and colon have multiple receptive fields. Am J Physiol Regul Integr Comp Physiol 2001, 280:R1371-R1381.
77. Morrison JF Splanchnic slowly adapting mechanoreceptors with punctate receptive fields in the mesentery and gastrointestinal tract of the cat. J Physiol 1973, 233:349-361.
78. Agostoni E, Chinnock JE, De Daly MB, Murray JG Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat. J Physiol 1957, 135:182-205.
79. Sauter JF, Niijima A, Berthoud HR, Jeanrenaud B Vagal neurons and pathways to the rat's lower viscera: an electrophysiological study. Brain Res Bull 1983, 11:487-491.
80. Broussard DL, Altschuler SM Brainstem viscerotopic organization of afferents and efferents involved in the control of swallowing. Am JMed 2000, 108(suppl 4a):79S-86S.
81. Burdyga G, Lai S, Varro A, Dimaline R, Thompson DG, Dockray GJ Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin. J Neurosci 2004, 24:2708-2715.
82. Collman PI, Tremblay L, Diamant NE The distribution of spinal and vagal sensory neurons that innervate the esophagus of the cat. Gastroenterology 1992, 103:817-822.
83. Green T, Dockray GJ Characterization of the peptidergic afferent inner-vation of the stomach in the rat, mouse and guinea-pig. Neuroscience 1988, 25:181-193.
84. Heike CJ, Hill KM Immunohistochemical study of neuropeptides in vagal and glossopharyngeal afferent neurons in the rat. Neuroscience 1988, 26:539-551.
85. Ichikawa H, Heike CJ The coexistence of TrkA with putative transmitter agents and calcium-binding proteins in the vagal and glossopharyngeal sensory neurons of the adult rat. Brain Res 1999, 846:268-273.
86. Kalia M, Sullivan JM Brainstem projections of sensory and motor components of the vagus nerve in the rat. J Comp Neurol 1982, 211:248-265.
87. Altschuler SM, Bao XM, Bieger D, Hopkins DA, Miselis RR Viscerotopic representation of the upper alimentary tract in the rat: sensory ganglia and nuclei of the solitary and spinal trigeminal tracts. J Comp Neurol 1989, 283:248-268.
88. Neuhuber WL, Sandoz PA Vagal primary afferent terminals in the dorsal motor nucleus of the rat: are they making monosynaptic contacts on preganglionic efferent neurons?. Neurosci Lett 1986, 69:126-130.
89. McNeill DL, Chandler MJ, Fu QG, Foreman RD Projection of nodose ganglion cells to the upper cervical spinal cord in the rat. Brain Res Bull 1991, 27:151-155.
90. Qin C, Chandler MJ, Jou CJ, Foreman RD Responses and afferent pathways of C1-C2 spinal neurons to cervical and thoracic esophageal stimulation in rats. JNeurophysiol 2004, 91:2227-2235.
91. Qin C, Chandler MJ, Miller KE, Foreman RD Responses and afferent pathways of C (l)-C (2) spinal neurons to gastric distension in rats. Auton Neurosci 2003, 104:128-136.
92. Loewy AD Central autonomie pathways. Central regulation of autonomie functions 1990, 88-103. Oxford University Press, New York. A.D. Loewy, K.M. Spyer (Eds.).
93. Fryscak T, Zenker W, Kantner D Afferent efferent innervation of the rat esophagus. A tracing study with horseradish peroxidase and nuclear yellow. Anat Embryol (Berl) 1984, 170:63-70.
94. Rinaman L, Card JP, Schwaber JS, Miselis RR Ultrastructural demon-stration of a gastric monosynaptic vagal circuit in the nucleus of the solitary tract in rat. J Neurosci 1989, 9:1985-1996.
95. Rogers RC, Hermann GE Central connections of the hepatic branch of the vagus nerve: a horseradish peroxidase histochemical study. J Auton Nerv Syst 1983, 7:165-174.
96. Shapiro RE, Miselis RR The central organization of the vagus nerve innervating the stomach of the rat. J Comp Neurol 1985, 238:473-488.
97. Cunningham ET, Sawchenko PE A circumscribed projection from the nucleus of the solitary tract to the nucleus ambiguus in the rat: anatomical evidence for somatostatin-28-immunoreactive interneurons subserving reflex control of esophageal motility. J Neurosci 1989, 9:1668-1682.
98. Cunningham ET, Simmons DM, Swanson LW, Sawchenko PE Enkephalin immunoreactivity and messenger RNA in a discrete projection from the nucleus of the solitary tract to the nucleus ambiguous in the rat. J Comp Neurol 1991, 307:1-16.
99. Herbert H, Moga MM, Saper CB Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J Comp Neurol 1990, 293:540-580.
100. Herbert H, Saper CB Organization of medullary adrenergic and noradrenergic projections to the periaqueductal gray matter in the rat. J Comp Neurol 1992, 315:34-52.
101. Loewy AD, Burton H Nuclei of the solitary tract: efferent projections to the lower brain stem and spinal cord of the cat. J Comp Neurol 1978, 181:421-449.
102. Norgren R Projections from the nucleus of the solitary tract in the rat. Neuroscience 1978, 3:207-218.
103. Otake K, Ezure K, Lipski J, Wong She RB Projections from the commissural subnucleus of the nucleus of the solitary tract: an antero-grade tracing study in the cat. J Comp Neurol 1992, 324:365-378.
104. Ricardo JA, Koh ET Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat. Brain Res 1978, 153:1-26.
105. Ross CA, Ruggiero DA, Reis DJ Projections from the nucleus tractus solitarii to the rostral ventrolateral medulla. J Comp Neurol 1985, 242:511-534.
106. Bianchi R, Corsetti G, Rodella L, Tredici G, Gioia M Supraspinal connections and termination patterns of the parabrachial complex determined by the biocytin anterograde tract-tracing technique in the rat. JAnat 1998, 193:417-430. pt 3.
107. Fulwiler CE, Saper CB Subnuclear organization of the efferent connections of the parabrachial nucleus in the rat. Brain Res 1984, 319:229-259.
108. Saper CB, Loewy AD Efferent connections of the parabrachial nucleus in the rat. Brain Res 1980, 197:291-317.
109. Craig AD Pain mechanisms: labeled lines versus convergence in central processing. Annu Rev Neurosci 2003, 26:1-30.
110. Ito S, Craig AD Vagal input to lateral area 3a in cat cortex. J Neurophysiol 2003, 90:143-154.
111. Farkas E, Jansen AS, Loewy AD Periaqueductal gray matter projection to vagal preganglionic neurons and the nucleus tractus solitarius. Brain Res 1997, 764:257-261.
112. Jiang C, Fogel R, Zhang X Lateral hypothalamus modulates gut-sensitive neurons in the dorsal vagal complex. Brain Res 2003, 980:31-47.
113. Zhang X, Cui J, Tan Z, Jiang C, Fogel R The central nucleus of the amygdala modulates gut-related neurons in the dorsal vagal complex in rats. J Physiol 2003, 553:1005-1018.
114. Cervero F, Connell LA Fine afferent fibers from viscera do not terminate in the substantia gelatinosa of the thoracic spinal cord. Brain Res 1984, 294:370-374.
115. Morgan C, deGroat WC, Nadelhaft I The spinal distribution of sympathetic preganglionic and visceral primary afferent neurons that send axons into the hypogastric nerves of the cat. J Comp Neurol 1986, 243:23-40.
116. Morgan C, Nadelhaft I, deGroat WC The distribution within the spinal cord of visceral primary afferent axons carried by the lumbar colonic nerve of the cat. Brain Res 1986, 398:11-17.
117. Ammons WS, Blair RW, Foreman RD Responses of primate T1-T5 spinothalamic neurons to gallbladder distension. Am J Physiol 1984, 247:R995-R1002.
118. Ammons WS, Foreman RD Responses of T2-T4 spinal neurons to stimulation of the greater splanchnic nerves of the cat. Exp Neurol 1984, 83:288-301.
119. Cervero F, Connell LA, Lawson SN Somatic and visceral primary afferents in the lower thoracic dorsal root ganglia of the cat. J Comp Neurol 1984, 228:422-431.
120. Miranda A, Peles S, Rudolph C, Shaker R, Sengupta JN Altered visceral sensation in response to somatic pain in the rat. Gastroenterology 2004, 126:1082-1089.
121. Ness TJ, Gebhart GF Characterization of neuronal responses to noxious visceral and somatic stimuli in the medial lumbosacral spinal cord of the rat. J Neurophysiol 1987, 57:1867-1892.
122. Ness TJ, Gebhart GF Characterization of neurons responsive to noxious colorectal distension in the T13-L2 spinal cord of the rat. J Neurophysiol 1988, 60:1419-1438.
123. Ness TJ, Gebhart GF Characterization of superficial T13-L2 dorsal horn neurons encoding for colorectal distension in the rat: comparison with neurons in deep laminae. Brain Res 1989, 486:301-309.
