Brain-gut axis in health and disease

Gastroenterology

Volumn 114, Issue 3, 1998, Pages 559-578

  Aziz, Q ^a   Thompson, D G ^a  

^a HOPE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; WATER O 15;

ABDOMINAL PAIN; AMBIGUUS NUCLEUS; AUTONOMIC NERVOUS SYSTEM; BRAIN; BRAIN STEM; DEFECATION; DIARRHEA; EMOTION; EVOKED CORTICAL RESPONSE; HUMAN; ILEUS; INCONTINENCE; INTESTINE; INTESTINE INNERVATION; MAGNETOENCEPHALOGRAPHY; MOTONEURON NUCLEUS; MYENTERIC PLEXUS; NERVE TRANSECTION; NODOSE GANGLION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SENSORY RECEPTOR; SOLITARY TRACT NUCLEUS; SPINAL CORD TRANSSECTION; SPINAL GANGLION; STOMACH DISTENSION; SWALLOWING; SYMPATHETIC NERVE CELL; VAGUS NERVE;

EID: 0031890006     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70540-2     Document Type: Article

References (155)

1. TP. Almy Historical perspectives of functional bowel disease WJ Snape Pathogenesis of functional bowel disease. 1989 Plenum New York 1 11
2. W. Beaumont Experiments and observations on the gastric juice and the physiology of digestion 1959 Dover New York [Facsimile of the original publication of 1833.]
3. I. Pavlov The work of digestive glands [English translation from Russian by W. H. Thompson.] 1910 Griffin London
4. WB. Cannon The influence of emotional states on the functions of the alimentary canal Am J Med Sci 137 1909 480 487
5. S Wolf HG. Wolff Human gastric function: an experimental study of a man and his stomach 1943 Oxford University New York
6. WE. Whitehead Effects of psychological factors on gastrointestinal function WJ Snape Pathogenesis of functional bowel disease. 1989 Plenum New York 37 53
7. F Creed E. Guthrie Psychological factors in the irritable bowel syndrome Gut 28 1987 1307 1318
8. L Buéno S Collins J-L. Junien Stress and digestive motility. Section II. Experimental approach in humans 1989 Libbey London 63 111
9. JR Wood M Camilleri PA Low JR. Malagelada Brain stem tumor presenting as upper gut motility disorder Gastroenterology 89 1985 1411 1414
10. C Gordon R Langton Hewer DT. Wade Dysphagia in acute stroke Br Med J 295 1987 411 414
11. RD Fealey JH Szurszewski JL Merrit EP. DiMagno Effect of traumatic spinal cord transection on human upper gastrointestinal motility and gastric emptying Gastroenterology 87 1984 69 75
12. BJ Gunterberg I Kewenter I Petersen B. Stener Anorectal function after major resections of the sacrum with bilateral or unilateral sacrifice of sacral nerves Br J Surg 63 1976 546 554
13. DG Thompson HD Ritchie DL. Wingate Patterns of small intestinal motility in duodenal ulcer patients before and following vagotomy Gut 23 1982 517 524
14. LG. Ungerleider Functional brain imaging studies of cortical mechanisms for memory Science 270 1995 769 775
15. DL. Schacter Illusory memories: a cognitive neuroscience analysis Proc Natl Acad Sci USA 24 1996 13527 13733
16. PR Jolles PR Chapman A. Alavi PET, CT and MRI in the evaluation of neuropsychiatric disorders: current applications J Nucl Med 30 1989 1589 1606
17. JD Lewine WW. Orrison Clinical electroencephalography and event-related potentials WW Orrison DF Lewine JA Sanders MF Hartshorne Functional brain imaging. 1995 Mosby–Year Book St. Louis MO 327 368
18. JD Lewine WW. Orrison Magnetoencephalography and magnetic source imaging WW Orrison DF Lewine JA Sanders MF Hartshorne Functional brain imaging. 1995 Mosby–Year Book St. Louis, MO 369 417
19. WW Orrison Jr JD. Lewine Magnetic source imaging in neurosurgical practice Perspect Neurol Surg 4 1993 141 148
20. RA Gillis JA Quest FD Pagini WP. Norman Control centers in the central nervous system for regulating gastrointestinal motility SG Schultz JD Wood BB Rauner Handbook of physiology. 1989 Oxford University New York 621 683 Section 6. The gastrointestinal system
