Capsaicin sensitivity and voltage-gated sodium currents in colon sensory neurons from rat dorsal root ganglia

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 277, Issue 6 40-6, 1999, Pages

  Su, Xin ^a   Wachtel, Ruth E ^a,b   Gebhart, G F ^a  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Bradykinin; Prostaglandin E2; Serotonin; Tetrodotoxin; Visceral pain

Indexed keywords

CAPSAICIN;

ACTION POTENTIAL; ANALGESIC ACTIVITY; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CELL MEMBRANE DEPOLARIZATION; COLON; CONTROLLED STUDY; DRUG SENSITIVITY; ION CONDUCTANCE; MALE; NERVE CONDUCTION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SODIUM CURRENT; SPINAL GANGLION;

EID: 0033392458     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1999.277.6.g1180     Document Type: Article

References (43)

1. Akopian, A. N., L. Sivilotti, and J. N. Wood. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 379: 257-262, 1996.
2. Arbuckle, J. B., and R. J. Docherty. Expression of tetrodotoxin-resistant sodium channels in capsaicin-sensitive dorsal root ganglion neurons of adult rats. Neurosci. Lett. 185: 70-73, 1995.
3. Bevan, S. J., and R. J. Docherty. Cellular mechanisms of the action of capsaicin. In: Capsaicin in the Study of Pain, edited by John N. Wood. San Diego, CA: Academic, 1993, p. 27-44.
4. Bevan, S. J., and J. Szolcsányi. Sensory neuron-specific actions of capsaicin: mechanisms and applications. Trends Pharmacol. Sci. 11: 330-333, 1990.
5. Bleakman, D., J. R. Brorson, and R. J. Miller. The effect of capsaicin on voltage-gated calcium currents and calcium signals in cultured dorsal root ganglion cells. Br. J. Pharmacol. 101: 423-431, 1990.
6. Caffrey, J. M., D. L. Eng, J. A. Black, S. G. Waxman, and J. D. Kocsis. Three types of sodium channels in adult rat dorsal root ganglion neurons. Brain Res. 592: 283-297, 1992.
7. 4 receptors couple positively to tetrodotoxin-insensitive sodium channels in a subpopulation of capsaicin-sensitive rat sensory neurons. J. Neurosci. 17: 7181-7189, 1997.
8. Caterina, M. J., M. A. Schumacher, M. Tominaga, T. A. Rosen, J. D. Levine, and D. Julius. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389: 816-824, 1997.
9. Docherty, R. J., B. Robertson, and S. Bevan. Capsaicin causes prolonged inhibition of voltage-activated calcium currents in adult rat dorsal root ganglion neurons in culture. Neuroscience 40: 513-521, 1991.
10. Dray, A. Neuropharmacological mechanisms of capsaicin and related substances. Biochem. Pharmacol. 44: 611-615, 1992.
11. Dray, A. Therapeutic potential of capsaicin-like molecules. Mechanism of action of capsaicin-like molecules on sensory neurons. Life Sci. 51: 1759-1765, 1992.
12. Elliott, A. A., and J. R. Elliott. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia. J. Physiol (Lond.) 463: 39-56, 1993.
13. 2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic-AMP-protein kinase A cascade. J. Physiol. (Lond.) 495: 429-440, 1996.
14. Gold, M. S., S. Dastmalchi, and J. D. Levine. Co-expression of nociceptor properties in dorsal root ganglion neurons from the adult rat in vitro. Neuroscience 71: 265-275, 1996.
15. + current in nociceptors. Proc. Natl. Acad. Sci. USA 93: 1108-1112, 1996.
16. Goso, C., S. Evangelista, M. Tramontana, S. Manzini, P. M. Blumberg, and A. Szallasi. Topical capsaicin administration protects against trinitrobenzene sulfonic acid-induced colitis in the rat. Eur. J. Pharmacol. 249: 185-190, 1993.
17. Grosskreutz, J., S. Quasthoff, M. Kühn, and P. Grafe. Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmyelinated C fibres of biopsied human sural nerve in vitro. Neurosci. Lett. 208: 49-52, 1996.
18. Heyman, I., and H. P. Rang. Depolarizing responses to capsaicin in a subpopulation of rat dorsal root ganglion cells. Neurosci. Lett. 56: 69-75, 1985.
19. Holzer, P. Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol. Rev. 43: 143-201, 1991.