124. Peles S, Miranda A, Shaker R, Sengupta JN Acute nociceptive somatic stimulus sensitizes neurones in the spinal cord to colonic distension in the rat. J Physiol 2004, 560:291-302.
125. Zhang X, Gokin AP, Giesler GJ Responses of spinohypothalamic tract neurons in the thoracic spinal cord of rats to somatic stimuli and to graded distention of the bile duct. Somatosens Mot Res 2002, 19:5-17.
126. Berkley KJ, Hubscher CH, Wall PD Neuronal responses to stimula-tion of the cervix, uterus, colon, and skin in the rat spinal cord. J Neurophysiol 1993, 69:545-556.
127. Ness TJ, Gebhart GF Visceral pain: a review of experimental studies. Pain 1990, 41:167-234.
128. Apkarian AV, Hodge CJ Primate spinothalamic pathways: I.A quan-titative study of the cells of origin of the spinothalamic pathway. J Comp Neurol 1989, 288:447-473.
129. Willis WD, Kenshalo DR, Leonard RB The cells of origin of the primate spinothalamic tract. J Comp Neurol 1979, 188:543-573.
130. Burstein R, Ciffer KD, Giesler GJ Cells of origin of the spinohy-pothalamic tract in the rat. J Comp Neurol 1990, 291:329-344.
131. Katter JT, Burstein R, Giesler GJ The cells of origin of the spino-hypothalamic tract in cats. J Comp Neurol 1991, 303:101-112.
132. Chaouch A, Menetrey D, Binder D, Besson JM Neurons at the origin of the medial component of the bulbopontine spinoreticular tract in the rat: an anatomical study using horseradish peroxidase retrograde. J Comp Neurol 1983, 214:309-320.
133. Kevetter GA, Haber LH, Yezierski RP, Chung JM, Martin RF, Willis WD Cells of origin of the spinoreticular tract in the monkey. J Comp Neurol 1982, 207:61-74.
134. Menetrey D, Roudier F, Besson JM Spinal neurons reaching the lateral reticular nucleus as studied in the rat by retrograde transport of horseradish peroxidase. J Comp Neurol 1983, 220:439-452.
135. Hylden JL, Anton F, Nahin RL Spinal lamina I projection neurons in the rat: collateral innervation of parabrachial area and thalamus. Neuroscience 1989, 28:27-37.
136. Mouton LJ, Holstege G Three times as many lamina I neurons project to the periaqueductal gray than to the thalamus: a retrograde tracing study in the cat. Neurosci Lett 1998, 255:107-110.
137. Traub RJ, Murphy A Colonie inflammation induces fos expression in the thoracolumbar spinal cord increasing activity in the spin-oparabrachial pathway. Pain 2002, 95:93-102.
138. Menetrey D, Basbaum AI Spinal and trigeminal projections to the nucleus of the solitary tract: a possible substrate for somatovisceral and viscerovisceral reflex activation. J Comp Neurol 1987, 255:439-450.
139. Menetrey D, De Pommery J Origins of spinal ascending pathways that reach central areas involved in visceroception and visceronoci-ception in the rat. Eur J Neurosci 1991, 3:249-259.
140. Traub RJ, Sengupta JN, Gebhart GF Differential c-fos expression in the nucleus of the solitary tract and spinal cord following noxious gastric distention in the rat. Neuroscience 1996, 74:873-884.
141. Al Chaer ED, Lawand NB, Westlund KN, Willis WD Pelvic visceral input into the nucleus gracilis is largely mediated by the postsynaptic dorsal column pathway. J Neurophysiol 1996, 76:2675-2690.
142. Al Chaer ED, Lawand NB, Westlund KN, Willis WD Visceral noci-ceptive input into the ventral posterolateral nucleus of the thalamus: a new function for the dorsal column pathway. J Neurophysiol 1996, 76:2661-2674.
143. Willis WD, Al Chaer ED, Quast MJ, Westlund KN A visceral pain pathway in the dorsal column of the spinal cord. Proc Natl Acad Sci USA 1999, 96:7675-7679.
144. Aziz Q, Thompson DG Brain-gut axis in health and disease. Gastroenterology 1998, 114:559-578.
145. Giesler GJ, Ciffer KD Postsynaptic dorsal column pathway of the rat. II. Evidence against an important role in nociception. Brain Res 1985, 326:347-356.
146. Palecek J The role of dorsal columns pathway in visceral pain. Physiol Res 2004, 53(suppl l):S125-S130.
147. Gebhart GF Descending modulation of pain. Neurosci Biobehav Rev 2004, 27:729-737.
148. Gschossmann JM, Mayer EA, Miller JC, Raybould HE Subdiaphragmatic vagal afferent innervation in activation of an opioi-dergic antinociceptive system in response to colorectal distension in rats. Neurogastroenterol Motil 2002, 14:403-4108.
149. McCarter GC, Reichling DB, Levine JD Mechanical transduction by rat dorsal root ganglion neurons in vitro. Neurosci Lett 1999, 273:179-182.
150. Snitsarev V, Whiteis CA, Abboud FM, Chapleau MW Mechanosensory transduction of vagal and baroreceptor afferents revealed by study of isolated nodose neurons in culture. Auton Neurosci 2002, 98:59-63.
151. Su X, Wachtel RE, Gebhart GF Mechanosensitive potassium channels in rat colon sensory neurons. J Neurophysiol 2000, 84:836-843.
152. Lai J, Porreca F, Hunter JC, Gold MS Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol 2004, 44:371-397.
153. Waxman SG, Cummins TR, Dib-Hajj S, Fjell J, Black JA Sodium channels, excitability of primary sensory neurons, and the molecular basis of pain. Muscle Nerve 1999, 22:1177-1187.
154. Goldin AL, Barchi RL, Caldwell JH, Hofmann F, Howe JR, Hunter JC, Kallen RG, Mandel G, Meisler MH, Netter YB, Noda M, Tamkun MM, Waxman SG, Wood JN, Catterall WA Nomenclature of voltage-gated sodium channels. Neuron 2000, 28:365-368.
155. Black JA, Liu S, Tanaka M, Cummins TR, Waxman SG Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain. Pain 2004, 108:237-247.
156. Bielefeldt K, Ozaki N, Gebhart GF Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons. Gastroenterology 2002, 122:394-405.
157. Bielefeldt K, Ozaki N, Gebhart GF Mild gastritis alters voltage-sensitive sodium currents in gastric sensory neurons in rats. Gastroenterology 2002, 122:752-761.
158. Stewart TM, Beyak MJ, Vanner SJ Ileitis modulates potassium and sodium currents in guinea pig dorsal root ganglia sensory neurons. J Physiol 2003, 553:797-807.
159. Gold MS, Zhang L, Wrigley DL, Traub RJ Prostaglandin E (2) modu-lates TTX-R I (Na) in rat colonic sensory neurons. J Neurophysiol 2002, 88:1512-1522.
160. Su X, Wachtel RE, Gebhart GF Capsaicin sensitivity and voltage-gated sodium currents in colon sensory neurons from rat dorsal root ganglia. Am J Physiol 1999, 277:G1180-G1188.
161. Akopian AN, Souslova V, England S, Okuse K, Ogata N, Ure J, Smith A, Kerr BJ, McMahon SB, Boyce S, Hill R, Stanfa LC, Dickenson AH, Wood JN The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci 1999, 2:541-548.
162. Renganathan M, Cummins TR, Waxman SG Contribution of Na (v) 1.8 sodium channels to action potential electrogenesis in DRG neurons. J Neurophysiol 2001, 86:629-640.
163. Cummins TR, Dib-Hajj SD, Black JA, Akopian AN, Wood JN, Waxman SG A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons. J Neurosci 1999, 19:RC43.
164. Ogata N, Ohishi Y Molecular diversity of structure and function of the voltage-gated Na+ channels. Jpn J Pharmacol 2002, 88:365-377.
165. Herzog RI, Cummins TR, Waxman SG Persistent TTX-resistant Nan-current affects resting potential and response to depolarization in simulated spinal sensory neurons. J Neurophysiol 2001, 86:1351-1364.
166. Black JA, Cummins TR, Yoshimura N, de Groat WC, Waxman SG Tetrodotoxin-resistant sodium channels Na (v) 1.8/SNS Na (v) 1.9/NaN in afferent neurons innervating urinary bladder in control and spinal cord injured rats. Brain Res 2003, 963:132-138.
167. Bielefeldt K, Ozaki N, Gebhart GF Role of nerve growth factor in modulation of gastric afferent neurons in the rat. Am J Physiol Gastrointest Liver Physiol 2003, 284:G499-G507.
168. Fjell J, Cummins TR, Dib-Hajj SD, Fried K, Black JA, Waxman SG Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons. Brain Res Mol Brain Res 1999, 67:267-282.
