Exogenous leptin inhibits the secretion of pancreatic juice via a duodenal CCK1-vagal-dependent mechanism in anaesthetized rats

Regulatory Peptides

Volumn 114, Issue 1, 2003, Pages 15-20

  Matyjek, R ^a   Herzig, K H ^b   Kato, S ^c   Zabielski, R ^a  

^a KIELANOWSKI INSTITUTE OF ANIMAL PHYSIOLOGY AND NUTRITION   (Poland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c RAKUNO GAKUEN UNIVERSITY   (Japan)

Author keywords

Capsaicin; CCK8; Enzyme secretion; Leptin; Vagotomy

Indexed keywords

AMYLASE; BILE ACID; CAPSAICIN; CHOLECYSTOKININ; CHOLECYSTOKININ OCTAPEPTIDE; CHOLECYSTOKININ RECEPTOR; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; LEPTIN; M PROTEIN; TRYPSIN;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BOLUS INJECTION; CANNULATION; DOSE RESPONSE; DRUG INJECTION VOLUME; DUODENUM; IN VITRO STUDY; MALE; NONHUMAN; PANCREAS ACINUS; PANCREAS JUICE; PANCREAS SECRETION; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; RECEPTOR BLOCKING; STIMULATION; VAGOTOMY; VAGUS NERVE STIMULATION; VATER PAPILLA;

EID: 0038403615     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(03)00064-8     Document Type: Article

References (35)

