Characterization of adenosine receptors evoking excitation of mesenteric afferents in the rat

British Journal of Pharmacology

Volumn 125, Issue 6, 1998, Pages 1352-1360

  Kirkup, A J ^a   Eastwood, C ^a,c   Grundy, D ^a   Chessell, I P ^b   Humphrey, P P A ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c Astra Pharmaceuticals Ltd   (United Kingdom)

Author keywords

Adenosine receptors; Afferent nerves; CGS21680; DPCPX; GR79236; IB MECA; In vivo; Jejunum; NECA; ZM241385

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 6 N (2 HYDROXYCYCLOPENTYL)ADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; BETHANECHOL;

ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; FEMALE; HYPOTENSION; INTESTINE INNERVATION; INTESTINE PRESSURE; JEJUNUM; MALE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE;

EID: 0031797988     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702202     Document Type: Article

References (44)

1. 1-purinoceptors mediating contraction of the rat colon muscularis mucosae. Br. J. Pharmacol., 105, 400-404.
2. BAILEY, S.J. & HOURANI, S.M.O. (1990). A study of the purinoceptors mediating contraction in the rat colon. Br. J. Pharmacol., 100, 753-756.
3. BAILEY, S.J. & HOURANI, S.M.O. (1992). Effects of purines on the longitudinal muscle of the rat colon. Br. J. Pharmacol., 105, 885-892.
4. BARAJAS-LÒPEZ, C., SURPRENANT, A. & NORTH, R.A. (1991). Adenosine A-1 and adenosine A-2 receptors mediate presynaptic inhibition and postsynaptic excitation in guinea-pig submucosal neurons. J. Pharmacol. Exp. Ther., 258, 490-495.
5. 2A adenosine receptor antagonists. Bioorg. Med. Chem. Lett., 4, 2539-2544.
6. BLEEHEN, T., HOBBIGER, F. & KEELE, C.A. (1976). Identification of algogenic substances in human erythrocytes. J. Physiol., 262, 131-149.
7. BRUNS, R.F., FERGUS, J.H., BADGER, E.W., BRISTOL, J.A., SANTAY, L.A., HARTMAN, J.D., HAYS, S.J. & HUANG, C.C. (1987). Binding of the A-1 selective adenosine antagonist 8-cyclopentyl-1,3dipropylxanthine to rat brain membranes. Naun. Schmied. Arch. Pharmacol., 334, 59-63.
8. BRUNSDEN, A., MAUBACH, K. & GRUNDY, D. (1998). Sensitization of bradykinin-induced excitability in serosal afferents from rat jejunum in vitro. Neurogastroenterol. & Motil., Proc. 16th Symp. on Gastro. Motil., 10, 63.
9. BURNSTOCK, G. & WOOD, J.N. (1996). Purinergic receptors: their role in nociception and primary afferent neurotransmission. Curr. Opin. Neurobiol., 6, 526-532.
10. 6-2-(4-aminophenyl)ethyladenosine in the rat. Drug Dev. Res., 30, 147-152.
11. CHERNIAK, N.S., RUNOLD, M., PRABHAKAR, N.R. & MITRA, J. (1987). Effect of adenosine on vagal sensory pulmonary afferents. Fedn Proc. Fedn Am. Socs Biol. 46, 825.
12. COLLIS, M.G. & HOURANI, S.M.O. (1993). Adenosine receptor subtypes. Trends Pharmacol. Sci., 14, 360-366.
13. EASTWOOD, C. & GRUNDY, D. (1996). Mast cell modulation of intestinal afferents. Gastroenterol., 110, A659.
14. EDLUND, A., FREDHOLM, B.B., PATRIGUANI, P., PATRONO, C., WENNMALM, A. & WENNMALM, M. (1983). Release of two vasodilators-adenosine and prostacyclin from isolated rabbit hearts during controlled hypoxia. J. Physiol., 340, 487-501.
15. 2b receptors evoke interleukin-8 secretion in human mast cells. J. Clin. Invest., 96, 1979-1986.
16. 2B adenosine receptor subtypes. Biochem. Pharmacol., 55, 627-633.
17. 3 receptors mediate hypotension in the angiotensin II-supported circulation of the pithed rat. Br. J. Pharmacol., 109, 3-5.
18. FREDHOLM, B.B., ABBRACCHIO, M.P., BURNSTOCK, G., DALY, J.W., HARDEN, T.K., JACOBSON, K.A., LEFF, P. & WILLIAMS, M. (1994). Nomenclature and classification of purinoceptors. Pharmacol. Rev., 46, 143-156.