169. Hille B The superfamily of voltage-gated channels. Ion channels of excitable membranes 2001, 62-94. Sinauer Associates, Sunderland, MA.
170. Dang K, Bielefeldt K, Gebhart GF Gastric ulcers reduce A-type potassium currents in rat gastric sensory ganglion neurons. Am J Physiol Gastrointest Liver Physiol 2004, 286:G573-G579.
171. Ramji N, Bunnett NW, Vanner SJ Characterization of K currents in mouse DRG neurons and their modulation by PAR2 agonists. Can J Gastroenterol 2004, 18:145.
172. Yoshimura N, de Groat WC Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation. J Neurosci 1999, 19:4644-4653.
173. Yoshimura N, Seki S, Erickson KA, Erickson VL, Hancellor MB, de Groat WC Histological and electrical properties of rat dorsal root ganglion neurons innervating the lower urinary tract. J Neurosci 2003, 23:4355-4361.
174. Yoshimura N, White G, Weight FF, de Groat WC Different types of Na+ and A-type K+ currents in dorsal root ganglion neurones innervating the rat urinary bladder. J Physiol 1996, 494:1-16. pt 1.
175. Moore BA, Stewart TM, Hill C, Vanner SJ TNBS ileitis evokes hyper-excitability and changes in ionic membrane properties of nociceptive DRG neurons. Am J Physiol Gastrointest Liver Physiol 2002, 282:G1045-G1051.
176. Zagorodnyuk VP, Chen BN, Costa M, Brookes SJ 4-aminopyridine-and dendrotoxin-sensitive potassium channels influence excitability of vagal mechano-sensitive endings in guinea-pig oesophagus. Br J Pharmacol 2002, 137:1195-1206.
177. Glazebrook PA, Ramirez AN, Schild JH, Shieh CC, Doan T, Wible BA, Kunze DL Potassium channels Kvl.l Kvl.2 Kvl.6 influence excitability of rat visceral sensory neurons. J Physiol 2002, 541:467-482.
178. Cordoba-Rodriguez R, Moore KA, Kao JP, Weinreich D Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. Proc Natl Acad Sci U S A 1999, 96:7650-7657.
179. Jafri MS, Moore KA, Taylor GE, Weinreich D Histamine HI receptor activation blocks two classes of potassium current, IK (rest) and IAHP, to excite ferret vagal afferents. J Physiol 1997, 503:533-546. pt 3.
180. Fox AJ, Barnes PJ, Venkatesan P, Belvisi MG Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig. J Clin Invest 1997, 99:513-519.
181. Lin J, Kunze W, Stanisz A, Hess A, Grundy D, Hillsley K, Stead R Inflammation of mouse jejunum induces long term excitation in drg neurons projecting to the viscera. Gastroenterology 2004, 126 (A):896.
182. Robinson RB, Siegelbaum SA Hyperpolarization-activated cation currents: from molecules to physiological function. Annu Rev Physiol 2003, 65:453-480.
183. Doan TN, Kunze DL Contribution of the hyperpolarization-activated current to the resting membrane potential of rat nodose sensory neurons. J Physiol 1999, 514:125-138. pt 1.
184. Linden DR, Sharkey KA, Mawe GM Enhanced excitability of myen-teric AH neurones in the inflamed guinea-pig distal colon. J Physiol 2003, 547:589-601.
185. Yoshimura N, Seki S, de Groat WC Nitric oxide modulates Ca (2+) channels in dorsal root ganglion neurons innervating rat urinary bladder. J Neurophysiol 2001, 86:304-311.
186. Su X, Wachtel RE, Gebhart GF Inhibition of calcium currents in rat colon
187. Shin JB, Martinez-Salgado C, Heppenstall PA, Lewin GR A T-type calcium channel required for normal function of a mammalian mechanoreceptor. Nat Neurosci 2003, 6:724-730.
188. Ruch TC Pathophysiology of pain 1961, 350-368. Saunders, Philadelphia. T.C. Ruch, H.D. Patton, J.W. Woodbury, A.L. Towe (Eds.).
189. Iggo A Tension receptors in the stomach and the urinary bladder. J Physiol 1955, 128:593-607.
190. Paintal AS A study of gastric stretch receptors; their role in the peripheral mechanism of satiation of hunger and thirst. J Physiol 1954, 126:255-270.
191. Paintal AS Vagal sensory receptors and their reflex effects. Physiol Rev 1973, 53:159-227.
192. Grundy D Mechanoreceptors in the gastrointestinal tract. J Smooth Muscle Res 1993, 29:37-46.
193. Grundy D, Salih AA, Scratcherd T Modulation of vagal efferent fiber discharge by mechanoreceptors in the stomach, duodenum and colon of the ferret. J Physiol 1981, 319:43-52.
194. Rong W, Hillsley K, Davis JB, Hicks GA, Winchester WJ, Grundy D Jejunal afferent nerve sensitivity in wild type and TRPV1 knockout mice. J Physiol 2004, 560:867-881.
195. Habler HJ, Janig W, Koltzenburg M Myelinated primary afferents of the sacral spinal cord responding to slow filling and distension of the cat urinary bladder. J Physiol 1993, 463:449-460.
196. Habler HJ, Janig W, Koltzenburg M Receptive properties of myelinated primary afferents innervating the inflamed urinary bladder of the cat. J Neurophysiol 1993, 69:395-405.
197. Rong W, Spyer KM, Burnstock G Activation and sensitisation of low and high threshold afferent fibers mediated by P2X receptors in the mouse urinary bladder. J Physiol 2002, 541:591-600.
198. Hillsley K, Kirkup AJ, Grundy D Direct and indirect actions of 5-hydroxytryptamine on the discharge of mesenteric afferent fibers innervating the rat jejunum. J Physiol 1998, 506:551-561. pt 2.
199. Gregersen H Biomechanics of the gastrointestinal tract: new perspectives in motility research and diagnositics 2003, Springer, London.
200. Tassicker BC, Hennig GW, Costa M, Brookes SJ Rapid anterograde and retrograde tracing from mesenteric nerve trunks to the guinea-pig small intestine in vitro. Cell Tissue Res 1999, 295:437-452.
201. Booth CE, Kirkup AJ, Hicks GA, Humphrey PP, Grundy D Somatostatin sst (2) receptor-mediated inhibition of mesenteric afferent nerves of the jejunum in the anesthetized rat. Gastroenterology 2001, 121:358-369.
202. Sengupta JN, Gebhart GF Characterization of mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat. J Neurophysiol 1994, 71:2046-2060.
203. Su X, Gebhart GF Mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat are polymodal in character. J Neurophysiol 1998, 80:2632-2644.
204. Su X, Julia V, Gebhart GF Effects of intracolonic opioid receptor agonists on polymodal pelvic nerve afferent fibers in the rat. J Neurophysiol 2000, 83:963-970.
205. Su X, Sengupta JN, Gebhart GF Effects of kappa opioid receptor-selective agonists on responses of pelvic nerve afferents to noxious colorectal distension. J Neurophysiol 1997, 78:1003-1012.
206. Ozaki N, Gebhart GF Characterization of mechanosensitive splanch-nic nerve afferent fibers innervating the rat stomach. Am J Physiol Gastrointest Liver Physiol 2001, 281:G1449-G1459.
207. Ozaki N, Sengupta JN, Gebhart GF Mechanosensitive properties of gastric vagal afferent fibers in the rat. J Neurophysiol 1999, 82:2210-2220.
208. Andrew LK, Blackshaw LA Colonic mechanoreceptor inputs to rat lumbo-sacral dorsal horn neurones: distribution, thresholds and chemosensory modulation. Neurogastroenterol Motil 2001, 13:333-337.
209. Page AJ, Martin CM, Blackshaw LA Vagal mechanoreceptors and chemoreceptors in mouse stomach and esophagus. J Neurophysiol 2002, 87:2095-2103.
210. Clarke GD, Davison JS Mucosal receptors in the gastric antrum and small intestine of the rat with afferent fibers in the cervical vagus. J Physiol 1978, 284:55-67.
211. Habler HJ, Janig W, Koltzenburg M Activation of unmyelinated afferent fibers by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol 1990, 425:545-562.
212. Michaelis M, Habler HJ, Boczek-Funcke A, Janig W Vesico-sympathetic reflexes in cat vasoconstrictor neurones supplying skin and skeletal muscle depend on the integrity of the sacral bladder afferents. Neurosci Lett 1996, 219:99-102.
213. Gebhart GF Peripheral contributions to visceral hyperalgesia. Can J Gastroenterol 1999, 13(suppl A):37A-41A.
214. McMahon S, Koltzenburg M The changing role of primary afferent neurones in pain. Pain 1990, 43:269-272.
215. Iggo A Receptors in the stomach and the bladder. J Physiol 1954, 126:29-30P.
216. Iggo A Gastro-intestinal tension receptors with unmyelinated afferent fibers in the vagus of the cat. Q J Exp Physiol Cogn Med Sci 1957, 42:130-143.
