Opioid-receptor-mediated excitation of rat mesenteric afferent fibres supplying the rat jejunum

Neurogastroenterology and Motility

Volumn 12, Issue 6, 2000, Pages 517-522

  Eastwood, C ^a   Grundy, D ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

5 HT; Afferents; CCK; Opioids; Small intestine; Vagus nerve

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; CHOLECYSTOKININ; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; OPIATE RECEPTOR; SEROTONIN;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ELECTROPHYSIOLOGY; EXCITATION; INTESTINE DISTENSION; INTESTINE MOTILITY; JEJUNUM; MALE; MESENTERY; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SENSORY NERVE CONDUCTION; STRETCH RECEPTOR; VAGUS NERVE; VAGUS NERVE STIMULATION;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, LEUCINE-2-ALANINE; JEJUNUM; MALE; NEURONS, AFFERENT; RATS; RATS, WISTAR; RECEPTORS, OPIOID; VAGOTOMY; VAGUS NERVE;

EID: 0034536724     PISSN: 13501925     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2982.2000.00226.x     Document Type: Article

References (24)

1. Opioids in visceral pain
2. Effects of kappa opioid receptor-selective agonists on responses of pelvic nerve afferents to noxious colorectal distension
3. Effects of kappa opioids in the inflamed rat colon
4. Differential effects of mu-, delta-, and kappa-opioid receptor agonists on mechanosenstive gastric vagal afferent fibres in the rat
5. Intravenous morphine-induced activation of vagal afferents: Peripheral, spinal, and CNS substrates mediating inhibition of spinal nociception and cardiovascular responses
6. Role of vagal afferents in the antinociception produced by morphine and U-50,488H in the colonic pain reflex in rats
7. Vagal afferent modulation of nociception
8. Sensitivity to 5-hydroxytryptamine in different afferent subpopulations within mesenteric nerves supplying the rat jejunum
9. Sensitivity of vagal mucosal afferents to cholecystokinin and its role in afferent signal transduction in the rat
10. The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine
11. Dose-dependent antagonism of spinal opioid receptor agonists by nalaxone and naltrindole: Additional evidence for delta-opioid receptor subtypes in the rat
12. Autoradiographic localization of mu- and delta-type opioid receptors in the gastrointestinal tract of the rat and guinea pig
13. Localization of mu-opioid receptor-like immunoreactivity in the central components of the vagus nerve: A light and electron microscope study in the rat
14. Opiate effects on rabbit vagus nerve: Electrophysiology and radioligand binding
15. Serotinin and cholecystokinin activate different populations of rat mesenteric vagal afferents
16. Cholecystokinin type A and type B receptors and their modulation of opioid analgesia
17. Effects of duodenal nutrients on sensory and motor responses of the human stomach to distension
18. Volume-sensitive synaptic input to neurons in guinea pig inferior mesenteric ganglion
19. Opioid receptors
20. Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat
21. Direct excitatory opiate effects mediated by non-synaptic actions on rat medial vestibular neurons
22. Opioids can evoke direct receptor-mediated excitatory effects on sensory neurons
23. Facilitatory effects of opioids on the discharges of visceral nociceptors
24. + channels in sensory ganglion neurons