Sensitivity of vagal mucosal afferents to cholecystokinin and its role in afferent signal transduction in the rat

Journal of Physiology

Volumn 497, Issue 2, 1996, Pages 473-481

  Richards, W ^a,c   Hillsley, K ^b   Eastwood, C ^a   Grundy, D ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR; DEVAZEPIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; EXTRACELLULAR FLUID; HORMONE RELEASE; INTESTINE INNERVATION; MALE; MESENTERY; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SIGNAL TRANSDUCTION; SMALL INTESTINE; SMALL INTESTINE MUCOSA; VAGOTOMY; VAGUS NERVE;

EID: 0029989404     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021781     Document Type: Article

References (27)

1. BERTHOUD, H. R., KRESSEL, M., RAYBOULD, H. E. & NEUHUBER, W. L. (1995). Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by in vivo Dil-tracing. Anatomy and Embryology 191, 203-212.
2. 8) on two classes of gastroduodenal vagal afferent fibre. Journal of lhe Autonomic. Nervous System 31, 191-202.
3. CALINGASAN, N., RITTER, S., RITTER, R. & BRENNER, L. (1992). Low-dose near-celiac arterial cholecystokinin suppresses food intake in rats. American Journal of Physiology 263, R572-577.
4. CERVERO, F. & SHARKEY, K. A. (1988). An electrophysiological and anatomical study of intestinal afferent fibres in the rat. Journal of Physiology 401, 381-397.
5. COTTRELL, D. F. & IGGO, A. (1984). Mucosal enteroceptors with vagal afferent fibres in the proximal duodenum of sheep. Journal of Physiology 354, 497-522.
6. DAVISON, J. S. & CLARKE, G. D. (1988). Mechanical properties and sensitivity to CCK of vagal gastric slowly adapting mechano-receptors. American Journal of Physiology 255, G55-61.
7. FORSTER, E. R., GREEN, T., ELLIOT, M., BREMNER, A. & DOCKRAY, G. J. (1990). Gastric emptying in rats: role of afferent neurons and cholecystokinin. American Journal of Physiology 258, G552-556.
8. GORES, G. J., LARUSSO, N. F. & MILLER, L. J. (1986). Hepatic processing of cholecystokinin peptides. I. Structural specificity and mechanisms of hepatic extraction. American Journal of Physiology 250, G344-349.
9. GRUNDY, D., BAGAEV, V. & HILLSLEY, K. (1995). Inhibition of gastric mechanoreceptor discharge by cholecystokinin in the rat. American Journal of Physiology 268, G355-360.
10. GRUNDY, D. & SCRATCHERD, T. (1989). Sensory afferents from the gastrointestinal tract. In American Handbook of Physiology, vol. I, part I, Motility and Circulation, ed. WOODS, J., pp. 593-620. Oxford University Press, New York.
11. KURAMOTO, H. & FURNESS, J. B. (1989). Distribution of enteric nerve cells that project from the small intestine to the coeliac ganglion in the guinea-pig. Journal of the Autonomic Nervous System 27, 241-248.
12. LI, Y. & OWYANG, C. (1993). Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion. Journal of Clinical Investigation 92, 418-424.
13. MORAN, T. H., SMITH, G. P., HOSTETLER, A. M. & MCHUGH, P. R. (1987). Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches. Brain Research 415, 149-152.
14. RAYBOULD, H. E. & DAVISON, J. S. (1989). Perivagal application of capsaicin abolishes the response of vagal gastric mechanoreceptors to cholecystokinin. Society of Neuroscience Abstracts 15, 973.
15. RAYBOULD, H. E. & TACHE, Y. (1988). Cholecystokinin inhibits gastric motility and emptying via a capsaicin-sensitive vagal pathway in rats. American Journal of Physiology 255, G242-246.
16. REIDELBERGER, R. D. (1992). Abdominal vagal mediation of the satiety effects of exogenous and endogenous cholecystokinin in rats. American Journal of Physiology 263, R1354-1358.
17. REIDELBERGER, R. D. & O'ROURKE, M. F. (1989). Potent cholecystokinin antagonist L364,718 stimulates food intake in rats. American Journal of Physiology 257, R1512-1518.
18. REIDELBERGER, R. D., VARGA, G., LIEHR, R.-M., CASTELLANOS, D. A., ROSENQUIST, G. L., WONG, H. C. & WALSH, J. H. (1994). Cholecystokinin suppresses food intake by a nonendocrine mechanism in rats. American Journal of Physiology 267, H901-908.
19. SCHWARTZ, G. J., MCHUGH, P. R. & MORAN, T. H. (1991). Integration of vagal afferent responses to gastric loads and cholecystokinin in rats. American Journal of Physiology 261, R64-69.
20. SCHWARTZ, G. J., MCHUGH, P. R. & MORAN, T. H. (1993). Gastric loads and cholecystokinin synergistically stimulate rat gastric vagal afferents. American Journal of Physiology 265, R872-876.
21. SCHWARTZ, G. J. & MORAN, T. H. (1996). Sub-diaphragmatic vagal afferent integration of meal-related gastrointestinal signals. Neuorscience and Biobehavioural Reviews 20, 47-56.
22. SHILLABEER, G. & DAVISION, J. S. (1987). Proglumide, a cholecystokinin antagonist, increases gastric emptying in rats. American Journal of Physiology 252, R353-360.
23. SMITH, G. P., JEROME, C., CUSHIN, B. J., ETERNO, R. & SIMANSKY, K. J. (1981). Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat. Science 213, 1036-1037.
24. SZURSZEWSKI, J. H. (1989). Colonic mechanosensory afferent fibres to prevertebral ganglion cells. In Nerves and the Gastrointestinal Tract, Falk Symposium 50, ed. SINGER, M. V. & GOEBELL, H., pp. 243-252. Kluwer Academic Publishers, Lancaster, UK.
25. TAMURA, C. & RITTER, R. C. (1991). Transient, selective attenuation of oleate and CCK-induced suppression of sham feeding by intra-intestinal capsaicin infusion. Society of Neuroscience Abstracts 17, 542.
26. WANG, L. M., LI, Y. & OWYANG, C. (1994). Gastroduodenal mucosal vagal afferent fibers mediate physiological action of cholecystokinin on pancreatic secretion. Gastroenterology 106, A849.
27. WELLER, A., SMITH, G. & GIBBS, J. (1990). Endogenous cholecystokinin reduces feeding in young rats. Science 247, 1589-1591.