21. DG. Thompson Extrinsic autonomic control of human gastrointestinal transit MA Kamm JE Lennard-Jones Gastrointestinal transit: pathophysiology and pharmacology. 1991 Wrightson Biomedical Petersfield, England 13 20
22. C Roman J. Gonella Extrinsic control of digestive tract motility 2nd ed LR Johnson Physiology of the gastrointestinal tract. 1987 Raven New York 507 553
23. J Christensen DJ. DeClare Comparative anatomy of the oesophagus Gastroenterology 67 1974 407 408
24. KE Matzel RA Schmidt EA. Tanagho Neuroanatomy of the striated muscular anal continence mechanisms. Implications for the use of neurostimulation Dis Colon Rectum 33 1990 666 673
25. JB Furness M. Costa The enteric nervous system 1987 Churchill Livingstone New York
26. MD. Gershon The enteric nervous system Annu Rev Neurosci 4 1981 227 272
27. JD. Wood Physiology of enteric neurons LR Johnson Physiology of the gastrointestinal tract. 1987 Raven New York 1 41
28. M Costa SJH. Brookes The enteric nervous system Am J Gastroenterol 89 1994 S129 S137
29. JN Sengupta GF. Gebhart Gastrointestinal afferent fibres and sensation 3rd ed LJ Johnson Physiology of the gastrointestinal tract. 1994 Raven New York 483 519
30. AS. Paintal Vagal afferent fibres Ergeb Physiol Biol Chem Exp Pharmacol 52 1963 74 156
31. PLR. Andrews Vagal afferent innervation of the gastrointestinal tract Prog Brain Res 67 1986 65 86
32. SM Altschuler X Bao D Bieger DA Hopkins RR. Miselis Viscerotopic representation of the upper alimentary tract in the rat: sensory ganglia and nuclei of the solitary and spinal trigeminal tracts J Comp Neurol 283 1989 248 268
33. SM Altschuler L Rinaman RR. Miselis Viscerotopic representation of the alimentary tract in the dorsal and ventral vagal complexes in the rat S Ritter RC Ritter CD Barnes Neuroanatomy and physiology of abdominal vagal afferents. 1992 CRC Boca Raton, FL 21 53
34. JN Sengupta D Coauvar RK. Goyal Characteristics of vagal esophageal tension—sensitive afferent fibres in the opossum J Neurophysiol 61 1989 1001 1010
35. RK Goyal JN Sengupta JK. Saha Properties of esophageal mechanosensitive receptors GE Holle Advances in the innervation of the gastrointestinal tract. 1992 Elsevier Science New York 523 546
36. A Randich GF. Gebhart Vagal afferent modulation of nociception Brain Res Rev 17 1992 77 99
37. EA Mayer GF. Gebhart Basic and clinical aspects of visceral hyperalgesia Gastroenterology 107 1994 271 293
38. D Bieger DA. Hopkins Viscerotopic representation of the upper alimentary tract in the medulla oblongata in the rat: the nucleus ambiguus J Comp Neurol 262 1987 546 562
39. EA Fox TL. Powley Longitudinal columnar organization within the dorsal motor nucleus represents separate branches of the abdominal vagus Brain Res 341 1985 269 282
40. TL Powley H-R Berthoud EA Fox W. Laughton The dorsal vagal complex forms a sensory-motor lattice: the circuitry of gastrointestinal reflexes S Ritter RC Ritter CD Barnes Neuroanatomy and physiology of abdominal vagal afferents. 1992 CRC Boca Raton, FL 55 79
41. RA Leslie DJM Reynolds INC. Lawes Central connections of the nuclei of the vagus nerve S Ritter RC Ritter CD Barnes Neuroanatomy and physiology of abdominal vagal afferents. 1992 CRC Boca Raton, FL 81 98
42. RC Rogers GE. Hermann Central regulation of brainstem gastric vago-vagal control circuits S Ritter RC Ritter CD Barnes Neuroanatomy and physiology of abdominal vagal afferents. 1992 Boca Raton FL 99 134
43. PE. Sawchenko Central connections of the sensory and motor nuclei of the vagus nerve J Auton Nerv Syst 9 1983 13 26