217. Andrews PL, Grundy D, Scratcherd T Vagal afferent discharge from mechanoreceptors in different regions of the ferret stomach. J Physiol 1980, 298:513-524.
218. Zagorodnyuk VP, Chen BN, Costa M, Brookes SJ Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus. J Physiol 2003, 553:575-587.
219. McMahon SB Sensitisation of gastrointestinal tract afferents. Gut 2004, 53(suppl 2):1113-1115.
220. Cottrell DF, Iggo A Tension receptors with vagal afferent fibers in the proximal duodenum and pyloric sphincter of sheep. J Physiol 1984, 354:457-475.
221. Clerc N, Mei N Vagal mechanoreceptors located in the lower oesophageal sphincter of the cat. J Physiol 1983, 336:487-498.
222. Bessou P, Perl ER A movement receptor of the small intestine. J Physiol 1966, 182:404-426.
223. Corey DP, Hudspeth AJ Analysis of the microphonic potential of the bullfrog's sacculus. J Neurosci 1983, 3:942-961.
224. Sachs F Biophysics of mechanoreception. Membr Biochem 1986, 6:173-195.
225. Raybould HE, Gschossman JM, Ennes H, Lembo T, Mayer EA Involvement of stretch-sensitive calcium flux in mechanical transduction in visceral afferents. J Auton Nerv Syst 1999, 75:1-6.
226. Goodman MB, Schwarz EM Transducing touch in Caenorhabditis elegans. Annu Rev Physiol 2003, 65:429-452.
227. Hamill OP, Martinac B Molecular basis of mechanotransduction in living cells. Physiol Rev 2001, 81:685-740.
228. Clapham DE TRP channels as cellular sensors. Nature 2003, 426:517-524.
229. Suzuki M, Mizuno A, Kodaira K, Imai M Impaired pressure sensation in mice lacking TRPV4 J Biol. Chem 2003, 278:22664-22668.
230. Mizuno A, Matsumoto N, Imai M, Suzuki M Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol 2003, 285:C96-C101.
231. Liedtke W, Tobin DM, Bargmann CI, Friedman JM Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci U S A 2003, 100(suppl 2):14531-14536.
232. Zhang L, Jones S, Costa M, Brookes SH Detection of mechanosensi-tive ion channels and associated proteins in vagal visceral afferent neurones of the mouse using RT-PCR. Gastroenterology 2004, 126:1801.
233. Corey DP, Garcia-Anoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Geleoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, Zhang DS TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 2004, 432:723-730.
234. Babes A, Zorzon D, Reid G Two populations of cold-sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factor. EurJ Neurosci 2004, 20:2276-2282.
235. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 1999, 398:436-441.
236. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000, 288:306-313.
237. Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D Bradykinin and nerve growth factor release the capsaicin receptor from Ptdlns (4,5) P2-mediated inhibition. Nature 2001, 411:957-962.
238. Hwang SW, Cho H, Kwak J, Lee SY, Kang CJ, Jung J, Cho S, Min KH, Suh YG, Kim D, Oh U Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci U S A 2000, 97:6155-6160.
239. Jin X, Morsy N, Winston J, Pasricha PJ, Garrett K, Akbarali HI Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase. Am J Physiol Cell Physiol 2004, 287:C558-C563.
240. Krishtal O The ASICs: signaling molecules? Modulators?. Trends Neurosci 2003, 26:477-483.
241. Yiangou Y, Facer P, Smith JA, Sangameswaran L, Eglen R, Birch R, Knowles C, Williams N, Anand P Increased acid-sensing ion channel ASIC-3 in inflamed human intestine. Eur J Gastroenterol Hepatol 2001, 13:891-896.
242. Drew LJ, Rohrer DK, Price MP, Blaver KE, Cockayne DA, Cesare P, Wood JN Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol 2004, 556:691-710.
243. Roza C, Puel JL, Kress M, Baron A, Diochot S, Lazdunski M, Waldmann R Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing. J Physiol 2004, 558:659-669.
244. Page AJ, Brierley SM, Martin CM, Martinez-Salgado C, Wemmie JA, Brennan TJ, Symonds E, Omari T, Lewin GR, Welsh MJ, Blackshaw LA The ion channel ASIC 1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology 2004, 127:1739-1747.
245. Burnstock G Purine-mediated signalling in pain and visceral perception. Trends Pharmacol Sci 2001, 22:182-188.
246. Wynn G, Rong W, Xiang Z, Burnstock G Purinergic mechanisms contribute to mechanosensory transduction in the rat colorectum. Gastroenterology 2003, 125:1398-1409.
247. Bertrand PP ATP and sensory transduction in the enteric nervous system. Neuroscientist 2003, 9:243-260.
248. Bertrand PP, Bornstein JC ATP as a putative sensory mediator: activation of intrinsic sensory neurons of the myenteric plexus via P2X receptors. J Neurosci 2002, 22:4767-4775.
249. Kirkup AJ, Booth CE, Chessell IP, Humphrey PP, Grundy D Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat. J Physiol 1999, 520:551-563. pt 2.
250. Bulbring E, Crema A The release of 5-hydroxytryptamine in relation to pressure exerted on the intestinal mucosa. J Physiol 1959, 146:18-28.
251. Grundy D, Blackshaw LA, Hillsley K Role of 5-hydroxytryptamine in gastrointestinal chemosensitivity. Dig Dis Sci 1994, 39:44S-47S.
252. Derkach V, Surprenant A, North RA 5-Ht3 receptors are membrane ion channels. Nature 1989, 339:706-709.
253. Raybould HE, Glatzle J, Robin C, Meyer JH, Phan T, Wong H, Sternini C Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying. Am J Physiol Gastrointest Liver Physiol 2003, 284:G367-G372.
254. Coldwell JR, Howarth GL, Blackshaw LA Increased colonic afferent sensitivity to 5-HT in inflammation and after recovery. Gastroenterology 2004, 126:708.
255. Kozlowski CM, Green A, Grundy D, Boissonade FM, Bountra C The 5-HT (3) receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat. Gut 2000, 46:474-480.
256. Zeitz KP, Guy N, Malmberg AB, Dirajlal S, Martin WJ, Sun L, Bonhaus DW, Stucky CL, Julius D, Basbaum AI The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci 2002, 22:1010-1019.
257. Peters JA, Malone HM, Lambert JJ An electrophysiological investi-gation of the properties of 5-HT3 receptors of rabbit nodose ganglion neurones in culture. Br J Pharmacol 1993, 110:665-676.
258. Blackshaw LA, Grundy D Effects of 5-hydroxytryptamine on discharge of vagal mucosal afferent fibers from the upper gastroin-testinal tract of the ferret. J Auton Nerv Syst 1993, 45:41-50.
259. Burnstock G, Wood JN Purinergic receptors: their role in nociception and primary afferent neurotransmission. Curr Opin Neurobiol 1996, 6:526-532.
260. Castelucci P, Robbins HL, Poole DP, Furness JB The distribution of purine P2X (2) receptors in the guinea-pig enteric nervous system. Histochem Cell Biol 2002, 117:415.
261. Wang ZJ, Neuhuber WL Intraganglionic laminar endings in the rat esophagus contain purinergic P2X2 and P2X3 receptor immunoreac-tivity. Anat Embryol (Berl) 2003, 207:363-371.
262. Page AJ, O'Donnell TA, Blackshaw LA P2X purinoceptor-induced sensitization of ferret vagal mechanoreceptors in oesophageal inflam-mation. J Physiol 2000, 523:403-411. pt 2.
263. Wynn G, Ma B, Ruan HZ, Burnstock G Purinergic component of mechanosensory transduction is increased in a rat model of colitis. Am J Physiol Gastrointest Liver Physiol 2004, 287:G647-G657.
264. Lewis C, Neidhart S, Holy C, North RA, Buell G, Surprenant A Coexpression of P2X (2) and P2X (3) receptor subunits can account for ATP-gated currents in sensory neurons. Nature 1995, 377:432-435.
265. McRoberts JA, Coutinho SV, Marvizon JC, Grady EF, Tognetto M, Sengupta JN, Ennes HS, Chaban VV, Amadesi S, Creminon C, Lanthorn T, Geppetti P, Bunnett NW, Mayer EA Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology 2001, 120:1737-1748.
266. Sengupta JN, Petersen J, Peles S, Shaker R Response properties of antral mechanosensitive afferent fibers and effects of ionotropic glutamate receptor antagonists. Neuroscience 2004, 125:711-723.
267. Patterson LM, Zheng H, Ward SM, Berthoud HR Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastroin-testinal tract. Cell Tissue Res 2003, 311:277-287.