1. Frederich R.C., Lollmann B., Hamann A., Napolitano-Rosen A., Kahn B.B., Lowell B.B.et al. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J. Clin. Invest. 96:1995;1658-1663.
2. Masuzaki H., Ogawa Y., Sagawa N., Hosoda K., Matsumoto T., Mise H.et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat. Med. 3:1997;1029-1033.
3. Bado A., Levasseur S., Attoub S., Kermorgant S., Laigneau J.P., Bortoluzzi M.N.et al. The stomach is a source of leptin. Nature. 394:1998;790-793.
4. Sobhani I., Bado A., Vissuzaine C., Buyse M., Kermorgant S., Laigneau J.P.et al. Leptin secretion and leptin receptor in the human stomach. Gut. 47:2000;178-183.
5. Mix H., Widjaja A., Jandl O., Cornberg M., Kaul A., Goke M.et al. Expression of leptin and leptin receptor isoforms in the human stomach. Gut. 47:2000;481-486.
6. Morton N.M., Emilsson V., Liu Y.L., Cawthorne M.A. Leptin action in intestinal cells. J. Biol. Chem. 273:1998;26194-26201.
7. Lostao M.P., Urdaneta E., Martinez-Anso E., Barber A., Martinez J.A. Presence of leptin receptors in rat small intestine and leptin effect on sugar absorption. FEBS Lett. 423:1998;302-306.
8. Kieffer T.J., Heller R.S., Habener J.F. Leptin receptors expressed on pancreatic beta-cells. Biochem. Biophys. Res. Commun. 224:1996;522-527.
9. Harris D.M., Flannigan K.L., Go V.L., Wu S.V. Regulation of cholecystokinin-mediated amylase secretion by leptin in rat pancreatic acinar tumor cell line AR42J. Pancreas. 19:1999;224-230.
10. Jaworek J., Bonior J., Leja-Szpak A., Nawrot K., Kot M., Tomaszewszka R.et al. Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin. J. Physiol. Pharmacol. 53:2002;51-74.
11. Brzozowski T., Konturek P.C., Konturek S.J., Pajdo R., Duda A., Pierzchalski P.et al. Leptin in gastroprotection induced by cholecystokinin or by a meal. Role of vagal and sensory nerves and nitric oxide. Eur. J. Pharmacol. 374:1999;263-276.
12. Yuan C.S., Attele A.S., Wu J.A., Zhang L., Shi Z.Q. Peripheral gastric leptin modulates brain stem neuronal activity in neonates. Am. J. Physiol. 277:1999;G626-G630.
13. Konturek P.C., Brzozowski T., Sulekova Z., Meixner H., Hahn E.G., Konturek S.J. Enhanced expression of leptin following acute gastric injury in rat. J. Physiol. Pharmacol. 50:1999;587-595.
14. Seufert J., Kieffer T.J., Habener J.F. Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice. Proc. Natl. Acad. Sci. U. S. A. 96:1999;674-679.
15. Konturek S.J., Konturek J.W. Cephalic phase of pancreatic secretion. Appetite. 34:2000;197-205.
16. Li Y., Owyang C. Pancreatic secretion evoked by cholecystokinin and non-cholecystokinin-dependent duodenal stimuli via vagal afferent fibres in the rat. J. Physiol. 494:1996;773-782.
17. Zabielski R., Lesniewska V., Borlak J., Gregory P.C., Kiela P., Pierzynowski S.G.et al. Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves. Regul. Pept. 78:1998;113-123.
18. Deng X., Whitcomb D.C. Neurohormonal control of the exocrine pancreas. Curr. Opin Gastroenterol. 14:1998;362-368.
19. Nemecz M., Preininger K., Englisch R., Furnsinn C., Schneider B., Waldhausl W.et al. Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver. Hepatology. 29:1999;166-172.
20. Jaworek J., Bonior J., Tomaszewska R., Jachimczak B., Kot M., Bielanski W.et al. Involvement of cyclooxygenase-derived prostaglandin E2 and nitric oxide in the protection of rat pancreas afforded by low dose of lipopolysaccharide. J. Physiol. Pharmacol. 52:2001;107-126.
21. Pierzynowski S.G., Westrom B.R., Svendsen J., Karlsson B.W. Development of exocrine pancreas function in chronically cannulated pigs during 1-13 weeks of postnatal life. J. Pediatr. Gastroenterol. Nutr. 10:1990;206-212.
22. Williams J.A., Korc M., Dormer R.L. Action of secretagogues on a new preparation of functionally intact, isolated pancreatic acini. Am. J. Physiol. 235:1978;E517-E524.
23. Wang Y.H., Tache Y., Sheibel A.B., Go V.L., Wei J.Y. Two types of leptin-responsive gastric vagal afferent terminals: an in vitro single-unit study in rats. Am. J. Physiol. 273:1997;R833-R837.
24. Gaige S., Abysique A., Bouvier M. Effects of leptin on cat intestinal vagal mechanoreceptors. J. Physiol. 543:2002;679-689.
25. Buyse M., Ovesjo M.L., Goiot H., Guilmeau S., Peranzi G., Moizo L.et al. Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve. Eur. J. Neurosci. 14:2001;64-72.
26. Burdyga G., Spiller D., Morris R., Lal S., Thompson D.G., Saeed S.et al. Expression of the leptin receptor in rat and human nodose ganglion neurones. Neuroscience. 109:2002;339-347.
27. Barrachina M.D., Martinez V., Wang L., Wei J.Y., Tache Y. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc. Natl. Acad. Sci. U. S. A. 94:1997;10455-10460.
28. Ahima R.S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E.et al. Role of leptin in the neuroendocrine response to fasting. Nature. 382:1996;250-252.
29. Hardie L.J., Rayner D.V., Holmes S., Trayhurn P. Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem. Biophys. Res. Commun. 223:1996;660-665.
30. Sinha M.K., Ohannesian J.P., Heiman M.L., Kriauciunas A., Stephens T.W., Magosin S.et al. Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J. Clin. Invest. 97:1996;1344-1347.
31. Guilmeau S., Nagain-Domaine C., Buysse M., Tsocas A., Roze C., Bado A. Modulation of exocrine pancreatic secretion by leptin through CCK1-receptors and afferent vagal fibres in the rat. Eur. J. Pharmacol. 447:2002;99-107.
32. Kulkarni R.N., Wang Z.L., Wang R.M., Hurley J.D., Smith D.M., Ghatei M.A.et al. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J. Clin. Invest. 100:1997;2729-2736.
33. Fehmann H.C., Berghofer P., Brandhorst D., Brandhorst H., Hering B., Bretzel R.G.et al. Leptin inhibition of insulin secretion from isolated human islets. Acta Diabetol. 34:1997;249-252.
34. Poitout V., Rouault C., Guerre-Millo M., Briaud I., Reach G. Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans. Endocrinology. 139:1998;822-826.
35. Pralong F.P., Roduit R., Waeber G., Castillo E., Mosimann F., Thorens B.et al. Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. Endocrinology. 139:1998;4264-4268.