44. R. Norgren Projections of the nucleus of the solitary tract in the rat Neuroscience 2 1978 207 218
45. I Nadelhaft J Roppolo C Morgan WC. DeGroat Parasympathetic preganglionic neurons and visceral primary afferents in monkey sacral spinal cord revealed following application of horseradish peroxidase to pelvic nerve J Comp Neurol 216 1983 36 52
46. WC DeGroat J. Krier The sacral parasympathetic reflex pathway regulating colonic motility and defecation in the cat J Physiol Lond 276 1978 481 500
47. OR Langworthy SJ. Rosenberg Control by the central nervous system of rectal smooth muscle J Neurophysiol 2 1939 356 360
48. JN. Langley The autonomic nervous system 1921 Heffer Cambridge, England
49. F Cervero RD. Foreman Sensory innervation of the viscera AD Loewy KM Spyer Central regulation of autonomic function. 1990 Oxford University New York 104 125
50. F Cervero LA Connel SN. Lawson Somatic and visceral primary afferents in the lower thoracic dorsal root ganglia of the cat J Comp Neurol 228 1984 422 431
51. W Jänig JFB. Morrison Functional properties of spinal visceral afferents supplying abdominal and pelvic organs, with special emphasis on visceral nociception Prog Brain Res 67 1986 78 114
52. RD Foreman RW Blair RM. Webber Viscerosomatic convergence on T-T spinoreticular, spinoreticular-spinothalamic and spinothalamic tract neurons in the cat Exp Neurol 85 1984 597 619
53. WS Ammons MN Girardot RD. Foreman T2-T5 spinothalamic neurons projecting to medial thalamus with viscerosomatic input J Neurophysiol 54 1985 73 89
54. R Melzack PD. Wall The challenge of pain 1982 Basic Books New York
55. R Melzack KL. Casey Sensory, motivational and central control determinants of pain D Kenshalo The skin senses. 1968 Thomas Springfield, Illinois 423 444
56. PL Gildenberg RM. Hirshberg Limited myelotomy for the treatment of intractable cancer pain J Neurol Neurosurg Psychiatr 47 1984 94 96
57. RP Yezierski RH. Schwartz Response and receptive-field properties of spinomesencephalic tract cells in the cat J Neurophysiol 55 1986 76 96
58. AD. Loewy Central autonomic pathways AD Loewy KM Spyer Central regulation of autonomic function. 1990 Oxford University New York 88 103
59. DF Cechetto CB. Saper Role of cerebral cortex in autonomic function AD Loewy M Spyer Central regulation of autonomic function. 1990 Oxford University New York 208 223
60. JN Sengupta JK Saha RK. Goyal Stimulus-response function studies of esophageal mechanosensitive nociceptors in sympathetic afferents of opossum J Neurophysiol 64 1990 796 812
61. I Euchner-Wamser JN Sengupta GF Gebhart ST. Meller Characterisation of responses of T2-T4 spinal cord neurons to esophageal distension in the rat J Neurophysiol 69 1993 868 883
62. EA Mayer H. Raybould Role of neural control in gastrointestinal motility and visceral pain WJ Snape Pathogenesis of functional bowel disease. 1989 Plenum New York 13 35
63. EA Mayer HE. Raybould Role of visceral afferent mechanisms in functional bowel disorders Gastroenterology 99 1990 1688 1704
64. JB Furness M. Costa Sympathetic influences on gastrointestinal function JB Furness M Costa The enteric nervous system. 1987 Churchill Livingstone Edinburgh 200 238
65. DL Kreulen JH. Szurszewski Reflex pathways in the abdominal prevertebral ganglia; evidence for a colo-colonic inhibitory reflex J Physiol (London) 295 1979 21 32
66. H. Rostad Colonic motility in the cat. IV. Peripheral pathways mediating the effects induced by hypothalamic and mesencephalic stimulation Acta Physiol Scand 89 1973 154 168
67. A. Jean Brainstem control of swallowing: localisation and organisation of the central pattern generator for swallowing A Taylor Neurophysiology of the jaws and teeth. 1990 Macmillan New York 294 321
