Two TTX-resistant Na+ currents in mouse colonic dorsal root ganglia neurons and their role in colitis-induced hyperexcitability

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 287, Issue 4 50-4, 2004, Pages

  Beyak, Michael J ^a   Ramji, Noor ^a   Krol, Karmen M ^a   Kawaja, Michael D ^a   Vanner, Stephen J ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b HOTEL DIEU HOSPITAL   (Canada)

Author keywords

Nociception colon; Sodium channels; Tyrosine kinase A positive neurons

Indexed keywords

PROTEIN TYROSINE KINASE; SODIUM CHANNEL; SODIUM ION; TETRODOTOXIN;

ABDOMINAL PAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE EXCITABILITY; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SODIUM CURRENT; SPINAL GANGLION;

ANESTHETICS, LOCAL; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; COLITIS; COLON; FEMALE; GANGLIA, SPINAL; KINETICS; LECTINS; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED STRAINS; NEURONS, AFFERENT; NEUROPEPTIDES; NOCICEPTORS; RECEPTOR, TRKA; SODIUM; SODIUM CHANNELS; TETRODOTOXIN;

EID: 4644290610     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00154.2004     Document Type: Article

References (51)

1. Akopian AN, Sivilotti L, and Wood JN. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 379: 257-262, 1996.
2. Bielefeldt K, Ozaki N, and Gebhart GF. Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons. Gastroenterology 122: 394-405, 2002.
3. Bielefeldt K, Ozaki N, and Gebhart GF. Role of nerve growth factor in modulation of gastric afferent neurons in the rat. Am J Physiol Gastrointest Liver Physiol 284: G499-G507, 2003.
4. v 19/NaN in afferent neurons innervating urinary bladder in control and spinal cord injured rats. Brain Res 963: 132-138, 2003.
5. Blackshaw LA and Gebhart GF. The pharmacology of gastrointestinal nociceptive pathways. Curr Opin Pharmacol 2: 642-649, 2002.
6. Cummins TR, Dib-Hajj SD, Black JA, Akopian AN, Wood JN, and Waxman SG. A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons. J Neurosci 19: RC43, 1999.
7. Dang K, Bielefeldt K, and Gebhart GF. Gastric ulcers reduce A-type potassium currents in rat gastric sensory ganglion neurons. Am J Physiol Gastrointest Liver Physiol 286: G573-G579, 2004.
8. v19: a sodium channel with unique properties. Trends Neurosci 25: 253-259, 2002.
9. Dmitrieva N, Shelton D, Rice AS, and McMahon SB. The role of nerve growth factor in a model of visceral inflammation. Neuroscience 78: 449-459, 1997.
10. v1.9 (NaN) in nociceptive primary afferent neurons. J Neurosci 22: 7425-7433, 2002.
11. Fjell J, Cummins TR, Davis BM, Albers KM, Fried K, Waxman SG, and Black JA. Sodium channel expression in NGF-overexpressing transgenic mice. J Neurosci Res 57: 39-47, 1999.
12. Fjell J, Cummins TR, Dib-Hajj SD, Fried K, Black JA, and Waxman SG. Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons. Brain Res Mol Brain Res 67: 267-282, 1999.
13. Fjell J, Cummins TR, Fried K, Black JA, and Waxman SG. In vivo NGF deprivation reduces SNS expression and TTX-R sodium currents in IB4-negative DRG neurons. J Neurophysiol 81: 803-810, 1999.
14. Na: an underlying mechanism of inflammatory hyperalgesia. Proc West Pharmacol Soc 42: 111-112, 1999.
15. + currents and inflammatory hyperalgesia. Proc Natl Acad Sci USA 96: 7645-7649, 1999.
16. 2-induced changes in passive and active electrophysiological properties. J Neurophysiol 91: 2524-2531 2004.
17. Na in rat colonic sensory neurons. J Neurophysiol 88: 1512-1522, 2002.
18. Goldin AL, Barchi RL, Caldwell JH, Hofmann F, Howe JR, Hunter JC, Kallen RG, Mandel G, Meisler MH, Netter YB, Noda M, Tamkun MM, Waxman SG, Wood JN, and Catterall WA. Nomenclature of voltage-gated sodium channels. Neuron 28: 365-368, 2000.
19. + current affects resting potential and response to depolarization in simulated spinal sensory neurons. J Neurophysiol 86: 1351-1364, 2001.
20. Hille B. The superfamily of voltage-gated channels. In: Ion Channels of Excitable Membranes. Sunderland, MA: Sinauer Associates, 2001, p. 62-94.
21. v 1.8 in NGF-induced hyperalgesia, but not neuropathic pain. Neuroreport 12: 3077-3080, 2001.
22. Kidd BL and Urban LA. Mechanisms of inflammatory pain. Br J Anaesth 87: 3-11, 2001.
23. Lai J, Hunter JC, and Porreca F. The role of voltage-gated sodium channels in neuropathic pain. Curr Opin Neurobiol 13: 291-297, 2003.