268. Ward SM, Bayguinov J, Won KJ, Grundy D, Berthoud HR Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract. J Comp Neurol 2003, 465:121-135.
269. Blackshaw LA, Page AJ, Partosoedarso ER Acute effects of capsaicin on gastrointestinal vagal afferents. Neuroscience 2000, 96:407-416.
270. Sugiuar T, Bielefeldt K, Gebhart GF TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation. J Neurosci 2004, 24:9521-9530.
271. Schmidt B, Hammer J, Holzer P, Hammer HF Chemical nociception in the jejunum induced by capsaicin. Gut 2004, 53:1109-1116.
272. Chan CL, Facer P, Davis JB, Smith GD, Egerton J, Bountra C, Williams NS, Anand P Sensory fibers expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency. Lancet 2003, 361:385-391.
273. Matthews PJ, Aziz Q, Facer P, Davis JB, Thompson DG, Anand P Increased capsaicin receptor TRPV1 nerve fibers in the inflamed human esophagus. Eur J Gastroenterol Hepatol 2004, 16:897-902.
274. Yiangou Y, Facer P, Dyer NH, Chan CL, Knowles C, Williams NS, Anand P Vanilloid receptor 1 immunoreactivity in inflamed human bowel. Lancet 2001, 357:1338-1339.
275. Akiba Y, Nakamura M, Nagata H, Kaunitz JD, Ishii H Acid-sensing pathways in rat gastrointestinal mucosa. J Gastroenterol 2002, 37(suppl 14):133-138.
276. Holzer P Sensory neuron responses to mucosal noxae in the upper gut: relevance to mucosal integrity and gastrointestinal pain. Neurogastroenterol Motil 2002, 14:459-475.
277. Raybould HE, Sternini C, Eysselein VE, Yoneda M, Holzer P Selective ablation of spinal afferent neurons containing CGRP attenuates gastric hyperemic response to acid. Peptides 1992, 13:249-254.
278. Zhang L, Jones S, Brody K, Costa M, Brookes SX Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse. Am J Physiol Gastrointest Liver Physiol 2004, 286:G983-G991.
279. Immke DC, McCleskey EW Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons. Nat Neurosci 2001, 4:869-870.
280. Sutherland SP, Benson CJ, Adelman JP, McCleskey EW Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons. Proc Natl Acad Sci U S A 2001, 98:711-716.
281. Beyak MJ, Grundy D Nicotinic agonists activate mouse gastric vagal afferents in vitro. Gastroenterology 2004, 126:838 (A).
282. Jiang W, Kirkup AJ, Berthoud H, Kreis ME, Grundy D Effects of neuronal nicotinic acetylcholine receptor antagonists on jejunal mesenteric afferent firing evoked by nicotinic agonist DMPP. Gastroenterology 2002, 122:159.
283. Hamm HE The many faces of G protein signaling J Biol. Chem 1998, 273:669-672.
284. Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E Expression of bitter taste receptors of the T2R family in the gastroin-testinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci U.S.A 2002, 99:2392-2397.
285. Buchan AM, Squires PE, Ring M, Meloche RM Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterology 2001, 120:1128-1139.
286. 2+-sensing receptor. Proc Natl Acad Sci U S A 2000, 97:4814-4819.
287. Page AJ, Blackshaw LA GABA (B) receptors inhibit mechanosensi-tivity of primary afferent endings. J Neurosci 1999, 19:8597-8602.
288. Page AJ, Cheng E, Slattery J, Blackshaw LA Potent inhibition of vagal mechanosensitivity by galanin. Gastroenterology 2003, 124:1011.
289. Page AJ, Dorian CM, O'Donnell TA, Mattison JP, Blackshaw LA The metabotropic glutamate receptor mGluR4 is required for normal visceral mechanotransduction. Neurogastroenterol Motil 2004, 16:839.
290. Grundy D Neuroanatomy of visceral nociception: vagal and splanchnic afferent. Gttf 2002, 51(suppl 1):12-15.
291. Kirkup AJ, Brunsden AM, Grundy D Receptors transmission in the brain-gut axis: potential for novel therapies. I. Receptors on visceral afferents. Am J Physiol Gastrointest Liver Physiol 2001, 280:G787-G794.
292. Kirkup AJ, Jiang W, Bunnett NW, Grundy D Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats. J Physiol 2003, 552:589-601.
293. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA The G protein-coupled receptor repertoires of human and mouse. Proc NatlAcad Sci U S A 2003, 100:4903-4908.
294. Lai S, McLaughlin J, Barlow J, D'Amato M, Giacovelli G, Varro A, Dockray GJ, Thompson DG Cholecystokinin pathways modulate sensations induced by gastric distension in humans. Am J Physiol Gastrointest Liver Physiol 2004, 287:G72-G79.
295. Jones MP, Hoffman S, Shah D, Patel K, Ebert CC The water load test: observations from healthy controls and patients with functional dyspepsia. Am J Physiol Gastrointest Liver Physiol 2003, 284:G896-G904.
296. Sallet JA, Marchesini JB, Paiva DS, Komoto K, Pizani CE, Ribeiro ML, Miguel P, Ferraz AM, Sallet PC Brazilian multicenter study of the intragastric balloon. Obes Surg 2004, 14:991-998.
297. Blackshaw LA, Grundy D, Scratcherd T Vagal afferent discharge from gastric mechanoreceptors during contraction and relaxation of the ferret corpus. J Auton Nerv Syst 1987, 18:19-24.
298. Chi MM, Fan G, Fox EA Increased short-term food satiation and sensitivity to cholecystokinin in neurotrophin-4 knock-in mice. Am J Physiol Regul Integr Comp Physiol 2004, 287:R1044-R1053.
299. McLaughlin J, Grazia LM, Jones MN, D'Amato M, Dockray GJ, Thompson DG Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroenterology 1999, 116:46-53.
300. McLaughlin JT, Lomax RB, Hall L, Dockray GJ, Thompson DG, Warhurst G Fatty acids stimulate cholecystokinin secretion via an acyl chain length-specific, Ca2+-dependent mechanism in the enteroendocrine cell line STC-1. J Physiol 1998, 513:11-18. pt 1.
301. Richards W, Hillsley K, Eastwood C, Grundy D Sensitivity of vagal mucosal afferents to cholecystokinin and its role in afferent signal transduction in the rat. J Physiol 1996, 497:473-481. pt 2.
302. Lai S, Kirkup AJ, Brunsden AM, Thompson DG, Grundy D Vagal afferent responses to fatty acids of different chain length in the rat. AmJ Physiol Gastrointest Liver Physiol 2001, 281:G907-G915.
303. Glatzle J, Darcel N, Rechs AJ, Kalogeris TJ, Tso P, Raybould HE Apolipoprotein A-IV stimulates duodenal vagal afferent activity to inhibit gastric motility via a CCK1 pathway. Am J Physiol Regul Integr Comp Physiol 2004, 287:R354-R359.
304. Anika SM, Houpt TR, Houpt KA Cholecystokinin and satiety in pigs. AmJ Physiol 1981, 240:R310-R318.
305. Cuber JC, Bernard C, Levenez F, Chayvialle JA [Lipids, proteins and carbohydrates stimulate the secretion of intestinal cholecystokinin in the pig]. Reprod Nutr Dev 1990, 30:267-275.
306. Nishi T, Hara H, Hira T, Tomita F Dietary protein peptic hydrolysates stimulate cholecystokinin release via direct sensing by rat intestinal mucosal cells. Exp BiolMed (Maywood) 2001, 226:1031-1036.
307. Eastwood C, Maubach K, Kirkup AJ, Grundy D The role of endogenous cholecystokinin in the sensory transduction of luminal nutrient signals in the rat jejunum. Neurosci Lett 1998, 254:145-148.
308. Moran TH, McHugh PR Cholecystokinin suppresses food intake by inhibiting gastric emptying. Am J Physiol 1982, 242:R491-R497.
309. Moran TH, Baldessarini AR, Salorio CF, Lowery T, Schwartz GJ Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin. Am J Physiol 1997, 272:R1245-R1251.
310. Li Y, Zhu J, Owyang C Electrical physiological evidence for highand low-affinity vagal CCK-A receptors. Am J Physiol 1999, 277:G469-G477.
311. Lankisch TO, Tsunoda Y, Lu Y, Owyang C Characterization of CCK (A) receptor affinity states and Ca (2+) signal transduction in vagal nodose ganglia. Am J Physiol Gastrointest Liver Physiol 2002, 282:G1002-G1008.
312. Li Y, Hao Y, Owyang C High-affinity CCK-A receptors on the vagus nerve mediate CCK-stimulated pancreatic secretion in rats. Am J Physiol 1997, 273:G679-G685.
313. Weatherford SC, Laughton WB, Salabarria J, Danho W, Tilley JW, Netterville LA, Schwartz GJ, Moran TH CCK satiety is differentially mediated by high-and low-affinity CCK receptors in mice and rats. AmJ Physiol 1993, 264:R244-R249.