68. DO. Carpenter Central nervous system mechanisms in deglutition and emesis Motility and circulation JD Wood Handbook of physiology. The gastrointestinal system. Volume 1 1989 American Physiological Society Washington, DC 685 714
69. AJ. Miller Deglutition Physiol Rev 62 1982 129 184
70. A Jean A. Car Input to the swallowing medullary neurons from the peripheral afferent fibres and the swallowing cortical area Brain Res 178 1979 567 572
71. RE Martin BJ. Sessle The role of the cerebral cortex in swallowing Dysphagia 8 1993 195 202
72. PW Nathan MC. Smith Spinal pathways for defecation and sensation from the lower bowel J Neurol Neurosurg 16 1953 245 256
73. S. Nakagawa Onuf's nucleus of the sacral cord in a South American monkey (Saimiri): its location and bilateral cortical input from area 4 Brain Res 191 1980 337 344
74. T Ueyama H Arakawa N. Mizuno Contralateral termination of pudendal nerve fibers in the gracile nucleus of the rat Neurosci Lett 62 1985 113 117
75. H. Fukuda Projections of the afferents from the distal colon onto the cerebral cortex of the dog (abstr) Auton Nerv Syst 16 1978 33
76. KH. Chiappa Principles of evoked potentials KH Chiappa Evoked potentials in clinical medicine. 1983 Raven New York 1 25
77. HH. Jasper The 10-20 electrode system of the international federation Electroencepholog Clin Neurophysiol 10 1958 371 375
78. E Donchin E Callaway R Cooper JE Desmedt WR Goff SA Hillyard S. Saturn Publication criteria for studies of evoked potential (EP) in man. Report of a committee Prog Clin Neurophysiol 1 1977 1 11
79. FH. Duffy Brain electrical activity mapping: issues and answers FH Duffy Topographic mapping of brain electrical activity. 1986 Butterworths New York 401 417
80. FH. Duffy Topographic mapping of brain electrical activity: clinical applications and issues K Maurer Topographic brain mapping of EEG and evoked potentials. 1989 Springer–Verlag Berlin 19 52
81. CC. Wood Application of dipole localization methods to source identification of human evoked potentials Ann NY Acad Sci 388 1982 139 155
82. T Frieling P Enck M. Wienbeck Cerebral responses evoked by electrical stimulation of the esophagus in normal subjects Gastroenterology 97 1989 475 478
83. G Tougas P Hudoba D Fitzpatrick RH Hunt ARM. Upton Cerebral-evoked potential responses following direct vagal stimulation and oesophageal electrical stimulation in humans Am J Physiol 264 1993 G486 G491
84. O Frøbert L Arendt-Nielsen P Bak OK Anderson P Funch-Jensen JP. Bagger Electrical stimulation of the esophageal mucosa. Perception and brain evoked potentials Scand J Gastroenterol 29 1994 776 781
85. O Frøbert L Arendt-Nielsen P Bak P Funch-Jensen JP. Bagger Oesophageal sensation assessed by electrical stimuli and brain evoked potentials—a new model for visceral nociception Gut 37 1995 603 609
86. CH Sollenbohmer P Enck D Haussinger T. Frieling Electrically evoked cerebral potentials during esophageal distension at perception and pain threshold Am J Gastroenterol 91 1996 970 975
87. PI Collman L Tremblay NE. Diamant The distribution of spinal and vagal sensory neurons that innervate the esophagus of the cat Gastroenterology 103 1992 817 822
88. DO Castell JD Wood T Freiling FS Wright RF. Vieth Cerebral electrical potentials evoked by balloon distention of the human esophagus Gastroenterology 98 1990 662 666
89. AJPM Smout MS Devore DO. Castell Cerebral potentials evoked by oesophageal distension in humans Am J Physiol 259 1990 G955 G959
90. KR DeVault S Beacham LJ Streletz DO. Castell Cerebral evoked potentials: a method of quantification of central nervous system response to esophageal pain Dig Dis Sci 38 1993 2241 2246
