4-Aminopyridine- and dendrotoxin-sensitive potassium channels influence excitability of vagal mechano-sensitive endings in guinea-pig oesophagus

British Journal of Pharmacology

Volumn 137, Issue 8, 2002, Pages 1195-1206

  Zagorodnyuk, Vladimir P ^a   Nan Chen, Bao ^a   Costa, Marcello ^a   Brookes, Simon J H ^a  

^a FLINDERS UNIVERSITY   (Australia)

Author keywords

Afferents; Oesophagus; Potassium channels; Vagus nerve

Indexed keywords

4 AMINOPYRIDINE; ALPHA DENDROTOXIN; APAMIN; BARIUM; CHARYBDOTOXIN; DENDROTOXIN; DENDROTOXIN K; GLIBENCLAMIDE; IBERIOTOXIN; OMEGA CONOTOXIN GVIA; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ELECTRIC POTENTIAL; ESOPHAGUS; FEMALE; GUINEA PIG; MALE; MECHANORECEPTOR; NONHUMAN; PRIORITY JOURNAL; TENSION; VAGUS NERVE;

4-AMINOPYRIDINE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELAPID VENOMS; ESOPHAGUS; FEMALE; GUINEA PIGS; MALE; MECHANORECEPTORS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; VAGUS NERVE;

EID: 0036955139     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704964     Document Type: Article

References (30)

1. + channels in mammalian skeletal muscle cells. Eur. J. Pharmacol., 236, 419-426.
2. Bargmann, C.I. (1998). Neurobiology of the Caenorhabditis elegans genome. Science, 282, 2028-2033.
3. Brookes, S.J.H., Chen, B.N., Costa, M. & Humphreys, C.M.S. (1999). Initiation of peristalsis by circumferential stretch in flat sheets of guinea-pig ileum. J. Physiol., 516.2, 528-538.
4. + currents involved in action-potential repolarization. J. Neurophysiol., 71, 561-574.
5. Cordoba-Rodriguez, R., Moore, K.A., Kao, J.P. & Weinreich, D. (1999). Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. Proc. Natl. Acad. Sci. U.S.A., 96, 7650-7657.
6. Davenport, P.W., Sant'Ambrogio, F.B. & Sant'Ambrogio, G. (1981). Adaptation of tracheal stretch receptors. Respir. Physiol., 44, 339-349.
7. Doan, T.N. & Kunze, D.L. (1999). Contribution of the hyperpolarization-activated current to the resting membrane potential of rat nodose sensory neurons. J. Physiol., 514, 125-138.
8. Ducreux, C. & Puizillout, J.J. (1995). A-current modifies the spike of C-type neurones in the rabbit nodose ganglion. J. Physiol., 486, 439-451.
9. Garcia, M.L., Galvez, A., Garcia-Calvo., King, V.G., Vazquez, J. & Kaczorowski, G.J. (1991). Use of toxins to study potassium channels. J. Bioenerg. Biomembr., 23, 615-646.
10. Garcia, M.L., Knaus, H.G., Munujos, P., Slaughter, R.S. & Kaczorowski, G.J. (1995). Charybdotoxin and its effects on potassium channels. Am. J. Physiol., 269, C1-C10.
11. Glazebrook, P.A., Ramirez, A.N., Schild, J.H., Shieh, C.C., Doan, T., Wible, B.A. & Kunze, D.L. (2002). Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons. J. Physiol., 541, 467-482.
12. + channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol. Pharmacol., 45, 1227-1234.
13. HARPER, A.A. (1991). Similarities between some properties of the soma and sensory receptors of primary afferent neurones. Exp. Physiol., 76, 369-377.
14. Harvey, A.L. (2001). Twenty years of dendrotoxins. Toxicon, 39, 15-26.
15. Hay, M. & Kunze, D.L. (1994a). Calcium-activated potassium channels in rat visceral sensory afferents. Brain Res., 639, 333-336.
16. Hay, M. & Kunze, D.L. (1994b). An intermediate conductance calcium-activated potassium channel in rat visceral sensory afferent neurons. Neurosci. Lett., 167, 179-182.
17. Higashi, H., Ueda, N., Nishi, S., Gallagher, J.P. & Shinnick-Gallagher, P. (1982). Chemoreceptors for serotonin (5-HT), acetylcholine (ACh), bradykinin (BK), histamine (H) and gamma-aminobutyric acid (GABA) on rabbit visceral afferent neurons. Brain Res. Bull., 8, 23-32.
18. Jan, L.Y. & Jan, Y.N. (1997). Voltage-gated and inwardly rectifying potassium channels. J. Physiol., 505, 267-282.
19. Lesage, F. & Lazdunski, M. (2000). Molecular and functional properties of two-pore-domain potassium channels. Am. J. Physiol., 279, F793-F801.
20. Kf) in rat dorsal root ganglion neurones. J. Physiol., 503, 285-301.
21. McAlexander, M.A., Myers, A.C. & Undem, B.J. (1999). Adaptation of guinea-pig vagal airway afferent neurones to mechanical stimulation. J. Physiol., 1, 239-247.
22. McAlexander, M.A. & Undem, B.J. (2000). Potassium channel blockade induces action potential generation in guinea-pig airway vagal afferent neurones. J. Auton. Nerv. Syst., 78, 158-164.
23. McManus, O.B. (1991). Calcium-activated potassium channels: regulation by calcium. J. Bioenerg. Biomembr., 23, 537-560.
24. Reid, G., Scholz, A., Bostock, H. & Vogel, W. (1999). Human axons contain at least five types of voltage-dependent potassium channel. J. Physiol., 518, 681-696.
25. Robertson, B., Owen, D., Stow, J., Butler, C. & Newland, C. (1996). Novel effects of dendrotoxin homologues on subtypes of mammalian Kv1 potassium channels expressed in Xenopus oocytes. FEBS Lett., 383, 26-30.
26. Stansfeld, C.E., Marsh, S.J., Halliwell, J.V. & Brown, D.A. (1986). 4-Aminopyridine and dendrotoxin induce repetitive firing in rat visceral sensory neurones by blocking a slowly inactivating outward current. Neurosci. Lett., 64, 299-304.
27. Undem, B.J. & Weinreich, D. (1993). Electrophysiologial properties and chemosensitivity of guinea pig nodose ganglion neurons in vitro. J. Auton. Nerv. Syst., 44, 17-33.
28. Zagorodnyuk, V.P. & Brookes, S.J.H. (2000). Transduction sites of vagal mechanoreceptors in the guinea pig esophagus. J. Neurosci., 20, 6249-6255.
29. Zagorodnyuk, V.P., Chen, B.N. & Brookes, S.J.H. (2001). Intraganglionic laminar endings are mechano-transduction sites of vagal tension receptors in the guinea-pig stomach. J. Physiol., 534, 255-268.
30. Zagorodnyuk, V.P., Chen, B.M., Costa, M. & Brookes, S.J.H. (2002). Calcium- and voltage-dependent potassium channels control excitability of vagal mechanoreceptors in guinea-pig oesophagus. Proc. Au. Neurosci. Soc., 13, 52P.