314. Schwartz GJ, McHugh PR, Moran TH Pharmacological dissociation of responses to CCK and gastric loads in rat mechanosensitive vagal afferents. Am J Physiol 1994, 267:R303-R308.
315. Kim M, Cooke HJ, Javed NH, Carey HY ChristofiF, Raybould HE D-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells. Gastroenterology 2001, 121:1400-1406.
316. Raybould HE, Cooke HJ, ChristofiFL Sensory mechanisms: trans-mitters, modulators and reflexes. Neurogastroenterol Motil 2004, 16(suppl l):60-63.
317. Mei N Vagal glucoreceptors in the small intestine of the cat. J Physiol 1978, 282:485-506.
318. Zhu JX, Zhu XY, Owyang C, Li Y Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat. J Physiol 2001, 530:431-442.
319. Hillsley K, Grundy D Serotonin and cholecystokinin activate different populations of rat mesenteric vagal afferents. Neurosci Lett 1998, 255:63-66.
320. Chua SC, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, Leibel RL Phenotypes of mouse diabetes and rat fatty due to muta-tions in the OB (leptin) receptor. Science 1996, 271:994-996.
321. Burdyga G, Spiller D, Morris R, Lai S, Thompson DG, Saeed S, Dimaline R, Varro A, Dockray GJ Expression of the leptin receptor in rat and human nodose ganglion neurones. Neuroscience 2002, 109:339-347.
322. Gaige S, Abysique A, Bouvier M Effects of leptin on cat intestinal vagal mechanoreceptors. J Physiol 2002, 543:679-689.
323. Matyjek R, Herzig KH, Kato S, Zabielski R Exogenous leptin inhibits the secretion of pancreatic juice via a duodenal CCKl-vagal-dependent mechanism in anaesthetized rats. Regul Pept 2003, 114:15-20.
324. Kreier F, Fliers E, Voshol PJ, Van Eden CG, Havekes LM, Kalsbeek A, Van Heijningen CL, Sluiter AA, Mettenleiter TC, Romijn JA, Sauerwein HP, Buijs RM Selective parasympathetic innervation of subcutaneous and intra-abdominal fat-functional implications. J Clin Invest 2002, 110:1243-1250.
325. Burdyga G, Lai S, Spiller D, Jiang W, Thompson D, Attwood S, Saeed S, Grundy D, Varro A, Dimaline R, Dockray GJ Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans. Gastroenterology 2003, 124:129-139.
326. Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, Kangawa K, Nakazato M The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 2002, 123:1120-1128.
327. Gomez R, Navarro M, Ferrer B, Trigo JM, Bilbao A, Del A, I Cippitelli A, Nava F, Piomelli D, Rodriguez dF A peripheral mecha-nism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci 2002, 22:9612-9617.
328. Jiang W, Lal S, Thompson DG, Grundy D Differential effect of cannabinoid (CB) 1 agonist on jejunal mesenteric afferent responses to cholecystokinin, serotonin and capsaicin in fed and fasted rats. Gastroenterology 2004, 126:A164.
329. Gaetani S, Oveisi F, Piomelti D Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide. Neuropsychopharmacology 2003, 28:1311-1316.
330. Nielsen MJ, Petersen G, Astrup A, Hansen HS Food intake is inhibited by oral oleoylethanolamide. J Lipid Res 2004, 45:1027-1029.
331. Oveisi F, Gaetani S, Eng KT, Piomelli D Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration. Pharmacol Res 2004, 49:461-466.
332. Rodriguez dF, Navarro M, Gomez R, Escuredo L, Nava F, Fu J, Murillo-Rodriguez E, Giuffrida A, LoVerme J, Gaetani S, Kathuria S, Gall C, Piomelli D An anorexic lipid mediator regulated by feeding. Nature 2001, 414:209-212.
333. Ahern GP Activation of TRPV1 by the satiety factor oleoylethanolamide. J BiolChem 2003, 278:30429-30434.
334. Guzman M, Lo VJ, Fu J, Oveisi F, Blazquez C, Piomelli D Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). J BiolChem 2004, 279:27849-27854.
335. Niijima A Glucose-sensitive afferent nerve fibers in the hepatic branch of the vagus nerve in the guinea-pig. J Physiol 1982, 332:315-323.
336. Niijima A, Meguid MM An electrophysiological study on amino acid sensors in the hepato-portal system in the rat. Obes Res 1995, 3(suppl5):741S-745S.
337. la Fleur SE, Ji H, Manalo SL, Friedman MI, Dallman ME The hepatic vagus mediates fat-induced inhibition of diabetic hyperphagia. Diabetes 2003, 52:2321-2330.
338. Dantzer R Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci 2001, 933:222-234.
339. Liu C, Mueller M, Jiang W, Grundy D, Kreis ME Differential afferent sensitivity to mucosal lipopolysaccharide (LPS) from Salmonella typhimurium and Escherichia coli in the rat jejunum. Gastroenterology 2004, 126:1088.
340. Niijima A The afferent discharges from sensors for interleukin 1 beta in the hepatoportal system in the anesthetized rat. J Auton Nerv Syst 1996, 61:287-291.
341. Ge X, Yang Z, Duan L, Rao Z Evidence for involvement of the neural pathway containing the peripheral vagus nerve, medullary visceral zone and central amygdaloid nucleus in neuroimmunomod. Brain Res 2001, 914:149-158.
342. Laye S, Bluthe RM, Kent S, Combe C, Medina C, Parnet P, Kelley K, Dantzer R Subdiaphragmatic vagotomy blocks induction of IL-1 beta mRNA in mice brain in response to peripheral LPS. Am J Physiol 1995, 268:R1327-R1331.
343. Goehler LE, Gaykema RP, Nguyen KT, Lee JE, Tilders FJ, Maier SF, Watkins LR Interleukin-1 beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?. J Neurosci 1999, 19:2799-2806.
344. Borovikova LY, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, Wang H, Abumrad N, Eaton JW, Tracey KJ Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000, 405:458-462.
345. Mazelin L, Theodorou V, More J, Fioramonti J, Bueno L Protective role of vagal afferents in experimentally-induced colitis in rats. J Auton Nerv Syst 1998, 73:38-45.
346. Bozkurt A, Cakir B, Ercan F, Yegen BC Anti-inflammatory effects of leptin and cholecystokinin on acetic acid-induced colitis in rats: role of capsaicin-sensitive vagal afferent fibers. Regul Pept 2003, 116:109-118.
347. Janig W, Khasar SG, Levine JD, Miao FJ The role of vagal visceral afferents in the control of nociception. Prog Brain Res 2000, 122:273-287.
348. Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF, Trevisani M, Manni C, Geppetti P, McRoberts JA, Ennes H, Davis JB, Mayer EA, Bunnett NW Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J Neurosci 2004, 24:4300-4312.
349. Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat Med 2001, 7:821-826.
350. Vergnolle N, Hollenberg MD, Sharkey KA, Wallace JL Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. Br J Pharmacol 1999, 127:1083-1090.
351. Barreau F, Cartier C, Ferrier L, Fioramonti J, Bueno L Nerve growth factor mediates alterations of colonic sensitivity and mucosal barrier induced by neonatal stress in rats. Gastroenterology 2004, 127:524-534.
352. Hoogerwerf WA, Gondesen K, Klimpel G, Kosler B, Xiao S, Winston W, Willis W, Pasricha PJ Mast cells are required for the development of chronic visceral pain: a study with mast cell reconstitution in W/Wv mice. Gastroenterology 2004, 126:A168.
353. Jiang W, Kreis ME, Eastwood C, Kirkup AJ, Humphrey PP, Grundy D 5-HT (3) and histamine H (l) receptors mediate afferent nerve sensitivity to intestinal anaphylaxis in rats. Gastroenterology 2000, 119:1267-1275.
354. Kreis ME, Mueller MH, Reber D, Glatzle J, Enck P, Grundy D Stress-induced attenuation of brain stem activation following intestinal anaphylaxis in the rat. Neurosci Lett 2003, 345:187-191.
355. Kreis ME, Müller M, Zittel TT, Glatzle J, Grundy D Mediators of neuronal activation in the rat brainstem following intestinal anaphylaxis. Neurosci Lett 2000, 289:45-48.
356. Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, Pasquinelli G, Morselli-Labate AM, Grady EF, Bunnett NW, Collins SM, Corinaldesi R Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004, 126:693-702.
357. O'Sullivan M, Clayton N, Breslin NP, Harman I, Bountra C, McLaren A, O'Morain CA Increased mast cells in the irritable bowel syndrome. Neurogastroenterol Motil 2000, 12:449-4157.
358. Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, Crowell MD, Sharkey KA, Gershon MD, Mawe GM, Mose PL Molecular defects in mucosal serotonin content and decreased sero-tonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 2004, 126:1657-1664.