91. BL Weusten H Lam L Akkermanns G Van Berge-Hennebouwen AJ. Smout Influence of age on cerebral potentials evoked by esophageal distension in humans Eur J Clin Invest 24 1994 627 631
92. BL Weusten H Franssen GH Wieneke AJ. Smout Multichannel recording of cerebral potentials evoked by esophageal balloon distension in humans Dig Dis Sci 39 1994 2074 2083
93. H Franssen B.LAM Weusten GH Wieneke AJPM Smout Source modeling of esophageal evoked potentials Electroencephalogr Clin Neurophysiol 100 1996 85 95
94. Q Aziz PL Furlong J Barlow A Hobson S Alani J Bancewicz M Ribbands GFA Harding DG. Thompson Topographic mapping of cortical potentials evoked by distension of the human proximal and distal oesophagus Electroencephalog Clin Neurophysiol 96 1995 219 228
95. AJP Smout MS DeVore CB Dalton DO. Castell Cerebral potentials evoked by oesophageal distension in patients with non-cardiac chest pain Gut 33 1992 298 302
96. KR DeVault S Beacham DO Castell LJ Streletz JF. Ditunno Esophageal sensation in spinal cord–injured patients: balloon distension and cerebral evoked potential recording Am J Physiol 271 1996 G937 G941
97. J Christensen GF. Lund Esophageal responses to distension and electrical stimulation J Clin Invest 48 1969 408 419
98. MM Mesulam EF. Mufson The insula of Reil in man and monkey. Architectonics, connectivity and function A Peters EG Jones Cerebral cortex. 1985 Plenum New York 179 226
99. O Frobert L Arendt-Nielsen P Bak P Funch-Jensen J. Peder Bagger Pain perception and brain evoked potentials in patients with angina despite normal coronary angiograms Heart 75 1996 436 441
100. RE Clouse RM. Carney The psychological profile of non-cardiac chest pain patients Eur J Gastroenterol Hepatol 12 1995 1160 1165
101. W Rathmann P Enck T Frieling FA. Gries Visceral afferent neuropathy in diabetic gastroparesis Diabetes Care 14 1991 1086 1089
102. P Meunier L Collet R Ducleaux S. Chéry-Croze Endorectal cerebral potentials in humans Int J Neurosci 37 1987 193 196
103. T Frieling P Enck M. Wienbeck Cerebral responses evoked by electrical stimulation of rectosigmoid in normal subjects Dig Dis Sci 34 1989 202 205
104. V Loening-Baucke NW Read T. Yamada Cerebral evoked potentials after rectal stimulation Electroencephalogr Clin Neurophysiol 80 1991 490 495
105. V Loening-Baucke NW Read T. Yamada Further evaluation of the afferent nervous pathways from the rectum Am J Physiol 262 1992 G927 G933
106. P Delechenault AM Leroi T Bruna P Denis J. Weber Cerebral potentials evoked by electrical stimulation of the anal canal Dis Colon Rectum 36 1993 55 56
107. L Collet P Meunier R Duclaux S Chery-Croze P. Falipou Cerebral evoked potentials after endorectal mechanical stimulations in humans Am J Physiol 254 1988 G477 G482
108. V Loening-Baucke T. Yamada Cerebral potentials evoked by rectal distension in humans Electroencephalogr Clin Neurophysiol 88 1993 447 452
109. V Loening-Baucke T. Yamada Is the afferent pathway from the rectum impaired in children with chronic constipation and encopresis Gastroenterology 109 1995 397 403
110. CTM Speakman MA Kamm M. Swash Rectal sensory evoked potentials: as assessment of their clinical value Int J Colorect Dis 8 1993 23 28
111. SJ Williamson Z-L Lü D Karron L. Kuafman Advantages and limitations of magnetic source imaging Brain Topogr 4 1991 169 180
112. CC Gallen EC Hirschkoff DC. Buchanan Magnetoencephalography and magnetic source imaging. Capabilities and limitations Funct Neuroimaging 5 1995 227 249
113. PL Furlong Q Aziz KD Singh DG Thompson A Hobson GFA. Harding Cortical localization of magnetic fields evoked by esophageal distension Electroencephalogr Clin Neurophysiol 1997 (in press)