19. GURDEN, M.F., COATES, J., ELLIS, F., EVANS, B., FOSTER, M., HORNBY, E., KENNEDY, I., MARTIN, D.P., STRONG, P., VARDEY, C.J. & WHEELDON, A. (1993). Functional characterization of three adenosine receptor types. Br. J. Pharmacol., 109, 693-698.
20. HANCOCK, D.L. & COUPAR, I.M. (1995a). Functional characterization of the adenosine receptor mediating inhibition of intestinal secretion. Br. J. Pharmacol., 114, 152-156.
21. HANCOCK, D.L. & COUPAR, I.M. (1995b). Functional characterization of the adenosine receptor mediating inhibition of peristalsis in the rat jejunum. Br. J. Pharmacol., 115, 739-744.
22. HILL, S.J. (1990). Distribution, properties and functional characteristics of three classes of histamine receptors. Pharmacol. Rev., 42, 45-83.
23. HILLSLEY, K., KIRKUP, A.J. & GRUNDY, D. (1998). Direct and indirect actions of 5-hydroxytryptamine on the discharge of mesenteric afferent fibres innervating the rat. J. Physiol., 506, 551-561.
24. 2 selective adenosine receptor agonist with preferential hypotensive activity. J. Pharm. Exp. Ther., 251, 47-55.
25. JACOBSON, K.A., NIKODIJEVIC, O., SHI, D., GALLO-RODRIQUEZ, C., OLAH, M.E., STILES, G.L. & DALY, J.W. (1993). A role for central A-3-adenosine receptors: Mediation of behavioral depressant effects. FEBS Lett., 336, 57-60.
26. 2 receptors in rat brain. J. Pharmacol. Exp. Ther., 251, 888-893.
27. KATAYAMA, Y. & MORITA, K. (1989). Adenosine 5′-Triphosphate modulates membrane potassium conductance in guinea-pig myenteric neurones. J. Physiol., 408, 373-390.
28. KATHOLI, R.E., MCCANN, W.P. & WOODS, W.T. (1985). Intrarenal adenosine produces hypertension via renal nerves in the one-kidney, one clip rat. Hypertension 7 (suppl. 1), 188-193.
29. KIRKUP, A.J., EASTWOOD, C., GRUNDY, D., CHESSELL, I.P. & HUMPHREY, P.P.A. (1997). Activation of adenosine receptors increases rat mesenteric afferent nerve discharge. Br. J. Pharmacol. 120 (Proc. Suppl.), 18P.
30. MCQUEEN, D.S. & RIBEIRO, J.A. (1986). Pharmacological characterization of the receptor involved in chemoexcitation induced by adenosine. Br. J. Pharmacol., 88, 615-620.
31. 1-purinoceptors on rat isolated duodenum longitudinal muscle and muscularis mucosae. Br. J. Pharmacol., 117, 170-174.
32. NICHOLLS, J. & HOURANI, S.M.O. (1997). Characterization of adenosine receptors on rat ileum, ileal longitudinal muscle and muscularis mucosae. Eur. J. Pharmacol., 338, 143-150.
33. 1-purinoceptors on rat duodenum and urinary bladder. Br. J. Pharmacol., 105, 639-642.
34. 125I-4-aminobenzyl-5′-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A-3 adenosine receptor. Mol. Pharmacol., 45, 978-982.
35. OLAH, M.E. & STILES, G.L. (1995). Adenosine receptor subtypes: characterization and therapeutic regulation. Annu. Rev. Pharmacol. Toxicol., 35, 581-606.
36. 3 receptor agonist iodobenzyl-5-N-methyl carboxamidoadenosine, IB-MECA, in anaesthetized cats. Br. J. Pharmacol., 120 (Proc. suppl.), 16P.
37. 3 receptor. Br. J. Pharmacol., 113, 741-748.
38. 2a-selective adenosine receptor antagonist. Br. J. Pharmacol., 115, 1096-1102.
39. STEBBINS, C.L., SMITH, R.C. & LONGHURST, J.C. (1985). Effect of prostaglandins on bradykinin-induced visceral-cardiac reflexes. Am. J. Physiol., 249, H155-H163
40. TAIWO, Y.O. & LEVINE, J.D. (1990). Direct cutaneous hyperalgesia induced by adenosine. Neurosci., 38, 757-762.
41. TREZISE, D.J., KENNEDY, I. & HUMPHREY, P.P.A. (1993). Characterization of purinoceptors mediating depolarization of rat isolated vagus nerve. Br. J. Pharmacol., 110, 1055-1060.
42. 3 adenosine receptor. Mol. Pharmacol., 45, 1101-1111.
43. WILLIAMS, R.M., BERTHOUD, H.R. & STEAD, R.H. (1995). Association between vagal afferent nerve fibres and mast cells in rat jejunal mucosa. Gastroenterol., 108, A941.
44. 3 adenosine receptor. Proc. Natl. Acad. Sci. U.S.A., 89, 7432-7436.