359. Linden DR, Chen JX, Gershon MD, Sharkey KA, Mawe GM Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol 2003, 285:G207-G216.
360. Dunlop SP, Jenkins D, Spiller RC Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome. Am J Gastroenterol 2003, 98:1578-1583.
361. Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M, Neal KR Increased rectal mucosal enteroendocrine cells, T lympho-cytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 2000, 47:804-811.
362. Camilleri M, Chey WY, Mayer EA, Northcutt AR, Heath A, Dukes GE, McSorley D, Mangel AM A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome. Arch Intern Med 2001, 161:1733-1740.
363. Novick J, Miner P, Krause R, Glebas K, Bliesath H, Ligozio G, Ruegg P, Lefkowitz M A randomized, double-blind, placebo-controlled trial of tegaserod in female patients suffering from irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2002, 16:1877-1888.
364. Schikowski A, Thewissen M, Mathis C, Ross HG, Enck P Serotonin type-4 receptors modulate the sensitivity of intramural mechanore-ceptive afferents of the cat rectum. Neurogastroenterol Motil 2002, 14:221-227.
365. Cardenas CG, Del Mar LP, Cooper BY, Scroggs RS 5HT4 receptors couple positively to tetrodotoxin-insensitive sodium channels in a subpopulation of capsaicin-sensitive rat sensory neurons. J Neurosci 1997, 17:7181-7189.
366. Grider JR, Kuemmerle JF, Jin JG 5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HTlp receptors on sensory CGRP neurons. Am J Physiol 1996, 270:G778-G782.
367. Yoshioka M, Ikeda T, Abe M, Togashi H, Minami M, Saito H Pharmacological
368. Fu LW, Longhurst JC Role of 5-HT3 receptors in activation of abdominal sympathetic C fiber afferents during ischaemia in cats. J Physiol 1998, 509:729-740. pt 3.
369. Fu LW, Longhurst JC Interleukin-lbeta sensitizes abdominal visceral afferents of cats to ischaemia and histamine. J Physiol 1999, 521:249-260. pt 1.
370. Fu LW, O'Neill CA, Longhurst JC Increased histamine and 5-HT in portal vein plasma and mesenteric lymph during brief ischemia and reperfusion-Am. J Physiol 1997, 273:H1135-H1141.
371. Bulmer DCE, Jiang W, Hicks GA, Davis JB, Winchester WJ, Grundy D Vagal selective effects of ruthenium red on the jejunal afferent fiber response to ischaemia in the rat. Neurogastroenterol Motil 2005, 17:102-111.
372. Fu LW, Pan HL, Longhurst JC Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through HI receptors. Am J Physiol 1997, 273:H2726-H2737.
373. Longhurst JC, Rotto DM, Kaufman MP, Stahl GL Ischemically sensitive abdominal visceral afferents: response to cyclooxygenase blockade. Am J Physiol 1991, 261:H2075-H2081.
374. Pan HL, Stahl GL, Rendig SV, Carretero OA, Longhurst JC Endogenous BK stimulates ischemically sensitive abdominal visceral C fiber afferents through kinin B2 receptors. Am J Physiol 1994, 267:H2398-H2406.
375. Rendig SV, Pan HL, Longhurst JC Brief mesenteric ischemia increases PGE2, but not PGI2, in intestinal lymph of cats. Am J Physiol 1994, 266:R1692-R1696.
376. Stahl GL, Longhurst JC Ischemically sensitive visceral afferents: importance of H+ derived from lactic acid and hypercapnia. Am J Physiol 1992, 262:H748-H753.
377. Stahl GL, Pan HL, Longhurst JC Activation of ischemia-and reperfusion-sensitive abdominal visceral C fiber afferents. Role of hydrogen peroxide and hydroxyl radicals. Circ Res 1993, 72:1266-1275.
378. Jiang W, Grundy D Role of serotonin and mast cell degranulation in the acute jejunal ischemia evoked afferent excitation. Gastroenterology 2003, 124:S1698.
379. Brunsden AM, Jacob S, Bardhan KD, Grundy D Mesenteric afferent nerves are sensitive to vascular perfusion in a novel preparation of rat ileum in vitro. Am J Physiol Gastrointest Liver Physiol 2002, 283:G656-G665.
380. Holzer P Local microcirculatory reflexes and afferent signalling in response to gastric acid challenge. Gut 2000, 47(suppl 4):iv46-iv48.
381. Rozsa Z, Jacobson ED Capsaicin-sensitive nerves are involved in bile-oleate-induced intestinal hyperemia. Am J Physiol 1989, 256:G476-G481.
382. Rozsa Z, Sharkey KA, Jancso G, Varro V Evidence for a role of capsaicin-sensitive mucosal afferent nerves in the regulation of mesenteric blood flow in the dog. Gastroenterology 1986, 90:906-910.
383. Vanner S, Surprenant A Neural reflexes controlling intestinal micro-circulation. Am J Physiol 1996, 271:G223-G230.
384. Chai CY, Wu WC, Hwang JJ, Wang MR, Kuo JS Attenuation of cardiovascular reactions of vocalized and non-vocalized defence areas of periaqueductal grey following lesions in dorsomedial or ventrolateral medulla of cats. J Auton Nerv Syst 1997, 64:115-127.
385. Florczyk AP, Schurig JE, Bradner WT Cisplatin-induced emesis in the Ferret: a new animal model. Cancer Treat Rep 1982, 66:187-189.
386. Andrews PL, Davis CJ, Bingham S, Davidson HI, Hawthorn J, Maskell L The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity. Can J Physiol Pharmacol 1990, 68:325-345.
387. Hillsley K, Grundy D Plasticity in the mesenteric afferent response to cisplatin following vagotomy in the rat. J Auton Nerv Syst 1999, 76:93-98.
388. Reynolds DJ, Barber NA, Grahame-Smith DG, Leslie RA Cisplatin-evoked induction of c-fos protein in the brainstem of the ferret: the effect of cervical vagotomy and the anti-emetic 5-HT3 receptor antagonist granisetron (BRL 43694). Brain Res 1991, 565:231-236.
389. King GL, Rabin BM, Weatherspoon JK 5-HT3 receptor antagonists ameliorate emesis in the ferret evoked by neutron or proton radiation. Aviat Space Environ Med 1999, 70:485-492.
390. Ritchie J Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 1973, 14:125-132.
391. Ozaki N, Sengupta JN, Gebhart GF Differential effects of mu-, delta-, and kappa-opioid receptor agonists on mechanosensitive gastric vagal afferent fibers in the rat. J Neurophysiol 2000, 83:2209-2216.
392. Clarke GD, Davison JS Tension receptors in the esophagus and stomach of the rat. J Physiol 1975, 244:41P-42P.
393. Monnikes H, Ruter J, König M, Grote C, Kobelt P, Klapp BF, Arnold R, Wiedenmann B, Tebbe JJ Differential induction of c-fos expression in brain nuclei by noxious and non-noxious colonic distension: role of afferent C-fibers and 5-HT3 receptors. Brain Res 2003, 966:253-264.
394. White JC, Sweet WH Abdominal visceral disease. Pain and the neurosurgeon: a forty-year experience 1969, 560. Charles C. Thomas, Springfield, IL.
395. Gold MS, Shuster MJ, Levine JD Role of a Ca (2+)-dependent slow afterhyperpolarization in prostaglandin E2-induced sensitization of cultured rat sensory neurons. Neurosci Lett 1996, 205:161-164.
396. Spiller RC Postinfectious irritable bowel syndrome. Gastroenterology 2003, 124:1662-1671.
397. Bercik P, Wang L, Verdu EF, Mao YK, Blennerhassett P, Khan WI, Kean I, Tougas G, Collins SM Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction. Gastroenterology 2004, 127:179-187.
398. Laird JM, Souslova V, Wood JN, Cervero F Deficits in visceral pain referred hyperalgesia in Navl.8 (SNS/PN3)-null mice. J Neurosci 2002, 22:8352-8356.
399. Wu S, Zhu M, Wang W, Wang Y, Li Y, Yew DT Changes of the expres-sion of 5-HT receptor subtype mRNAs in rat dorsal root ganglion by complete Freund's adjuvant-induced inflammation. Neurosci Lett 2001, 307:183-186.
400. Tohda C, Sasaki M, Konemura T, Sasamura T, Itoh M, Kuraishi Y Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity. J Neurochem 2001, 76:1628-163 5.
401. Xu GY, Huang LY Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons. J Neurosci 2002, 22:93-102.
402. Lamb K, Kang YM, Gebhart GF, Bielefeldt K Nerve growth factor and gastric hyperalgesia in the rat. Neurogastroenterol Motil 2003, 15:355-361.
403. Linden DR, Sharkey KA, Ho W, Mawe GM Cyclooxygenase-2 contributes to dysmotility and enhanced excitability of myenteric AH neurones in the inflamed guinea pig distal colon. J Physiol 2004, 557:191-205.