114. A Schnitzler J Volkmann P Enck T Frieling H-J Friend OW. White Cortical representation of visceral and somatic sensation in humans Soc Neurosci Abstr 22 1996 50.13
115. MF. Hartshorne Positron emission tomography WW Orrison JD Lewine JA Sanders MF Hartshorne Functional brain imaging 1995 187 212
116. CJ. Aine A conceptual overview and critique of functional neuroimaging in humans. I. MRI/fMRI and PET Crit Rev Neurobiol 9 1995 229 309
117. ME. Raichle Circulatory and metabolic correlates of brain function in normal humans Section 1. The nervous system Higher functions of the brain VB Mountcastle F Plumand SR Geiger Handbook of physiology. Volume V 1987 American Physiological Society Washington, DC 643 673
118. J-C. Hsieh Central processing of pain. Functional brain imaging studies with PET. PhD Thesis 1995 Stockholm University, Sweden ISBN:91-628-1722-1
119. Q Aziz J Andersson S Valind A Sundin S Hamdy AKP Jones ER Foster B Langstrom DG. Thompson Identification of human brain loci processing esophageal sensation using positron emission tomography Gastroenterology 113 1997 50 60
120. JD Talbot S Marrett AC Evans E Meyer MC Bushnell GH. Duncan Multiple representations of pain in human cerebral cortex Science 251 1991 1355 1358
121. DHS Silverman JA Munakata H Ennes MA Mandelkern CK Hon EA. Mayer Regional cerebral activity in normal and pathological perception of visceral pain Gastroenterology 112 1997 64 72
122. J Munakata DHS Silvermann CK Hoh MA Mandelkern W Blahd EA. Mayer Rectosigmoid sensitization correlates with thalamic response to rectal pain: an O-15-water PET study of normal subjects and IBS patients (abstr) Gastroenterology Suppl 1996 A720
123. EA Mayer J Munakata M Mandelkern K Hoh A Kodner B Naliboff DHS. Silvermann Correlation of cortical and subcortical brain activation with autonomic responses to rectal stimuli in humans (abstr) Gastroenterology Suppl 1996 A715
124. S Morley V. Pallin Scaling the affective domain of pain: a study of the dimensionality of verbal descriptors Pain 62 1995 39 49
125. JA Sanders WW. Orrison Functional magnetic resonance imaging WW Orrison DF Lewine JA Sanders MF Hartshorne Functional brain imaging. 1995 Mosby–Year Book, St. Louis, MO 239 326
126. JV Hajnal R Myers A Oatridge JE Schwieso IR Young GM. Bydder Artifacts due to stimulus correlated motion in functional imaging of the brain Magn Reson Med 31 1994 283 291
127. M Kern RC Arndorfer A Jesmanowicz L Estkowski J Hyde R. Shaker Proximal and distal esophageal viscero sensation have different cerebral cortical activity regions and characteristics (abstr) Gastroenterology Suppl 1996 693
128. D Hughes APK Jones L. Robinson Q Aziz S Hamdy DG. Thompson Functional MRI at one tesla: localisation of the cortical centres for oesophageal function Neuroradiol Abstr 37 1995 164
129. R Shaker M Kern RC Arndorfer A Jesmanowicz J. Hyde Cerebral cortical FMRI responses to esophageal acid exposure and distension: a comparative study (abstr) Gastroenterology Suppl 1996 A395
130. F Binkofski A Schnitzler P Enck S Posse T Frieling Q Aziz HW Muller-Gartner HJ. Freund Stimulation of the esophagus activates secondary somatosensory and insular cortex: a fMRI study (abstr) Neuroimage 5 1997 S205
131. AT Barker R Jalinous IL. Freestone Non-invasive magnetic stimulation of the human motor cortex Lancet 1 1985 1106 1107
132. AT Barker IL Freestone R Jalinous JA. Jarrat Magnetic stimulation of the human brain and peripheral nervous system: an introduction and the results of an initial clinical evaluation Neurosurgery 20 1987 100 109