20. Hu-Tsai, M., J. Winter, and C. J. Woolf. Regional differences in the distribution of capsaicin-sensitive target-identified adult rat dorsal root ganglion neurons. Neurosci. Lett. 143: 251-254, 1992.
21. Ikeda, S. R., and G. G. Schofield. Tetrodotoxin-resistant sodium current of rat nodose neurones: monovalent cation selectivity and divalent cation block. J. Physiol. (Lond.) 389: 255-270, 1987.
22. Kostyuk, P. G., N. S. Veselovsky, and A. Y. Tsyndrenko. Ionic currents in the somatic membrane of rat dorsal root ganglion neurons. I. Sodium currents. Neuroscience 12: 2423-2430, 1981.
23. Kress, M., and P. W. Reeh. Chemical excitation and sensitization in nociceptors. In: Neurobiology of Nociceptors, edited by C. Belmonte and F. Cervero. Oxford, UK: Oxford University Press, 1996, p. 258-297.
24. 2+ dependence in rat trigeminal ganglion cells. J. Neuropkysiol. 75: 1503-1514, 1996.
25. Liu, L., Y. Wang, and S. A. Simon. Capsaicin activated currents in rat dorsal root ganglion cells. Pain 64: 191-195, 1996.
26. Marsh, S. J., C. E. Stansfeld, D. A. Brown, R. Davey, and D. McCarthy. The mechanism of action of capsaicin on sensory C-type neurons and their axons in vitro. Neuroscience 23: 275-289, 1987.
27. McLean, M. J., P. B. Bennett, and R. M. Thomas. Subtypes of dorsal root ganglion neurons based on different inward currents as measured by whole-cell voltage clamp. Mol. Cell. Biochem. 80: 95-107, 1988.
28. + channels in neurons of the rat dorsal root ganglia. Dev. Brain Res. 65: 93-100, 1992.
29. + channels in neurons of rat dorsal root ganglia. J. Membr. Biol. 129: 71-80, 1992.
30. + channels in rat dorsal root ganglia. J. Physiol. (Lond.) 466: 9-37, 1993.
31. Petersen, M., and R. H. LaMotte. Relationships between capsaicin sensitivity of mammalian sensory neurons, cell size and type of voltage gated Ca-currents. Brain Res. 561: 20-26, 1991.
32. Petersen, M., F.-K. Pierau, and M. Weyrich. The influence of capsaicin on membrane currents in dorsal root ganglion neurones of guinea-pig and chicken. Pflügers Arch. 409: 403-410, 1987.
33. Roy, M. L., and T. Narahashi. Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. J. Neurosci. 12: 2104-2111, 1992.
34. Roy, M. L., E. Reuveny, and T. Narahashi. Single-channel analysis of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. Brain Res. 650: 341-346, 1994.
35. Sangameswaran L., L. M. Fish, B. D. Koch, D. K. Rabert, S. G. Delgado, M. Ilnicka, L. B. Jakeman, S. Novakovic, K. Wong, P. Sze, E. Tzoumaka, G. R. Stewart, R. C. Herman, H. Chan, R. M. Eglen, and J. C. Hunter. A novel tetrodotoxin-sensitive sodium channel expressed in rat and human dorsal root ganglia. J. Biol. Chem. 272: 14805-14809, 1997.
36. Sengupta, J. N., and G. F. Gebhart. Characterization of mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat. J. Neurophysiol. 71: 2046-2060, 1994.
37. Su, X., and G. F. Gebhart. Mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat are polymodal in character. J. Neurophysiol. 80: 2632-2644, 1998.
38. Su, X., R. E. Wachtel, and G. F. Gebhart. Inhibition of calcium currents in rat colon sensory neurons by κ- but not μ- or δ-opioids. J. Neurophysiol. 80: 3112-3119, 1998.
39. Vlachová, V., and L. Vyklický. Capsaicin-induced membrane currents in cultured sensory neurons of the rat. Physiol. Res. 42: 301-311, 1993.
40. Winter, J. Characterization of capsaicin-sensitive neurones in adult rat dorsal root ganglion cultures. Neurosci. Letters 80: 134-140, 1987.
41. Winter, J., S. Bevan, and E. A. Campbell. Capsaicin and pain mechanisms. Brit. J. Anaesth. 75: 157-168, 1995.
42. Winter, J., A. Dray, J. N. Wood, J. C. Yeats, and S. Bevan. Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin. Brain Res. 520: 131-140, 1990.
43. Wood, J. N., J. Winter, I. F. James, H. P. Rang, J. Yeats, and S. Bevan. Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture. J. Neurosci. 8: 3208-3220, 1988.