24. Lai J, Porreca F, Hunter JC, and Gold MS. Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol 44: 371-397, 2004.
25. Lamb K, Kang YM, Gebhart GF, and Bielefeldt K. Nerve growth factor and gastric hyperalgia in the rat. Neurogastroenterol Motil 15: 355-361, 2003.
26. Mannion RJ, Costigan M, Decosterd I, Amaya F, Ma QP, Holstege JC, Ji RR, Acheson A, Lindsay RM, Wilkinson GA, and Woolf CJ. Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. Proc Natl Acad Sci USA 96: 9385-9390, 1999.
27. Mayer EA and Raybould HE. Role of visceral afferent mechanisms in functional bowel disorders. Gastroenterology 99: 1688-1704, 1990.
28. Moore BA, Stewart TM, Hill C, and Vanner SJ. TNBS ileitis evokes hyperexcitability and changes in ionic membrane properties of nociceptive DRG neurons. Am J Physiol Gastrointest Liver Physiol 282: G1045-G1051, 2002.
29. Morris GP, Beck PL, Herridge MS, Depew WT, Szewczuk MR, and Wallace JL. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 96: 795-803, 1989.
30. Priestley JV, Michael GJ, Averill S, Liu M, and Willmott N. Regulation of nociceptive neurons by nerve growth factor and glial cell line derived neurotrophic factor. Can J Physiol Pharmacol 80: 495-505, 2002.
31. v 1.8 sodium channels to action potential electrogenesis in DRG neurons. J Neurophysiol 86: 629-640, 2001.
32. v1.5 underlies the 'third TTX-R sodium current' in rat small DRG neurons. Brain Res Mol Brain Res 106: 70-82, 2002.
33. Renganathan M, Gelderblom M, Black JA, and Waxman SG. Expression of Nav1.8 sodium channels perturbs the firing patterns of cerebellar Purkinje cells. Brain Res 959: 235-242, 2003.
34. Robinson DR, McNaughton PA, Evans ML, and Hicks GA. Characterization of the primary spinal afferent innervation of the mouse colon using retrograde labelling. Neurogastroenterol Motil 16: 113-124, 2004.
35. + channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. J Physiol 550: 921-926, 2003.
36. Satin J, Kyle JW, Chen M, Bell P, Cribbs LL, Fozzard HA, and Rogart RB. A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties. Science 256: 1202-1205, 1992.
37. Scholz J and Woolf CJ. Can we conquer pain? Nat Neurosci 5, Suppl: 1062-1067, 2002.
38. Stewart TM, Beyak MJ, and Vanner SJ. Ileitis modulates potassium and sodium currents in guinea pig dorsal root ganglia sensory neurons. J Physiol 552: 797-807 2003.
39. + channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model. Neuroreport 9: 967-972, 1998.
40. Traub RJ. Evidence for thoracolumbar spinal cord processing of inflammatory, but not acute colonic pain. Neuroreport 11: 2113-2116, 2000.
41. Traub RJ and Murphy A. Colonic inflammation induces fos expression in the thoracolumbar spinal cord increasing activity in the spinoparabrachial pathway. Pain 95: 93-102, 2002.
42. v1.8 peripheral nerve sodium channels. J Neurosci 21: 7909-7918, 2001.
43. Waxman SG. Transcriptional channelopathies: an emerging class of disorders. Nat Rev Neurosci 2: 652-659, 2001.
44. Waxman SG, Cummins TR, Black JA, and Dib-Hajj S. Diverse functions and dynamic expression of neuronal sodium channels. Novartis Found Symp 241: 34-51, 2002.
45. Waxman SG, Cummins TR, Dib-Hajj S, Fjell J, and Black JA. Sodium channels, excitability of primary sensory neurons, and the molecular basis of pain. Muscle Nerve 22: 1177-1187, 1999.
46. Wood JN and Baker M. Voltage-gated sodium channels. Curr Opin Pharmacol 1: 17-21, 2001.
47. Woolf CJ and Costigan M. Transcriptional and posttranslational plasticity and the generation of inflammatory pain. Proc Natl Acad Sci USA 96: 7723-7730, 1999.
48. Yiangou Y, Birch R, Sangameswaran L, Eglen R, and Anand P. SNS/PN3 and SNS2/NaN sodium channel-like immunoreactivity in human adult and neonate injured sensory nerves. FEBS Lett 467: 249-252, 2000.
49. Yoshimura N and de Groat WC. Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation. J Neurosci 19: 4644-4653, 1999.
50. Yoshimura N, Seki S, Erickson KA, Erickson VL, Hancellor MB, and de Groat WC. Histological and electrical properties of rat dorsal root ganglion neurons innervating the lower urinary tract. J Neurosci 23: 4355-4361, 2003.
51. v1.8(PN3/SNS) in a rat model of visceral pain. J Neurosci 21: 8690-8696, 2001.