133. JC Rothwell PD Thompson BL Day S Boyd CD. Marsden Stimulation of the human motor cortex through the scalp Exp Physiol 76 1991 159 200
134. M. Faraday Experimental research in electricity Quaritch 1 1839 1 15
135. R. Jalinous Technical and practical aspects of magnetic nerve stimulation J Clin Neurophysiol 8 1991 10 25
136. WJ Levy VE Amassian UD Schmid CA. Jungries Mapping of motor cortex gyral sites non-invasively by transcranial magnetic stimulation in normal subjects and patients Electroencephalogr Clin Neurophysiol Suppl 43 1991 51 75
137. Q Aziz JC Rothwell S Hamdy J Barlow DG. Thompson The topographic representation of esophageal motor function on the human cerebral cortex Gastroenterology 111 1996 855 862
138. S Hamdy Q Aziz JC Rothwell KD Singh J Barlow DG Hughes RC Tallis DG. Thompson The cortical topography of human swallowing musculature in health and disease Nat Med 2 1996 1217 1224
139. KD Singh S Hamdy Q Aziz DG. Thompson Topographic mapping of transcranial magnetic stimulation data on surface rendered MR images of the brain Electroencephalogr Clin Neurophysiol 105 1997 345 351
140. S. Bridgers The safety of transcranial magnetic stimulation reconsidered: evidence regarding cognitive and other cerebral effects Electroencephalogr Clin Neurophysiol Suppl 43 1991 170 179
141. Q Aziz JC Rothwell J Barlow A Hobson S Alani J Bancewicz DG. Thompson Esophageal myoelectric responses to magnetic stimulation of the human cortex and the extra-cranial vagus nerve Am J Physiol 267 1994 G827 G835
142. Q Aziz JC Rothwell J Barlow DG. Thompson Modulation of oesophageal responses to magnetoelectric stimulation of the human brain by swallowing and by vagal stimulation Gastroenterology 109 1995 1437 1445
143. NE. Diamant A glimpse at the central mechanism for swallowing Gastroenterology 109 1995 1700 1702
144. NE. Diamant Firing up the swallowing mechanism Nat Med 2 1996 1190 1191
145. GF Rossi A. Brodal Corticofugal fibres to the brain-stem reticular formation. An experimental study in the cat J Anat 90 1956 42 62
146. F. Walberg Do the motor nuclei of cranial nerves receive corticofugal fibers? An experimental study in cat Brain 80 1957 597 605
147. S Hamdy Q Aziz JC. Rothwell A Hobson J Barlow DG. Thompson Cranial nerve modulation of human cortical swallowing motor pathways Am J Physiol 272 1997 G802 G808
148. JA Robbins RL Levine A Maser JC Rosenbek GB. Kempster Swallowing after unilateral stroke of the cerebral cortex Arch Phys Med Rehab 74 1993 1295 1300
149. S Hamdy R Crone Q Aziz JC Rothwell RC Tallis DG. Thompson Does dysphagia in unilateral hemispheric stroke depend on cerebral asymmetry of swallowing motor function (abstr)? J Physiol 491 1996 118P
150. S Hamdy Q Aziz R Crone JC Rothwell DG Hughes RC Tallis DG. Thompson Explaining oropharyngeal dysphagia after unilateral hemispheric stroke Lancet 350 1997 686 692
151. C Ertekin MV Hansen LE Larsson R. Sjödahl Examination of the descending pathway to the external anal sphincter and pelvic floor muscles by transcranial cortical stimulation Electroencephalogr Clin Neurophysiol 75 1990 500 510
152. J Herdmann K Bielefeldt P. Enck Quantification of motor pathways to the pelvic floor in humans Am J Physiol 260 1991 G720 G723
153. GK Turnbull Q Aziz S Hamdy J Barlow K Singh S Alani DG. Thompson Representation of the anal sphincter on the human cerebral cortex (abstr) Gut 35 1994 S30
154. J Herdmann P Enck P Zacchi-Deutschbein U. Ostermann Speed and pressure characteristics of external anal sphincter contractions Am J Physiol 32 1995 G225 G231
155. KJ Moriarty AM. Dawson Functional abdominal pain: further evidence that the whole gut is affected Br Med J 284 1982 1670 1672