404. Gould HJ III, England JD, Soignier RD, Nolan P, Minor LD, Liu ZP, Levinson SR, Paul D Ibuprofen blocks changes in Nav 1.7 1.8 sodium channels associated with complete Freund's adjuvant-induced inflammation in rat. J Pain 2004, 5:270-280.
405. Clerc N Afferent innervation of the lower oesophageal sphincter of the cat. An HRP study. J Auton Nerv Syst 1983, 9:623-636.
406. Hudson LC, Cummings JF The origins of innervation of the esophagus of the dog. Brain Res 1985, 326:125-136.
407. Khurana RK, Petras JM Sensory innervation of the canine esophagus, stomach, and duodenum. Am JAnat 1991, 192:293-306.
408. Sang Q, Goyal RK Lower esophageal sphincter relaxation and activation of medullary neurons by subdiaphragmatic vagal stimulation in the mouse. Gastroenterology 2000, 119:1600-1609.
409. Brtva RD, Iwamoto GA, Longhurst JC Distribution of cell bodies for primary afferent fibers from the stomach of the cat. Neurosci Lett 1989, 105:287-293.
410. Elfvin LG, Lindh B A study of the extrinsic innervation of the guinea pig pylorus with the horseradish peroxidase tracing technique. JCompNeurol 1982, 208:317-324.
411. Hudson LC The location of extrinsic efferent and afferent nerve cell bodies of the normal canine stomach. J Auton Nerv Syst 1989, 28:1-14.
412. Scharoun SL, Barone FC, Wayner MJ, Jones SM Vagal and gastric connections to the central nervous system determined by the transport of horseradish peroxidase. Brain Res Bull 1984, 13:573-583.
413. Carobi C, Magni F The afferent innervation of the liver: a horseradish peroxidase study in the rat. Neurosci Lett 1981, 23:269-274.
414. Magni F, Carobi C The afferent and preganglionic parasympathetic innervation of the rat liver, demonstrated by the retrograde transport of horseradish peroxidase. J Auton Nerv Syst 1983, 8:237-260.
415. Furuzawa Y, Ohmori Y, Watanabe T Anatomical localization of sympathetic postganglionic and sensory neurons innervating the pancreas of the cat. J Vet Med Sci 1996, 58:243-248.
416. Sharkey KA, Williams RG Extrinsic innervation of the rat pancreas: demonstration of vagal sensory neurones in the rat by retrograde tracing. Neurosci Lett 1983, 42:131-135.
417. Sharkey KA, Williams RG, Dockray GJ Sensory substance P innerva-tion of the stomach pancreas. Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing. Gastroenterology 1984, 87:914-921.
418. Cottrell DF, Greenhorn JG The vagal and spinal innervation of the gastro-duodenal junction of sheep. Q J Exp Physiol 1987, 72:513-524.
419. Cervero F, Sharkey KA An electrophysiological and anatomical study of intestinal afferent fibers in the rat. J Physiol 1988, 401:381-397.
420. Hopkins DA, Armour JA Ganglionic distribution of afferent neurons innervating the canine heart and cardiopulmonary nerves. J Auton NervSyst 1989, 26:213-222.
421. Kuo DC, Oravitz JJ, deGroat WC Tracing of afferent and efferent pathways in the left inferior cardiac nerve of the cat using retrograde and transganglionic transport of horseradish peroxida. Brain Res 1984, 321:111-118.
422. Lee KH, Kim J, Chung JM Segmental distribution of dorsal root ganglion cells with axons in the inferior cardiac nerve. Neurosci Lett 1984, 52:185-190.
423. Ruhle W, Dembowsky K, Czachurski J, Seller H Segmentai distribution of afferent fibers in the left inferior cardiac nerve of the cat studied by anterograde transport of horseradish peroxidase. Neurosci Lett 1985, 56:353-358.
424. Applebaum AE, Vance WH, Coggeshall RE Segmental localization of sensory cells that innervate the bladder. J Comp Neurol 1980, 192:203-209.
425. Nadelhaft I, Vera PL Central nervous system neurons infected by pseudorabies virus injected into the rat urinary bladder following unilateral transection of the pelvic nerve. J Comp Neurol 1995, 359:443-456.
426. Pascual JI, Insausti R, Gonzalo LM Urinary bladder innervation in male rat: termination of primary afferents in the spinal cord as determined by transganglionic transport of WGA-HRP. J Urol 1993, 150:500-504.
427. Vera PL, Nadelhaft I Afferent and sympathetic innervation of the dome and the base of the urinary bladder of the female rat. Brain Res Bull 1992, 29:651-658.
428. Vizzard MA, Erdman SL, de Groat WC Localization of NADPH diaphorase in bladder afferent and postganglionic efferent neurons of the rat. J Auton Nerv Syst 1993, 44:85-90.
429. Wang HF, Shortland P, Park MJ, Grant G Retrograde and transgan-glionic transport of horseradish peroxidase-conjugated cholera toxin B subunit, wheatgerm agglutinin and isolectin B4 from Griffonia simplicifolia I in primary afferent neurons innervating the rat urinary bladder. Neuroscience 1998, 87:275-288.
430. Blackshaw LA, Grundy D Effects of cholecystokinin (CCK-8) on two classes of gastroduodenal vagal afferent fiber. J Auton Nerv Syst 1990, 31:191-201.
431. Cox JE, Randich A CCK-8 activates hepatic vagal C-fiber afferents. Brain Res 1997, 776:189-194.
432. Wei JY, Wang YH Effect of CCK pretreatment on the CCK sensitivity of rat polymodal gastric vagal afferent in vitro. Am J Physiol Endocrinol Metab 2000, 279:E695-E706.
433. Naruse S, Kitagawa M, Ishiguro H, Hayakawa T Feedback regulation of pancreatic secretion by peptide YY. Peptides 2002, 23:359-365.
434. Zai H, Haga N, Fujino MA, Itoh Z Effect of peptide YY on gastric motor and secretory activity in vagally innervated and denervated corpus pouch dogs. Regul Pept 1996, 61:181-188.
435. Kirkup AJ, Eastwood C, Grundy D, Chessell IP, Humphrey PP Characterization of adenosine receptors evoking excitation of mesenteric afferents in the rat. Br J Pharmacol 1998, 125:1352-1360.
436. Kreis ME, Haupt W, Kirkup AJ, Grundy D Histamine sensitivity of mesenteric afferent nerves in the rat jejunum. Am J Physiol 1998, 275:G675-G680.
437. Kreis ME, Jiang W, Kirkup AJ, Grundy D Cosensitivity of vagal mucosal afferents to histamine and 5-HT in the rat jejunum. Am J Physiol Gastrointest Liver Physiol 2002, 283:G612-G617.
438. Brunsden AM, Grundy D Sensitization of visceral afferents to bradykinin in rat jejunum in vitro. J Physiol 1999, 521:517-527. pt 2.
439. Gold MS, Traub RJ Cutaneous and colonic rat DRG neurons differ with respect to both baseline and PGE2-induced changes in passive and active electrophysiological properties. J Neurophysiol 2004, 91:2524-2531.
440. Maubach KA, Grundy D The role of prostaglandins in the bradykinin-induced activation of serosal afferents of the rat jejunum in vitro. J Physiol 1999, 515:277-285. pt l.
441. Haupt P, Janig W, Kohler W Response pattern of visceral afferent fibers, supplying the colon, upon chemical and mechanical stimuli. Pflugers Arch 1983, 398:41-47.
442. Sengupta JN, Saha JK, Goyal RK Differential sensitivity to bradykinin of esophageal distension-sensitive mechanoreceptors in vagal and sympathetic afferents of the opossum. J Neurophysiol 1992, 68:1053-1067.
443. Eastwood C, Grundy D Opioid-receptor-mediated excitation of rat mesenteric afferent fibers supplying the rat jejunum. Neurogastroenterol Motil 2000, 12:517-522.
444. Sengupta JN, Snider A, Su X, Gebhart GF Effects of kappa opioids in the inflamed rat colon. Pain 1999, 79:175-185.
445. Sengupta JN, Su X, Gebhart GF Kappa, but not mu or delta, opioids attenuate responses to distention of afferent fibers innervating the rat colon. Gastroenterology 1996, 111:968-980.
446. Partosoedarso ER, Young RL, Blackshaw LA GABA (B) receptors on vagal afferent pathways: peripheral and central inhibition. Am J Physiol Gastrointest Liver Physiol 2001, 280:G658-G668.
447. Smid SD, Young RL, Cooper NJ, Blackshaw LA GABA (B) R expressed on vagal afferent neurones inhibit gastric mechanosensitivity in ferret proximal stomach. Am J Physiol Gastrointest Liver Physiol 2001, 281:G1494-G1501.